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| 1 | Abnormal subchondral bone remodeling and its association with articular cartilage degradation in knees of type 2 diabetes patients显示文摘Type 2 diabetes(T2 D) is associated with systemic abnormal bone remodeling and bone loss. Meanwhile,abnormal subchondral bone remodeling induces cartilage degradation, resulting in osteoarthritis(OA).Accordingly, we investigated alterations in subchondral bone remodeling, microstructure and strength in knees from T2 D patients and their association with cartilage degradation. Tibial plateaus were collected from knee OA patients undergoing total knee arthroplasty and divided into non-diabetic(n = 70) and diabetes(n = 51) groups. Tibial plateaus were also collected from cadaver donors(n = 20) and used as controls.Subchondral bone microstructure was assessed using micro-computed tomography. Bone strength was evaluated by micro-finite-element analysis. Cartilage degradation was estimated using histology. The expression of tartrate-resistant acidic phosphatase(TRAP), osterix, and osteocalcin were calculated using immunohistochemistry. Osteoarthritis Research Society International(OARSI) scores of lateral tibial plateau did not differ between non-diabetic and diabetes groups, while higher OARSI scores on medial side were detected in diabetes group. Lower bone volume fraction and trabecular number and higher structure model index were found on both sides in diabetes group. These microstructural alterations translated into lower elastic modulus in diabetes group. Moreover, diabetes group had a larger number of TRAP^+ osteoclasts and lower number of Osterix^+ osteoprogenitors and Osteocalcin^+ osteoblasts. T2 D knees are characterized by abnormal subchondral bone remodeling and microstructural and mechanical impairments, which were associated with exacerbated cartilage degradation. In regions with intact cartilage the underlying bone still had abnormal remodeling in diabetes group, suggesting that abnormal bone remodeling may contribute to the early pathogenesis of T2 D-associated knee OA. | Yan Chen Yong-Can Huang Chun Hoi Yan Kwong Yuen Chiu Qingjun Wei Jingmin Zhao X Edward Guo Frankie Leung William W Lu | 2017 | Bone Research2017，5，4： | 10 |
| 2 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 3 | Intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT): a randomised pilot trial显示文摘 | Craig S Anderson Yining Huang Ji Guang Wang Hisatomi Arima Bruce Neal Bin Peng Emma Heeley Christian Skulina Mark W Parsons Jong Sung Kim Qing Ling Tao Yue Chun Li Jian Dong Jiang Li Wen Tai Jin Li Zhang En Xu Yan Cheng Stephane Heritier Lewis B Morgenste | 2008 | Lancet Neurology2008，，5： | 4 |
| 4 | Development of aorta-to-right atrial fistula following closure of secundum atrial septal defect using the Amplatzer septal occluder显示文摘 | CHUN D S TURRENTINE M W MOUSTAPHA A | 2003 | Cathet Cardio vasc Interv2003，58，： | 1 |
| 5 | An onboard processor and adaptive scanning controller for the secondgeneration precipitation radar显示文摘 | Fischman M A Berkun A C Chun W | 2005 | IEEE Transactions on Geoscienee and Remote Sensing2005，43，4： | 1 |
| 6 | Selective removal of HzS from coke oven gas显示文摘 | Park D W Chun S W Jang J Y | 1998 | Catalysis Today1998，44，14： | 1 |
| 7 | A novel startup scheme of stator-flux-oriented vector-controlled induction motor drive without torque jerk显示文摘 | Chun T W Choi M K Bose B K | 2003 | IEEE Transactions on Industry Applications2003，39，3： | 1 |
| 8 | 查看详情显示文摘 | Chun J W Anthony R G | | 0，，： | 1 |
| 9 | Source apportionment of visibility degradation problems in Brisbane (Australia) using the multiple linear regression techniques显示文摘 | Chun Y C Simpson R W Mctainsh G H | 1999 | J Atmospheric Environment1999，33，19： | 1 |
| 10 | Modification of epoxy resins with polysiloxane thermoplastic polyurethane for electronic encapsulation显示文摘 | TSUNG H H CHUN S W | 1996 | Polymer1996，37，13： | 1 |
| 11 | An Efficient Rerouting Scheme for MPLS-base Recovery and Its Performance Evaluation显示文摘 | Ahn G Jang J Chun W | 2001 | Telecommunication Systems2001，19，34： | 1 |
| 12 | Selective oxidation of H2S in the presence of ammonia and water using Co304/Si02 catalyst显示文摘 | Chun S W Jang J Y Park D W | 1997 | Korean Journal of Chemical Engineering1997，14，3： | 1 |
| 13 | Long-term effeects of green tea ingestion on atherosclerotic biological markers in smoker显示文摘 | Lee W Min WK Chun S | 2005 | Clin Biochem2005，38，5： | 1 |
| 14 | Cloning and expression of interferon-α/γ from a domestic porcine breed and its effect on classical swine fever virus 显示文摘 | Chun X Wu D Wu W X | 2005 | Vet Immunol Immunopathol2005，104，： | 1 |
| 15 | Caspase-10 is an initiator caspase in death receptor signaling 显示文摘 | Wang J Chun HJ Wong W | 2001 | Proc Natl Acad Sci U S A2001，98，13： | 1 |
| 16 | Removal of hydrogen sulfide contained in smelt-off-gas by selective oxidation over Co3 04/'SiO2 catalyst显示文摘 | Park D W Chun S W Park B K | 2001 | Journal of Chemical Engineering of Japan2001，34，2： | 1 |
| 17 | Rhus verniciflua Stokes flavonoid extracts have anti-oxidant,anti-microbial and a-glucosidase inhibitory effect显示文摘 | Kim J S Kwon Y S Chun W J | 2010 | Food Chemistry2010，120，2： | 1 |
| 18 | A pilot study of mu- tilpule intravitreal injections of ranibizumah in patients with center- involving clinically significant diabetic macular edema 显示文摘 | Chun D W lAeier J S Topping T M | 2006 | Oph- thalmology2006，113，10： | 1 |
| 19 | Synthesis and modification of trifunctional epoxy resin with amine terminated polydimethyl siloxanes for semiconductor encapsulation application显示文摘 | SHICH J Y HO T H CHUN S W | 1996 | Journal of Polymer Research1996，3，2： | 1 |
| 20 | Hypoxia-inducible factor 1 alpha obstructs a Wnt signaling pathway by inhibiting the hARD1- mediated activation of beta-catenin 显示文摘 | Lim J H Chun Y S Park J W | 2008 | Cancer Res2008，68，13： | 1 |
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