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37篇 您的检索式：作者名="Ciuclan"

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	题名	作者	年代	出处	被引量
1	Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage显示文摘	Steven Dooley Jafar Hamzavi Loredana Ciuclan Patricio Godoy Iryna Ilkavets Sabrina Ehnert Elke Ueberham Rolf Gebhardt Stephan Kanzler Andreas Geier Katja Breitkopf Honglei Weng Peter R. Mertens	2008	Gastroenterology2008，，2：	2
2	Profibrogenic transforming growth factor-13/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes显示文摘	Weng HL Ciuclan L Liu Y	2007	Hepatology2007，46，4：	1
3	TGF-/Smad signaling in the injured liver 显示文摘	Breitkopf K Godoy P Ciuclan L	2006	Z Gastroenterol2006，44，1：	1
4	Profibrogenic transfor- ming growth factor beta/activin receptor - like kinase 5 signaling via connective tissue growth factor expression in hepatocytes 显示文摘	Weng HL Ciuclan L Liu Y	2007	Hepatology2007，46，：	1
5	Smad7 dependent expression signature highlights BMP2 and HK2 signaling in HSC transdifferentiation显示文摘AIM: To analyse the influence of Smad7, antagonist of transforming growth factor (TGF)-β canonical signaling pathways on hepatic stellate cell (HSC) transdifferentia-tion in detail. METHODS: We systematically analysed genes regulated by TGF-β/Smad7 in activated HSCs by microarray analy-sis and validated the results using real time polymerase chain reaction and Western blotting analysis. RESULTS: We identif ied 100 known and unknown tar-gets underlying the regulation of Smad7 expression and delineated 8 gene ontology groups. Hk2, involved in glycolysis, was one of the most downregulated proteins, while BMP2, activator of the Smad1/5/8 pathway, was extremely upregulated by Smad7. However, BMP2 de-pendent Smad1 activation could be inhibited in vitro by Smad7 overexpression in HSCs. CONCLUSION: We conclude (1) the existence of a tight crosstalk of TGF-β and BMP2 pathways in HSCs and (2) a Smad7 dependently decreased sugar metabolism ameliorates HSC activation probably by energy with-drawal.	Bernd Denecke Lucia Wickert Loredana Ciuclan Steven Dooley Nadja M Meindl-Beinker Yan Liu	2010	World Journal of Gastroenterology2010，16，41：	1
6	TGF-β/Smad signaling in the injured liver显示文摘	Breitkopf K Godoy P Ciuclan L	2006	Z Gastroenterol2006，44，1：	1
7	Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage 显示文摘	Dooley S Hamzavi J Ciuclan L	2008	Gastroenterology2008，135，2：	1
8	TGF -beta/ Smad signaling in the injured liver 显示文摘	BREITKOPF K GODOY P CIUCLAN L	2006	Z Gastroenterol2006，44，1：	1
9	Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension显示文摘	Thomas M Ciuclan L Hussey M J	2013	Pharmacol Ther2013，138，3：	1
10	TGF-beta/Smad signaling in the injured liver显示文摘	Breitkopf K Godoy P Ciuclan L	2006	Z Gastroenterol2006，44，1：	1
11	Hepatocyte-Specific Smad7 Expression Attenuates TGF-β–Mediated Fibrogenesis and Protects Against Liver Damage显示文摘	Steven Dooley Jafar Hamzavi Loredana Ciuclan Patricio Godoy Iryna Ilkavets Sabrina Ehnert Elke Ueberham Rolf Gebhardt Stephan Kanzler Andreas Geier Katja Breitkopf Honglei Weng Peter R. Mertens	2008	Gastroenterology2008，，2：	1
12	TGF-beta/ Smad signaling in the injured liver显示文摘	Breitkopf K Godoy P Ciuclan L Singer MV Dooley S	2006	Z Gastroenterol2006，44，：	1
13	Profibrogenic TGF-β/activin preceptor-like kinase 5 signaling via CTGF expression in hepatocytos显示文摘	Weng HL Ciuclan L Liu Y		0，，：	1
14	Profibrogenic transforming growth factor-beta/activin receptor-like kinase 5 signaling via connective tissue growth factor expression in hepatocytes显示文摘	Weng HL Ciuclan L Liu Y	2007	Hepatology2007，46，4：	1
15	Hepatocyte-specific Smad7 expression attenuates TGF-beta-mediated fibrogenesis and protects against liver damage 显示文摘	DOOLEY S HAMZAV J CIUCLAN L	2008	Gastroenterology2008，135，2：	1
16	TGF beta/Smad sigaling in the injured liver 显示文摘	Brcitkopf K Godoy P Ciuclan L	2006	Z Gastroemterol2006，44，1：	1
17	TGF -beta/Smad signa- ling in the injured liver显示文摘	Breitkopf K Godoy P Ciuclan L	2006	Z Gastroenterol2006，44，：	1
18	TGF-beta/ Smad signaling in the injured liver 显示文摘	Breitkopf K Godoy P Ciuclan L	2006	Z Gastro- enterol2006，44，1：	1
19	Imatinib attenuates hypoxia-induced pulmonary arterial hypertension pathology via reduction in 5-hydroxytryptamine through inhibition of tryptophan hydroxylase 1 expression显示文摘	Ciuclan L Hussey MJ Burton V	2013	Am J Respir Crit Care Med2013，187，：	1
20	Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension 显示文摘	Thomas M Ciuclan L Hussey MJ	2013	Pharmaco] Ther2013，138，3：	1

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