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| 1 | Diagnostic value of drain amylase for detecting intrathoracic leakage after esophagectomy显示文摘AIM:To investigate the value of elevated drain amylase concentrations for detecting anastomotic leakage(AL) after minimally invasive Ivor-Lewis esophagectomy(MIILE).METHODS:This was a retrospective analysis of prospectively collected data in two hospitals in the Netherlands. Consecutive patients undergoing MI-ILE were included. A Jackson-Pratt drain next to the dorsal side of the anastomosis and bilateral chest drains were placed at the end of the thoracoscopic procedure. Amylase levels in drain fluid were determined in all patients during at least the first four postoperative days. Contrast computed tomography scans and/or endoscopic imaging were performed in cases of a clinically suspected AL. Anastomotic leakage was defined as any sign of leakage of the esophago-gastric anastomosis on endoscopy,re-operation,radiographic investigations,post mortal examination or when gastro-intestinal contents were found in drain fluid. Receiver operator characteristic curves were used to determine the cut-off values. Sensitivity,specificity,positive predictive value,negative predictive value,risk ratio and overall test accuracy were calculated for elevated drain amylase concentrations.RESULTS:A t o t a l o f 8 9 p a t ie n t s w e re in c lu d e d between March 2013 and August 2014. No differences in group characteristics were observed between patients with and without AL,except for age. Patients with AL were older than were patients without AL(P = 0.01). One patient(1.1%) without AL died within 30 d after surgery due to pneumonia and acute respiratory distress syndrome. Anastomotic leakage that required any intervention occurred in 15 patients(16.9%). Patients with proven anastomotic leakage had higher drain amylase levels than patients without anastomotic leakage [median 384 IU/L(IQR 34-6263) vs median 37 IU/L(IQR 26-66),P = 0.003]. Optimal cut-off values on postoperative days 1,2,and 3 were 350 IU/L,200 IU/L and 160 IU/L,respectively. An elevated amylase level was found in 9 of the 15 patients with AL. Five of these 9 patients had early elevations of their amylase levels,with a median of 2 d(IQR 2-5) before signs and symptoms occurred.CONCLUSION:Measurement of drain amylase levels is an inexpensive and easy tool that may be used to screen for anastomotic leakage soon after MI-ILE. However,clinical validation of this marker is necessary. | Gijs HK Berkelmans Ewout A Kouwenhoven Boudewijn JJ Smeets Teus J Weijs Luis C Silva Corten Marc J van Det Grard AP Nieuwenhuijzen Misha DP Luyer | 2015 | World Journal of Gastroenterology2015，21，30： | 3 |
| 2 | Results of cemented femoral revisions for periprosthetic femoral fractures in the elderly显示文摘 | Corten K Macdonald SJ Mc Calden RW | 2012 | J Arthroplasty2012，27，2： | 1 |
| 3 | Measurement of mandibular bone density ex vivo and in vivo by dualenergy X-ray absorp tiometry显示文摘 | Corten FG Van't HofMA BuijsWC | | 0，，03： | 1 |
| 4 | Results of cemented femoral revisions for periprosthetic femoral fractures in the elderly显示文摘 | Corten K Macdonald SJ McCalden RW | 2012 | J Arthroplasty2012，27，2： | 1 |
| 5 | Lubeluzole in acute ischemic stroke treatment: A double-blind study with an 8-hour inclusion window comparing a 10-rag daily dose of lubeluzole with placebo 显示文摘 | Diener HC Cortens M Ford G | 2000 | Stroke2000，31，11： | 1 |
| 6 | Protein engineering for directed immobilization显示文摘 | Redeker ES Ta DT Cortens D | 2013 | Bioconjugate Chemistry2013，24，： | 1 |
| 7 | The minimum 10-year results of a second-generation cementless acetabular shell with a polished inner surface显示文摘 | Teo YS Corten K McCalden RW | | 0，，07： | 1 |
| 8 | A mixed-mode crack analysis of isotropic solids using conservation laws of elasticity 显示文摘 | Yau J Wang S Corten H | 1980 | Journal of Applied Mechanics1980，47，2： | 1 |
| 9 | What works best,a cemented or cementless primary total hip arthroplasty?:minimum 17-year follow up of a randomized controlled trial显示文摘 | Corten K Bourne RB Charron KD | 2011 | Clin Orthop Relat Res2011，469，1： | 1 |
| 10 | Using annotated peptide mass spectrum libraries for protein identification显示文摘 | Craig R Cortens J C Fenyo D | 2006 | Journal of Proteome Research2006，5，： | 1 |
| 11 | A mixed-mode crack analysis of isotropic solids using conservation laws of elasticity 显示文摘 | Yau F J Wang S S Corten H T | 1980 | Journal of Applied Mechanics1980，47，： | 1 |
| 12 | Open source system for analyzing,validating,and storing protein identification data显示文摘 | Craig R Cortens JP Beavis RC | | 0，，06： | 1 |
| 13 | Measurement of mandibular bone density ex vivo and in vivo by dual-energy X-ray absorptiometry显示文摘 | Corten FG Van't Hof MA Buijs WC | 1993 | Arch Oral Biol1993，38，3： | 1 |
| 14 | Effect of size on elastic-plastic fracture toughness parameters显示文摘 | Putatunda S K Rigsbee J M Corten H T | 1985 | Journal of Testing and Evaluation1985，13，3： | 1 |
| 15 | Results of ce- mented femoral revisions for periprosthetic femoral fractures in the elderly显示文摘 | Corten K Macdonald SJ McCalden RW | 2012 | J Arthroplasty2012，27，2： | 1 |
| 16 | What works best,a cemented or cementless primary total hip arthro- plasty: minimum 17-year followup of a randomized controlled trial显示文摘 | CORTEN K BOURNE R B CHARRON K D | 2011 | Clin Orthop Relat R2011，469，1： | 1 |
| 17 | Using Annotated Peptide Mass Spectrum Libraries for Protein Identification显示文摘 | Beavis R C Craig R Cortens J C | | 0，，08： | 1 |
| 18 | Lubeluzole in acute ischemic stroke treatment显示文摘 | Diener HC Cortens M Ford G | 2000 | Stroke2000，31，： | 1 |
| 19 | Gastrocnemius flap reconstruction of soft-tissue defects following infected total kneereplacement显示文摘 | Corten K Struelens B Evans B | 2013 | Bone Joint J2013，95，9： | 1 |
| 20 | Measurement of mandibular bone density ex vivo and in vivo by dual energy X-ray absorptiomety显示文摘 | Corten FGA Van' t Hof MA Bui js WCAM | 1993 | Archs Oral Biol1993，38，3： | 1 |
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