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| 1 | Separation,identification,and quantification of active constituents in Fructus Psoraleae by high-performance liquid chromatography with UV,ion trap mass spectrometry,and electrochemical detection显示文摘The qualitative and quantitative analysis of active constituents in Fructus Psoraleae is presented by high-performance liquid chromatography (HPLC) coupled with different detections.Extracts of Fructus Psoraleae were examined by HPLC with ion trap mass spectrometry (IT-MS) and 18 major compounds of coumarins,benzofuran glycosides,flavonoids,and meroterpene were identified.The determination of four major constituents including bavachin,isobavachalcone,bavachinin,and bakuchiol was accomplished by HPLC with UV,MS,and electrochemical detection (ECD).These methods were evaluated for a number of validation characteristics (repeatability,LOD,calibration range,and recovery).ECD obtained a high sensitivity for analysis of the four components;MS provided a high selectivity and sensitivity for determination of bavachin,isobavachalcone,and bavachinin in negative-ion mode.After optimization of the methods,separation,identification.and quantification of the four components in Fructus Psoraleae were comprehensively tested by HPLC with UV,MS,and ECD. | Qinhua Chen,Yuan Li,Zilin Chen Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University),Ministry of Education,and Wuhan University School of Pharmaceutical Sciences,Wuhan,430071,China | 2012 | Journal of Pharmaceutical Analysis2012，2，2： | 7 |
| 2 | On the coupled NBEM and FEM for a class of nonlinear exterior Dirichlet problem in R^(2*)显示文摘In this paper, based on the natural boundary reduction advanced by Feng and Yu, we couple the finite elementapproach with the natural boundary element method to study theweak solvability and Galerkin approximation of a class ofnonlinear exterior boundary value problems. The analysis is mainlybased on the variational formulation with constraints.We provethe error estimate of the finite element solution and obtain theasymptotic rate of convergence. Finally, we also give anumerical example. | WU Zhengpeng, KANG Tong & YU DehaoInstitute of Computational Mathematics and Scientific/Engineering Computing, Academy of Mathematics and System Sciences, Chinese Academy of Sciences, Beijing 100080, China Department of Applied Mathematics, Beijing Broadcasting Institute, Beijing 100024, China Combinatorial and Computational Mathematics Center, Pohang University of Science and Technology, Phoang 790-784, Republic of Korea | 2004 | Science China Mathematics2004，47，z1： | 4 |
| 3 | New developments in small molecular compounds for anti-hepatitis C virus(HCV) therapy显示文摘Infection with hepatitis C virus(HCV) affects approximately 170 million people worldwide.However,no vaccine or immunoglobulin is currently available for the prevention of HCV infection.The standard of care(SOC) involving pegylated interferon-α(PEG-IFN α) plus ribavirin(RBV) for 48 weeks results in a sustained virologic response in less than 50% of patients with chronic hepatitis C genotype 1,the most prevalent type of HCV in North America and Europe.Recently,reliable in vitro culture systems have been developed for accelerating antiviral therapy research,and many new specifically targeted antiviral therapies for hepatitis C(STAT-C) and treatment strategies are being evaluated in clinical trials.These new antiviral agents are expected to improve present treatment significantly and may potentially shorten treatment duration.The aim of this review is to summarize the current developments in new anti-HCV drugs. | Jing TONG1,2,You-wei WANG2,Yuan-an LU1,2(1Department of Public Health Sciences,University of Hawaii,Honolulu,Hawaii 96822,USA)(2Key Laboratory of Combinatorial Biosynthesis and Drug Discovery,Ministry of Education,Institute of Traditional Chinese Medicine & Natural Products,School of Pharmaceutical Sciences,Wuhan University,Wuhan 430071,China) | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，1： | 2 |
| 4 | Auctions design显示文摘 | Pekec Rothkopf Combinatorial | 2003 | Management Science2003，49，11： | 1 |
| 5 | Functional relationships established for key mediators of apop- tosis显示文摘 | THORNBERRY NA RANO TA PE- TERSON EP et aL A combinatorial approach defines specificities of mem- bers of the caspase family and granzyme B | 1997 | J Biol Chem1997，272，17： | 1 |
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