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| 1 | Hepatitis C virus recurrence after liver transplantation:A 10-year evaluation显示文摘AIM: To evaluate the predictors of 10-year survival of patients with hepatitis C recurrence. METHODS: Data from 358 patients transplanted between 1989 and 2010 in two Italian transplant centers and with evidence of hepatitis C recurrence were analyzed. A χ2, Fisher's exact test and Kruskal Wallis' test were used for categorical and continuous variables, respectively. Survival analysis was performed at 10 years after transplant using the Kaplan-Meier method, and a log-rank test was used to compare groups. A P level less than 0.05 was considered significant for all tests. Multivariate analysis of the predictive role of different variables on 10-year survival was performed by a stepwise Cox logistic regression.RESULTS: The ten-year survival of the entire population was 61.2%. Five groups of patients were identified according to the virological response or lack of a response to antiviral treatment and, among those who were not treated, according to the clinical status(mild hepatitis C recurrence, 'too sick to be treated' and patients with comorbidities contraindicating the treatment). While the 10-year survival of treated and untreated patients was not different(59.1% vs 64.7%, P = 0.192), patients with a sustained virological response had a higher 10-year survival rate than both the 'non-responders'(84.7% vs 39.8%, P < 0.0001) and too sick to be treated(84.7% vs 0%, P < 0.0001). Sustained virological responders had a survival rate comparable to patients untreated with mild recurrence(84.7% vs 89.3%). A sustained virological response and young donor age were independent predictors of 10-year survival. CONCLUSION: Sustained virological response significantly increased long-term survival. Awaiting the interferon-free regimen global availability, antiviral treatment might be questionable in selected subjects with mild hepatitis C recurrence. | Stefano Gitto Luca Saverio Belli Ranka Vukotic Stefania Lorenzini Aldo Airoldi Arrigo Francesco Giuseppe Cicero Marcello Vangeli Lucia Brodosi Arianna Martello Panno Roberto Di Donato Matteo Cescon Gian Luca Grazi Luciano De Carlis Antonio Daniele Pinna Mauro Bernardi Pietro Andreone | 2015 | World Journal of Gastroenterology2015，21，13： | 2 |
| 2 | Folate targeted coated SPIONs as efficient tool for MRI显示文摘The development of more sensitive diagnostic tools allowing an early-stageand highly efficient medical imaging of tumors remains a challenge. Magneticnanoparticles seem to be the contrast agents with the highest potential, if properlyconstructed. Therefore, in this study, hybrid magnetic nanoarchitectures weredeveloped using a new amphiphilic inulin-based graft copolymer (INU-LA-PEG-FA) as coating material for 10-nm spinel iron oxide (magnetite, Fe304)superparamagnetic nanoparticles (SPION). Folic acid (FA) covalently linked tothe coating copolymer in order to be exposed onto the nanoparticle surface waschosen as the targeting agent because folate receptors are upregulated in manycancer types. Physicochemical characterization and in vitro biocompatibilitystudy was then performed on the prepared magnetic nanoparticles. The improvedtargeting and imaging properties of the prepared FA-SPIONs were furtherevaluated in nude mice using 7-Tesla magnetic resonance imaging (MRI).FA-SPIONs exhibited the ability to act as efficient contrast agents in conventionalMRI, providing a potential nanoplatform not only for tumor diagnosis but alsofor cancer treatment, through the delivery of anticancer drug or locoregional magnetic hvverthermia. | Cinzia Scialabba Roberto Puleio Davide Peddis Gaspare Varvaro Pietro Calandra Giovanni Cassata Luca Cicero Mariano Licciardi Gaetano Giammona | 2017 | Nano Research2017，10，9： | 2 |
| 3 | CEO compensation contagion: Evidence from an exogenous shock显示文摘 | Frederick L. Bereskin David C. Cicero | 2012 | Journal of Financial Economics2012，，： | 2 |
| 4 | Nasal bone hypoplasia in trisomy 21 at 15-22 weeks' gestation 显示文摘 | Cicero S Sonek JD Mckenna DS | 2003 | Ultrasound Obstet Gynecol2003，21，： | 1 |
| 5 | Vascular remodeling and prothrombotic markers in subjects affected by familial combined hyperlipidemia and/or metabolic syndrome in primary prevention for cardiovascular disease 显示文摘 | Cicero AF Derosa G Manca M | 2007 | Endothelium2007，14，5： | 1 |
| 6 | Nasal bone assessment in prenatal screening for trisomy 21显示文摘 | Sonek JD Cicero S Neiger R | 2006 | Am J Obstet Gynecol2006，195，： | 1 |
| 7 | Irbesartan and hydrochlorothiazide asso-ciation in the treatment of hypertension显示文摘 | Derosa G Ferrari I Cicero AF | 2009 | Curr Vasc Pharmacol2009，7，2： | 1 |
| 8 | Subjective effects of Le- pidium meyenii (Maca) extract on well-being and sexual perform- ances in patients with mild erectile dysfunction : a randomised, doub- le-blind clinical trial显示文摘 | Zenico T Cicero A F G Valmorri L | 2009 | Andro|ogia2009，41，2： | 1 |
| 9 | Charismatic Leadership andOrganizational Outcomes: The Mediating Role of Em- ployees~ Work-Group Identification显示文摘 | CICERO L PIERRO A | 2007 | International Journal of Psychology2007，42，5： | 1 |
| 10 | Blood pressure lowering effect of lactotripeptides assumed as functional foods: a meta - analysis of current available clinical trials 显示文摘 | Cicero AF Gerocarni B Laghi L | 2011 | Journal of Human Hypertension2011，25，7： | 1 |
| 11 | Fixed combination of zofenopril plus hydrochlorothiazide in the management of hypertension:a review of available data显示文摘 | Borghi C Cicero AF | 2006 | Vasc Health Risk Manag2006，2，4： | 1 |
| 12 | Nasal bone in first-trimester screening for trisomy 21显示文摘 | CICERO S AVGIDOU K REMBOUSKOS G | | 0，，01： | 1 |
| 13 | Autoimmune pancreatitis:CT patterns and their changes after steroid treatment显示文摘 | Manfredi R Graziani R Cicero C | | 0，，： | 1 |
| 14 | Function of the malesex organs in heroin and methadone显示文摘 | Cicero TJ Bell RD Wiest WG | 1975 | N Eng l J Med1975，292，17： | 1 |
| 15 | Nasal bone assessment in prenatal screening for trisomy 21 显示文摘 | Sonek JD Cicero S Neiger R | 2006 | Am J Obstet Gynecol2006，195，： | 1 |
| 16 | DNA barcoding: promise and pitfalls 显示文摘 | Moritz C Cicero C | 2004 | PLoS Biol2004，2，10： | 1 |
| 17 | Gas chromatography-mass sPectrometry characterization of the varnish and glue of an ancient 18th century double bass显示文摘 | Caruso F Orecchios Cicero MG | 2007 | J Chromatogr A2007，1147，2： | 1 |
| 18 | Avian community structure in a large urban park:controls of local richness and diversity显示文摘 | Cicero C | 1989 | landscape and Urban Planing1989，17，： | 1 |
| 19 | Short cold storage enhances the anthocyanin contents and level of transcripts related to their biosynthesis in blood oranges 显示文摘 | Crife T Petrone C Lo Cicero L | 2011 | J Agric Food Chem2011，60，1： | 1 |
| 20 | Antidiabetic properties of berberine: from cellular pharmacology to clinical effects 显示文摘 | Cicero AF Tartagni E | 2012 | Hosp Pract2012，40，2： | 1 |
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