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| 1 | Concurrence of iridocorneal endothelial syndrome in a patient with glaucomatocyclitic crisis显示文摘Dear Sir,Iam Jin A Choi,from the Department of Ophthalmology of St.Vincent Hospital of Suwon,Kyungki-do,South Korea.I write to present a case report of a young female treated with the diagnosis of Posner-Schlossman syndrome for several years,in which she was ultimately proved to have iridocorneal endothelial(ICE)syndrome.Posner-Schlossman syndrome(PS syndrome)is characterized by recurrent attacks of mild anterior uveitis with marked elevation of intraocular pressure(IOP)[1].The exact etiology of this syndrome is not fully established yet.However,the possible role of herpes simplex virus(HSV)is suggested by a study that revealed DNA evidence of the virus in all aqueous specimens of patients during acute attacks in PS syndrome[1,2].ICE is a spectrum of disease | Jin A Choi Yi Ryeung Park Tae Yoon La | 2014 | International Journal of Ophthalmology(English edition)2014，7，2： | 4 |
| 2 | Exploitation of pepper EST–SSRs and an SSR-based linkage map显示文摘 | Gibum Yi Je Min Lee Sanghyeob Lee Doil Choi Byung-Dong Kim | 2006 | Theoretical and Applied Genetics2006，，1： | 3 |
| 3 | Post-transplantation sequential entecavir monotherapy following 1-year combination therapy with hepatitis B immunoglobulin显示文摘 | Nam-Joon Yi Jong Young Choi Kyung-Suk Suh Jai Young Cho Minjung Baik Geun Hong Kwang-Woong Lee Won Kim Yoon Jun Kim Jung-Hwan Yoon Hyo-Suk Lee Dong Goo Kim | 2013 | Journal of Gastroenterology2013，，12： | 3 |
| 4 | Bioinspired urease-powered micromotor as an active oral drug delivery carrier in stomach显示文摘Self-propelling micro-and nano-motors(MNMs)have been extensively investigated as an emerging oral drug delivery carrier for gastrointestinal(GI)tract diseases.However,the propulsion of current MNMs reported so far is mostly based on the redox reaction of metals(such as Zn and Mg)with severe propulsion gas generation,remaining non-degradable residue in the GI tract.Here,we develop a bioinspired enzyme-powered biopolymer micromotor mimicking the mucin penetrating behavior of Helicobacter pylori in the stomach.It converts urea to ammonia and the subsequent increase of pH induces local gel-sol transition of the mucin layer facilitating the penetration into the stomach tissue layer.The successful fabrication of micromotors is confirmed by high-resolution transmission electron microscopy,electron energy loss spectroscopy,dynamic light scattering analysis,zeta-potential analysis.In acidic condition,the immobilized urease can efficiently converted urea to ammonia,comparable with that of neutral condition because of the increase of surrounding pH during propulsion.After administration into the stomach,the micromotors show enhanced penetration and prolonged retention in the stomach for 24 h.Furthermore,histological analysis shows that the micromotors are cleared within 3 days without causing any toxicity in the GI tract.The enhanced penetration and retention of the micromotors as an active oral delivery carrier in the stomach would be successfully harnessed for the treatment of various GI tract diseases. | Hyunsik Choi Sang Hoon Jeong Tae Yeon Kim Jeeyoon Yi Sei Kwang Hahn | 2022 | Bioactive Materials2022，7，3： | 3 |
| 5 | Long-Term Outcome of Laparoscopic Versus Open Liver Resection for Hepatocellular Carcinoma: A Case-Controlled Study with Propensity Score Matching显示文摘 | Hyeyoung Kim Kyung-Suk Suh Kwang-Woong Lee Nam-Joon Yi Geun Hong Suk-Won Suh Tae Yoo Min-Su Park YoungRok Choi Hae Won Lee | 2014 | Surgical Endoscopy2014，，3： | 3 |
| 6 | Immune enhancement effect of an herb complex extract through the activation of natural killer cells and the regulation of cytokine levels in a cyclophosphamide-induced immunosuppression rat model显示文摘Objective: To investigate the effects of a herb complex extract(HCE) prepared from Cornus officinalis Sieb. Et Zucc., Eriobotrya japonica Lindley, and olive leaves on immune response of mouse spleen NK cells in vitro and in vivo analysis. Methods: The activity of natural killer(NK) cells was measured in splenocytes and YAC-1 cells. Mice were immunosuppressed using cyclophosphamide(5 mg/kg body weight). Three different doses of HCE(200, 400, and 800 mg/kg body weight) and red ginseng extract(800 mg/kg body weight) which was used as standard immunomodulatory herb were administered orally for 4 weeks. The body weight, dietary, water intake, organs(liver, thymus, and spleen) weight, completed blood count, and cytokines(tumor necrosis factor alpha, interferon gamma, and interleukin-2) production was measured. Results: At the maximum concentration of HCE, the activity of NK cells was increased by 48.5%. HCE increased liver, spleen, and thymus weights without altering numbers of white blood cells, lymphocytes, and neutrophils in a cyclophosphamide-induced immunosuppression rat model. However, HCE recovered the inhibited cytokine expression; HCE(800 mg/kg) increased cytokines levels. The results indicate the immune enhancement potential of this HCE. Conclusion: The HCE enhances immunity by increasing NK cell activity, regulating cytokine levels, and maintaining spleen weight. Therefore, it may be used as a potential immunity enhancer. | Sung Min Woo Woo Rin Choi Dooly Jang Chun Sik Yi Hae Lim Kim Kyung Hyeon Kim Jong Tae Kim Won Hee Choi Seung Hee Jang Min Jeung Kim Ji Hyang Wee Yeon Ki Kim Bao Le | 2018 | Asian Pacific Journal of Tropical Medicine2018，11，12： | 2 |
| 7 | Laser micromachining of CNT/Fe/Al_2O_3 nanocomposites显示文摘CNT/Fe/Al2O3 mixed powders were synthesized from Fe/Al2O3 nanopowders using thermal CVD for the homogeneous dispersion of carbon nanotubes CNTs. CNTs consisted of MWNT, and the diameter was approximately 20-30 nm. After sintering, CNTs were homogenously located throughout Al2O3 grain boundary and were buckled. A femto-second laser installed with special optical systems was used for micromachining of the nanocomposites. The relationship between material ablation rate and energy fluence was theoretically investigated and compared with experimental results from cross-sectional SEM analysis. The nanocomposites which have higher content of CNT show a fairly good machining result due to its higher thermal conductivity and smaller grain size as well as lower light transmittance. | Kwang-Ryul KIM Byoung-Deog CHOI Jun-Sin YI Sung-Hak CHO Yong-Ho CHOA Dong-Soo SHIN Dong-Ho BAE Myung-Chang KANG Young-Keun JEONG | 2009 | 中国有色金属学会会刊:英文版2009，19，B09： | 2 |
| 8 | Whole-genome,transcriptome,and methylome analyses provide insights into the evolution of platycoside biosynthesis in Platycodon grandiflorus,a medicinal plant显示文摘Triterpenoid saponins(TSs)are common plant defense phytochemicals with potential pharmaceutical properties.Platycodon grandiflorus(Campanulaceae)has been traditionally used to treat bronchitis and asthma in East Asia.The oleanane-type TSs,platycosides,are a major component of the P.grandiflorus root extract.Recent studies show that platycosides exhibit anti-inflammatory,antiobesity,anticancer,antiviral,and antiallergy properties.However,the evolutionary history of platycoside biosynthesis genes remains unknown.In this study,we sequenced the genome of P.grandiflorus and investigated the genes involved in platycoside biosynthesis.The draft genome of P.grandiflorus is 680.1 Mb long and contains 40,017 protein-coding genes.Genomic analysis revealed that the CYP716 family genes play a major role in platycoside oxidation.The CYP716 gene family of P.grandiflorus was much larger than that of other Asterid species.Orthologous gene annotation also revealed the expansion ofβ-amyrin synthases(bASs)in P.grandiflorus,which was confirmed by tissue-specific gene expression.In these expanded gene families,we identified key genes showing preferential expression in roots and association with platycoside biosynthesis.In addition,wholegenome bisulfite sequencing showed that CYP716 and bAS genes are hypomethylated in P.grandiflorus,suggesting that epigenetic modification of these two gene families affects platycoside biosynthesis.Thus whole-genome,transcriptome,and methylome data of P.grandiflorus provide novel insights into the regulation of platycoside biosynthesis by CYP716 and bAS gene families. | Jungeun Kim Sang-Ho Kang Sin-Gi Park Tae-Jin Yang Yi Lee Ok Tae Kim Oksung Chung Jungho Lee Jae-Pil Choi Soo-Jin Kwon Keunpyo Lee Byoung-Ohg Ahn Dong Jin Lee Seung-il Yoo In-Gang Shin Yurry Um Dae Young Lee Geum-Soog Kim Chang Pyo Hong Jong Bhak Chang-Kug Kim | 2020 | Horticulture Research2020，7，1： | 2 |
| 9 | Rapid Preparation of Monolithic Columns for Capillary Electrochromatography Separation显示文摘Fritless packed silica gel columns were prepared using sol-gel technology. The part of a 75 μm i.d. capillary was filled with a mixture of methacryloxypropyltrimethoxysilane, toluene and hydrochloric acid. Four different photoinitiators such as benzoin methyl ether, Irgacure 819, Irgacure 1700 and Irgacure 1800 were added in the presence or absence of sodium dodecyl sulfate during the polymerization process. The above eight solutions were irradiated at 365 nm about 5-10 min to prepare the porous monolithic sol-gel columns by a one-step process. | Wen Jun GONG Yi Jun ZHANG Yu Ping ZHANG Seong Ho CHOI | 2006 | Chinese Chemical Letters2006，17，6： | 2 |
| 10 | Living-Donor Liver Transplantation Associated With Higher Incidence of Hepatocellular Carcinoma Recurrence Than Deceased-Donor Liver Transplantation显示文摘 | Min-Su Park Kwang-Woong Lee Suk-Won Suh Tae You YoungRok Choi Hyeyoung Kim Geun Hong Nam-Joon Yi Choon-Hyuck David Kwon Jae-Won Joh Suk-Koo Lee Kyung-Suk Suh | 2014 | Transplantation Journal2014，，1： | 2 |
| 11 | Hypothyroidism affects astrocyte and microglial morphology in type 2 diabetes显示文摘In the present study,we investigated the effects of hypothyroidism on the morphology of astrocytes and microglia in the hippocampus of Zucker diabetic fatty rats and Zucker lean control rats.To induce hypothyroidism,Zucker lean control and Zucker diabetic fatty rats at 7 weeks of age orally received the vehicle or methimazole,an anti-thyroid drug,treatment for 5 weeks and were sacrificed at 12 weeks of age in all groups for blood chemistry and immunohistochemical staining.In the methimazole-treated Zucker lean control and Zucker diabetic fatty rats,the serum circulating triiodothyronine(T3)and thyroxine(T4)levels were significantly decreased compared to levels observed in the vehicle-treated Zucker lean control or Zucker diabetic fatty rats.This reduction was more prominent in the methimazole-treated Zucker diabetic fatty group.Glial fibrillary acidic protein immunoreactive astrocytes and ionized calcium-binding adapter molecule 1(Iba-1)-immunoreactive microglia in the Zucker lean control and Zucker diabetic fatty group were diffusely detected in the hippocampal CA1 region and dentate gyrus.There were no significant differences in the glial fibrillary acidic protein and Iba-1 immunoreactivity in the CA1 region and dentate gyrus between Zucker lean control and Zucker diabetic fatty groups.However,in the methimazole-treated Zucker lean control and Zucker diabetic fatty groups,the processes of glial fibrillary acidic protein immunoreactive astrocytes and Iba-1 immunoreactive microglia,were significantly decreased in both the CA1region and dentate gyrus compared to that in the vehicle-treated Zucker lean control and Zucker diabetic fatty groups.These results suggest that diabetes has no effect on the morphology of astrocytes and microglia and that hypothyroidism during the onset of diabetes prominently reduces the processes of astrocytes and microglia. | Sung Min Nam Yo Na Kim Dae Young Yoo Sun Shin Yi Jung Hoon Choi In Koo Hwang Je Kyung Seong Yeo Sung Yoon | 2013 | Neural Regeneration Research2013，8，26： | 2 |
| 12 | Feasibility of Single-Beat Full-Volume Capture Real-Time Three-Dimensional Echocardiography and Auto-Contouring Algorithm for Quantification of Left Ventricular Volume: Validation with Cardiac Magnetic Resonance Imaging显示文摘 | Sung-A Chang Sang-Chol Lee Eun-Young Kim Seung-Hee Hahm Shin Yi Jang Sung-Ji Park Jin-Oh Choi Seung Woo Park Yeon Hyeon Choe Jae K. Oh | 2011 | Journal of the American Society of Echocardiography2011，，8： | 2 |
| 13 | Folate depletion impairs DNA excision repair in the colon of the rat 显示文摘 | Kim YI Weitzel JN | 1998 | Gut1998，43，： | 1 |
| 14 | AtMYB21,a gene encoding a flower-specific transcription factor,is regulated by COP1显示文摘 | Shin B Choi G Yi H | 2002 | The Plant Journal2002，30，1： | 1 |
| 15 | Therapeutic effects of BCG vaccination in adult asthmatic patients:arandomized controlled trial显示文摘 | Choi IS Koh YI | 2002 | Ann Allergy Asthma Immunol2002，88，： | 1 |
| 16 | Lateral torsional buckling of I-girder with corrugated webs under uni- form bending显示文摘 | Moon J Yi J-W Choi B H | 2009 | Thin-Walled Structures2009，47，1： | 1 |
| 17 | Continuum-based design sensitivity analysis and optimization of nonlinear shell structures using meshfree method 显示文摘 | Kiyoung Yi Choi K K Kim N H | 2006 | International Journal for Numerical Methods in Engineering2006，68，： | 1 |
| 18 | Clinical evaluation of 3 types of plate osteosynthesis for fixation of condylar neck fractures 显示文摘 | Choi BH Yi CK Yoo JH | 2001 | J Oral Maxillofac Surg2001，59，7： | 1 |
| 19 | Association study of microRNA polymorphisms with risk of idiopathic recurrent spontaneous abortion in Korean women显示文摘 | Young Joo Jeon Yi Seul Choi HyungChul Rah Su Yeoun Kim Dong Hee Choi Sun Hee Cha Ji Eun Shin Sung Han Shim Woo Sik Lee Nam Keun Kim | 2011 | Gene2011，，2： | 1 |
| 20 | A disposable biosensor with Prussian blue deposited electrode显示文摘 | Yi I-J Kim J-H Choi Y J | 2006 | Microelectron Eng2006，83，49： | 1 |
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