4篇
您的检索式：作者名="Christopher Nishimura"
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| 1 | Crosstalk between the B7/CD28 and EGFR pathways:Mechanisms and therapeutic opportunities显示文摘Somatic activating mutations in the epidermal growth factor receptor(EGFR)are one of the most common oncogenic drivers in cancers such as non-small-cell lung cancer(NSCLC),metastatic colorectal cancer,glioblastoma,head and neck cancer,pancreatic cancer,and breast cancer.Molecular-targeted agents against EGFR signaling pathways have shown robust clinical efficacy,but patients inevitably experience acquired resistance.Although immune checkpoint inhibitors(ICIs)targeting PD-1/PD-L1 have exhibited durable anti-tumor responses in a subset of patients across multiple cancer types,their efficacy is limited in cancers harboring activating gene alterations of EGFR.Increasing studies have demonstrated that upregulation of new B7/CD28 family members such as B7-H3,B7x and HHLA2,is associated with EGFR signaling and may contribute to resistance to EGFR-targeted therapies by creating an immunosuppressive tumor microenvironment(TME).In this review,we discuss the regulatory effect of EGFR signaling on the PD-1/PD-L1 pathway and new B7/CD28 family member pathways.Understanding these interactions may inform combination therapeutic strategies and potentially overcome the current challenge of resistance to EGFR-targeted therapies.We also summarize clinical data of anti-PD-1/PD-L1 therapies in EGFR-mutated cancers,as well as ongoing clinical trials of combination of EGFR-targeted therapies and anti-PD-1/PD-L1 immunotherapies. | Xiaoxin Ren Yixian Li Christopher Nishimura Xingxing Zang | 2022 | Genes & Diseases2022，9，5： | 1 |
| 2 | Outcome of 622 Adults With Asymptomatic, Hemodynamically Significant Aortic Stenosis During Prolonged Follow-Up显示文摘 | Patricia A. Pellikka Maurice E. Sarano Rick A. Nishimura Joseph F. Malouf Kent R. Bailey Christopher G. Scott Marion E. Barnes A Jamil Tajik | 2005 | Circulation2005，，： | 1 |
| 3 | Leptin resistance contributes to obesity and hypertension in mouse models of Bardet-Biedl syndrome显示文摘 | Rahmouni Kamal Fath Melissa A Seo Seongjin Thedens Daniel R Berry Christopher J Weiss Robert Nishimura Darryl Y Sheffield Val C | 2008 | Journal of Clinical Investigation2008，，： | 1 |
| 4 | The noninvasive assessment of left ventricular diastolic function with two-dimensional and Doppler echocardiography显示文摘 | Jae K. Oh Christopher P. Appleton Liv K. Hatle Rick A. Nishimura James B. Seward A.Jamil Tajik | 1997 | Journal of the American Society of Echocardiography1997，，3： | 1 |
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