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| 1 | Dual stimuli-responsive polyurethane-based hydrogels as smart drug delivery carriers for the advanced treatment of chronic skin wounds显示文摘The design of multi-stimuli-responsive vehicles for the controlled and localized release of drugs is a challenging issue increasingly catching the attention of many research groups working on the advanced treatment of hard-to-close wounds.In this work,a thermo-and pH-responsive hydrogel(P-CHP407)was prepared from an ad hoc synthesized amphiphilic poly(ether urethane)(CHP407)exposing a significant amount of-COOH groups(8.8±0.9 nmol/g_(polymer)).The exposure of acid moieties in P-CHP407 hydrogel led to slightly lower initial gelation temperature(12.1◦C vs.14.6◦C,respectively)and gelation rate than CHP407 hydrogel,as rheologically assessed.Nanoscale hydrogel characterization by Low Field NMR(LF-NMR)spectroscopy suggested that the presence of carboxylic groups in P-CHP407 caused the formation of bigger micelles with a thicker hydrated shell than CHP407 hydrogels,as further proved by Dynamic Light Scattering analyses.In addition,P-CHP407 hydrogel showed improved capability to change its internal pH compared to CHP407 one when incubated with an alkaline buffer(pH 8)(e.g.,pH_(change_5min)=3.76 and 1.32,respectively).Moreover,LF-NMR characterization suggested a stronger alkaline-pH-induced interaction of water molecules with micelles exposing-COOH groups.Lastly,the hydrogels were found biocompatible according to ISO 10993 and able to load and release Ibuprofen:delivery kinetics of Ibuprofen was enhanced by P-CHP407 hydrogels at alkaline pH,suggesting their potential use as smart delivery systems in the treatment of chronic infected wounds. | Rossella Laurano Monica Boffito Michela Abrami Mario Grassi Alice Zoso Valeria Chiono Gianluca Ciardelli | 2021 | Bioactive Materials2021，6，9： | 3 |
| 2 | Reconstitution of the protein kinase A response of the rat prolactin promoter:differential effects of distinct Pit-1 isoforms and functional interaction with Oct-1显示文摘 | Diamond S E Chiono M Gutierrez-Hartmann A | 1999 | Mol Endocrinol1999，13，2： | 1 |
| 3 | The ultrasoundguided transversus abdominis plane block for anterior iliac crest bone graft postoperative pain relief:a prospective descriptive study显示文摘 | Chiono J Bernard N Bringuier S | 2010 | Reg Anesth Pain Med2010，35，6： | 1 |
| 4 | Blends of poly-(epsilon-eaprolactone) and polysaecharides in tissue engineering applications 显示文摘 | CIARDELLI G CHIONO V VOZZI G | 2005 | Biomacromolecules2005，6，4： | 1 |
| 5 | Polymeric mem- branes for guided bone regeneration 显示文摘 | Gentile P Chiono V Tonda-Turo C | 2011 | Bioteehnol J2011，6，10： | 1 |
| 6 | Reconstitution of the protein kinase A response of the rat prolactin promoter:Differential effects of distinct Pit-1 isoforms and functional interaction with Oct-1显示文摘 | Diamond SE Chiono M Gutierrez-Hartmann A | 1999 | Mol Endocrinol1999，13，2： | 1 |
| 7 | Incorporation of PLGA nanoparticles into porous chitosan-gelatin scaffolds: Influence on the physical properties and cell behavior显示文摘 | Nandagiri VK Gentile P Chiono V | 2011 | J Mech Behav Biomed Mater2011，4，7： | 1 |
| 8 | Polymeric membranes for guided bone regeneration显示文摘 | Gentile P Chiono V Tonda-Turo C | 2011 | Biotechnol J2011，6，10： | 1 |
| 9 | collagen for bone tissue regeneration显示文摘 | Ferreira AM Gentile P Chiono V | | 0，，09： | 1 |
| 10 | Genipin-crosslinked ehitosan/ gelatin blends for biomedical applications 显示文摘 | Valeria Chiono Ettore Pulieri Giovanni Vozzi Gianluca Ciardelli Arti Ahluwalia Paolo Giusti | 2008 | J Mater Sci: Mater Med2008，，19： | 1 |
| 11 | Molecularly imprinted submicronspheres for applications in a novel model biosensor-film显示文摘 | Ilaria Morelli Valeria Chiono Giovanni Vozzi Gianluca Ciardelli Davide Silvestri Paolo Giusti | 2010 | Sensors & Actuators: B Chemical2010，，1： | 1 |
| 12 | Collagen for bone tissue regeneration显示文摘 | Ferreira AM Gentile P Chiono V | 2012 | Acta Biomater2012，8，9： | 1 |
| 13 | Silk Fibroin/Gelatin Blend Films Crosslinked with Enzymes for Biomedical Applications显示文摘 | Taddei P Chiono V Anghileri A | 2013 | Macromolecular Bioscience2013，13，11： | 1 |
| 14 | Molecularly imprinted submicron-spheres for applications in a novel model biosensor-film显示文摘 | Morelli I Chiono V Vozzi G | | 0，，： | 1 |
| 15 | Genipin-crosslinked chitosan/gelatin blends for biomedical applieations显示文摘 | Chiono V Pulieri E Vozzi G | 2008 | J Mater Sci Mater Med2008，19，2： | 1 |
| 16 | Investigation on humic matter from decomposing poplar bark显示文摘 | Roletto E Chiono R Barberis E | 1985 | Agricultural Wastes1985，12，4： | 1 |
| 17 | Materials for peripheral nerve regeneration显示文摘 | Ciardelli G Chiono V | | 0，，01： | 1 |
| 18 | Collagen for bone tissue regeneration 显示文摘 | Ferreira A M Gentile P Chiono V | 2012 | Acta Biomaterialia2012，8，9： | 1 |
| 19 | Reactive compatibilizer precursors for LDPE/PA6 blends:1 Ethylene/acrylic acid eopolymers显示文摘 | Filippi S Chiono V Polacco G | 2002 | Macromol Chem Phys2002，203，： | 1 |
| 20 | Incorporation of PL- GA nanoparticles into porous chitosan-gelatin scaffolds: influ- ence on the physical properties and cell behavior 显示文摘 | Nandagiri VK Gentile P Chiono V | 2011 | J Mech Behav Biomed Mater2011，4，7： | 1 |
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