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| 1 | Prognostic factors and time-related changes influence results of colorectal liver metastases surgical treatment:A single-center analysis显示文摘AIM:To analyze the prognostic factors involved in survival and cancer recurrence in patients undergoing surgical treatment for colorectal liver metastases(CLM) and to describe the effects of time-related changes on survival and recurrence in these patients.METHODS:From January 1994 to January 2006,236 patients with CLM underwent surgery with the aim of performing curative resection of neoplastic disease at our institution and 189(80%) of these patients underwent resection of CLM with curative intention.Preoperative,intraoperative and postoperative data,including primary tumor and CLM pathology results,were retrospectively reviewed.Patients were divided into two time periods:a first period from January 1994 to January 2000(n = 93),and a second period from February 2000 to January 2006(n = 143).RESULTS:Global survival at 1,3 and 5 years in patients undergoing hepatic resection was 91%,54% and 47%,respectively.Patients with preoperative extrahepatic disease,carcinoembryonic antigen(CEA) levels over 20 ng/dL,more than four nodules or extrahepatic invasion at pathological analysis had worse survival.Tumor recurrence rate at 1 year was 48.3%,being more frequent in patients with preoperative and pathological extrahepatic disease and CEA levels over 20 ng/dL.Although patients in the second time period had more adverse prognostic factors,no differences in overall survival and recurrence were observed between the two periods.CONCLUSION:Despite advances in surgical technique and better adjuvant treatments and preoperative imaging,careful patient staging and selection is crucial to continue offering a chance of cure to patients with CLM. | Josep Martí María Marta Modolo Josep Fuster Jaume Comas Rebeca Cosa Joana Ferrer Victor Molina Juan Romero Constantino Fondevila Ramón Charco Juan Carlos García-Valdecasas | 2009 | World Journal of Gastroenterology2009，15，21： | 9 |
| 2 | Biventricular pacing improve clinical behavior and reduces prevalence of ventricular arrythymia in patients with heart failure显示文摘 | Martinelli FM Pedrosa AA Cosa R | 2002 | Arq Bras Cardiol2002，78，1： | 1 |
| 3 | Overexpression of the Bt Cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals 显示文摘 | De Cosa B Moar W Lee S B | 2001 | Nature Biotechnology2001，19，： | 1 |
| 4 | Is laparoscopic resection adequate in patients with neoroendocrine pancreatic tumors 显示文摘 | Fernandaz-Cruz L Blanco L Cosa R | 2008 | World J Surg2008，32，5： | 1 |
| 5 | curative laparoscopic resection for pancreatic neoplasms:a critical analysis from a single institution显示文摘 | Fernández-Cruz L Cosa R Blanco L | 2007 | J Gastrointest Surg2007，11，12： | 1 |
| 6 | Overexpression of the Bt Cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals显示文摘 | De Cosa B Moar W Lee SB | 2001 | Nat Biotechnol2001，19，1： | 1 |
| 7 | Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals显示文摘 | De Cosa B Moar W Lee S B | 2001 | Nature Biotechnology2001，19，1： | 1 |
| 8 | Photophysical properties of fluorescent DNA - dys bound to single - and double - stranded DNA in aqueous buffered solution显示文摘 | Cosa G Focsaneanu K S Mclean J R | 2001 | Photochemistry and Photobiology2001，73，： | 1 |
| 9 | Over expression of the Bt Cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals显示文摘 | De COSA B MOAR W LEE S B | 2001 | Nature Biotechnology2001，19，： | 1 |
| 10 | Pancreatogastrostomy with gastric partition after pylorus-preserving pancreatoduodenectomy versus conventional pancreatojejunostomy:a prospective randomized study显示文摘 | Fernandez-Cruz L Cosa R Blanco L | | 0，，06： | 1 |
| 11 | Bioflocculant production by Bacillus sp. Gilbert isolated from a marine environment in South Africa显示文摘 | A. M. Ugbenyen S. Cosa L. V. Mabinya A. I. Okoh | 2014 | Applied Biochemistry and Microbiology2014，，1： | 1 |
| 12 | Is laparoscopic resection adequate in patients with neuroendocrine pancreatic tumours显示文摘 | Fernández-Cruz L Blanco L Cosa R | 2008 | World J Surg2008，32，5： | 1 |
| 13 | Curative laparo- scopic resection for pancreatic neoplasms:A critical analysis from a single institution显示文摘 | Fernandez-Cruz L Cosa R Blanco L | 2007 | J Gastrointest Surg2007，11，12： | 1 |
| 14 | Tunable Fabry-Pérot filter based on one-dimensional photonic crystals with liquid crystal components显示文摘 | J Cosa J Ferre-Borrulla J Pallaresa | 2009 | Opt Communications2009，282，： | 1 |
| 15 | Pancreatogastrostomy with gastric partition after pylorus-preserving pancreatoduode- uectomy versus conventional pancreatojejunostomy: A prospec- tive randomized study 显示文摘 | Fernandez-Cruz L Cosa R Blanco L | 2008 | Ann Surg2008，248，6： | 1 |
| 16 | Overexpression of the Bt cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals显示文摘 | De Cosa B Moar W Lee S | 2001 | Nature Biotechnology2001，19，1： | 1 |
| 17 | Overexpression of the Bt Cry2Aa2 operon in chloroplasts leads to formation of insecticidal crystals显示文摘 | De Cosa B Moar W Lee S B | 2001 | Nat Biotech2001，19，： | 1 |
| 18 | DNA damage detection technique applying time-resolved fluorescence measurements 显示文摘 | Cosa G Vinette AL McLean JR | 2002 | AnalChem2002，74，24： | 1 |
| 19 | Ultra grain re- finement and hardening of IF-steel during accumulative roll- bonding显示文摘 | Cosa A L M Reis A C C Kestens L | 2005 | Mater Sci Eng A2005，406，12： | 1 |
| 20 | Pancreatogastrosto-my with gastric partition after pylorus-preserving pancreatoduo-denectomy versus conventional pancreatojejunostomy: a pro-spertive randomized study 显示文摘 | Femandez-Cmz L Cosa R Blanro L | 2008 | Ann Surg2008，248，6： | 1 |
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