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| 1 | Consensus on the digestive endoscopic tunnel technique显示文摘With the digestive endoscopic tunnel technique(DETT), many diseases that previously would have been treated by surgery are now endoscopically curable by establishing a submucosal tunnel between the mucosa and muscularis propria(MP). Through the tunnel, endoscopic diagnosis or treatment is performed for lesions in the mucosa, in the MP, and even outside the gastrointestinal(GI) tract.At present, the tunnel technique application range covers the following:(1)Treatment of lesions originating from the mucosal layer, e.g., endoscopic submucosal tunnel dissection for oesophageal large or circular early-stage cancer or precancerosis;(2) treatment of lesions from the MP layer, per-oral endoscopic myotomy, submucosal tunnelling endoscopic resection, etc.; and(3) diagnosis and treatment of lesions outside the GI tract, such as resection of lymph nodes and benign tumour excision in the mediastinum or abdominal cavity. With the increasing number of DETTs performed worldwide, endoscopic tunnel therapeutics, which is based on DETT, has been gradually developed and optimized. However, there is not yet an expert consensus on DETT to regulate its indications, contraindications, surgical procedure, and postoperative treatment.The International DETT Alliance signed up this consensus to standardize the procedures of DETT. In this consensus, we describe the definition, mechanism,and significance of DETT, prevention of infection and concepts of DETTassociated complications, methods to establish a submucosal tunnel, and application of DETT for lesions in the mucosa, in the MP and outside the GI tract(indications and contraindications, procedures, pre-and postoperative treatments, effectiveness, complications and treatments, and a comparison between DETT and other operations). | Ning-Li Chai Hui-Kai Li En-Qiang Linghu Zhao-Shen Li Shu-Tian Zhang Yu Bao Wei-Gang Chen Philip WY Chiu Tong Dang Wei Gong Shu-Tang Han Jian-Yu Hao Shui-Xiang He Bing Hu1 Bing Hu2 Xiao-Jun Huang Yong-Hui Huang Zhen-Dong Jin Mouen A Khashab James Lau Peng Li Rui Li De-Liang Liu Hai-Feng Liu Jun Liu Xiao-Gang Liu Zhi-Guo Liu Ying-Cai Ma Gui-Yong Peng Long Rong Wei-Hong Sha Pateek Sharma Jian-Qiu Sheng Shui-Sheng Shi Dong Wan Seo Si-Yu Sun Gui-Qi Wang Wen Wang Qi Wu Hong Xu Mei-Dong Xu Ai-Ming Yang Fang Yao Hong-Gang Yu Ping-Hong Zhou Bin Zhang Xiao-Feng Zhang Ya-Qi Zhai | 2019 | World Journal of Gastroenterology2019，25，7： | 5 |
| 2 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 3 | The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) : stenting versus carotid endarterectomy for carotid disease显示文摘 | Mantese V A Timaran C H Chiu D | 2010 | Stroke2010，41，10： | 1 |
| 4 | Cellular eardiomyoplasty:Myocardial regeneration with satellite cell implantation显示文摘 | Chiu R C J Zibaitis A Kao R L | 1995 | Ann Thorac Surg1995，60，： | 1 |
| 5 | Trafficgrooming algorithms for reducing electronic multipexing costs in WDM ring networks显示文摘 | CHIU A L MODIANO E H | 2002 | IEEE/OSA J Linghtwave Technology2002，18，： | 1 |
| 6 | Bidirectional regulation of neuronal nitric-oxide synthase phosphorylation at serine 847 by the N-methyl-D-aspartate receptor显示文摘 | RAMEAU G A CHIU L Y ZIFF E B | 2004 | J Biol Chem2004，279，14： | 1 |
| 7 | A sensitive and robust method for the determination of alkylphenol polyethoxylates and their carboxylic acids and their transformation in a trickling filter wastewater treatment plant显示文摘 | Koh Y K K Chiu T Y Boobis A R Cartmell E Pollard S J T Scrimshaw M D I_ester J N | 2008 | Chemosphere2008，73，4： | 1 |
| 8 | Soil-water transfermechanism for solidified dredged materials 显示文摘 | Zhu W Zhang C Chiu A C F | 2007 | Jour-nal of Geotechnical and Geoenvironment Engineering2007，133，5： | 1 |
| 9 | Emergy- based fuzzy optimization approach for water reuse in an eco-industrial park 显示文摘 | MOHAMMAD SADEGH TASKHIRI TAN R R CHIU A S F | 2011 | Resources Conservation and Recycling2011，55，： | 1 |
| 10 | A functional phylogenomic view of the seed plants显示文摘 | Lee EK Cibrian-Jaramillo A Kolokotronis SO Katari MS Stamatakis A Ott M Chiu JC Little DP Stevenson DW McCombie WR | | 0，，： | 1 |
| 11 | Applications of industrial ecology:an overview of the special issue显示文摘 | KORHONEN J HUISINGH D CHIU A S F | 2004 | Jounal of Cleaner Production2004，12，8910： | 1 |
| 12 | Maximum and mean velocities and entropy in open-channel flow显示文摘 | Chiu Chao-lin Said C A | 1995 | Journal of Hydraulic Engineering ASCE1995，121，1： | 1 |
| 13 | Risk factors for falls in hospitalized older medical patients 显示文摘 | Pei CK Chiu A | 1999 | J Gerontol A Biol Sci Med Sci1999，54，1： | 1 |
| 14 | Influence of embryonic cardiomyocyte transplantation on the progression of heart failure in a rat model of extensive myocardial infarction显示文摘 | Etzion S Chiu RC Zibaitis A Kao RL | 2001 | Mol Cell Cardiol2001，33，7： | 1 |
| 15 | Dynamic response for motion capture animation显示文摘 | Zordan B V Majkowsk A Chiu B | 2005 | ACM Transactions on Graphics2005，24，3： | 1 |
| 16 | Hypovitaminosis D is associated with insulin resistance and β cell dysfunction显示文摘 | Chiu KC Chu A Go VL | 2004 | Am J Clin Nutr2004，79，： | 1 |
| 17 | Reactive oxygen species: current knowledge and applications in cancer research and therapeutic 显示文摘 | LAU A T WANG Y CHIU J F | 2008 | J Cell Biochem2008，104，2： | 1 |
| 18 | A novel mouse model of lipotoxic cardio- myopathy显示文摘 | Chiu HC Kovacs A Ford DA | 2001 | J Clin Invest2001，107，7： | 1 |
| 19 | 查看详情显示文摘 | Keller U Miller D A B Boyd G D Chiu T H Ferguson J F Asom M T | | 0，，： | 1 |
| 20 | Focused Assessment with Sonography for Trauma (FAST) :results from an interna- tional consensus conference 显示文摘 | Scalea TM Rodriguez A Chiu WC | 1999 | J Trauma1999，46，3： | 1 |
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