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| 1 | Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery显示文摘AIM: To evaluate the surface expression of triggering receptor on myeloid cell 1 (TREM-1), class Ⅱ major histocompatibility complex molecules (HLA-DR), andthe expression of the splicing variant (svTREM-1) ofTREM-1 in septic patients and those subjected to major abdominal surgery.METHODS: Using flow cytometry, we examined the surface expression of TREM-1 and HLA-DR in peripheral blood monocytes from 11 septic patients, 7 elective gastrointestinal surgical patients, and 10 healthy volunteers. svTREM-1 levels were analyzed by RT-PCR. RESULTS: Basal expression of TREM-1 and HLA-DR in healthy volunteers was 35.91±14.75 MFI and75.8±18.3%, respectively. In septic patients, TREM-1 expression was 59.9±23.9 MFI and HLA-DR expression was 44.39±20.25%, with a significant differencebetween healthy and septic groups (P<0.05) for bothmolecules. In the surgical patients, TREM-1 and HLA-DR expressions were 56.8±20.85 MFI and 71±13.8% before surgery and 72.65±29.92 MlFI and 72.82±22.55% after surgery. TREM-1 expression was significantly different(P = 0.0087) between the samples before and aftersurgery and svTREM-1 expression was 0.8590±0.1451 MF1, 0.8820±0.1460 MF1, and 2.210±0.7873MF1 in the healthy, surgical (after surgery) and septic groups, respectively. There was a significant difference (P = 0.048) in svTREM-1 expression between the healthy and surgical groups and the septic group.CONCLUSION: TREM-1 expression is increased during systemic inflammatory conditions such as sepsis and the postoperative phase. Simultaneous low expression of HLA-DR molecules correlates with the severity of illness and increases susceptibility to infection. Additionally, TREM-1 expression is distinctly different in surgical patients at different stages of the inflammatory response before and after surgery. Thus, surface TREM-1 appears to be an endogenous signal during the course of the inflammatory response. svTREM-1 expression is significantly increased during sepsis, appearing to be an indicator of severity of illness. Together, these data indicate that TREM-1 may play an important role in establishing and amplifying the systemic inflammatory response. TREM-1, HLA-DR, and svTREM-1 expression analysis can provide useful diagnostic and prognostic indicators during SIRS, CARS, and sepsis. | Nestor González-Roldán Eduardo Ferat-Osorio Rosalía Aduna-Vicente Isabel Wong-Baeza Noemí Esquivel-Callejas Horacio Astudillo-de la Vega Patricio Sánchez-Fernández Lourdes Arriaga-Pizano Miguel Angel Villasís-Keever Constantino López-Macías Armando Isibasi | 2005 | World Journal of Gastroenterology2005，11，47： | 9 |
| 2 | Predictors of suboptimal bowel preparation in asymptomatic patients undergoing average-risk screening colonoscopy显示文摘AIM To identify risk factors for a suboptimal preparation among a population undergoing screening or surveillance colonoscopy.METHODS Retrospective review of the University of Michigan and Veteran's Administration(VA) Hospital records from 2009 to identify patients age 50 and older who underwent screening or surveillance procedure and had resection of polyps less than 1 cm in size and no more than 2 polyps. Patients with inflammatory bowel disease or a family history of colorectal cancer were excluded. Suboptimal procedures were defined as procedure preparations categorized as fair, poor or inadequate by the endoscopist. Multivariable logistic regression was used to identify predictors of suboptimal preparation.RESULTS Of 4427 colonoscopies reviewed, 2401 met our inclusion criteria and were analyzed. Of our population, 16% had a suboptimal preparation. African Americans were 70% more likely to have a suboptimal preparation(95%CI: 1.2-2.4). Univariable analysis revealed that narcotic and tricyclic antidepressants(TCA) use, diabetes, prep type, site(VA vs non-VA), and presence of a gastroenterology(GI) fellow were associated with suboptimal prep quality. In a multivariable model controlling for gender, age, ethnicity, procedure site and presence of a GI fellow, diabetes [odds ratio(OR) = 2.3; 95%CI: 1.6-3.2], TCA use(OR = 2.5; 95%CI: 1.3-4.9), narcotic use(OR = 1.7; 95%CI: 1.2-2.5) and Miralax-Gatorade prep vs 4L polyethylene glycol 3350(OR = 0.6; 95%CI: 0.4-0.9) were associated with a suboptimal prep quality. CONCLUSION Diabetes, narcotics use and TCA use were identified as predictors of poor preparation in screening colonoscopies while Miralax-Gatorade preps were associated with better bowel preparation. | Shail M Govani Eric E Elliott Stacy B Menees Stephanie L Judd Sameer D Saini Constantinos P Anastassiades Annette L Urganus Suzanna J Boyce Philip S Schoenfeld | 2016 | World Journal of Gastrointestinal Endoscopy2016，8，17： | 7 |
| 3 | 查看详情显示文摘 | C H B Silva D C Ferreira V R L Constantino | | 0，，08： | 1 |
| 4 | Self-assembled films of poly( o - ethoxyani- line) complexed with sulfonated lignin 显示文摘 | PATERNO L G CONSTANTINO C OLIVEIRA O N | 2002 | Colloids and Surfaces B2002，23，： | 1 |
| 5 | NMR and theoretical investigation of the keto-enol tautomerism in cyclohexane-1, 3-diones 显示文摘 | Junior V L Constantino M G Silva G V J da | 2007 | J Molecular Structure2007，828，： | 1 |
| 6 | Aniline polymerization into montmorillonite clay:a spectroscopic investigation of the intercalated conducting polymer显示文摘 | Nascimento G M do Constantino V R L Landers R | 2004 | Macromolecules2004，37，25： | 1 |
| 7 | A Failure Mechanismof the Fine Neogene Formations: an Example from Thasos,Greece显示文摘 | CONSTANTINOS L GARYFALIA K | 2007 | Landslides2007，，4： | 1 |
| 8 | Spectroscopic characterization of doped poly(benzidine) and its nanocomposite with cationic clay显示文摘 | Gustavo M do Nascimento Vera R L Constantino Marcia L A Temperini | 2004 | Journal of Physical Chemistry B2004，108，18： | 1 |
| 9 | Basic properties of Mg2+ 1-x + Al3+ x layered double hydroxides intercalated by carbonate, hydroxide, chloride, and sulfate anions显示文摘 | Constantino V R L Pinnavaia T J | 1995 | Inorg Chem1995，34，4： | 1 |
| 10 | 显示文摘 | Izumi C M S Constantino V R L Ferreira A M C | 2006 | Synth Met2006，156，910： | 1 |
| 11 | Long- term complications and mortality in young-onset diabetes: type 2 diabetes is more hazardous and lethal than type i diabetes 显示文摘 | Constantino MI Molyneaux L Limacher-Gisler F | 2013 | Diabetes Care2013，36，： | 1 |
| 12 | Nanostructured films of perylene derivatives: High performance materials for taste sensor applications 显示文摘 | CONSTANTINO C J L ANTUNES P A VENANCIO E C | 2004 | Sensor Letters2004，2，2： | 1 |
| 13 | Financing environ- mental services: The Costa Rican experience and its implications显示文摘 | Chomitz K Brenes E Constantino L | 1999 | The Science of the Total Environment1999，240，： | 1 |
| 14 | Interaction mechanism of poly ( o - ethoxyani- line) and collagen blends 显示文摘 | PIZA M A CONSTANTINO C J L VENANCIO E C | 2003 | Polymer2003，44，： | 1 |
| 15 | Value differences as determinants of importers' perceptions of exporters un- ethical behavior: the impact on relationship quality and performance 显示文摘 | Constantinos N L Leonidas C L | 2013 | International Business Review2013，，22： | 1 |
| 16 | Basic Properties of Mg1-x/2+ Alx 3+ Layered Double Hydroxides Intercalated by Carbonate, Hydroxide, Chloride and Sulfate Anions显示文摘 | Constantino V R L Pinnavaia T J | 1995 | Inorg Chem1995，34，： | 1 |
| 17 | The Direct and Stress-buffering Effects of Self-organization on Psycho- logical Adjustment显示文摘 | Constantino M J Wilson K R Horowitz L M Pinel E C | 2006 | Journal of Social and Clinical Psychology2006，25，3： | 1 |
| 18 | Layered H2K2Nb6O17 exfoliation promoted by n-butylamine 显示文摘 | Bizeto M A Constantino V R L | 2004 | Materials Research Bulletin2004，39，： | 1 |
| 19 | A transmitter diversity scheme for wideband CDMA systems based on space-time spreading 显示文摘 | Bertrand Hochwald Thomas L Marzetta Constantinos B Papadias | 2001 | IEEE J Select Areas Commun2001，19，1： | 1 |
| 20 | Surface Potentials of Polyaniline LB Films显示文摘 | Constantino C J L Dhanabalan A Riul Jr A | 1999 | Synthetic Metals1999，101，： | 1 |
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