|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Role of ion channels in gastrointestinal cancer显示文摘In their seminal papers Hanahan and Weinberg described oncogenic processes a normal cell undergoes to be transformed into a cancer cell.The functions of ion channels in the gastrointestinal(GI)tract influence a variety of cellular processes,many of which overlap with these hallmarks of cancer.In this review we focus on the roles of the calcium(Ca^2+),sodium(Na^+),potassium(K^+),chloride(Cl^-)and zinc(Zn^2+)transporters in GI cancer,with a special emphasis on the roles of the KCNQ1 K+channel and CFTR Cl-channel in colorectal cancer(CRC).Ca^2+is a ubiquitous second messenger,serving as a signaling molecule for a variety of cellular processes such as control of the cell cycle,apoptosis,and migration.Various members of the TRP superfamily,including TRPM8,TRPM7,TRPM6 and TRPM2,have been implicated in GI cancers,especially through overexpression in pancreatic adenocarcinomas and down-regulation in colon cancer.Voltage-gated sodium channels(VGSCs)are classically associated with the initiation and conduction of action potentials in electrically excitable cells such as neurons and muscle cells.The VGSC NaV1.5 is abundantly expressed in human colorectal CRC cell lines as well as being highly expressed in primary CRC samples.Studies have demonstrated that conductance through NaV1.5 contributes significantly to CRC cell invasiveness and cancer progression.Zn2+transporters of the ZIP/SLC39A and ZnT/SLC30A families are dysregulated in all major GI organ cancers,in particular,ZIP4 up-regulation in pancreatic cancer(PC).More than 70 K+channel genes,clustered in four families,are found expressed in the GI tract,where they regulate a range of cellular processes,including gastrin secretion in the stomach and anion secretion and fluid balance in the intestinal tract.Several distinct types of K+channels are found dysregulated in the GI tract.Notable are hERG1 upregulation in PC,gastric cancer(GC)and CRC,leading to enhanced cancer angiogenesis and invasion,and KCNQ1 down-regulation in CRC,where KCNQ1 expression is associated with enhanced disease-free survival in stage II,III,and IV disease.Cl-channels are critical for a range of cellular and tissue processes in the GI tract,especially fluid balance in the colon.Most notable is CFTR,whose deficiency leads to mucus blockage,microbial dysbiosis and inflammation in the intestinal tract.CFTR is a tumor suppressor in several GI cancers.Cystic fibrosis patients are at a significant risk for CRC and low levels of CFTR expression are associated with poor overall disease-free survival in sporadic CRC.Two other classes of chloride channels that are dysregulated in GI cancers are the chloride intracellular channels(CLIC1,3&4)and the chloride channel accessory proteins(CLCA1,2,4).CLIC1&4 are upregulated in PC,GC,gallbladder cancer,and CRC,while the CLCA proteins have been reported to be down-regulated in CRC.In summary,it is clear,from the diverse influences of ion channels,that their aberrant expression and/or activity can contribute to malignant transformation and tumor progression.Further,because ion channels are often localized to the plasma membrane and subject to multiple layers of regulation,they represent promising clinical targets for therapeutic intervention including the repurposing of current drugs. | Kyle J Anderson Robert T Cormier Patricia M Scott | 2019 | World Journal of Gastroenterology2019，25，38： | 19 |
| 2 | Corporate Environmental Disclosure,Financial Markets and the Media:An International Perspective显示文摘 | Aerts W Cormier D Magnan M | 2008 | Ecological Economics2008，，64： | 1 |
| 3 | Absence of functional type 1 parathyroid hormone (PTH)/PTH - related protein receptors in humans is associated with abnormal breast development and tooth impaction 显示文摘 | WYSOLMERSKI J J CORMIER S PHILBRICK W M | 2001 | J Clin Endocrinol Metab2001，86，4： | 1 |
| 4 | Intra- industry Imitationin Corporate Environmental Reporting : An InternationalPerspective 显示文摘 | Aerts W Cormier D Magnan M | 2006 | Journal of Accounting & Public Policy2006，25，3： | 1 |
| 5 | Use of clinical risk factor in elderly women with low bone mineral density to identify women at higher risk of hip fracture at the EPIDOS prospective study显示文摘 | Dargent M Douchin C Cormier P | 2002 | Osteoporosis Int2002，13，： | 1 |
| 6 | A Review on inertiaand linear friction welding of Ni - based superalloys 显示文摘 | Chamanfar A Jahazi M Cormier J | 2015 | Metalluipcal and Materials Transactions A2015，46，4： | 1 |
| 7 | Transdermal delivery of anti- sense oligonucleotides with microprojection patch (Macroflux) technology显示文摘 | Lin W Cormier M Samiee A | 2001 | Pharm Res2001，18，12： | 1 |
| 8 | Environmental Reporting Management:A Continental European Perspective显示文摘 | Cormier D Magnan M | 2003 | Journal of Accounting and Public Policy2003，22，1： | 1 |
| 9 | Translation control during mitosis 显示文摘 | Breton M Cormier P Bell R | 2005 | Biochemie2005，87，910： | 1 |
| 10 | Environmental reporting man- agement: a continental european perspective 显示文摘 | CORMIER D MAGNAN M | 2003 | Journal of Accounting and Public Policy2003，22，1： | 1 |
| 11 | Corporate environmental disclosure, financial market mechanism 显示文摘 | AERTS W CORMIER D MAGNAN M | 2008 | The Quarterly Journal of Economics2008，84，3： | 1 |
| 12 | On a possible mechanism of the methane steam reforming in a gliding arc reactor显示文摘 | Rusu I Cormier J M | 2003 | Chemical Engineering Journal2003，91，： | 1 |
| 13 | Assessing ecological risk in watersheds: A case study of problem formulation in the Big Darby Creek Watershed,Ohio,USA 显示文摘 | Cormier S M Smith M Norton S | 2000 | Environmental Toxicology and Chemistry2000，19，4： | 1 |
| 14 | Transcatheter valve implantation for patients with aortic stenosis:a position statement from the European Association of Cardio-Thoracic Surgery (EACTS) and the European Society of Cardiology (ESC), in collaboration with the European Association of Percutaneous Cardiovascular Interventions(EAPCI)显示文摘 | Vahanian A Alfieri O Al- Attar N Antunes M J Bax J Cormier B | 2008 | Eur Heart J2008，29，： | 1 |
| 15 | Ethnic differences among patients with coetaneous melanoma 显示文摘 | Cormier JN Xing Y Ding M | 2006 | Arch Intern Med2006，166，17： | 1 |
| 16 | Transdermal delivery of antisense oligonucleotides with microprojection patch(Macroflux) technology显示文摘 | Lin WQ Cormier M Samiee A | 2001 | Pharm Res2001，18，12： | 1 |
| 17 | Late preferm birth显示文摘 | Loftin RW Habli M Snyder CC Cormier CM Lewis DF De-franco EA | 2010 | Rev Obstet Gynecol2010，3，1： | 1 |
| 18 | Corporate environmental disclosure, financial markets and the media: an international perspective显示文摘 | Aerts W Cormier D Magnan M | 2008 | Ecological Economics2008，3，15： | 1 |
| 19 | Estrogen receptor distribution in enucleated breast cancer cell lines 显示文摘 | Welshons W V Cormier E M Wolf M F | 1988 | Endocrinology1988，122，： | 1 |
| 20 | Environmental Disclosure Quality in Large German Companies: Economic Incen- tives, Public Pressures or Institutional Conditions? 显示文摘 | CORMIER D MAGNAN M VELTHOVEN V B | 2005 | European Accounting Review2005，14，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员