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| 1 | Endoscopic variceal ligation compared with endoscopic injection sclerotherapy for treatment of esophageal variceal hemorrhage:A meta-analysis显示文摘AIM:To compare the effect of endoscopic variceal ligation(EVL)with that of endoscopic injection sclerotherapy(EIS)in the treatment of patients withesophageal variceal bleeding.METHODS:We performed a systematic literature search of multiple online electronic databases.Metaanalysis was conducted to evaluate risk ratio(RR)and95%confidence interval(CI)of combined studies for the treatment of patients with esophageal variceal bleeding between EVL and EIS.RESULTS:Fourteen studies comprising 1236 patients were included in the meta-analysis.The rebleeding rate in actively bleeding varices patients in the EVL group was significantly lower than that in the EIS group(RR=0.68,95%CI:0.57-0.81).The variceal eradication rate in actively bleeding varices patients in the EVL group was significantly higher than that in the EIS group(RR=1.06,95%CI:1.01-1.12).There was no significant difference about mortality rate between the EVL group and EIS group(RR=0.95,95%CI:0.77-1.17).The rate of complications in actively bleeding varices patients in the EVL group was significantly lower than that in the EIS group(RR=0.28,95%CI:0.13-0.58).CONCLUSION:Our meta-analysis has found that EVL is better than EIS in terms of the lower rates of rebleeding,complications,and the higher rate of variceal eradication.Therefore,EVL is the first choice for esophageal variceal bleeding. | Cong Dai Wei-Xin Liu Min Jiang Ming-Jun Sun | 2015 | World Journal of Gastroenterology2015，21，8： | 89 |
| 2 | The Chromosome-Level Reference Genome of Tea Tree Unveils Recent Bursts of Nonautonomous LTR Retrotransposons in Driving Genome Size Evolution显示文摘Dear Editor,The tea tree Camellia sinensis,a member of the genus Camellia in the Theaceae family,includes two major cultivated varieties,C.sinensis var.assamica(CSA\Assam type)and C.sinensis var.sinensis(CSS;Chinese type)(Ming and Bartholomew,2007).Due to the high economic importance of the tea tree,considerable efforts have been made to explore genetic basis of the biosynthesis of natural metabolites that determine health benefits and diverse tea flavors(Shi et al.,2011;Li et al.,2011;Li et al.,2015;Xia et aL,2017;Liu et al.,2019). | Qun-Jie Zhang Wei L i Kui Li Hong Nan Cong Shi Yun Zhang Zhang-Yan Dai Yang-Lei Lin Xiao-Lan Yang Yan Tong Dan Zhang Cui Lu Li-Ying Feng Chen-Feng Wang Xiao-Xin Liu Jian-An Huang Wen-Kai Jiang Xing-Hua Wang Xing-Cai Zhang Evan E.Eichler Zhong-Hua Liu and Li-Zhi Gao | 2020 | Molecular Plant2020，13，7： | 27 |
| 3 | Stable carbon and hydrogen isotopes of gases from the large tight gas fields in China显示文摘By the end of the year 2010,a total of 15 large tight gas fields have been found in China,located in the Ordos,Sichuan,and Tarim basins.The annual production and total reserves of these fields in 2010 were 222.5×108and 28657×108m3,respectively,accounting for 23.5%and 37.3%,respectively,of the total annual production and reserves of natural gases in China.They took a major part of all natural gas production and reserves in China.According to the analyses of 81 gas samples,the stable carbon and hydrogen isotopic compositions of tight gases in China have following characteristics:(1)Plots of 13C1-13C2-13C3,13C1-C1/C2+3and 13C1-13C2demonstrate the coal-derived origin of tight gases in China;(2)For the primary alkane gases,both carbon and hydrogen isotopic values increase with increasing molecular mass,i.e.,13C1<13C2<13C3<13C4and2H1<2H2<2H3;(3)The isotopic differences of 13C2-13C1,13C3-13C1,2H2-2H1and 2H3-2H1decrease with increasing Ro(%)and C1/C1–4;(4)There are seven causes for the carbon and hydrogen isotopic reversal,however,the carbon and hydrogen isotopic reversal of tight gases in China is caused mainly by multiple stages of gas charge and accumulation. | DAI JinXing NI YunYan HU GuoYi HUANG ShiPeng LIAO FengRong YU Cong GONG DeYu WU Wei | 2014 | Science China Earth Sciences2014，57，1： | 17 |
| 4 | A single Eu^(2+)-activated high-color-rendering oxychloride white-light phosphor for white-light-emitting diodes显示文摘Single-phased,high-color-rendering index(CRI)white-light phosphors are emerging as potential phosphor-converted white-light-emitting diodes(WLEDs)and as an alternative to blends of tricolor phosphors.However,it is a challenge to create a high CRI white light from a single-doped activator.Here,we present a high CRI(Ra 591)white-light phosphor,Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl:Eu^(2+),composed of Sr5(PO4)3Cl as the beginning member and Sr_(5)(BO_(3))_(3)Cl as the end member.This work utilized the solid-solution method,and tunable Eu^(2+) emission was achieved.Color-tunable Eu^(2+) emissions in response to structural variation were observed in Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl solid solutions.This was further confirmed using X-ray Rietveld refinement,electron paramagnetic resonance spectroscopy,and in the photoluminescence spectra.The color-tunable emissions included the white light that originated from the combination of the blue emission of Sr_(5)(PO_(4))_(3)Cl:Eu^(2+) and an induced Eu^(2+) yellow emission at approximately 550 nm in the solid solution.Importantly,the white-light phosphors showed a greater R9590.2 under excitation at 365 nm.This result has rarely been reported in the literature and is greater than that of(R9514.3)commercial Y_(3)A_(l5)O_(12):Ce^(3+)-based WLEDs.These findings demonstrate the great potential of Sr_(5)(PO_(4))_(3-x)(BO_(3))_(x)Cl:0.04Eu^(2+) as a white-light phosphor for near-UV phosphor-converted WLEDs.These results also provide a shortcut for developing a high CRI white-light phosphor from a single Eu^(2+)-doped compound. | Peng-Peng Dai Cong Li Xin-Tong Zhang Jun Xu Xi Chen Xiu-Li Wang Yan Jia Xiaojun Wang Yi-Chun Liu | 2016 | Light(Science & Applications)2016，5，1： | 14 |
| 5 | High precision in-situ Pb isotopic analysis of sulfide minerals by femtosecond laser ablation multi-collector inductively coupled plasma mass spectrometry显示文摘An in-situ microanalysis of Pb isotopic compositions in sulfide minerals is carried out by using femtosecond laser-ablation multi-collector inductively coupled plasma mass spectrometry(fs LA-MC-ICP-MS).High-temperature-activated carbon was used to filter Hg contained in the carrier gas,which reduced the Hg background signal by 48%and also lowered the detection limit of the analysis.Fractionation and mass discrimination effects existing in the ICP-MS analytical processes were corrected using an internal reference Tl in conjunction with an external reference NIST SRM 610.The proposed method was used to analyze the Pb isotopic compositions of chalcopyrite,pyrite,and sphalerite from the Dulong Sn-Zn-In polymetallic ore district.The results showed that in this ore district,the sulfide minerals and different grains of the same sulfide mineral show a large variation in Pb content up to 1000-fold.The studied pyrites show relatively higher Pb contents and homogeneous Pb isotopic compositions,whereas the sphalerites have low Pb contents but most variable Pb isotopic compositions.It is suggested that the large variation of Pb isotopic composition may reflect a late hydrothermal superimposition on the primary sulfide formation.In addition,radiogenic Pb accumulated by radioactive decay of trace amounts of U over time in the host minerals may also be one of the causes for the large variation range of Pb content and Pb isotopic composition of those low-Pb sphalerites.Chalcopyrite and sphalerite grains with Pb content greater than 10 ppm presented a consistent Pb isotopic distribution,whereas all the sulfide grains with Pb content greater than 100 ppm had consistent Pb isotopic composition within 2s measurement uncertainties.The in-situ analysis of Pb isotopic composition agreed well with the results obtained by conventional chemical methods within2s measurement uncertainties,indicating that the data obtained by fs LA-MC-ICP-MS are reliable.Additionally,this study indicates that the Pb isotopic composition could truthfully record the source of ore-forming minerals only for sulfide minerals with high Pb content.On the contrary,the Pb isotopic composition of low-Pb sulfide minerals may be affected by trace amounts of U in the host minerals that may lead to a highly radiogenic Pb isotope ratio.Alternatively,it is also possible that late fluid metasomatic overprinting may alter the Pb isotopic compositions. | YUAN HongLin YIN Cong LIU Xu CHEN KaiYun BAO ZhiAn ZONG ChunLei DAI MenNing LAI ShaoCong WANG Rong JIANG ShaoYong | 2015 | Science China Earth Sciences2015，58，10： | 14 |
| 6 | Studying the mechanical properties of the soil-root interface using the pullout test method显示文摘It is important to quantify the effect of the root diameter, the embedment length of the root and load speed on the soil-root interface mechanical properties for studying the root anchorage. The soilroot interface mechanical properties can be obtained through the pullout force and root slippage curve(F-S curve). About 120 Pinus tabulaeformis single roots whose diameters ranged from 1 mm to 10 mm divided into 6 groups based on different root embedment length(50 mm, 100 mm and 150 mm) and different load velocity(10 mm·min^(-1), 50 mm·min^(-1), 100 mm·min^(-1) and 300 mm·min^(-1)) were investigated using the pullout method. This study aims to explore the mechanical properties of the soil-root interface in the real conditions using the pullout test method. The results showed two kinds of pullout test failure modes during the experimental process: breakage failure and pullout failure. The results showed that the roots were easier to be broken when the root diameter was smaller or the loading speed was larger. The relationship between the maximum anchorage force and root diameter was linear and the linearly dependent coefficient(R^2) was larger than 0.85. The anchorage force increased with the root embedment length. An increase of 10%^(-1)5% for the maximumanchorage force was found when load speed increased from 10 to 300 mm.min^(-1). The mean peak slippage of the root was from 13.81 to 35.79 mm when the load velocity varied from 10 to 300 mm.min^(-1). The study will be helpful for the design of slopes reinforced by vegetation and in predicting risk of uprooting of trees, and will have practical benefits for understanding the mechanism of landslide. | JI Xiao-dong CONG Xu DAI Xian-qing ZHANG Ao CHEN Li-hua | 2018 | Journal of Mountain Science2018，15，4： | 13 |
| 7 | Probiotics and irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is common gastrointestinal problems.It is characterized by abdominal pain or discomfort,and is associated with changes in stool frequency and/or consistency.The etiopathogenesis of IBS may be multifactorial,as is the pathophysiology,which is attributed to alterations in gastrointestinal motility,visceral hypersensitivity,intestinal microbiota,gut epithelium and immune function,dysfunction of the brain-gut axis or certain psychosocial factors.Current therapeutic strategies are often unsatisfactory.There is now increasing evidence linking alterations in the gastrointestinal microbiota and IBS.Probiotics are living organisms which,when ingested in certain numbers,exert health benefits beyond inherent basic nutrition.Probiotics have numerous positive effects in the gastrointestinal tract.Recently,many studies have suggested that probiotics are effective in the treatment of IBS.The mechanisms of probiotics in IBS are very complex.The purpose of this review is to summarize the evidence and mechanisms for the use of probiotics in the treatment of IBS. | Cong Dai Chang-Qing Zheng Min Jiang Xiao-Yu Ma Li-Juan Jiang | 2013 | World Journal of Gastroenterology2013，19，36： | 13 |
| 8 | Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014显示文摘Background:H7N9 continues to cause human infections and remains a pandemic concern.Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation,including infectious disease prevention and control investment.However,there are limited data on such impacts.Methods:Hospitalized laboratory-confirmed H7N9 patients or their families in Jiangsu Province of China were interviewed.Patients’direct medical costs of hospitalization were derived from their hospital bills.A generalized linear model was employed to estimate the mean direct medical costs of patients with different characteristics.Results:The mean direct cost of hospitalization for H7N9 was estimated to be¥71060(95%CI,48180–104820),i.e.,US$10996(95%CI,7455–16220),and was¥12060(US$1861),¥136120(US$21001)and¥218610(US$33728)for those who had mild or severe symptoms or who died,respectively.The principal components of the total fees differed among patients with different disease severity,although medication fees were always the largest contributors.Disease severity,proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient’s direct medical cost of hospitalization.Conclusions:The direct medical costs of hospitalized patients with H7N9 are significant,and far surpass the annual per capita income of Jiangsu Province,China.The influencing factors identified should be taken into account when developing related health insurance policies and making health resource allocation.Trial registration:Not applicable.This is a survey study with no health care intervention implemented on human participants. | Xiang Huo Li-Ling Chen Lei Hong Lun-Hui Xiang Fen-Yang Tang Shan-Hui Chen Qiang Gao Cong Chen Qi-gang Dai Chuan-Wu Sun Ke Xu Wen-Jun Dai Xian Qi Chang-Cheng Li Hui-Yan Yu Yin Zhou Hao-Di Huang Xing-Yang Pan Chang-sha Xu Ming-Hao Zhou Chang-Jun Bao | 2016 | Infectious Diseases of Poverty2016，5，1： | 10 |
| 9 | Special AT-rich sequence-binding protein 1 promotes cell growth and metastasis in colorectal cancer显示文摘AIM: To evaluate the expression of special AT-rich sequence-binding protein 1 (SATB1 ) gene in colorectal cancer and its role in colorectal cancer cell proliferation and invasion.METHODS: Immunohistochemistry was used to detect the protein expression of SATB1 in 30 colorectal cancer (CRC) tissue samples and pair-matched adjacent nontumor samples. Cell growth was investigated after enhancing expression of SATB1. Wound-healing assay and Transwell assay were used to investigate the impact of SATB1 on migratory and invasive abilities of SW480 cells in vitro . Nude mice that received subcutaneous implantation or lateral tail vein were used to study the effects of SATB1 on tumor growth or metastasis in vivo . RESULTS: SATB1 was over-expressed in CRC tissues and CRC cell lines. SATB1 promotes cell proliferation and cell cycle progression in CRC SW480 cells. SATB1 over-expression could promote cell growth in vivo . In addition, SATB1 could significantly raise the ability of cell migration and invasion in vitro and promote the ability of tumor metastasis in vivo . SATB1 could up-regulate matrix metalloproteases 2, 9, cyclin D1 and vimentin, meanwhile SATB1 could down-regulate E-cadherin in CRC. CONCLUSION: SATB1 acts as a potential growth and metastasis promoter in CRC. SATB1 may be useful as a therapeutic target for CRC. | Xue-Feng Fang Zhi-Bo Hou Xin-Zheng Dai Cong Chen Jing Ge Hong Shen Xiao-Feng Li Li-Ke Yu Ying Yuan | 2013 | World Journal of Gastroenterology2013，19，15： | 9 |
| 10 | Exosomes:key players in cancer and potential therapeutic strategy显示文摘Exosomes are extracellular vesicles secreted by most eukaryotic cells and participate in intercellular communication.The components of exosomes,including proteins,DNA,mRNA,microRNA,long noncoding RNA,circular RNA,etc.,which play a crucial role in regulating tumor growth,metastasis,and angiogenesis in the process of cancer development,and can be used as a prognostic marker and/or grading basis for tumor patients.Hereby,we mainly summarized as followed:the role of exosome contents in cancer,focusing on proteins and noncoding RNA;the interaction between exosomes and tumor microenvironment;the mechanisms that epithelial-mesenchymal transition,invasion and migration of tumor affected by exosomes;and tumor suppression strategies based on exosomes.Finally,the application potential of exosomes in clinical tumor diagnosis and therapy is prospected,which providing theoretical supports for using exosomes to serve precise tumor treatment in the clinic. | Jie Dai Yangzhou Su Suye Zhong Li Cong Bang Liu Junjun Yang Yongguang Tao Zuping He Chao Chen Yiqun Jiang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 8 |
| 11 | Laparoscopic distal pancreatectomy with or without splenectomy: spleen-preservation does not increase morbidity显示文摘BACKGROUND: The indications for laparoscopic spleen-preserving distal pancreatectomy (LSPDP) and its morbidity compared with laparoscopic distal pancreatectomy with splenectomy (LDPS) are ill-defined. This study aimed to share the indications for spleen-preservation and investigate the safety and outcome of LSPDP at our institution. METHODS: A retrospective review of patients who were scheduled to receive laparoscopic surgery for distal pancreatic lesions was conducted. The indications, surgical procedures, intra-operative data, and outcomes of the two procedures were collected and compared by statistical analysis. RESULTS: LDPS and LSPDP were successfully performed in 16 and 21 patients respectively, whereas they were converted to open surgery in 9 patients. There were no significant differences in age, gender, operation time, blood loss, and conversion rate between the LDPS and LSPDP groups. The mean tumor size showed an inter-group difference (5.05 vs 2.53 cm, P<0.001). There were no significant differences in complication and morbidity rates between the two groups. All patients remained alive without recurrence during a follow-up of 9 to 67 months (median 35).CONCLUSION: LSPDP has a morbidity and outcome comparable to LDPS. | Yu-Pei Zhao, Xiao Du, Meng-Hua Dai, Tai-Ping Zhang, Quan Liao, Jun-Chao Guo, Lin Cong ,Ge Chen Department of General Surgery, Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730, China | 2012 | Hepatobiliary & Pancreatic Diseases International2012，11，5： | 8 |
| 12 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 13 | Determination of lead isotope compositions of geological samples using femtosecond laser ablation MC-ICPMS显示文摘Lead isotopic compositions of international silicate glasses,feldspar and copper-based samples are obtained using femtosecond laser ablation multiple collector inductively coupled plasma mass spectrometry(fLA-MC-ICPMS).Some international glass standards for the microanalysis are applied to evaluate the method reported here.The Pb isotopic composition of these NIST glasses(SRM 610,612,614),USGS(BHVO-2G,BCR-2G,BIR-1G and GSD-1G)and MPI-DING glasses(GOR132-G,KL2-G,T1-G,StHs60/80-G)agree well with recommended values in 2 s error.One of 15 copper-based metals is found to have homogenized Pb isotope data and can be used as an external calibration standard and quality control sample for chalcopyrite,ancient coins,etc.,to trace the genesis of metal deposit and culture exchange among different dynasties(GBW02137,208Pb/204Pb=37.9661±0.0005(2 s),207Pb/204Pb=15.5770±0.0002(2 s),206Pb/204Pb=17.7462±0.0002(2 s)).We also prepared a feldspar glass to serve as the external calibration standard/QC for Pb isotope analysis using fLA-MC-ICPMS. | YUAN HongLin CHEN KaiYun BAO ZhiAn ZONG ChunLei DAI MengNing FAN Chao YIN Cong | 2013 | Chinese Science Bulletin2013，58，32： | 5 |
| 14 | Networking retinomorphic sensor with memristive crossbar for brain-inspired visual perception显示文摘Compared to human vision,conventional machine vision composed of an image sensor and processor suffers from high latency and large power consumption due to physically separated image sensing and processing.A neuromorphic vision system with brain-inspired visual perception provides a promising solution to the problem.Here we propose and demonstrate a prototype neuromorphic vision system by networking a retinomorphic sensor with a memristive crossbar.We fabricate the retinomorphic sensor by using WSe_(2)/h-BN/Al_(2)O_(3)van der Waals heterostructures with gate-tunable photoresponses,to closely mimic the human retinal capabilities in simultaneously sensing and processing images.We then network the sensor with a large-scale Pt/Ta/Hf O_(2)/Ta one-transistor-one-resistor(1 T1 R)memristive crossbar,which plays a similar role to the visual cortex in the human brain.The realized neuromorphic vision system allows for fast letter recognition and object tracking,indicating the capabilities of image sensing,processing and recognition in the full analog regime.Our work suggests that such a neuromorphic vision system may open up unprecedented opportunities in future visual perception applications. | Shuang Wang Chen-Yu Wang Pengfei Wang Cong Wang Zhu-An Li Chen Pan Yitong Dai Anyuan Gao Chuan Liu Jian Liu Huafeng Yang Xiaowei Liu Bin Cheng Kunji Chen Zhenlin Wang Kenji Watanabe Takashi Taniguchi Shi-Jun Liang Feng Miao | 2021 | National Science Review2021，8，2： | 5 |
| 15 | Isoproterenol-induced FKBP12.6/12 downregulation is modulated by ETA and ETB receptors and reversed by argirhein, a derivative of rhein显示文摘 | Guo-lin ZHANG De-zai DAI Tao XI Xiao-dong CONG Yun ZHANG Yin DAI | 2011 | Acta Pharmacologica Sinica2011，32，2： | 5 |
| 16 | Performance Analysis of a Combined Absorption Refrigeration-Liquid Desiccant Dehumidification THIC System Driven by Low-Grade Heat Source显示文摘Traditional condensing air-conditioning systems consume large amounts of energy in hot and humid areas,and it is difficult to achieve simultaneous control of temperature and humidity.A combined absorption refrigeration(AR)and liquid desiccant dehumidification(LDD)air-conditioning system based on cascade utilization of low-grade heat source is proposed.The system can realize independent control of temperature and humidity and carry out profound recovery of low-grade heat sources.Under the design conditions,the heat utilization rate C reaches 21.05%,which is 2.73 times that of the conventional absorption refrigeration reference system.A parametric sensitivity analysis is performed to optimize the system.The C increases from 9.79%to 18.55%and the coefficient of performance C O P t increases from 0.33 to 0.35 with an increase in chilled water temperature from 7°C to 15°C.With an increase in regenerant solution temperature from 60°C to 70°C,the C achieves the optimal value of 21.05%at 68°C.C decreases from 21.05%to 15.05%as the concentration of the regenerant solution increases from 36%to 40%.Under variable environmental temperature and humidity,the C the proposed system changes within a small range and stays much higher than that of the reference system with the same quality heat source,which indicates that the proposed system has a better adaptability to changing environmental parameters. | XU Cong SUI Jun DAI Yuze LIU Feng LIU Hao | 2020 | Journal of Thermal Science2020，29，5： | 5 |
| 17 | Dairy product consumption and gastric cancer risk: A meta-analysis显示文摘AIM: To investigate whether dairy product consumption is a risk factor for gastric cancer. METHODS: We searched the Pub Med and Web of Science databases for English-language studies on dairy product consumption and gastric cancer risk that were published between October 1980 and September 2013. One author independently extracted data and assessed study quality. Based on the heterogeneity results, we used either the fixed effects model or the random effects model to compute the summary relative risks and 95% confidence intervals(CIs). We also analyzed subgroups according to the study design, geographic region, sex, and whether there were adjustments for confounders(smoking and drinking) with respect to the sources of heterogeneity.RESULTS:We found 39 studies that were potentiallyeligible for inclusion in this meta-analysis,including 10cohort studies and 29 case-control studies.The summary relative risk for gastric cancer,comparing the highest and lowest dairy product consumption categories,was 1.06(95%CI:0.95-1.18).Specific analyses for milk,butter,and margarine yielded similar results,but the results for cheese and yogurt were different.There was significant heterogeneity for all studies(Q=112.61;P=0.000;I2=67.1%).No publication bias was observed(Egger’s test:P=0.135;Begg’s test:P=0.365).There was a nonsignificant association between dairy product consumption and gastric cancer risk in the subgroup analysis for the study design,sex,geographic region,and whether there were adjustments for confounders(smoking and drinking).CONCLUSION:In our meta-analysis,dairy product consumption was associated with a nonsignificantly increased risk of gastric cancer.However,this result should be verified using large,well-designed prospective studies. | Yan Sun Lian-Jie Lin Li-Xuan Sang Cong Dai Min Jiang Chang-Qing Zheng | 2014 | World Journal of Gastroenterology2014，20，42： | 5 |
| 18 | Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)显示文摘BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for MACE.RESULTS In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real world, PCSK-9 inhibitors combined with statins could significantly reduce LDL-C levels among patients with very high risk of ASCVD in China. The long-term clinical benefits for patients received PCSK-9 inhibitor to reduce the risk of MACE is still unclear and requires further study. | Yu-Qi LIU Dan-Dan LI Meng CHAI Hong-Liang CONG Xiao-Qiang CONG Jun DAI Rong-Pin DU Ming GAO Jin-Cheng GUO Yan-Qing GUO Xiao-Jian HONG Rong-Chong HUANG Feng-Shun JIA Jia-Yu LI Qing LI Jia-Mei LIU Xin-Ping LIU Yu-Guo LIU Hong-Gang NIE Bing SHAO Xiao-Yu SHEN Hai-Qing SONG Yi-Jun SONG Li-Jun WANG Shuo WANG Dong-Mei WU Jing XIA Zhi-Yong YANG Hong-Ying YU Hui ZHANG Tie-Mei ZHANG Ji-Yi ZHAO Liang-Chen ZHAO Ming-Qi ZHENG Yun-Dai CHEN | 2021 | Journal of Geriatric Cardiology2021，18，4： | 5 |
| 19 | Expression of Obesity Hormone Leptin in Human Colorectal Cancer显示文摘Objective:The obesity hormone,leptin,has been found to participate in the development and proliferation of normal and malignant tissues.The aim of this study was to evaluate the role of leptin in human colorectal cancer.Methods:Serum leptin levels were measured via ABC-ELLSA in 30 colorectal cancers and 24 normal controls.Leptin concentration in colorectal cancer was analyzed in terms of selected clinicopathological features and some oncogenes.Results:The mean concentration of leptin was significantly higher for colorectal cancers(3.54±1.46 ng/ml) than normal controls(2.27±0.99 ng/ml),no gender difference was observed in this study.Leptin expression in poorly differentiated tumors was obviously lower than those in moderately and well differentiated tumors.There were no statistically significant correlations between leptin and the serum CEA and CA199 in colorectal cancers(P>0.05),and between leptin and the expressions of K-RAS,P53,APC,DCC genes in tumor tissues(P>0.05).Conclusion:Leptin is overexpressed in human colorectal cancer,which is related to the differentiation degrees of the tumor.There is no correlation between leptin expression and changes of oncogenes in colorectal cancers. | Jin-chun Cong Xian-wei Dai Ming-yang Shen Jun-jiang Wang Chun-sheng Chen Hong Zhang Lei Qiao | 2009 | Chinese Journal of Cancer Research2009，21，2： | 4 |
| 20 | Effect of Cold-Water Irrigation on Grain Quality Traits in japonica Rice Varieties from Yunnan Province,China显示文摘The response of grain quality traits to cold-water irrigation and its correlation with cold tolerance were studied in 11 japonica rice varieties from Yunnan Province, China. The results indicated that the response of grain quality traits to the cold-water stress varied with rice varieties and grain quality traits. Under the cold-water stress, grain width, chalky rice rate, whiteness, 1000-grain weight, brown rice rate, taste meter value, peak viscosity, trough viscosity, breakdown viscosity and final viscosity significantly decreased, whereas grain length-width ratio, head rice rate, alkali digestion value, protein content and setback viscosity markedly increased. However, the other traits such as grain length, amylose content, milled rice rate, peak viscosity time and pasting temperature were not significantly affected by the cold-water stress. Significant correlations were discovered between phenotypic acceptability and cold response indices of taste meter value, protein content, peak viscosity and breakdown viscosity. Therefore, it would be very important to improve the cold tolerance of Yunnan rice varieties in order to stabilize and improve their eating quality. | ZHAO Guo-zhen LIU Ji-xin YANG Sea-jun YEA Jong-doo LIAO Xin-hua Su Zhen-xi SHI Rong JIANG Cong DAI Lu-yuan | 2009 | Rice science2009，16，3： | 4 |
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