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| 1 | The clinical impact of bacterial biofilms显示文摘Bacteria survive in nature by forming biofilms on surfaces and probably most, if not all, bacteria (and fungi) are capable of forming biofilms. A biofilm is a structured consortium of bacteria embedded in a self-produced polymer matrix consisting of polysaccharide, protein and extracellular DNA. Bacterial biofilms are resistant to antibiotics, disinfectant chemicals and to phagocytosis and other components of the innate and adaptive inflammatory defense system of the body. It is known, for example, that persistence of staphylococcal infections related to foreign bodies is due to biofilm formation. Likewise, chronic Pseudomonas aeruginosa lung infections in cystic fibrosis patients are caused by biofilm growing mucoid strains. Gradients of nutrients and oxygen exist from the top to the bottom of biofilms and the bacterial cells located in nutrient poor areas have decreased metabolic activity and increased doubling times. These more or less dormant cells are therefore responsible for some of the tolerance to antibiotics. Biofilm growth is associated with an increased level of mutations. Bacteria in biofilms communicate by means of molecules, which activates certain genes responsible for production of virulence factors and, to some extent, biofilm structure. This phenomenon is called quorum sensing and depends upon the concentration of the quorum sensing molecules in a certain niche, which depends on the number of the bacteria. Biofilms can be prevented by antibiotic prophylaxis or early aggressive antibiotic therapy and they can be treated by chronic suppressive antibiotic therapy. Promising strategies may include the use of compounds which can dissolve the biofilm matrix and quorum sensing inhibitors, which increases biofilm susceptibility to antibiotics and phagocytosis. | Niels Hoiby Oana Ciofu Helle Krogh Johansen Zhi-jun Song Claus Moser Peter Ostrup Jenser Soren Molin Michael Givskov Tim Tolker-Nieisen Thomas Bjamsholt | 2011 | International Journal of Oral Science2011，3，2： | 48 |
| 2 | Pseudomonas aeruginosa alginate is refractory to Th1 immune response and impedes host immune clearance in a mouse model of acute lung infection显示文摘 | Song ZJ Wu H Ciofu O | 2003 | J Med Microbiol2003，52，4： | 1 |
| 3 | The safety of the inside-out transobturator approach for transvaginal tape(TVT-O)treatment in stress urinary incontinence:French registry data on984women显示文摘 | Collinet P Ciofu C Costa P | 2008 | International Urogynecology Journal2008，5，： | 1 |
| 4 | Characterization of paired mucoid/non-mucoid Pseudomonas aeruginesa isolates from Danish cystic fibrosis patients:antibiotic resistance,b-lactamass activity and Riboprinting显示文摘 | Ciofu O Fussing V Bagge N | 2001 | J Antimicrob Chemother2001，48，3： | 1 |
| 5 | The safety of the inside-out transobtu-rator approach for transvaginal tape(TVT-O)treatment in stress uri-nary incontinence:French registry data on984women显示文摘 | Collinet P Ciofu C Costa P | 2008 | Int Uro-gynecol J Pelvic Floor Dysfunct2008，19，5： | 1 |
| 6 | Results of the tension-free of vaginal tape technique in the eldly显示文摘 | Sevestres Ciofu C Deval B | 2003 | Europan Urology2003，，44： | 1 |
| 7 | Duloxetine for mild to moderate postprostatectomy incontinence: preliminary results of a randomised, placebo-controlled trial显示文摘 | Cornu IN Merlet B Ciofu C | 2011 | Eur Urol2011，59，： | 1 |
| 8 | Mucoid conversion of Pseudomonas aeruginosa by hydrogen peroxide: a mechanism for virulence activation in the cystic fibrosis lung 显示文摘 | MATHEE K CIOFU O STERNBERG C | 1999 | Microbiology1999，145，6： | 1 |
| 9 | The safety of the inside-out transobturator approach for transvaginal tape(TVT-O) treatment in stress urinary incontinence:French registry data on 984 women显示文摘 | Collinet P Ciofu C Costa P | | 0，，05： | 1 |
| 10 | Antibiotic resistance of bacterial biofilms显示文摘 | Niels H?iby Thomas Bjarnsholt Michael Givskov S?ren Molin Oana Ciofu | 2010 | International Journal of Antimicrobial Agents2010，，4： | 1 |
| 11 | The safety of the inside- out transobturator approach for trans vaginal tape (TVT-O) treatment in stress urinary incontinence: French registry data on 984 women 显示文摘 | Collinet P Ciofu C Costa P | 2008 | Int Urogynecol J Pelvic Floor Dysfunct2008，19，5： | 1 |
| 12 | In vivo pharmacokinetics/pharmacodynamics of colistin imipenem in Pseudomonas aeruginosa biofilm infection and 显示文摘 | Hengzhuang W Wu H Ciofu O Song Z Hiby N | 2012 | Antimicrob Agents Chemother2012，56，5： | 1 |
| 13 | Pseudomonas aeruginosa isolates from patients with cystic fibrosis have different beta-lactamase expression phenotypes but are homogeneous in the ampC-ampR genetic region显示文摘 | Campbell JI Ciofu O H(o)iby N | 1997 | Antimicrob Agents Chemother1997，41，6： | 1 |
| 14 | The safety of the inside-out transobturator approach for transvaginal tape (TVT-O) treatment in stress urinary incontinence: French registry data on 984 women显示文摘 | Pierre Collinet Calin Ciofu Pierre Costa Michel Cosson Bruno Deval Philippe Grise Bernard Jacquetin Francois Haab | 2008 | International Urogynecology Journal2008，，5： | 1 |
| 15 | Highβ-lactamase levels change the pharmacodynamics ofβ-lactam antibiotics in Pseudomonas aeruginosa biofilms显示文摘 | Hengzhuang W Ciofu O Yang L | 2012 | Antimicrob Agents Chemother2012，57，1： | 1 |
| 16 | The efficiency of biologic therapy in a group of patients with rheumatoid arthritis显示文摘 | Gavril BI Ciofu C Stoica V | 2015 | J Med Life2015，8，1： | 1 |
| 17 | The saf- ety of the inside-out transobturator approach for transvaginal tape (TVT-O)treatment instress urinary incontinence : French reg-istry data on 984 women 显示文摘 | Collient P Ciofu C Costa P | 2008 | int Urogyn- ecol J Pelvic Floor Dysfunct2008，19，5： | 1 |
| 18 | Interactions between biocide cationic agents and bacterial biofilms显示文摘 | Jalal S Ciofu O Hoiby N | 2000 | Antimicrob Agents Chemother2000，44，： | 1 |
| 19 | Antibiotic resistance of bacterial biofilms显示文摘 | Niels H?iby Thomas Bjarnsholt Michael Givskov S?ren Molin Oana Ciofu | 2010 | International Journal of Antimicrobial Agents2010，，4： | 1 |
| 20 | In vivo pharmacokinetics/pharmacodynamics of colistin and imipenem in Pseudomonas aeruginosa biofilm infection 显示文摘 | HENGZHUANG W WU H CIOFU 0 | 2012 | Antimicrob Agents Chemother2012，56，5： | 1 |
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