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| 1 | Global, regional, and national prevalence of overweight and obesity in children and adults during 1980–2013: a systematic analysis for the Global Burden of Disease Study 2013显示文摘 | Marie Ng Tom Fleming Margaret Robinson Blake Thomson Nicholas Graetz Christopher Margono Erin C Mullany Stan Biryukov Cristiana Abbafati Semaw Ferede Abera Jerry P Abraham Niveen M E Abu-Rmeileh Tom Achoki Fadia S AlBuhairan Zewdie A Alemu Rafael Alfonso | 2014 | The Lancet2014，，： | 7 |
| 2 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 3 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 4 | Heat shock protein 90 inhibition by 17-DMAG lessens disease in the MRL/Ipr mouse model of systemic lupus erythematosus显示文摘热吃惊蛋白质 90 的提高的表示(HSP90 ) 在全身的豺狼座 erythematosus (SLE ) 的肾和浆液被发现了病人和 MRL/Mp-Fas lpr /Fas lpr (MRL/lpr ) 自体免疫的老鼠。如果 HSP90 的抑制将在 MRL/lpr 老鼠减少疾病,我们调查了。在在 vivo 的 vitro,有在 IL-6 的有免疫力刺激的显示出的减少的表示以前的 HSP90 禁止者 Geldanamycin 的 mesangial 房间的预告的处理, IL-12 和号码,我们发现当与 C57BL/6 相比鼠标和 MRL/lpr 鼠标与 HSP90 禁止者 17-DMAG 对待时, HSP90 表示在 MRL/lpr 肾被提高。与 17-DMAG 对待的 MRL/lpr 老鼠显示出减少的 proteinuria 并且减少了浆液 anti-dsDNA 抗体生产。Glomerulonephritis 和 glomerular IgG 和 C3 没被 17-DMAG 的管理显著地在 MRL/lpr 影响。17-DMAG 增加了 CD8 + T 房间,减少的双 negative T 房间,减少 CD4/CD8 比率和减少的小囊的 B 房间。这些研究建议 HSP90 可以在调整 T 房间区别和激活起一个作用并且 HSP90 抑制可以在豺狼座减少发炎。 | Samuel K Shimp III Cristen B Chafin Nicole L Regna Sarah E Hammond Molly A Read David L Caudell Marissa Nichole Rylander Christopher M Reilly | 2012 | Cellular & Molecular Immunology2012，9，3： | 3 |
| 5 | Quieting cross talk- the quorum sensing regulator LsrR as a possible target for fighting bacterial infections显示文摘 | Christopher M Byrd | 2009 | Cell Research2009，19，11： | 2 |
| 6 | Soil Deformation and Excess Pore Pressure Field Around a Closed-Ended Pile显示文摘 | Pestana J M Christopher E Hunt A M | 2002 | Journal of Geotechnical and Geoenvironmental Engineering2002，128，1： | 1 |
| 7 | Bis (fluoroalkyl) acrylic and methacrylic phosphate monomers, their polymers and some of their properties 显示文摘 | Timperley Christopher M Arbon Robert E Bird Michael | 2003 | Journal of Fluorine Chemistry2003，121，1： | 1 |
| 8 | Effects of using accurate climatic conditions for mechanistic-empirical pavement design显示文摘 | Tamer M B Christopher W R Daryl E H | 2011 | Journal of Transportation Engineering2011，137，： | 1 |
| 9 | Increasing rates of cardiac device infections among medicare beneficiaries: 1990–1999显示文摘 | Christopher H Cabell Paul A Heidenreich Vivian H Chu Christopher M Moore Martin E Stryjewski G.Ralph Corey Vance G Fowler | 2004 | American Heart Journal2004，，4： | 1 |
| 10 | Soil Deformation and Excess Pore Pressure Field Around a ClosedEnded Pile 显示文摘 | Pestana J M Hunt Christopher E Bray Jonathan D | 2002 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2002，125，1： | 1 |
| 11 | The effect of body contact series resistance on SOI CMOS amplifier stages显示文摘 | CHRISTOPHER F E WILLIAM R W BERNARD M T | 1997 | IEEE Trans Electron Devices1997，44，12： | 1 |
| 12 | Organic funetionalized molecular sieve as shape-selective catalyst 显示文摘 | Christopher W Katsuyuyki T Davas E M | 1998 | Nature1998，393，7： | 1 |
| 13 | Thrombin receptor antagonism –the potential of antiplatelet medication SCH 530348显示文摘 | Tracy E Macaulay Christopher Allen Khaled M Ziada | 2010 | Expert Opinion on Pharmacotherapy2010，，6： | 1 |
| 14 | Acetate and Formate Stress: Opposite Responses in the Proteome of Escherichia coli 显示文摘 | Christopher K Lisa M Nikki E | 2001 | Journal of Bacteriology2001，183，： | 1 |
| 15 | Surface functional groups on acid-activated nut- shell carbons显示文摘 | Christopher A Toles Wayne E Marshall Mitchell M Johns | 1999 | Carbon1999，37，8： | 1 |
| 16 | An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension显示文摘 | Sébastien Bonnet Evangelos D. Michelakis Christopher J. Porter Miguel A. Andrade-Navarro Bernard Thébaud Sandra Bonnet Alois Haromy Gwyneth Harry Rohit Moudgil M Sean McMurtry E Kenneth Weir Stephen L. Archer | 2006 | Circulation2006，，22： | 1 |
| 17 | Synthesis of the 3,-amino-fl- hydroxy acid of hapalosin via an asymmetric dihydroxy- lation route 显示文摘 | Martin E M Christoph H | 2000 | Tetrahedron2000，56，： | 1 |
| 18 | Detection of human papillomaviruses DNA in oral manifestation of lichen planus显示文摘 | Riethdorf S Christoph E | 1997 | Mund Kiefer Gesichtschir1997，1，3： | 1 |
| 19 | Nu cleic acid-based antiviral drugs against seasonal and avi an influenza viruses显示文摘 | Wong J P Christopher M E Salazar A M | 2007 | Vaccine2007，25，16： | 1 |
| 20 | Scanning fiber endoscopy with highly flexible, 1 mm catheterscopes for wide- field, full-color imaging显示文摘 | CAMERON M L CHRISTOPH J E | 2010 | Journal of Biophotonics2010，3，56： | 1 |
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