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| 1 | Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC. | Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson | 2005 | World Journal of Gastroenterology2005，11，42： | 4 |
| 2 | Recognition of changes in mi- crovascular and microstructural patterns upon magnifying endoscopy predicted the presence of extranodal gastric MALToma 显示文摘 | Chiu PW Wong TC Teoh AY | 2012 | J Interv Gastroenterol2012，2，1： | 1 |
| 3 | Correlation of serum L-carnitine and dehydro-epiandrosterone sulphate levels with age and sex in healthy adults 显示文摘 | Chiu KM Schmidt MJ Havighurst TC | 1999 | Age Ageing1999，28，2： | 1 |
| 4 | Proliferation inhibition, DNA damage, and cell-cycle arrest of human astrocytoma tells after aeryl- amide exposure显示文摘 | Chen JH Tsou TC Chiu IM | 2010 | Chem Res Toxicol2010，23，9： | 1 |
| 5 | Characteristics of primary osteomyelitis children in a medical center in Taipei 显示文摘 | Yeh TC Chiu NC Li WC | 2005 | -2002 J Formos Med As- soc2005，104，1： | 1 |
| 6 | A case-controlled comparison of single-site access versus conventional three-port laparoscopic appendectomy显示文摘 | Teoh AY Chiu PW Wong TC | | 0，，5： | 1 |
| 7 | Aloe emodin induces cell death through S phase arrest and caspase dependent pathways in human tongue squamous cancer SCC- 4 cells显示文摘 | Chiu TH Lai WW Hsia TC | 2009 | Anticancer Res2009，29，11： | 1 |
| 8 | Repeated mechani- cal loading enhances the expression of Indian hedgehog in condylar cartilage显示文摘 | Ng TC Chiu KW Rabie AB | 2006 | Front Biosci2006，11，： | 1 |
| 9 | Arterial spin-labeling in routine clinical practice:a preliminary experience of 200 cases and correlation with MRI and clinical findings显示文摘 | Chen TY Chiu L Wua TC | 2012 | Clin Imaging2012，36，： | 1 |
| 10 | Male gender and renal dysfunction are predictors of adverse outcome in nonpostoperative ischemic colitis patients 显示文摘 | Lee TC Wang HP Chiu HM | 2010 | J Clin Gastroentero12010，44，5： | 1 |
| 11 | A case-controlled comparison of single-site access versus conventional three-port laparoscopic appendectomy显示文摘 | Teoh AY Chiu PW Wong TC | | 0，，05： | 1 |
| 12 | Impact of hospital and physician characteristics on medical expenditures for acute myocardial infarc- tion hospitalization显示文摘 | Chen CS Liu TC Chiu WT | 2007 | Int J Cardiol2007，121，1： | 1 |
| 13 | A comparison of angiographic embolization with surgery after failed endoscopic hemostasis to bleeding peptic ulcers显示文摘 | Wong TC Wong KT Chiu PW | 2011 | Gastrointest Endosc2011，73，5： | 1 |
| 14 | A double-blind, pro-spective, randomised, controlled clinical trial of minimally invasive dynamic hip screw fixation of intertroehanterie fractures 显示文摘 | Wong TC Chiu Y Tsang WL | 2009 | Injury2009，40，4： | 1 |
| 15 | Rapid control of manic symptoms during combination of electroconvulsive therapy and lithi-um显示文摘 | Li TC Chiu HW Su PY | 2011 | J Neuropsychiatry Clin Neurosci2011，23，1： | 1 |
| 16 | A double-blind, pro- spective,randomised, controlled clinical trial of minimally invasive dynamic hip screw fixation of intertrochanteric {ractures显示文摘 | Wong TC Chiu Y Tsang WL | 2009 | Injury2009，40，4： | 1 |
| 17 | Casting versus percutaneous pinning for extra-articular fractures of the distal radius in an elderly Chinese population:a prospective randomised controlled trial显示文摘 | WONG TC CHIU Y TSANG WL | 2010 | J Hand Surg Eur Vol2010，35，3： | 1 |
| 18 | Repeated mechanicalloading enhances the expression of Indian hedgehog incondylar cartilage显示文摘 | Ng TC Chiu KW Rabie AB | 2006 | Front Biosci2006，11，： | 1 |
| 19 | Funetional performance and quality of life in patients with squamous esophageal carcinoma receiv- ing surgery or chemoradiation:results from a randomized trial显示文摘 | Teoh AY Yan Chiu PW Wong TC | 2011 | Ann Surg2011，253，1： | 1 |
| 20 | Impact of preoperative aortic cusp prolapse on long - term outcome after surgical closure of subarterial ventricular septal defect显示文摘 | Cheung YF Chiu CSW Yung TC | 2002 | Ann Thorac Surg2002，73，2： | 1 |
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