|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation显示文摘 | Xu A Chow WS | 2004 | J Clin Endocrinol Metab2004，89，： | 1 |
| 2 | Hyperhomocysteinemia and impaired vasomotor function in type 2 diabetesmellitus显示文摘 | Tan KC O K Chow WS Ai VH | 2002 | Eur J Clin Invest2002，32，5： | 1 |
| 3 | Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilation显示文摘 | Tan KC Xu A Chow WS | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 4 | Advanced glycation end prod- ucts and endothelial dysfunction in type 2 diabete显示文摘 | Tan KC Chow WS Ai VH | 2002 | Diabetes Care2002，25，6： | 1 |
| 5 | Xenografts of human hepatocellular carcinoma:a useful model for testing drugs显示文摘 | Huynh H Soo KC Chow PK | | 0，，14： | 1 |
| 6 | Systematic review ofoutcomes of liver resection for early hepatocellular carcinomawithin the Milan criteria 显示文摘 | Lim KC Chow PK Allen JC | 2012 | Br J Surg2012，99，12： | 1 |
| 7 | Pluronic L-81 ameliorates diabetic symptoms in db/db mice through transcriptional regulation of microsomal triglyceride transfer protein显示文摘AIM: To test whether oral L-81 treatment could im-prove the condition of mice with diabetes and to investigate how L-81 regulates microsomal triglyceride transfer protein (MTP) activity in the liver. METHODS: Genetically diabetic (db/db) mice were fed on chow supplemented with or without L-81 for 4 wk. The body weight, plasma glucose level, plasma lipid profile, and adipocyte volume of the db/db mice were assessed after treatment. Toxicity of L-81 was also evaluated. To understand the molecular mecha-nism, HepG2 cells were treated with L-81 and the effects on apolipoprotein B (apoB) secretion and mRNA level of the MTP gene were assessed.RESULTS: Treatment of db/db mice with L-81 sig-nificantly reduced and nearly normalized their body weight, hyperphagia and polydipsia. L-81 also markedly decreased the fasting plasma glucose level, improved glucose tolerance, and attenuated the elevated levels of plasma cholesterol and triglyceride. At the effective dosage, little toxicity was observed. Treatment of HepG2 cells with L-81 not only inhibited apoB secretion, but also signif icantly decreased the mRNA level of the MTP gene. Similar to the action of insulin, L-81 exerted its effect on the MTP promoter. CONCLUSION: L-81 represents a promising candidate in the development of a selective insulin-mimetic mol-ecule and an anti-diabetic agent. | Wo-Shing Au Li-Wei Lu Sidney Tam Otis King Hung Ko Billy KC Chow Ming-Liang He Samuel S Ng Chung-Man Yeung Ching-Chiu Liu Hsiang-Fu Kung Marie C Lin | 2009 | World Journal of Gastroenterology2009，15，24： | 1 |
| 8 | Hypertotal homocysteine-mia and impaired vasomotor function in type 2 diabetes melli-tus显示文摘 | Tan KC O K Chow WS | 2002 | Eur J Clin Invest2002，32，5： | 1 |
| 9 | MR imaging findings of enteroviral encephaloymelitis:an outbreak in Taiwan显示文摘 | Shen WC Chiu HH Chow KC | 1999 | AJNR Am J Neuroradiol1999，20，10： | 1 |
| 10 | Expression of rTSbeta as a 5-fluorouracil resistance marker in patients with primary breast cancer显示文摘 | Kuo SJ Wang HC Chow KC | 2008 | Oncol Rep2008，19，4： | 1 |
| 11 | Neoadjuvant and adjuvant therapy for surgical resection of hepatocellular carcinoma显示文摘 | Samuel M Chow PK Chan Shih-Yen E Machin D Soo KC | | 0，，01： | 1 |
| 12 | RAD001 (everolimus) inhabits tumor growth in xenograft models of human hepatocellular carcinoma 显示文摘 | Huynh H Chow KH Soo KC | 2009 | J Cell Mol Med2009，13，7： | 1 |
| 13 | Prognostic significance of nm23-H1 expression in esophageal squamous cell carcinoma显示文摘 | Wang LS Chow KC Lien YC | 2004 | Eur J Cardiothorac Surg2004，26，2： | 1 |
| 14 | A comparison of 1-and 3-minute lockout periods during patient-controlled sedation with midazolam显示文摘 | Rodrigo C Chow KC | 1995 | J Oral Maxillofac Surg1995，18，53： | 1 |
| 15 | Hypoadiponeetinemia is associated with impaired endothelium - dependent vasodilation 显示文摘 | Tan KC Xu A Chow WS | 2004 | J Clin Endocrinol Metab2004，89，2： | 1 |
| 16 | Inverse expression of dihy-drodiol dehydrogenase and glutathione-s-transferase in patients with esophageal squamous cell carcinoma显示文摘 | Wang LS Chow KC Wu YC | 2004 | Int J Cancer2004，111，2： | 1 |
| 17 | MR imaging findings of entero- viral encephaloymelitis: an outbreak in Taiwan显示文摘 | Shen WC Chiu HH Chow KC | 1999 | Am J Neuroradi- ol1999，20，10： | 1 |
| 18 | Prognostic significance of nm23-H1 expression in oral squamous cell carcinoma显示文摘 | Wang YF Chow KC Chang SY | 2004 | Br J Cancer2004，90，11： | 1 |
| 19 | Surgery for ret proportional sarcoma requiring major Vascular resection and reconstruction显示文摘 | Teo MC Chow PK Soo KC | 2005 | Asian J Surg2005，28，4： | 1 |
| 20 | Adult T-cell leukaemia/ lymphoma can mimic other lymphomas in a non-endemic area:dilemmas in diagnosis and treatment显示文摘 | Huang CT Lee YH Chow KC | 2014 | Intern Med J2014，44，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员