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5篇 您的检索式：作者名="Anthony TC Chan"

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		题名	作者	年代	出处	被引量
	1	Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.	Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson	2005	World Journal of Gastroenterology2005，11，42：	4
	2	Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘	Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang	2012	Lancet Oncology2012，，2：	1
	3	Coexpression of hypoxia - inducible factors 1 α and 2α, carbonic anhydrase IX, and vascular endothelial growth factor in nasopharyngeal carcinoma and relationship to survival 显示文摘	Edwin P Hui Anthony TC Chan Franeesco Pezzella	2002	Clin Cancer Res2002，8，8：	1
	4	Overall Survival After Concurrent Cisplatin- Radiotherapy Compared With Radiotherapy Alone in Locoregionally Advanced Nasopharyngeal Carcinoma 显示文摘	Chan Anthony TC Leung SF	2005	J Natl Cancer Inst2005，97，7：	1
	5	Addition of bevacizumab to standard chemoradiation for locoregionally advanced nasopharyngeal carcinoma (RTOG 0615): a phase 2 multi-institutional trial显示文摘	Nancy Y Lee Qiang Zhang David G Pfister John Kim Adam S Garden James Mechalakos Kenneth Hu Quynh T Le A Dimitrios Colevas Bonnie S Glisson Anthony TC Chan K Kian Ang	2012	Lancet Oncology2012，，2：	1

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