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| 1 | 乳腺囊内型乳头状癌显示文摘 | Collins L C Carlo V P Hwang H 魏兵(摘译) 步宏(审校) | 2006 | 临床与实验病理学杂志2006，22，5： | 38 |
| 2 | Molecular targets in the treatment of alcoholic hepatitis显示文摘Alcohol related costs to health and society are high. One of the most serious complications of alcohol misuse to the individual is the development of alcoholic hepatitis (AH), a clinical syndrome of jaundice and progressive inflammatory liver injury in patients with a history of recent heavy alcohol use. It has a poor outcome and few existing successful therapies. The use of glucocorticoids in patients with severe AH is still controversial and there remains a group of patients with glucocorticoid-resistant disease. However, as our understanding of the pathogenesis of the condition improves there are opportunities to develop new targeted therapies with specific actions to control liver inflammation without having a detrimental effect on the immune system as a whole. In this article we review the molecular mechanisms of AH concentrating on the activation of the innate and adaptive immune response. We consider existing treatments including glucocorticoids, anti-tumor necrosis factor therapy and pentoxifylline and their limitations. Using our knowledge of the disease pathogenesis we discuss possible novel therapeutic approaches. New targets include pro-inflammatory cytokines such as interleukin (IL)-17, chemokines and their receptors (for example IL-8, CXCL9 and CXCR3) and augmentation of anti-inflam- matory molecules such as IL-10 and IL-22. And there is also future potential to consider combination therapy to selectively modulate the immune response and gain control of disease. | Ashwin D Dhanda Richard WL Lee Peter L Collins C Anne McCune | 2012 | World Journal of Gastroenterology2012，18，39： | 9 |
| 3 | Is liver biopsy necessary in the management of alcoholic hepatitis?显示文摘Acute alcoholic hepatitis(AAH)is characterised by deep jaundice in patients with a history of heavy alcohol use,which can progress to liver failure.A clinical diagnosis of AAH can be challenging to make in patients without a clear alcohol history or in the presence of risk factors for other causes of acute liver failure.Other causes of acute on chronic liver failure such as sepsis or variceal haemorrhage should be considered.Liver biopsy remains the only reliable method to make an accurate diagnosis.However,there is controversy surrounding the use of liver biopsy in patients with AAH because of the risks of performing a percutaneous biopsy and limitations in access to transjugular biopsy.We review the existing literature and find there are few studies directly comparing clinical and histological diagnosis of AAH.In the small number of studies that have been conducted the correlation between a clinical and histological diagnosis of AAH is poor.Due to this lack of agreement together with difficulties in accessing transjugular liver biopsy outside tertiary referral centres and research institutions,we cannot advocate universal biopsy for AAH but there remains a definite role for liver biopsy where there is clinical diagnostic doubt or dual pathology.Italso adds value in a clinical trial context to ensure a homogeneous trial population and to further our understanding of the disease pathology.Further prospective studies are required to determine whether non-invasive markers can be used to accurately diagnose AAH. | Ashwin D Dhanda Peter L Collins C Anne McCune | 2013 | World Journal of Gastroenterology2013，19，44： | 4 |
| 4 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 5 | White-matter diffusion abnormalities in temporal-lobe epilepsy with and without mesial temporal sclerosis显示文摘 | Concha L Beaulieu C Collins DL | 2009 | J Neurol Neurosurg Psychiatry2009，80，： | 1 |
| 6 | Laparoscopic port-site recurrence following surgery for a stage IB squamous cell carcinoma of the cervix with negative lymph nudes显示文摘 | Kohlberger PD Edwards L Collins C | 2000 | Gynecol Oncol2000，79，2： | 1 |
| 7 | Comparing gel permeation chromatography and ultrafiltration for the molecular weight characterization of aquatic organic matter显示文摘 | Collins M R Kuo C J | 1987 | J AWWA1987，79，1： | 1 |
| 8 | High-accuracy Analog Measurements Via Interpolated FFT显示文摘 | Jane V K Collins W L Jr Davis D C | 1979 | IEEE Trans-M1979，28，2： | 1 |
| 9 | High-accuracy analog measurement via interpolated FFT 显示文摘 | Jain V K Collins W L Davis D C | 1979 | IEEE Trans IM1979，28，2： | 1 |
| 10 | A dynamic recurrent neural network-based controller for a rigid-flexible manipulator system显示文摘 | Tian L F Collins C | 2004 | Mechatronics2004，，14： | 1 |
| 11 | Crop rotation and residue management effects on soil carbon and microbial dynamics 显示文摘 | Collins H P Rasmussen P E Douglas C L | 1992 | Soil Science Society of America Journal1992，56，3： | 1 |
| 12 | Effects of non-structural proteins NS1 and NS2 of human respiratory syncytial virus on interferon regulatory factor 3, NFkappaB, and proinflammatory eytokines 显示文摘 | Spann K M Tran K C Collins P L | 2005 | J Virol2005，79，9： | 1 |
| 13 | Early and late reversal of rocuronium and vecuronium with neostigmine in adult and children显示文摘 | Bevan JC Collins L Fowler C | 1999 | Anesth Analg1999，89，： | 1 |
| 14 | Resultsfrom the 1995 national college health risk behavior survey显示文摘 | Douglas K A Collins J L Warren C | 1997 | J Am College Health1997，46，2： | 1 |
| 15 | Ductal carcinoma in situ with a basal-like phenotype: a possible precursor to invasive basallike breast cancer显示文摘 | Bryan B B Schnitt S J Collins L C | 2006 | Mod Pathol2006，19，： | 1 |
| 16 | Aspirin in the primary and secondary prevention of vascular disease:Collaborative meta-analysis of individual participant data from randomised trials显示文摘 | Baigent C Blackwell L Collins R | 2009 | Lancet2009，373，9678： | 1 |
| 17 | Accumulation of zinc and organic acids in roots of zinc tolerant and non-tolerant ecotypes of Deschampsia caespitosa显示文摘 | Godbold D L Horst W J Collins J C | 1984 | J Plant Physio1984，116，： | 1 |
| 18 | The natural history of cervical HPV infection: unresolved issues显示文摘 | Woodman C B Collins S I Young L S | 2007 | Nat Rev Cancer2007，7，1： | 1 |
| 19 | Review of the pest sta- tus and control options for Thrips palmi显示文摘 | Cannon R J C Matthews L Collins A D W | 2007 | Crop Protection2007，26，8： | 1 |
| 20 | A practical method for calculating largest Lyapunov exponents from small data sets 显示文摘 | Rosenstein M T Collins J J De L C J | 1993 | Physica D1993，65，： | 1 |
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