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1篇 您的检索式：作者名="Christophe P.G.Gerald"

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		题名	作者	年代	出处	被引量
	1	A classifier driven approach to find biomarkers for affective disorders from transcription profiles in blood显示文摘Gene expression profiles in blood are increasingly being used to identify biomarkers for different affective disorders.We have selected a set of 29 genes to generate expression profiles for healthy control subjects as well as for patients diagnosed with acute post-traumatic stress disorder(PTSD)and with borderline personality disorder(BPD).Measurements were performed by quantitative polymerase chain reaction(qPCR).Using the actual data in an anonymous form we constructed a series of artificial data sets with known gene expression profiles.These sets were used to test 14 classification algorithms and feature selection methods for their ability to identify the correct expression patterns.Application of the three most effective algorithms to the actual expression data showed that control subjects can be distinguished from BPD patients based on differential expression levels of the gene transcripts Gi2,GR and MAPK14,targets that may have links to stress related diseases.Controls can also be distinguished from acute PTSD patients by differential expression levels of the transcripts for ERK2 and RGS2 that are known to be associated with mood disorders and social anxiety.We conclude that it is possible to identify informative transcription profiles in blood samples from individuals with affective disorders.	Wiktor Mazin Joseph A.Tamm Irina A.Antonijevic Aicha Abdourahman Munish Das Roman Artymyshyn Birgitte Sφgaard Mary Walker Danka Savic Gordana Matic Svetozar Damjanovic Ulrik Gether Thomas Werge Lars VKessing Henrik Ullum Eva Haastrup Eric Vermetten Paul Markovitz Erik Mosekilde Christophe P.G.Gerald	2016	Advances in Precision Medicine2016，1，1：	0

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