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| 1 | Early-onset colorectal cancer:A review of current knowledge显示文摘Colorectal cancer(CRC)is one of the most prevalent malignancies worldwide.Although most prevalent among older people,its incidence above 50 years old has been decreasing globally in the last decades,probably as a result of better screening.Paradoxically,its incidence in patients below 50 years old[early-onset CRC(EO-CRC)]has been increasing,for reasons not yet fully understood.EOCRC’s increasing incidence is genre independent but shows racial disparities and has been described to occur worldwide.It follows a birth-cohort effect which probably reflects a change in exposure to CRC risk factors.Its incidence is predicted to double until 2030,which makes EO-CRC a serious public health issue.Both modifiable and non-modifiable risk factors have been identified-some are potential targets for preventive measures.EO-CRC is often diagnosed at advanced stages and histological features associated with poor prognosis have been described.EO-CRC presents some distinctive features:Microsatellite instability is common,but another subtype of tumours,both microsatellite and chromosome stable also seems relevant.There are no age-specific treatment protocols and studies on EO-CRC survival rates have shown conflicting data.Due to the higher germline pathological mutations found in EO-CRC patients,an accurate genetic risk evaluation should be performed.In this review,we summarize the current evidence on epidemiological,clinical,histopathological and molecular features of EO-CRC and discuss the contribution of genetics and lifestyle risk factors.We further comment on screening strategies and specific dimensions to consider when dealing with a younger cancer patient. | Margarida R Saraiva Isadora Rosa Isabel Claro | 2023 | World Journal of Gastroenterology2023，29，8： | 3 |
| 2 | Differential responses of spinal axons ,to transection: influence of the NG2 proteoglycan 显示文摘 | De Castro R Jr Tajrishi R Claros J | 2005 | Exp Neurol2005，192，2： | 1 |
| 3 | Effect of supplementa- tion of two sources and two levels of copper on lipid metabolism in Nellore beef cattle显示文摘 | Correa L B Zanetti M A Claro G R | 2012 | Meat Science2012，91，4： | 1 |
| 4 | US Food and Drug Administration approval summary:brentuximab vedotin for the treatment of relapsed Hodgkin lymphoma or relapsed system- ic anaplastic large- celt tymphoma 显示文摘 | De Claro R A McGinn K Kwitkowski V | 2012 | Clinical Cancer Re- search2012，18，21： | 1 |
| 5 | Synergis- tic effects of relationship managers' social networks on sales performance 显示文摘 | Gonzalez G R Claro D P Palmatier R W | 2014 | Journal of Marketing2014，78，1： | 1 |
| 6 | Diet and gastric cancer in Portugal a multivariate model显示文摘 | Azevedo LF Salgueiro LF Claro R | 1999 | Eur J Cancer Prey1999，8，1： | 1 |
| 7 | Comparison between percutancous nephrolithotomy and open stone proeedures显示文摘 | NETTO JR N R LEMOS G C DE ALMEIDA CLARO J F | 1988 | lnt Urol Nephrol1988，20，： | 1 |
| 8 | Diet and gastric cancer in Portugal--a multivariate model显示文摘 | Azevedo LF Salgueiro LF Claro R | 1999 | Eur J Cancer Prey1999，8，1： | 1 |
| 9 | Comparison of drug-eluting stents versus surgery for unprotected left main coronaryartery disease显示文摘 | Sanmartin M Baz J A Claro R | 2007 | Am J Cardiol2007，100，7： | 1 |
| 10 | Diet and gastric cancer in Portugal-a multivariate model显示文摘 | Azevedo LF Salguriro LF Claro R | 1999 | Eur J Cancer Prey1999，8，1： | 1 |
| 11 | bovine brain pbosphatidylserine attenuates scopolamine-induced amnesia显示文摘 | Claro FT Silva RH Frussa-Filho R | 1999 | Physiology & Behavior1999，67，4： | 1 |
| 12 | Determination and pharmacokinetic profile of liposomal foscarnet in rabbit ocular tissues after intravitreal administration 显示文摘 | Claro C Ruiz R Cordero E | 2009 | Exp Eye Res2009，88，3： | 1 |
| 13 | The typically mitochondrial DNA-encoded ATP6 subunit of the F1F0-ATPase is encoded by a nuclear gene in Chlamydomonas reinhardtii显示文摘 | Funes S Davidson E Claros M G Lis R V Martínez X P Acevedo M V King M P Halphen D G | 2002 | J Biol Chem2002，277，8： | 1 |
| 14 | Availability of added sugars in Brazil: distribution, food sources and time trends显示文摘 | LEVY R F CLARO R M | 2012 | Rev BrasEpidemiol2012，15，1： | 1 |
| 15 | Effects of copper and selenium supplementation on performance and lipid metabolism in confined brangus bulls显示文摘 | Netto A S zanetti M A claro G R | 2014 | Asian-Australasian Journal of Animal Sciences2014，27，4： | 1 |
| 16 | Effect of vitamins C and E on oxidative processes in human erythrocytes显示文摘 | CLARO L M LEONART M S COMAR S R | 2006 | Cell Biochem Funct2006，24，6： | 1 |
| 17 | Diet and gastric cancer in portugal--a multivariate model 显示文摘 | Azevedo LF Salgueiro LF Claro R | 1999 | Eur J Cancer Prev1999，8，1： | 1 |
| 18 | Is active sweating during heat acclimation required for improve- ments in peripheral sweat gland function 显示文摘 | Buono M J Numan T R CLaros R M | 2009 | Am J Physiol Regul Integr Comp Physiol2009，297，4： | 1 |
| 19 | Bilateral posterior fracture-disloca- tion of the shoulder: report of two cases 显示文摘 | Claro R Sousa R Massada M | 2009 | Int J Shoulder Surg2009，3，2： | 1 |
| 20 | 显示文摘 | de Castro JR Tajrishi R Claros J | 2005 | Exp Neurol2005，192，2： | 1 |
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