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| 1 | High-resolution microendoscopy for esophageal cancer screening in China: A cost-effectiveness analysis显示文摘AIM:To study the cost-effectiveness of high-resolution microendoscopy(HRME)in an esophageal squamous cell carcinoma(ESCC)screening program in China.METHODS:A decision analytic Markov model of ESCC was developed.Separate model analyses were conducted for cohorts consisting of an averagerisk population or a high-risk population in China.Hypothetical 50-year-old individuals were followed until age 80 or death.We compared three different strategies for both cohorts:(1)no screening;(2)standard endoscopic screening with Lugol’s iodine staining;and(3)endoscopic screening with Lugol’s iodine staining and an HRME.Model parameters were estimated from the literature as well as from GLOBOCAN,the Cancer Incidence and Mortality Worldwide cancer database.Health states in the model included non-neoplasia,mild dysplasia,moderate dysplasia,high-grade dysplasia,intramucosal carcinoma,operable cancer,inoperable cancer,and death.Separate ESCC incidence transition rates were generated for the average-risk and high-risk populations.Costs in Chinese currency were converted to international dollars(I$)and were adjusted to 2012dollars using the Consumer Price Index.RESULTS:The main outcome measurements for this study were quality-adjusted life years(QALYs)and incremental cost-effectiveness ratio(ICER).For the average-risk population,the HRME screening strategy produced 0.043 more QALYs than the no screening strategy at an additional cost of I$646,resulting in an ICER of I$11808 per QALY gained.Standard endoscopic screening was weakly dominated.Among the high-risk population,when the HRME screening strategy was compared with the standard screening strategy,the ICER was I$8173 per QALY.For both the high-risk and average-risk screening populations,the HRME screening strategy appeared to be the most cost-effective strategy,producing ICERs below the willingness-topay threshold,I$23500 per QALY.One-way sensitivity analysis showed that,for the average-risk population,higher specificity of Lugol’s iodine(>40%)and lower specificity of HRME(<70%)could make Lugol’s iodine screening cost-effective.For the high-risk population,the results of the model were not substantially affected by varying the follow-up rate after Lugol’s iodine screening,Lugol’s iodine test characteristics(sensitivity and specificity),or HRME specificity.CONCLUSION:The incorporation of HRME into an ESCC screening program could be cost-effective in China.Larger studies of HRME performance are needed to confirm these findings. | Chin Hur Sung Eun Choi Chung Yin Kong Gui-Qi Wang Hong Xu Alexandros D Polydorides Li-Yan Xue Katherine E Perzan Angela C Tramontano Rebecca R Richards-Kortum Sharmila Anandasabapathy | 2015 | World Journal of Gastroenterology2015，21，18： | 8 |
| 2 | Impact of social isolation on behavioral health in elderly: Systematic review显示文摘AIM: To examine and compare the effects of subjective and objective social isolation on behavioral health in elderly adults.METHODS: A systematic search of Pub Med was performed for original research articles from peerreviewed journals examining one of the following topics: 'Social isolation and sleep disturbance', 'social isolation and depression', or 'social isolation and fatigue in older adults'. Studies were selected following the criteria established based on the aim of this review. Data were extracted from the articles by two independent reviewers. Due to the heterogeneity in study designs and outcome measures of the included studies, qualitative and narrative analyses were conducted.RESULTS: The set criteria were used to select a total of 16 studies for the review. Of the 16, 13 were crosssectional studies. The characteristics of study populations were identified as follows. A total of 12 studies randomly selected subjects irrespective of pre-existing health conditions. Consequently, an unspecified number of the study subjects had chronic diseases in the studies compared. In addition, cultural and ethnic backgrounds of studies in this review were diverse, and included subjects living in North America, South America, Asia, Europe, and Oceania. Both subjective and objective types of social isolation increased behavioral symptoms, such as sleep disturbance, depressive symptoms, and fatigue in older adults. Furthermore, a few recent studies reported stronger effects of subjective social isolation than objective social isolation on sleep disturbance and depressive symptoms.CONCLUSION: Social isolation affects behavioral health in older adults. Compared to the objective social isolation, subjective social isolation contributes more significantly to sleep disturbance and depression. | Hanbyul Choi Michael R Irwin Hyong Jin Cho | 2015 | World Journal of Psychiatry2015，5，4： | 4 |
| 3 | Bone induction by BMP-2 transduced stem cells derived from human fat显示文摘 | Dragoo J L Choi J Y Lieberman J R Huang J, Zuk P A, Zhang J, Hedrick M H, Benhaim P | | 0，，： | 2 |
| 4 | Immunogenicity of the E1E2 proteins of hepatitis C virus expressed by recombinant adenoviruses 显示文摘 | Seong Y R Choi S Lim J S | 2001 | Vaccine2001，19，2022： | 2 |
| 5 | Environm-ental applications of semiconductor photocatalysis显示文摘 | Hoffmann M R Martin S T Choi W | 1995 | Chem Rev1995，95，1： | 2 |
| 6 | Experimental observations of the spatial anisotropy of the neutron emission in a medium energy plasma focus 显示文摘 | Aliaga-Rossel R Peter Choi | 1998 | IEEE Transactions on Plasma Science1998，26，4： | 2 |
| 7 | A robust approach to image enhancement based on fuzzy logic显示文摘 | Choi Y S Krishnapuram R | 1997 | IEEE Transaction on Image Processing1997，6，6： | 2 |
| 8 | The supply base and its complexity: Implications for transaction costs, risks, responsiveness, and innovation显示文摘 | Choi T Y Krause D R | 2006 | Journal of Operations Management2006，24，5： | 1 |
| 9 | Supracondylar humeral fractures in children 显示文摘 | Omid R Choi PD Skaggs DL | 2008 | J Bone Joint Surg ( Am )2008，90，5： | 1 |
| 10 | Existence of global solutions for the Shigesada-Kawasaki-Teramoto model with weak cross-diffusion显示文摘 | Choi Y S Lui R Yamada Y | 2003 | Discrete Contin Dynam Systems2003，9，5： | 1 |
| 11 | Modulation of skin collagen metabolism in aged and photoaged human skin in vivo显示文摘 | Chung J H Seo J Y Choi H R | 2001 | J Invest Dermatol2001，117，5： | 1 |
| 12 | Digital inkjet printing for chitosan-treated cotton fabric显示文摘 | P S R Choi C W M Yuen S K A Ku | 2005 | Fibers and Polymers2005，6，3： | 1 |
| 13 | Random sequence analy-sis of genomie DNA of a hyperthemophile:Aquifex pyrophilus显示文摘 | Kim S S Ryu J R | 1997 | Extremophiles1997，1，3： | 1 |
| 14 | Resurreccion,Consumer- Based Optimization of a Third-Generation Product Made from Peanut and Rice Flour 显示文摘 | I D Choi R D Phillips A V A | 2007 | Journal of Food Science2007，72，7： | 1 |
| 15 | Irinotecan and radiation in combined-modality therapy for solid tumors显示文摘 | Choy H Macrae R | 2001 | Oncology2001，15，8： | 1 |
| 16 | The role of metal ion dopants in quantum-sized TiO2:correlation between photoreactivity and charge cartier recombination dynamics 显示文摘 | Choi W Termin A Hoffmann M R | 1994 | J Phys Chem1994，98，13： | 1 |
| 17 | Dynamic Modeling and Vibration Control of Electrorheological Mounts 显示文摘 | Choi S B Hong S R | 2004 | Journal of Vibration and Acoustics2004，126，： | 1 |
| 18 | Serum response factor enhances liver metastasis of colorectal carcinoma via alteration of the E cadherin/beta catenin complex 显示文摘 | Choi H N Kim K R Lee J H | 2009 | Oncol Rep2009，21，1： | 1 |
| 19 | Apoptosis, necrosis, pro- liferation, and myofibroblast generation in the stroma following LASIK and PRK显示文摘 | Mohan RR Huteheon AE Choi R | 2003 | Exp Eye Res2003，76，1： | 1 |
| 20 | Seismic fragility of typical bridges in moderate seismiczones显示文摘 | Choi E DesRoches R Nielson B | 2004 | Engineering Structures2004，，24： | 1 |
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