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| 1 | Acinar cell injury induced by inadequate unfolded protein response in acute pancreatitis显示文摘Acute pancreatitis (AP) is an inflammatory disorder of pancreatic tissue initiated in injured acinar cells. Severe AP remains a significant challenge due to the lack of effective treatment. The widely-accepted autodigestion theory of AP is now facing challenges, since inhibiting protease activation has negligible effectiveness for AP treatment despite numerous efforts. Furthermore, accumulating evidence supports a new concept that malfunction of a self-protective mechanism, the unfolded protein response(UPR), is the driving force behind the pathogenesis of AP. The UPR is induced by endoplasmic reticulum(ER) stress, a disturbance frequently found in acinar cells, to prevent the aggravation of ER stress that can otherwise lead to cell injury. In addition, the UPR's signaling pathways control NFκB activation and autophagy flux, and these dysregulations cause acinar cell inflammatory injury in AP, but with poorly understood mechanisms. We therefore summarize the protective role of the UPR in AP, propose mechanistic models of how inadequate UPR could promote NFκB's pro-inflammatory activity and impair autophagy's protective function in acinar cells, and discuss its relevance to current AP treatment. We hope that insight provided in this review will help facilitate the research and management of AP. | Kaylene Barrera Albert Stanek Kei Okochi Zuzanna Niewiadomska Cathy Mueller Peiqi Ou Devon John Antonio E Alfonso Scott Tenner Chongmin Huan | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，2： | 9 |
| 2 | Anomaly Models of Spatial Structures for Copper-Molybdenum Ore Deposits and their Application显示文摘This paper discusses the enrichment and depletion regularities for porphyry copper-molybdenum ore deposits in different regions and varied deposit genetic types in the same area, taking three porphyry copper-molybdenum ore deposits (i.e., the Chengmenshan in Jiangxi, Wunugetushan in Inner Mongolia, Baishantang in Gansu) and two copper deposits in Gansu Province (the Huitongshan skarn deposit and Gongpoquan composite deposit) as case studies. The results show that porphyry Cu-Mo deposits or skarn copper deposits include both enrichment of the ore-forming elements and associated elements, and depletion of some lithophile dispersed elements, rare earth elements (REE) and some major elements. And the depleted elements vary with deposits, having generality and their own features. On a deposit scale, the positive anomalies of enriched elements and negative anomalies of depleted elements follow in a sequence to comprise regular anomaly models of spatial structures. The exploration in the Tongchang deposit in Jiangxi and Huitongshan deposit in Gansu suggests that anomaly models play a key role in the identification of mineral occurrences and deposits compared to one single enriched element anomaly. And the anomaly models exert a critical effect on the optimization of prospecting targets and their potential evaluation. | MA Shengming ZHU Lixin LIU Chongmin XI Mingjie TANG Shixin | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 9 |
| 3 | Mechanisms of interleukin-22's beneficial effects in acutepancreatitis显示文摘Acute pancreatitis(AP) is a disorder characterized by parenchymal injury of the pancreas controlled by immune cell-mediated inflammation. AP remains a significant challenge in the clinic due to a lack of specific and effective treatment. Knowledge of the complex mechanisms that regulate the inflammatory response in AP is needed for the development of new approaches to treatment, since immune cell-derived inflammatory cytokines have been recognized to play critical roles in the pathogenesis of the disease. Recent studies have shown that interleukin(IL)-22, a cytokine secreted by leukocytes, when applied in the severe animal models of AP, protects against the inflammation-mediated acinar injury. In contrast, in a mild AP model, endogenous IL-22 has been found to be a predominantly antiinflammatory mediator that inhibits inflammatory cell infiltration via the induction of Reg3 proteins in acinar cells, but does not protect against acinar injury in the early stage of AP. However, constitutively over-expressed IL-22 can prevent the initial acinar injury caused by excessive autophagy through the induction of the antiautophagic proteins Bcl-2 and Bcl-XL. Thus IL-22 plays different roles in AP depending on the severity of the AP model. This review focuses on these recently reported findings for the purpose of better understanding IL-22's regulatory roles in AP which could help to develop a novel therapeutic strategy. | Chongmin Huan Daniel Kim Peiqi Ou Antonio Alfonso Albert Stanek | 2016 | World Journal of Gastrointestinal Pathophysiology2016，7，1： | 7 |
| 4 | Acute pancreatitis in aging animals:Loss of pancreatitis-associated protein protection?显示文摘AIM:To investigate the effect of age on severity of acute pancreatitis(AP) using biochemical markers,histology and expression of the protective pancreatitisassociated proteins(PAPs).METHODS:AP was induced via intraductal injection of 4% sodium taurocholate in young and old rats.Sera and pancreata were assayed at 24 h for the parameters listed above;we also employed a novel molecular technique to assess bacterial infiltration using polymerase chain reaction to measure bacterial genomic ribosomal RNA.RESULTS:At 24 h after induction of AP,the pancreata of older animals had less edema(mean ± SE histologic score of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P < 0.05),decreased local inflammatory response(histologic score of stromal infiltrate:3.11 ± 0.27 vs 2.00 ± 0.17,P < 0.05) and increased bacterial infiltration(174% ± 52% increase from sham vs 377% ± 4%,P < 0.05).A decreased expression of PAP1 and PAP2 was demonstrated by Western blotting analysis and immunohistochemical staining.There were no differences in serum amylase and lipase activity,or tissue myeloperoxidase or monocyte chemotactic protein-1 levels.However,in the most-aged group,serum C-reactive protein levels were higher(young vs old:0.249 ± 0.04 mg/dL vs 2.45 ± 0.68 mg/dL,P < 0.05).CONCLUSION:In older animals,there is depressed PAP expression related to a blunted inflammatory response in AP which is associated with worsened bacterial infiltration and higher C-reactive protein level;this may explain the more aggressive clinical course. | Sophia Fu Albert Stanek Cathy M Mueller Nefertti A Brown Chongmin Huan Martin H Bluth Michael E Zenilman | 2012 | World Journal of Gastroenterology2012，18，26： | 5 |
| 5 | Suppressed oxygen extraction and degradation of LiNixMnyCo2O2 cathodes at high charge cut-off voltages显示文摘 | Jianming Zheng Pengfei Yan Jiandong Zhang Mark H. Engelhard Zihua Zhu Bryant J. Polzin Steve Trask Jie Xiao Chongmin Wang Jiguang Zhang | 2017 | Nano Research2017，10，12： | 5 |
| 6 | 强震作用下重力坝考虑辐射阻尼的一种简单模型显示文摘提出一种在强震作用下重力坝考虑地基辐射阻尼效应的动力反应的简单模型,该模型在无质量地基模型的坝体-地基交接面设置黏性阻尼器,并通过大量的计算统计确定阻尼器的系数。计算了100m级和200m级重力坝在不同频谱地震、不同地基弹性模量条件下的地震响应,结果表明,简单模型和弹簧-阻尼边界模型结果接近,误差在8%内。 | 潘坚文 Chongmin Song 张楚汉 | 2010 | 水利学报2010，40，4： | 4 |
| 7 | K2Ti6O13 Nanoparticle-Loaded Porous rGO Crumples for Supercapacitors显示文摘One-dimensional alkali metal titanates containing potassium,sodium,and lithium are of great concern owing to their high ion mobility and high specific surface area.When those titanates are combined with conductive materials such as graphene,carbon nanotube,and carbon nanofiber,they are able to be employed as efficient electrode materials for supercapacitors.Potassium hexa-titanate(K2Ti6O13,KTO),in particular,has shown superior electrochemical properties compared to other alkali metal titanates because of their large lattice parameters induced by the large radius of potassium ions.Here,we present porous rGO crumples(PGC)decorated with KTO nanoparticles(NPs)for application to supercapacitors.The KTO NP/PGC composites were synthesized by aerosol spray pyrolysis and post-heat treatment.KTO NPs less than 10 nm in diameter were loaded onto PGCs ranging from 3 to 5μm.Enhanced porous structure of the composites was obtained by the activation of rGO by adding an excessive amount of KOH to the composites.The KTO NP/PGC composite electrodes fabricated at the GO/KOH/TiO2 ratio of 1:3:0.25 showed the highest performance(275 F g−1)in capacitance with different KOH concentrations and cycling stability(83%)after 2000 cycles at a current density of 1 A g−1. | Chongmin Lee Sun Kyung Kim Hankwon Chang Hee Dong Jang | 2020 | Nano-Micro Letters2020，12，1： | 3 |
| 8 | Thiophene hydrodesulfurization over nickel phosphide catalysts: effect of the precursor composition and support显示文摘 | Stephanie J. Sawhill Kathryn A. Layman Daniel R. Van Wyk Mark H. Engelhard Chongmin Wang Mark E. Bussell | 2005 | Journal of Catalysis2005，，2： | 2 |
| 9 | 一种模拟弹性波在层状地基中传播的简化高阶双渐近透射边界显示文摘在强烈地震作用下,层状地基与结构之间的动力相互作用将对结构的动力响应产生重大影响,其难点是模拟波动在无限层状地基中传播引起的辐射阻尼效应.基于比例边界有限单元法(SBFEM)构建的层状介质标量波高阶双渐近透射边界能够在全频范围内快速收敛到准确解,具有很高的计算精度和计算效率,并且具有良好的数值稳定性.以二维水平等高层状地基为研究对象,将弹性动力学方程强行解耦得到两个独立的标量波方程,基于解耦的标量波方程构建了一种层状地基弹性波传播模拟的简化高阶双渐近透射边界.同标量波高阶双渐近透射边界一样,该透射边界具有良好的计算性能.数值算例结果表明,该透射边界对底部为固定边界条件的水平层状地基具有良好的模拟精度. | 高毅超 徐艳杰 金峰 SONG ChongMin | 2016 | 中国科学:技术科学2016，46，5： | 2 |
| 10 | Three dimensional K-Tz stress fields around the embedded center elliptical crack front in elastic plates显示文摘彻底地详细说明三维(3D ) 有限元素(FE ) 计算, out-of-plane 限制 T z 在模式嵌入中心椭圆的裂缝我有弹性的盘子被学习。T z 与 0.2, 0.4, 0.5, 0.6, 0.8 和 1.0 的方面比率(往来帐户) 在裂缝前面附近被获得。 T 从在有在裂缝前面的正常飞机增加规范的光线的距离( r/a )的到零的裂缝尖端的泊松比率ν
的近似价值的 z 减少排队,并且当椭圆的参数角度ϕ
从 0 ° 改变到 90 °a t 时,逐渐地增加一样的 r/a 。与升起到 1.0 的往来帐户, T z 正在变得将近独立于 ϕ
并且仅仅与 r/a 有关。为 T 为 T , 车验式 > z 被获得描述 T 为最不使用的嵌入的中心椭圆的裂缝的 z 在 0.2 ≤a/c≤1.0 的范围摆平方法。这些 T 和相应压力紧张因素 K 的 z 结果是很好合适的因为 3D 的分析嵌入中心椭圆的裂缝前面地,和二参数的 K-T z 原则被建议。 | Junhua Zhao Wanlin Guo Chongmin She Bo Meng | 2006 | Acta Mechanica Sinica2006，22，2： | 2 |
| 11 | Three-pa- rameter approach for elastic-plastic fracture of the semi- elliptical surface crack under tension 显示文摘 | Zhao Junhua Guo Wanlin She Chongmin | 2008 | International Journal of Mechanical Sciences2008，50，7： | 1 |
| 12 | Time-domain analysis of gravity dam–reservoir interaction using high-order doubly asymptotic open boundary显示文摘 | Xiang Wang Feng Jin Suriyon Prempramote Chongmin Song | 2011 | Computers and Structures2011，，7： | 1 |
| 13 | Consistent infinitesimal finite element cell method: three- dimensional vector wave equation显示文摘 | Wolf John P Song Chongmin | 1996 | International Journal for Numerical Methods in Engineering1996，39，13： | 1 |
| 14 | The scaled boundary finite element method - a primer derivation- s显示文摘 | John P Wolf Chongmin Song | 2000 | Computers & Structures2000，78，： | 1 |
| 15 | The scaled boundary finite-element method - a primer solution procedures显示文摘 | Chongmin Song John P Wolf | 2000 | Computers & Structures2000，78，： | 1 |
| 16 | The in- plane and out-of-plane stress constraint factors and K-T- Tz description of stress field near the border of a semi- elliptical surface crack 显示文摘 | Zhao Junhua Guo Wanlin She Chongmin | 2007 | International Journal of Fa- tigue2007，29，3： | 1 |
| 17 | Synthesis and characterization of phosphate-coated mesoporous titania and Cd-doping of same via ion exchange显示文摘 | Yongsoon S Bruce W A Chongmin Wang | 2007 | Inorganic Chemistry Communications2007，，10： | 1 |
| 18 | A numerical approach for the computation of dispersion relations for plate structures using the Scaled Boundary Finite Element Method显示文摘 | Hauke Gravenkamp Chongmin Song Jens Prager | 2012 | Journal of Sound and Vibration2012，，11： | 1 |
| 19 | Determination of thermal decomposition kinetics parameters of waste plastics by means of thermogravimetry显示文摘 | Miao Xincheng Zhang Chongmin | 2004 | JMST2004，，： | 1 |
| 20 | Numerical simulation of friction stir welding process显示文摘 | Dongun Kim Harsha Badarinarayan Ill Ryu Ji Hoon Kim Chongmin Kim Kazutaka Okamoto R. H. Wagoner Kwansoo Chung | 2009 | International Journal of Material Forming2009，，1： | 1 |
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