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| 1 | Computed tomography and patient risk:Facts,perceptions and uncertainties显示文摘Since its introduction in the 1970s, computed tomography(CT) has revolutionized diagnostic decision-making. One of the major concerns associated with the widespread use of CT is the associated increased radiation exposure incurred by patients. The link between ionizing radiation and the subsequent development of neoplasia has been largely based on extrapolating data from studies of survivors of the atomic bombs dropped in Japan in 1945 and on assessments of the increased relative risk of neoplasia in those occupationally exposed to radiation within the nuclear industry. However, the association between exposure to low-dose radiation from diagnostic imaging examinations and oncogenesis remains unclear. With improved technology, significant advances have already been achieved with regards to radiation dose reduction. There are several dose optimization strategies available that may be readily employed including omitting unnecessary images at the ends of acquired series, minimizing the number of phases acquired, and the use of automated exposure control as opposed to fixed tube current techniques. In addition, new image reconstruction techniques that reduce radiation dose have been developed in recent years with promising results. These techniques use iterative reconstruction algorithms to attain diagnostic quality images with reduced image noise at lower radiation doses. | Stephen P Power Fiachra Moloney Maria Twomey Karl James Owen J O'Connor Michael M Maher | 2016 | World Journal of Radiology2016，8，12： | 7 |
| 2 | Cost benefit analysis of the use of tranexamic acid in primary lower limb arthroplasty: A retrospective cohort study显示文摘AIM: To examine the cost benefit conferred by the perioperative administration of intravenous tranexamic acid(TXA) in lower limb arthroplasty.METHODS: This study evaluates the use of TXA in 200 consecutive lower limb arthroplasties performed in a single surgeon series. The initial 100 patients(control group) underwent surgery without perioperative administration of TXA while the subsequent 100 patients(TXA group) all received 1 g TXA at the time of induction of anaesthesia. Pre- and post-operative haemoglobin, platelet count, haematocrit, the use of blood product post-operatively, length of stay were examined. A financial analysis of both groups was then undertaken. RESULTS: The mean age of patients in both groups was 63 ± 13 years. There were no significant differences between groups in terms of gender(P = 0.47), proportion of total hip replacement to total knee replacement(P = 0.25) or pre-operative haemoglobin(P = 0.43). In the control group, the transfusion rate was 22%. In the TXA group, the transfusion rate dropped to 2%(P < 0.001). The mean post-operative haemoglobin was 10.82 ± 1.55g/dL in the control group vs 11.33 ± 1.27 g/dL in the TXA group(P = 0.01). The total cost of transfused blood products was €11055 and €603 respectively. The mean length of stay in the control group was 6.53 ± 5.93 d vs 5.47 ± 4.26 d in the TXA group(P = 0.15) leading to an estimated financial saving of €114586. There was one pulmonary embolus in the control group and one deep venous thrombosis in the TXA group.CONCLUSION: Intravenous TXA reduces blood loss in lower limb arthroplasty. This leads to lower transfusion rates, shorter length of stay in hospital and significant financial savings. | Niall P McGoldrick Eabhann M O'Connor Nikos Davarinos Rose Galvin John F Quinlan | 2015 | World Journal of Orthopedics2015，6，11： | 3 |
| 3 | C-reactive protein and radiographic findings of lower respiratory tract infection in infants显示文摘AIM To evaluate the association between C-reactive protein(CRP) and radiological evidence of lower respiratory tract infection(LRTI) in infants.METHODS All patients aged less than 4 years who presented with suspected lower respiratory tract infection,who received a peri-presentation chest radiograph and CRP blood measurement over an 18-mo period were included in the study.Age,gender,source of referral,CRP,white cell count,neutrophil count along with the patients' symptoms and radiologist's report were recorded.RESULTS Three hundred and eleven patients met the inclusioncriteria.Abnormal chest radiographs were more common in patients with elevated CRP levels(P < 0.01).Radiologic signs of LRTI were identified in 73.7% of chest radiographs when a patient had a CRP level between 50-99 mg/L.CRP levels were a better predictor of positive chest radiograph findings for those aged greater than I year compared to those 1 year or less.CONCLUSION CRP may be used in patients with suspected LRTI diagnosis to select those who are likely to have positive findings on chest radiograph,thus reducing unnecessary chest radiographs. | Maria Twomey Hannah Fleming Fiachra Moloney Kevin P Murphy Lee Crush Siobhan B O’Neill Oisin Flanagan Karl James Conor Bogue Owen J O’Connor Michael M Maher | 2017 | World Journal of Radiology2017，9，4： | 2 |
| 4 | 心理因素对膝关节置换术后恢复的影响显示文摘心理因素对膝关节置换术后功能恢复的影响目前尚无定论。作者进行了一项队列研究,纳入100例初次行膝关节置换术的患者,平均年龄71岁。6周时获随访97例,1年时获随访87例。患者术前完成疾病认知问卷、医院焦虑抑郁量表、恢复控制点量表和牛津大学膝关节功能评分。结果发现,术前功能评分对术后牛津大学膝关节评分和关节活动范围影响最大;此外,疾病认知问卷和抑郁影响术后6周时牛津大学膝关节功能评分,焦虑和抑郁还影响术后1年的牛津大学膝关节功能评分,但不影响关节活动范围。故作者认为,心理因素对膝关节置换术后功能的恢复有重要影响,应引起临床医师的重视。 | Hanusch B O'Connor D Ions P 李军 荆珏华 | 2014 | 临床骨科杂志2014，17，3： | 2 |
| 5 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 6 | Noninvasive prediction of residual blood flow with in the risk area during acute myocardial infarction: a multicenter validation study of patients undergoing direct coronary angioplasty 显示文摘 | Chareonthaitawee P Christian TF O'Connor MK | 1997 | Am Heart J1997，134，4： | 1 |
| 7 | Active control of a high-speed pantograph 显示文摘 | Connor D N O Eppinger S D Seering W P Womley D N | 1997 | Dynamic Systems Measurement and Control-Trans ASME1997，119，： | 1 |
| 8 | The protective effect of profound hypothermia on the canine central nervous system in surgery of the ascending aorta and the aortic arch显示文摘 | O Connor JV Wilding T Farmer P | 1986 | Ann Thorac Surg1986，41，： | 1 |
| 9 | Phase Ⅱ-Ⅰ-Ⅱ study of two different doses and schedules of pralatrexate,a high-affinity substrate for the reduced folate carrier,in patients with relapsed or refractory lymphoma reveals marked activity in T-cell malignancies显示文摘 | O'Connor OA Horwitz S Hamlin P | 2009 | J Clin Oncol2009，27，26： | 1 |
| 10 | A randomized, placebo controlled trial of natalizumab for relapsing multiple sclerosis 显示文摘 | POLMAN C O' CONNOR P HAVRDOVA E | 2006 | N Engl J Med2006，354，： | 1 |
| 11 | Diffusion tensor imaging abnormalities in cognitively impaired multiple sclerosis patients显示文摘 | Akbar N Lobaugh NJ O'Connor P | 2010 | Can J Neurol Sei2010，37，5： | 1 |
| 12 | Efficacy of anakinra in active ankylosing spondylitis : a clinical and magnetic resonance imaging study显示文摘 | Tan AL Marzo-Ortega H O' Connor P | 2004 | Ann Rheum Dis2004，63，9： | 1 |
| 13 | MOSFET optimization in deep submicron technology for charge amplifiers 显示文摘 | De Geronimo G O'Connor P | 2005 | IEEE Transactions on Nuclear Science2005，52，6： | 1 |
| 14 | The role of rituximab and chemotherapy in aggressive B-cell lymphoma:a preliminary report of dose-adjusted EPOCH-R显示文摘 | Wilson WH Gutierrez M O′Connor P | 2002 | Semin Oncol2002，29，12： | 1 |
| 15 | Solution procedure for the earthquake analysis of arch dam-reservoir systems with compressible water 显示文摘 | O'Connor J P F & Boot J C | 1988 | Earthquake Engineering and Structural Dynamics1988，，16： | 1 |
| 16 | The role of rituximab and chemotherapy in aggressive B-cell lymphoma: a preliminary report of dose- adjusted EPOCH - R显示文摘 | Wilson W H Gutierrez M O'Connor P | 2002 | Semin Oncol2002，29，12： | 1 |
| 17 | Phosphorus sorption capacities of wetland soils and stream sediments impacted by dairy effluent显示文摘 | Reddy K R O'Connor G A Gale P M | 1998 | J Environ Qual1998，27，： | 1 |
| 18 | Differential regulation of activator protein-1 and heat shock factor-1 in myocardial ischemia and reperfusion injury: role of poly(ADP-ribose) polymerase-1 显示文摘 | Zingarelli B Hake P W O Connor M | 2004 | Am J Physiol Heart Circ Physiol2004，286，4： | 1 |
| 19 | Distal femoral comparison of retrograde nail, retrograde prototype locking retrograde nail显示文摘 | Heiney J P Battula S fixation : A biomechanical intramedullary nail and Biomeeh ( Bristol Avon) O'Connor J A | 2012 | Clin2012，29，3： | 1 |
| 20 | Improving compliance with Helicobacter pylori eradication therapy:when and how?显示文摘 | O'CONNOR J P TANEIKE I O'MORAIN C | 2009 | Therap Adv Gastroenterol2009，2，5： | 1 |
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