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| 1 | Impact of ribavirin dose on retreatment of chronic hepatitis C patients显示文摘AIM: To study the efficacy and factors associated with a sustained virological response (SVR) in chronic hepatitis C (CHC) relapsing patients. METHODS: Out of 1228 CHC patients treated with pegylated interferon (PEG-IFN) and ribavirin (RBV), 165 (13%) had a relapse. Among these, 62 patients were retreated with PEG-IFN-2a or-2b and RBV. Clinical, biological, virological and histological data were collected. Initial doses and treatment modifications were recorded. The efficacy of retreatment and predictive factors for SVR were analyzed. RESULTS: An SVR was achieved in 42% of patients. SVR was higher in young (< 50 years) (61%) than old patients (27%) (P = 0.007), and in genotype 2 or 3 (57%) than in genotype 1 or 4 (28%) patients (P = 0.023). Prolonging therapy for at least 24 wk more than the previous course was associated with higher SVR rates (53% vs 28%, P = 0.04). Also, a better SVR rate was observed with RBV dose/body weight > 15.2 mg/kg per day (70% vs 35%, P = 0.04). In logistic regression, predictors of a response were age (P = 0.018), genotype (P = 0.048) and initial RBV dose/body weight (P = 0.022). None of the patients without a complete early virological response achieved an SVR (negative predictive value = 100%). CONCLUSION: Retreatment with PEG-IFN/RBV is effective in genotype 2 or 3 relapsers, especially in young patients. A high dose of RBV seems to be important for the retreatment response. | Christiane Stern Michelle Martinot-Peignoux Marie Pierre Ripault Nathalie Boyer Corinne Castelnau Dominique Valla Patrick Marcellin | 2012 | World Journal of Gastroenterology2012，18，23： | 1 |
| 2 | Risk Factors for Ileoanal J Pouch-Related Septic Complications in Ulcerative Colitis and Familial Adenomatous Polyposis显示文摘 | Udo A. Heuschen Ulf Hinz Erik H. Allemeyer Frank Autschbach Josef Stern Matthias Lucas Christian Herfarth Gundi Heuschen | 2002 | Annals of Surgery2002，，2： | 1 |
| 3 | An event-related fMRI study of the neurobehavioral impact of sleep deprivation on performance of a delayed-match-to-sample task显示文摘 | Christian Habeck Brian C. Rakitin James Moeller Nikolaos Scarmeas Eric Zarahn Truman Brown Yaakov Stern | 2003 | Cognitive Brain Research2003，，3： | 1 |
| 4 | IgG Antibodies against Deamidated Gliadin Peptides for Diagnosis of Celiac Disease in Patients with IgA Deficiency显示文摘 | Villalta Danilo Tonutti Elio Prause Christian Koletzko Sibylle Uhlig H Holm Vermeersch Pieter Bossuyt Xavier Stern Martin Laass Martin W Ellis Julia H Ciclitira Paul J Richter Thomas Daehnrich Cornelia Schlumberger Wolfgang Mothes Thomas | 2010 | Clinical Chemistry2010，，： | 1 |
| 5 | Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis显示文摘 | Udo A. Heuschen Ulf Hinz Erik H. Allemeyer Josef Stern Matthias Lucas Frank Autschbach Christian Herfarth Gundi Heuschen | 2001 | Gastroenterology2001，，4： | 1 |
| 6 | Backwash ileitis is strongly associated with colorectal carcinoma in ulcerative colitis显示文摘 | Udo A. Heuschen Ulf Hinz Erik H. Allemeyer Josef Stern Matthias Lucas Frank Autschbach Christian Herfarth Gundi Heuschen | 2001 | Gastroenterology2001，，4： | 1 |
| 7 | Minor Pressure Differences within the Fontan-Anastomosis in Patients with Total Cavopulmonary Connection by 4D-Flow Magnetic Resonance Imaging显示文摘Background: Pressure measurement in total cavopulmonary connection (TCPC) patients is a domain of cardiaccatheterization. 4D velocity encoded cardiovascular magnetic resonance (4D–flow MRI) offers an alternative forassessment of even minor pressure differences. The scope of this study was to measure even minor pressure differencesin the anastomosis of TCPC patients, who are clinically uncompromised. Methods: Twenty-four patients(median 15 years [8;34]) with TCPC were studied prospectively by 4D-flow MRI. Pressure differences betweensuperior vena cava (SVC) and extracardiac conduit (C) to both right pulmonary artery (RPA) and left pulmonaryartery (LPA) were assessed. Small fluid obstructions as vortices within the anastomosis were detected by flowpathlines from 4D-flow MRI. In two patients pressure differences were calculated also by computational flowdynamics (CFD) as a plausibility check for the order of magnitude. Results: Median values of pressure differencesin the anastomosis between SVC and RPA were 0.63 (0.21–2.1) mmHg, between C and RPA 0.67 (0.3–2.2)mmHg, between SVC and LPA 0.8 (0.3–2.4) mmHg and between C and LPA 0.7 (0.2–1.9) mmHg. Patients withpotential flow obstruction (stents, occluder, vortices) had significantly higher gradients at the anastomosis (p <0.05) than patients without potential obstructions, although the absolute values were small. CFD- and measurement-based pressure difference showed good agreement. Conclusion: 4D-flow MRI is able to detect minor pressuredifferences within the Fontan circuit even in patients with apparently satisfactory TCPC. Slightly higherpressure differences are due to the presence of small flow obstruction. | Nerejda Shehu Christian Meierhofer Anja Hennemuth Markus Hüllebrand Pavlo Yevtushenko Peter Ewert Stefan Martinoff Heiko Stern | 2023 | Congenital Heart Disease2023，18，4： | 0 |
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