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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Alcohol intake and risk of incident gout in men 显示文摘 | Choi HK Atkinson K Karlson EW | 2004 | Lancet2004，363，： | 1 |
| 3 | Prevalence of the metabolic syndrome in individuals with hyperuricemia 显示文摘 | Choi HK Ford ES | 2007 | Am J Med2007，120，： | 1 |
| 4 | Comparision of stenting with emergency surgery as palliative treatment for obstructing primary left-sided colirectal cancer显示文摘 | LowWL Choi HK ChuKW | 2003 | Br J Surg2003，，5： | 1 |
| 5 | Changes in bile duets after radiofrequency ablation of hepatocellular carcinoma: Frequency and clinical significance显示文摘 | Kim SH Lim HK Choi D | 2004 | American Journal of Roentgenology2004，183，12： | 1 |
| 6 | itomycin C induces apoptosis in cultured corneal ilbroblasts derived from type II granular corneal dystrophy corneas 显示文摘 | Kim TI Choi SI Lee HK | 2008 | Mol Vis2008，14，： | 1 |
| 7 | Analysis of risk factors for the development of incisional and parastomal hernias in patients after colorectal surgery显示文摘 | Song IH Ha HK Choi SG | 2012 | J Korean Soc Coloproctol2012，28，6： | 1 |
| 8 | Assessment of left ventricular rotation and torsion with two-dimensional speckle tracking echocardiography显示文摘 | Kim HK Sohn DW Choi SY | 2007 | J Am Soc Echocardiogr2007，20，1： | 1 |
| 9 | Laparoscopic and open anterior resection for upper and mid rectal cancer:an evaluation of outcomes显示文摘 | Law WL Lee YM Choi HK | 2006 | Dis Colon Rectum2006，49，8： | 1 |
| 10 | Hepatocellular carcinoma treated with percutaneous radio - frequency ablation : usefulness of power Doppler US with a mierobubble contrast agent in evaluating them- peutic response - preliminary results 显示文摘 | Choi D Lim HK Kim SH | 2000 | Radiology2000，217，2： | 1 |
| 11 | Lifestyle and gout 显示文摘 | Hak AE Choi HK | 2008 | Curr Opin Rheumatol2008，20，2： | 1 |
| 12 | Pathogenesis of Gout显示文摘 | CHOI HK MOUNT DB REGINATO AM | 2005 | Ann Intern Med2005，143，7： | 1 |
| 13 | Prevalence of gout and hyperu-ricemia in the US general population: the National Health and Nutrition Examination Survey 2007-2008显示文摘 | ZHU Y PANDYA B J CHOI HK | 2011 | Arthri- tis&Peumatism2011，63，： | 1 |
| 14 | Functional characteristics of two BKCa channel variants differentially expressed in rat brain tissues显示文摘 | Ha TS Jeong SY Cho SW Jeon HK Roh GS Choi WS Park CS | | 0，，： | 1 |
| 15 | Prevalence of gout and hyper-uricemia in the US general population:the National Healthand Nutrition Examination Survey 2007-2008显示文摘 | Zhu Y Pandya BJ Choi HK | 2011 | ArthritisRheum2011，63，10： | 1 |
| 16 | A gene expression signature of acquired chemoresistance to cisplatin and fluorouracii combination chemotherapy in gastric cancer patients显示文摘 | Kim HK Choi IJ Kim CG | 2011 | PLoS One2011，6，16： | 1 |
| 17 | Epidemiology of Gout 显示文摘 | Roddy E Choi HK | 2014 | Rheum Dis Clin North Am2014，40，2： | 1 |
| 18 | Purine - rich foods, dairy and protein intake, and the risk of gout in men显示文摘 | Choi HK Atkinson K Karlson EW | 2004 | N Engl J Med2004，350，： | 1 |
| 19 | Three-dimensional Multi-detector Row CT Portal Venography in the Evaluation of Portosystemic Collateral Vessels in Liver Cirrhosis显示文摘 | Kang HK Jeong YY Choi JH | 2002 | Radiographics2002，22，5： | 1 |
| 20 | Menopause, postmenopausal hormone use and serum uric acid levels in US women-the Third National Health and Nutrition Examination Survey 显示文摘 | Hak AE Choi HK | 2008 | Arthritis Res Ther2008，10，5： | 1 |
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