|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Exposure to blast shock waves via the ear canal induces deficits in vestibular afferent function in rats显示文摘The ears are air-filled structures that are directly impacted during blast exposure.In addition to hearing loss and tinnitus,blast victims often complain of vertigo,dizziness and unsteady posture,suggesting that blast exposure induces damage to the vestibular end organs in the inner ear.However,the underlying mechanisms remain to be elucidated.In this report,single vestibular afferent activity and the vestibuloocular reflex(VOR)were investigated before and after exposure to blast shock waves(~20 PSI)delivered into the left external ear canals of anesthetized rats.Single vestibular afferent activity was recorded from the superior branch of the left vestibular nerves of the blast-treated and control rats one day after blast exposure.Blast exposure reduced the spontaneous discharge rates of the otolith and canal afferents.Blast exposure also reduced the sensitivity of irregular canal afferents to sinusoidal head rotation at 0.5e2Hz.Blast exposure,however,resulted in few changes in the VOR responses to sinusoidal head rotation and translation.To the best of our knowledge,this is the first study that reports blast exposure-induced damage to vestibular afferents in an animal model.These results provide insights that may be helpful in developing biomarkers for early diagnosis of blast-induced vestibular deficits in military and civilian populations. | Yue Yu Jun Huang Xuehui Tang Jerome Allison David Sandlin Dalian Ding Yi Pang Chunming Zhang Tianwen Chen Nathan Yin Lan Chen William Mustain Wu Zhou Hong Zhu | 2020 | Journal of Otology2020，15，3： | 3 |
| 2 | An orally administrated nucleotide-delivery vehicle targeting colonic macrophages for the treatment of inflammatory bowel disease显示文摘 | Zhen Huang Jingjing Gan Lixin Jia Guangxing Guo Chunming Wang Yuhui Zang Zhi Ding Jiangning Chen Junfeng Zhang Lei Dong | 2015 | Biomaterials2015，，： | 1 |
| 3 | Hyperm- ethylated RASSF1A in maternal plasma:A Universal fetal DNA marker that improves the reliability of noninvasive prenatal diagnosis 显示文摘 | Chan KC Ding Chunming Gerovassili A | 2006 | Clin Chem2006，52，12： | 1 |
| 4 | Noninvasive prenatal detection of fetal trisomy 18 by epigenetic allelic ratio analysis in maternal plasma:Theoretical and empiri- cal considerations显示文摘 | Tong YK Ding Chunming Chiu RW | 2006 | Clin Chem2006，52，12： | 1 |
| 5 | A variational level set approach to segmentation and bias correction of images with intensity inhomogeneity显示文摘 | Li Chunming Huang Rui Ding Zhaohua | 2008 | MICCAI2008，5242，： | 1 |
| 6 | A Variational Level Set Approach to Segmentation and Bias Correction of Images with Intensity Inhomogeneity显示文摘 | Li Chunming Huang Rui Ding Zhaohua | 2008 | MICCAI Part Ⅱ LNCS2008，52，42： | 1 |
| 7 | Minimization of region-scalable fitting energy for image segmentation显示文摘 | LI Chunming KAO C Y GORE J C DING Zhaohua | 2008 | IEEE Transaction on Image Processing2008，17，10： | 1 |
| 8 | A level set method for image segmentation in the prensence of intensity inhomogeneities with application to MRI显示文摘 | Li Chunming Huang Rui Ding Zhaohua | 2011 | IEEE Transations on Image Processing2011，20，7： | 1 |
| 9 | A level set method for image segmentation in the presence of intensity inho- mogeneities with application to MRI显示文摘 | Li Chunming Huang Rui Ding Zhaohua | 2011 | IEEE Transactions on Image Processing2011，20，7： | 1 |
| 10 | Limited Feedback Design for MIMO Broadcast Channels with ARQ Mechanism显示文摘 | Xu Wei Zhao Chunming Ding Zhi | 2009 | IEEE Trans on Wireless Communications2009，8，4： | 1 |
| 11 | A level set method for image segmentation in the presence of intensity inhomogeneities with application to MRI 显示文摘 | Li Chunming Huang Rui Ding Zhaohua Gatenby J C Metaxas D N Gore J C | 2011 | IEEE Trans on Image Processing2011，20，7： | 1 |
| 12 | Recent progress of quantum dots for energy storage applications显示文摘The environmental problems of global warming and fossil fuel depletion are increasingly severe,and the demand for energy conversion and storage is increasing.Ecological issues such as global warming and fossil fuel depletion are increasingly stringent,increasing energy conversion and storage needs.The rapid development of clean energy,such as solar energy,wind energy and hydrogen energy,is expected to be the key to solve the energy problem.Several excellent literature works have highlighted quantum dots in supercapacitors,lithium-sulfur batteries,and photocatalytic hydrogen production.Here,we outline the latest achievements of quantum dots and their composites materials in those energy storage applications.Moreover,we rationally analyze the shortcomings of quantum dots in energy storage and conversion,and predict the future development trend,challenges,and opportunities of quantum dots research. | Quan Xu Yingchun Niu Jiapeng Li Ziji Yang Jiajia Gao Lan Ding Huiqin Ni Peide Zhu Yinping Liu Yaoyao Tang Zhong-Peng Lv Bo Peng Travis Shihao Hu Hongjun Zhou Chunming Xu | 2022 | Carbon Neutrality2022，1，1： | 1 |
| 13 | A level set method for image segmentation in the presence of intensity inhomogeneities with application to MRI显示文摘 | Li Chunming Huang Rui Ding Zhaohui | 2011 | IEEE Transactions on Image Processing2011，20，7： | 1 |
| 14 | A Level Set Method for Image Segmentation in the Presence of Intensity Inhomogeneities with Application to MRI显示文摘 | Li Chunming Huang Rui Ding Zhaohua | 2011 | IEEE Transactions on Image Processing2011，20，7： | 1 |
| 15 | Minimization of region-scalable fitting energy for image segmentation显示文摘 | Chunming Li Chiu-Yen Kao John C Gore Zhaohua Ding | 2008 | IEEE Trans Image Processing2008，17，10： | 1 |
| 16 | Kif4A mediates resistance to neoadjuvant chemoradiotherapy in patients with advanced colorectal cancer via regulating DNA damage response显示文摘More and more patients with advanced colorectal cancer(CRC)have benefited from surgical resection or ablation following neoadjuvant chemoradiotherapy(nCRT),but nCRT may be ineffective and have potential risks to some patients.Therefore,it is necessary to discover effective biomarkers for predicting the nCRT efficacy in CRC patients.Chromokinesin Kif4A plays a critical role in mitosis,DNA damage repair and tumorigenesis,but its relationship with nCRT efficacy in advanced CRC remains unclear.Here,we find that Kif4A expression in pretreated tumor tissue is positively correlated with poorer tumor regression after receiving nCRT(P=0.005).Knockdown of endogenous Kif4A causes an increased sensitivity of CRC cells to chemotherapeutic drugs 5-fluorouracil(5-FU)and Cisplatin(DDP),while overexpression of Kif4A enhances resistance of CRC cells to the chemotherapeutic drugs.Furthermore,depending on its motor domain and tail domain,Kif4A regulates DNA damage response(DDR)induced by 5-FU or DDP treatment in CRC cells.In conclusion,we demonstrate that Kif4A may be a potential independent biomarker for predicting the nCRT efficacy in advanced CRC patients,and Kif4A regulates chemosensitivity of CRC cells through controlling DDR. | Rui Zhang Shuanghui Liu Bojiang Gong Wenran Xie Youjuan Zhao Liang Xu Yi Zheng Shengnan Jin Chunming Ding Chang Xu Zhixiong Dong | 2022 | Acta Biochimica et Biophysica Sinica2022，54，7： | 1 |
| 17 | A level set method for image segmentation in the presence of in- tensity inhomogeneities with application to MRI 显示文摘 | Li Chunming Huang Rui Ding Zhaohua | 2011 | 1EEE TrarLactions on hnage Processing2011，20，7： | 1 |
| 18 | Research of 1770 MPa galvanized steel wire for stay cable of domestic bridges显示文摘This paper focuses on introducing the manufacture technology of 1 770 MPa galvanized steel wires for stay cables applied to domestic bridges.During the development practices of high strength galvanized wire for stay cables used in Sutong Bridge,Baosteel has established three key technologies based on research of manufacture technology and technical innovation.The three key technologies are:'Double Tensioning + limiter die' process,'dominant process + fine adjustment' in integrated optimization technology and 'three-level control' in hot dip galvanization.With these key technologies,Baosteel has produced 1 770 MPa galvanized wires for stay cable,which has high tensile strength,low relaxation and good torsion performances. | Ding Feng Sang Chunming Zhou Daiyi Bai Bingdong | 2009 | Engineering Sciences2009，7，1： | 1 |
| 19 | A level set method for image segmentation in the presence of intensity inhomogeneities with application to MRI 显示文摘 | Li Chunming Rui Huang Ding Zhaohua | 2011 | IEEE Transactions on Image Processing2011，20，7： | 1 |
| 20 | Development of novel-nanobody-based lateral-flow immunochromatographic strip test for rapid detection of recombinant human interferon a2b显示文摘Recombinant human interferon a2b(rhIFNa2b)is widely used as an antiviral therapy agent for the treatment of hepatitis B and hepatitis C.The current identification test for rhIFNa2b is complex.In this study,an anti-rhIFNa2b nanobody was discovered and used for the development of a rapid lateral flow strip for the identification of rhIFNa2b.RhIFNa2b was used to immunize an alpaca,which established a phage nanobody library.After five steps of enrichment,the nanobody I22,which specifically bound rhIFNa2b,was isolated and inserted into the prokaryotic expression vector pET28a.After subsequent purification,the physicochemical properties of the nanobody were determined.A semiquantitative detection and rapid identification assay of rhIFNa2b was developed using this novel nanobody.To develop a rapid test,the nanobody I22 was coupled with a colloidal gold to produce lateral-flow test strips.The developed rhIFNa2b detection assay had a limit of detection of 1 mg/mL.The isolation of I22 and successful construction of a lateral-flow immunochromatographic test strip demonstrated the feasibility of performing ligand-binding assays on a lateral-flow test strip using recombinant protein products.The principle of this novel assay is generally applicable for the rapid testing of other commercial products,with a great potential for routine use in detecting counterfeit recombinant protein products. | Xi Qin Maoqin Duan Dening Pei Jian Lin Lan Wang Peng Zhou Wenrong Yao Ying Guo Xiang Li Lei Tao Youxue Ding Lan Liu Yong Zhou Chuncui Jia Chunming Rao Junzhi Wang | 2022 | Journal of Pharmaceutical Analysis2022，12，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员