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| 1 | What exists beyond cag A and vacA? Helicobacter pylori genes in gastric diseases显示文摘Helicobacter pylori(H. pylori) infection is present in more than half the world's population and has been associated with several gastric disorders, such as gastritis, peptic ulceration, and gastric adenocarcinoma.The clinical outcome of this infection depends on host and bacterial factors where H. pylori virulence genes seem to play a relevant role. Studies of cag A and vac A genes established that they were determining factors in gastric pathogenesis. However, there are gastric cancer cases that are cag A-negative. Several other virulence genes have been searched for, but these genes remain less well known that cag A and vac A. Thus, this review aimed to establish which genes have been suggested as potentially relevant virulence factors for H. pylori-associated gastrointestinal diseases. We focused on the cag-pathogenicity island, genes with adherence and motility functions, and ice A based on the relevance shown in several studies in the literature. | Débora Menezes da Costa Eliane dos Santos Pereira Silvia Helena Barem Rabenhorst | 2015 | World Journal of Gastroenterology2015，21，37： | 6 |
| 2 | Perioperative blood transfusion decreases long-term survival in pediatric living donor liver transplantation显示文摘BACKGROUND The impact of perioperative blood transfusion on short-and long-term outcomes in pediatric living donor liver transplantation(PLDLT)must still be ascertained,mainly among young children.Clinical and surgical postoperative complications related to perioperative blood transfusion are well described up to three months after adult liver transplantation.AIM To determine whether transfusion is associated with early and late postoperative complications and mortality in small patients undergoing PLDLT.METHODS We evaluated the effects of perioperative transfusion on postoperative complications in recipients up to 20 kg of body weight,submitted to PLDLT.A total of 240 patients were retrospectively allocated into two groups according to postoperative complications:Minor complications(n=109)and major complications(n=131).Multiple logistic regression analysis identified the volume of perioperative packed red blood cells(RBC)transfusion as the only independent risk factor for major postoperative complications.The receiver operating characteristic curve was drawn to identify the optimal volume of the perioperative RBC transfusion related to the presence of major postoperative complications,defining a cutoff point of 27.5 mL/kg.Subsequently,patients were reallocated to a low-volume transfusion group(LTr;n=103,RBC≤27.5 mL/kg)and a high-volume transfusion group(HTr;n=137,RBC>27.5 mL/kg)so that the outcome could be analyzed.RESULTS High-volume transfusion was associated with an increased number of major complications and mortality during hospitalization up to a 10-year follow-up period.During a short-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and bleeding complications,with a decrease in rejection complications compared to the LTr.Over a long-term period,the HTr showed an increase in major infectious,cardiovascular,respiratory,and minor neoplastic complications,with a decrease in rejection complications.Additionally,Cox hazard regression found that high-volume RBC transfusion increased the mortality risk by 3.031-fold compared to low-volume transfusion.The Kaplan-Meier survival curves of the studied groups were compared using log-rank tests and the analysis showed significantly decreased graft survival,but with no impact in patient survival related to major complications.On the other hand,there was a significant decrease in both graft and patient survival,with high-volume RBC transfusion.CONCLUSION Transfusion of RBC volume higher than 27.5 mL/kg during the perioperative period is associated with a significant increase in short-and long-term postoperative morbidity and mortality after PLDLT. | Karina Gordon Estela Regina Ramos Figueira Joel Avancini Rocha-Filho Luiz Antonio Mondadori Eduardo Henrique Giroud Joaquim Joao Seda-Neto Eduardo Antunes da Fonseca Renata Pereira Sustovitch Pugliese Agustin Moscoso Vintimilla Jose Otavio Costa Auler Jr Maria Jose Carvalho Carmona Luiz Augusto Carneiro D'Alburquerque | 2021 | World Journal of Gastroenterology2021，27，12： | 6 |
| 3 | Chemokine Signaling via the CXCR2 Receptor Reinforces Senescence显示文摘 | Juan C. Acosta Ana O’Loghlen Ana Banito Maria V. Guijarro Arnaud Augert Selina Raguz Marzia Fumagalli Marco Da Costa Celia Brown Nikolay Popov Yoshihiro Takatsu Jonathan Melamed Fabrizio d’Adda di Fagagna David Bernard Eva Hernando Jesús Gil | 2008 | Cell2008，，6： | 2 |
| 4 | Counterbalancing patient demands with evidence:Results from a pan- Canadian randomized clinical trial of brief sup- portive - expressive group psyehothera-py for women with systemic lupus ery- thematosus显示文摘 | Dobkin PL Da Costa D Joseph L etal | 2002 | Ann Behav Med2002，24，2： | 1 |
| 5 | Application of a novel fuzzy classifier to fault detection and isolation of the DAMADICS bench_mark problem显示文摘 | BOCANIALA C D DA COSTA J S | 2006 | Control Engineering Practice2006，14，6： | 1 |
| 6 | Analysis and software implementation of a robust synchronizing PLL circuit based on the pq theory显示文摘 | Rolim L G B da Costa D R Aredes M | 2006 | IEEE Trans on Industrial Electronics2006，53，6： | 1 |
| 7 | Nitrogen incorporation into titanium diboride films deposited by dc magnetron sputtering: Structural modifications 显示文摘 | SANCHEZ C M T FONSECA-FILHO H D MAIA DA COSTA M E H | 2009 | Thin Solid Films2009，517，19： | 1 |
| 8 | Tuning of fractional PID controllers with Ziegler-Nichols-type rules 显示文摘 | VALERIO D SA DA COSTA J | 2006 | Signal Processing Journal2006，86，10： | 1 |
| 9 | Cooperative Dual-hop Relaying Systems with Beamforming over Nakagami - m Fading Channels 显示文摘 | Costa D B da Aissa S | 2009 | IEEE Transactions on Wireless Communications2009，8，8： | 1 |
| 10 | Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae 显示文摘 | Dallenne C Da Costa A Decre D | 2010 | J Antimicrob Chemother2010，65，3： | 1 |
| 11 | Diversity of rotavirus strains circulating in Northern Brazil after introduction of a rotavirus vaccine: High prevalence of G3P[6] genotype显示文摘 | Luana da Silva Soares Sylvia de Fátima dos Santos Guerra Alessilva do Socorro Lima de Oliveira Fabiola da Silva dos Santos Euzeni Maria de Fátima Costa de Menezes Joana d’Arc Pereira Mascarenhas Alexandre C. Linhares | 2014 | Virol2014，，6： | 1 |
| 12 | Development of a set ofmultiplex PCR assays for the detection of genes encoding importantbeta - lactamases in Enterobacteriaceae 显示文摘 | Dallenne C Da Costa A Deere D | 2010 | J Antimicrob Chemother2010，65，： | 1 |
| 13 | 显示文摘 | Uhlmann D Smart S da Costa J C D | 2010 | Sep Purif Technol*2010，76，2： | 1 |
| 14 | Development of a set of multiplex PCR assays for the detection of genes encoding important beta-lactamases in Enterobacteriaceae显示文摘 | Dallenne C Da Costa A Deere D | 2010 | J Antimicrob Chemother2010，65，3： | 1 |
| 15 | Walking behaviour and glycemic control in type 2 diabetes : seasonal and gender differences- study design and methods显示文摘 | Dasgupta K Chan C Da Costa D | 2007 | Cardiovasc Diabetol2007，15，6： | 1 |
| 16 | DNA adducts derived from administration of acrylamide and glycidamide to mice and rats显示文摘 | DOERGE D R DA COSTA G G MCDANIEL L P | 2005 | Mutat Res2005，580，12： | 1 |
| 17 | Effects of breed diet and muscle on fat deposition and eating quality in pigs 显示文摘 | Wood D Nute G R Richardson R I Whittington F M Southwood O Plastow G Mansbridge R da Costa N Chang K C | 2004 | Meat Science2004，67，4： | 1 |
| 18 | Tuning of fractional PID controllers with Ziegler-Niehols-type rules 显示文摘 | VALERIO D DA COSTA J S | 2006 | Signal Processing2006，86，10： | 1 |
| 19 | 显示文摘 | Duke M C da Costa J C D Lu G Q | 2004 | J Membr Sci2004，241，2： | 1 |
| 20 | Laparoscopic partial cholecystectomy for the difficult gallbladder:a systematicreview显示文摘 | Henneman D da Costa DW Vrouenraets BC | 2013 | Surg Endosc2013，27，2： | 1 |
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