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| 1 | Comparison of six methods of extracting mycobacterium tuberculosis DNA from processed sputum for testing by quantitative real time PCR显示文摘 | Aldous W K Pounder J I Cloud J L | 2005 | J Clin Microbiol2005，43，5： | 1 |
| 2 | Tranexamic acid for intracerebral haemorrhage within 2 hours of onset: protocol of a phase Ⅱ randomised placebo-controlled double-blind multicentre trial显示文摘Rationale Haematoma growth is common early after intracerebral haemorrhage(ICH),and is a key determinant of outcome.Tranexamic acid,a widely available antifibrinolytic agent with an excellent safety profile,may reduce haematoma growth.Methods and design Stopping intracerebral haemorrhage with tranexamic acid for hyperacute onset presentation including mobile stroke units(STOP-MSU)is a phase Ⅱ double-blind,randomised,placebo-controlled,multicentre,international investigator-led clinical trial,conducted within the estimand statistical framework.Hypothesis In patients with spontaneous ICH,treatment with tranexamic acid within 2 hours of onset will reduce haematoma expansion compared with placebo.Sample size estimates A sample size of 180 patients(90 in each arm)would be required to detect an absolute difference in the primary outcome of 20%(placebo 39%vs treatment 19%)under a two-tailed significance level of 0.05.An adaptive sample size re-estimation based on the outcomes of 144 patients will allow a possible increase to a prespecified maximum of 326 patients.Intervention Participants will receive 1 g intravenous tranexamic acid over 10 min,followed by 1 g intravenous tranexamic acid over 8 hours;or matching placebo.Primary efficacy measure The primary efficacy measure is the proportion of patients with haematoma growth by 24±6 hours,defined as either≥33%relative increase or≥6 mL absolute increase in haematoma volume between baseline and follow-up CT scan.Discussion We describe the rationale and protocol of STOP-MSU,a phase Ⅱ trial of tranexamic acid in patients with ICH within 2 hours from onset,based in participating mobile stroke units and emergency departments. | Nawaf Yassi Henry Zhao Leonid Churilov Bruce C V Campbell Teddy Wu Henry Ma Andrew Cheung Timothy Kleinig Helen Brown Philip Choi Jiann-Shing Jeng Annemarei Ranta Hao-Kuang Wang Geoffrey C Cloud Rohan Grimley Darshan Shah Neil Spratt Der-Yang Cho Karim Mahawish Lauren Sanders John Worthington Ben Clissold Atte Meretoja Vignan Yogendrakumar Mai Duy Ton Duc Phuc Dang Nguyen Thai My Phuong Huy-Thang Nguyen Chung Y Hsu Gagan Sharma Peter J Mitchell Bernard Yan Mark W Parsons Christopher Levi Geoffrey A Donnan Stephen M Davis | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 3 | Evaluation of a Modified Gen-Probe Amplified Direct Test for Detection of Mycobacterium tuberculosis Complex Organisms in Cerebrospinal Fluid显示文摘 | CLOUD JL SHUTT C ALDOUS W | 2004 | J Clin Microbiol(S0095-1137)2004，42，11： | 1 |
| 4 | Ganciclovir Treatment of Symptomatic Congenital Cytomegalovirus Infection:Results of a Phase Ⅱ Study显示文摘 | Cloud G Gruber W | 1997 | J Jnfect Dis1997，175，： | 1 |
| 5 | Ganciclovir treatment of symptomatic congenital cytomegalovirus infection:Results of a phase Ⅱ study显示文摘 | Cloud G Gruber W | 1997 | J Infect Dis1997，175，5： | 1 |
| 6 | A review显示文摘 | ROSSOW W B Measuring cloud properties from space | 1989 | J Climate1989，2，3： | 1 |
| 7 | New applications of well log parameters in coalbed methane(CBM)reservoir evaluation at the drunkards Wash Unit,Uinta Basin,Utah显示文摘 | Yang Y Cloud T A Van Kirk C W | 2005 | SPE 979882005，，： | 1 |
| 8 | Impact of Nasopharyngeal Swab Types on Detection of Bordetella pertussis by PCR and Culture显示文摘 | Cloud JL Hymas W Carroll KC | 2002 | J Clin Microbiol2002，40，： | 1 |
| 9 | Rapid display profiling of cancer progression directly from human tissue using a protein biochip显示文摘 | Cloud P P John W G David K O | 2000 | Drug Dev Res2000，49，1： | 1 |
| 10 | Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of phase Ⅱ study显示文摘 | Cloud G Gruber W | 1997 | J Infect Dis1997，175，5： | 1 |
| 11 | 5℃ 显示文摘 | Rosenfeld D Woodley W L Deep convective clouds with sustained supercooled liquid water down to -37 | 2000 | Nature2000，405，： | 1 |
| 12 | Man amplifiers: Machines that let you carry a ton显示文摘 | Cloud W | 1965 | Popular Science1965，187，5： | 1 |
| 13 | An Automated Scheme for the Removal of Cloud Contamination from AVHRR Radiances over Western Europe显示文摘 | A generalized scenario for cloud Geoscience and Remote Sensing Saunders R W | 1986 | International Journal of Remote Sensing1986，7，7： | 1 |
| 14 | Comparison of six methods of extracting Mycobacterium tuberculosis DNA from processed sputum for testing by quantitative real-time PCR显示文摘 | Aldous W K Pounder J I Cloud J Let ol | 2005 | J Clin Microbiol2005，43，5： | 1 |
| 15 | A simple and effective method for controllable synthesis of silver and silver oxide nanocrystals显示文摘 | CLOUD J E TAYLOR L W YANG YG | 2014 | RSCAdvances2014，4，24： | 1 |
| 16 | Comparison of six methods of extracting Mycobacterium tuberculosis DNA from processed sputum for testing by quantitative real-time PCR显示文摘 | Aldous W K Pounder J I Cloud J L | 2005 | J Clin Microbiol2005，43，5： | 1 |
| 17 | Electron emission from metals under high-energy hydrongen ion bombardment 显示文摘 | Aarset B Cloud R W | 1953 | Journal of Applied Playsics1953，25，： | 1 |
| 18 | Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase Ⅱ study显示文摘 | Whitley R J Cloud G Gruber W | 1997 | J Infect Dis1997，175，5： | 1 |
| 19 | Ganciclovir treatment of symptomatic congenital cytomegalovirus infection: results of a phase II study 显示文摘 | Whitley R J Cloud G Gruber W | 1997 | The Journal of Infectious Diseases1997，175，5： | 1 |
| 20 | Diagnosis and management of increased intracranial pressures in patients with AIDS显示文摘 | Graybill JR Sobel J Saag M van Der Horst C Powderly W Cloud G Riser L Hamill R Dismukes W | 2000 | Clin Infect Dis2000，30，1： | 1 |
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