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| 1 | Mechanisms responsible for propoxur resistance in the German cockroach,Blattella germanica(L)显示文摘 | J G S cot | 1991 | Pestic Sci1991，33，： | 1 |
| 2 | Long-term effects of neonatal hypoglycemia on brain growth and psychomotor deve|opment in small-for-gestational-age preterm infants显示文摘 | Duvanel C B Fawer C L Cotting J | 1999 | J pediatr1999，134，4： | 1 |
| 3 | Estimation of wind energy over roof of two perpendicular buildings显示文摘 | B Wang L D Cot L Adolphe | 2015 | Energy and Buildings2015，88，： | 1 |
| 4 | Targeting γ-secretase triggers the selective enrichment of oligomeric APP-CTFs in brain extracellular vesicles from Alzheimer cell and mouse models显示文摘Background:We recently demonstrated an endolysosomal accumulation of theβ-secretase-derived APP C-terminal fragment(CTF)C99 in brains of Alzheimer disease(AD)mouse models.Moreover,we showed that the treatment with theγ-secretase inhibitor(D6)led to further increased endolysosomal APP-CTF levels,but also revealed extracellular APP-CTF-associated immunostaining.We here hypothesized that this latter staining could reflect extracellular vesicle(EV)-associated APP-CTFs and aimed to characterize theseγ-secretase inhibitor-induced APPCTFs.Methods:EVs were purified from cell media or mouse brains from vehicle-or D6-treated C99 or APPswedish expressing cells/mice and analyzed for APP-CTFs by immunoblot.Combined pharmacological,immunological and genetic approaches(presenilin invalidation and C99 dimerization mutants(GXXXG))were used to characterize vesicle-containing APP-CTFs.Subcellular APP-CTF localization was determined by immunocytochemistry.Results:Purified EVs from both AD cell or mouse models were enriched in APP-CTFs as compared to EVs from control cells/brains.Surprisingly,EVs from D6-treated cells not only displayed increased C99 and C99-derived C83 levels but also higher molecular weight(HMW)APP-CTF-immunoreactivities that were hardly detectable in whole cell extracts.Accordingly,the intracellular levels of HMW APP-CTFs were amplified by the exosomal inhibitor GW4869.By combined pharmacological,immunological and genetic approaches,we established that these HMW APP-CTFs correspond to oligomeric APP-CTFs composed of C99 and/or C83.Immunocytochemical analysis showed that monomers were localized mainly to the trans-Golgi network,whereas oligomers were confined to endosomes and lysosomes,thus providing an anatomical support for the selective recovery of HMW APP-CTFs in EVs.The D6-induced APP-CTF oligomerization and subcellular mislocalization was indeed due toγ-secretase blockade,since it similarly occurred in presenilin-deficient fibroblasts.Further,our data proposed that besides favoring APP-CTF oligomerization by preventing C99 proteolysis,γ-secretase inhibiton also led to a defective SorLA-mediated retrograde transport of HMW APP-CTFs from endosomal compartments to the TGN.Conclusions:This is the first study to demonstrate the presence of oligomeric APP-CTFs in AD mouse models,the levels of which are selectively enriched in endolysosomal compartments including exosomes and amplified byγ-secretase inhibition.Future studies should evaluate the putative contribution of these exosome-associated APP-CTFs in AD onset,progression and spreading. | Inger Lauritzen Anaïs Bécot Alexandre Bourgeois Raphaëlle Pardossi-Piquard Maria-Grazia Biferi Martine Barkats Fréderic Checler | 2019 | Translational Neurodegeneration2019，8，1： | 1 |
| 5 | Ensuring the safety of vaccine cell substrates by massively parallel sequencing of the tmnscrip- tome 显示文摘 | Onions D Coté C Love B | 2011 | Vaccine2011，29，41： | 1 |
| 6 | Activation of AMP-activated protein kinase (AMPK) inhibits fatty acid synthesis in bovine mammary epithelial cells 显示文摘 | McFadden J W A Cot B | 2009 | Biochem Biophysi Res Commun2009，390，3： | 1 |
| 7 | PIERS proteinuria:relationship with adverse maternal and perinatal outcome显示文摘 | Payne B Magee LA CotéAM | 2011 | Obstet Gynaecol Can2011，33，6： | 1 |
| 8 | Anti-NMDA-receptor encephalitis: case report and literature review of an under?recognized condition显示文摘 | Day GS High SM Cot B | 2011 | J Gen Intern Med2011，26，7： | 1 |
| 9 | Effects of hypertonic saline solution on body weight and serum creatinine in patients with acute decompensated heart failure显示文摘AIM To test the safety and effectiveness of hypertonic saline solution(HSS + F) as a strategy for weight loss andprevention of further deterioration of renal function.METHODS Patients admitted with acute decompensated heart failure(ADHF) who received HSS + F were included in the study. After a period of a standard ADHF treatment, our patients received an intravenous infusion of furosemide(250 mg) combined with HSS(150 mL of 3% NaCl) twice a day for a mean duration of 2.3 d. Our primary outcomes were weight loss and a change in serum creatinine per day of treatment. The parameters of the period prior to treatment with HSS + F were compared with those of the period with HSS + F. RESULTS A total of 47 patients were included. The mean creatinine on admission was 155 μmol/L ± 65 μmol/L, the ejection fraction was 40% ± 17%. The experimental treatment(HSS + F) resulted in greater weight loss per day of treatment than the standard treatment(-1.4 kg/d ± 1.4 kg/d vs-0.4 kg/d ± 1.0 kg/d, P = 0.0168). Importantly, the change in creatinine was not significantly different.CONCLUSION This study supports the effectiveness of HSS + F on weight loss in patients with ADHF. The safety profile, particularly with regard to renal function, leads us to believe that HSS + F may be a valuable option for those patients presenting with ADHF who do not respond to conventional treatment with intravenous furosemide alone. | Gabrielle Lafrenière Patrick Béliveau Jean-Yves Bégin David Simonyan Sylvain Coté Valérie Gaudreault Zeev Israeli Shahar Lavi Rodrigo Bagur | 2017 | World Journal of Cardiology2017，9，8： | 1 |
| 10 | Anti-NMDA-receptor encephalitis: case report and literature review of an under-recognized condition 显示文摘 | Day GS High SM Cot B | 2011 | J Gen Intern Med2011，26，7： | 1 |
| 11 | Ami-NMDA-reccptor encephalitis : case report and literature review of an under-recognized condition 显示文摘 | Day G High S Cot B | 2011 | J Gen Intern Med2011，26，7： | 1 |
| 12 | Anti-NMDA-receptor encephalitis:case report and literature review of an under-recognized condition显示文摘 | Day GS High SM Cot B | | 0，，07： | 1 |
| 13 | A structural investigation of CaO-A12 03 glasses via27 A1 MAS-NMR显示文摘 | Mcmillan P F Petuskey W T Cot B | 1996 | J Non-Cryst Solids1996，195，3： | 1 |
| 14 | PIERS proteinuria:relationship with adverse maternal and perinatal outcome显示文摘 | Payne B Magee LA Coté AM | 2011 | Obstet Gynaecol Can2011，33，6： | 1 |
| 15 | Quantification of Phospholipids in In~mt Formula and (-;rowing Up Milk by High- Perfornaance Liquid Chromatography with Evaporative Light Scattering Detector显示文摘 | Braun M Flck B Cotting C | 2010 | Journal of AOAC International2010，3，： | 1 |
| 16 | A 10-year experience in paediatric spontaneous cerebral hemorrhage: which children with headache need more than a clinical examination? 显示文摘 | De Ribaupierre S Rilliet B Cotting J | 2008 | Swiss Med Wkly2008，138，56： | 1 |
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