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| 1 | Colometer:A real-time quality feedback system for screening colonoscopy显示文摘AIM:To investigate the performance of a new software-based colonoscopy quality assessment system.METHODS:The software-based system employs a novel image processing algorithm which detects the levels of image clarity,withdrawal velocity,and level of the bowel preparation in a real-time fashion from live video signal.Threshold levels of image blurriness and the withdrawal velocity below which the visualization could be considered adequate have initially been determined arbitrarily by review of sample colonoscopy videos by two experienced endoscopists.Subsequently,an overall colonoscopy quality rating was computed based on the percentage of the withdrawal time with adequate visualization(scored 1-5;1,when the percentage was 1%-20%;2,when the percentage was 21%-40%,etc.).In order to test the proposed velocity and blurriness thresholds,screening colonoscopy withdrawal videos from a specialized ambulatory colon cancer screening center were collected,automatically processed and rated.Quality ratings on the withdrawal were compared to the insertion in the same patients.Then,3 experienced endoscopists reviewed the collected videos in a blinded fashion and rated the overall quality of each withdrawal(scored 1-5;1,poor;3,average;5,excellent) based on 3 major aspects:image quality,colon preparation,and withdrawal velocity.The automated quality ratings were compared to the averaged endoscopist quality ratings using Spearman correlation coefficient.RESULTS:Fourteen screening colonoscopies were assessed.Adenomatous polyps were detected in 4/14(29%) of the collected colonoscopy video samples.As a proof of concept,the Colometer software rated colonoscope withdrawal as having better visualization than the insertion in the 10 videos which did not have any polyps(average percent time with adequate visualization:79% ± 5% for withdrawal and 50% ± 14% for insertion,P < 0.01).Withdrawal times during which no polyps were removed ranged from 4-12 min.The median quality rating from the automated system and the reviewers was 3.45 [interquartile range(IQR),3.1-3.68] and 3.00(IQR,2.33-3.67) respectively for all colonoscopy video samples.The automated rating revealed a strong correlation with the reviewer's rating(ρ coefficient= 0.65,P = 0.01).There was good correlation of the automated overall quality rating and the mean endoscopist withdrawal speed rating(Spearman r coefficient= 0.59,P = 0.03).There was no correlation of automated overall quality rating with mean endoscopists image quality rating(Spearman r coefficient= 0.41,P = 0.15).CONCLUSION:The results from a novel automated real-time colonoscopy quality feedback system strongly agreed with the endoscopists' quality assessments.Further study is required to validate this approach. | Dobromir Filip Xuexin Gao Leticia Angulo-Rodriguez Martin P Mintchev Shane M Devlin Alaa Rostom Wayne Rosen Christopher N Andrews | 2012 | World Journal of Gastroenterology2012，18，32： | 2 |
| 2 | Stable isotope incorporation triples the upper mass limit for determination of elemental composition by accurate mass measurement显示文摘 | Rodgers Ryan P Blumer Erin N Hendrickson Christopher L | 2000 | Journal of the American Society for Mass Spectrometry2000，10，11： | 1 |
| 3 | Particulate allergens potentiate allergic asthma in mice through sustained IgE-mediated mast cell activation显示文摘 | Jin Cong Shelburne Christopher P Li Guojie Potts Erin N Riebe Kristina J Sempowski Gregory D Foster W Michael Abraham Soman N | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 4 | Cyclic nucleotides 显示文摘 | RUSSELL P N CHRISTOPHER J S | 2004 | Phytochemistry2004，65，17： | 1 |
| 5 | Role of replication and CpG methylation in fragile X syndrome CGG Deletions in primate cells显示文摘 | Kerrie N E Michelle R L Christopher E P | 2005 | Am Hum Genet2005，76，： | 1 |
| 6 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 7 | Use of protein:creatinine ratio measurements on random urine samples for prediction of significant proteinuria: A systematic review显示文摘 | Christopher P P Ronald G N James C B | 2005 | Clinical Chemistry2005，51，9： | 1 |
| 8 | Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial显示文摘 | Stephen M Davis Geoffrey A Donnan Mark W Parsons Christopher Levi Kenneth S Butcher Andre Peeters P Alan Barber Christopher Bladin Deidre A De Silva Graham Byrnes Jonathan B Chalk John N Fink Thomas E Kimber David Schultz Peter J Hand Judith Frayne Graeme | 2008 | Lancet Neurology2008，，4： | 1 |
| 9 | Determination of total fluorine in blood at trace concentration levels by the Wickbold decomposition method with direct potentiometric detection 显示文摘 | Vladimir Capka Christopher P Bowers Joan N Narvesen Richard F Rossi | 2004 | Talanta2004，64，4： | 1 |
| 10 | Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration显示文摘 | Christopher J Andrei N Krzysztof P | 2014 | J Investiga Dermatol2014，134，3： | 1 |
| 11 | Zika virus in Gabon(Central Africa)-2007:a new threat from Aedes albopictus?显示文摘 | Grard G Mélanie C Illich Manfred M DieudonnéN Statiana MO Davy J Didier F Christophe P Eric Maurice L | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 12 | Assessment of HIV-1 sub- typing for Cameroon strains using phylogenetic analysis of pol gene se- quences显示文摘 | Richard N Christophe P Karine SS | 2003 | J Viroi Methods2003，110，1： | 1 |
| 13 | Behavioral alterations in adolescent and adult rats caused by a brief subtoxic exposure to chlorpyrifos during neurulation显示文摘 | ICENOGLE L M CHRISTOPHER N C BLACKWELDER W P | 2004 | Neurotoxicol Teratol2004，26，1： | 1 |
| 14 | Diversity of the genus Daphniopsis in the saline waters of Australia显示文摘 | HEBERT P D N CHRISTOPHER C W | 2000 | Can J Zool2000，78，： | 1 |
| 15 | Trading wind generation from short-term probabilistic forecasts of wind power显示文摘 | Pierre P Christophe C George N K | 2007 | IEEE Trans on Power Systems2007，22，3： | 1 |
| 16 | Molecular contribution to selection of intergeneric hybrids between sugarcane and the wild species Erianthus arundinaceus显示文摘 | George P Christopher MJ Carroll N J Berding N D'Hont A | 2000 | Genome2000，43，6： | 1 |
| 17 | A comprehensive map of the human urinary proteome显示文摘 | Marimuthu A O'Meally R N Chaerkady R Subbannayya Y Nanjappa V Kumar P Kelkar D S Pinto S M Sharma R Renuse S Goel R Christopher R Delanghe B Cole R N Harsha H C Pandey A | | 0，，06： | 1 |
| 18 | Increased dietary intake of co-3 polyunsaturated fatty acidsreduces pathological retinal angiogenesis显示文摘 | Kip M C San Giovanni J P Lofqvist C Christopher M A Chen J HiguchiA Hong S Elke A P Majchrzak S Carper D Ann H Kang J X Emily Y C Norman S Charles N S | 2007 | Nature Medicine2007，13，： | 1 |
| 19 | Mechanisms, polymerization rate scaling, and oxygen inhibi tion with an ultra-rapid monovinyl urethane acrylate 显示文摘 | Nell B Cramer Casey P O' Brien Christopher N Bowman | 2008 | Polymer2008，49，22： | 1 |
| 20 | A 5-GHz DirectConversion CMOS Transceiver显示文摘 | ZHANG P F THAI N CHRISTOPHER L | 2003 | IEEE Journal of Solid-State Circuits2003，38，02： | 1 |
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