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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Bilateral vs unilateral placement of metal stents for inoperable highgrade hilar biliary strictures: A systemic review and meta-analysis显示文摘BACKGROUND Bilateral vs unilateral biliary stenting is used for palliation in malignant biliary obstruction.No clear data is available to compare the efficacy and safety of bilateral biliary stenting over unilateral stenting.AIM To assess the efficacy and safety of bilateral vs unilateral biliary drainage in inoperable malignant hilar obstruction.METHODS PubMed,Embase,Scopus,and Cochrane databases,as well as secondary sources(bibliographic review of selected articles and major GI proceedings),were searched through January 2019.The primary outcome was the re-intervention rate.Secondary outcomes were a technical success,early and late complications,and stent malfunction rate.Pooled odds ratio(OR)and 95%confidence interval(CI)were calculated for each outcome.RESULTS A total of 9 studies were included(2 prospective Randomized Controlled Study,5 retrospective studies,and 2 abstracts),involving 782 patients with malignant hilar obstruction.Bilateral stenting had significantly lower re-intervention rate compared with unilateral drainage(OR=0.59,95%CI:0.40-0.87,P=0.009).There was no difference in the technical success rate(OR=0.7,CI:0.42-1.17,P=0.17),early complication rate(OR=1.56,CI:0.31-7.75,P=0.59),late complication rate(OR=0.91,CI:0.58-1.41,P=0.56)and stent malfunction(OR=0.69,CI:0.42-1.12,P=0.14)between bilateral and unilateral stenting for malignant hilar biliary strictures.CONCLUSION Bilateral biliary drainage had a lower re-intervention rate as compared to unilateral drainage for high grade inoperable malignant biliary strictures,with no significant difference in technical success,and early or late complication rates. | Munish Ashat Sumant Arora Jagpal S Klair Christopher A Childs Arvind R Murali Frederick C Johlin | 2019 | World Journal of Gastroenterology2019，25，34： | 5 |
| 3 | Nutritional value of dried algae diets for larvae of manila clam (Tapes philippinarum)显示文摘 | Laing I Child A R Janke A | 1990 | J Mar Boil Ass1990，70，： | 2 |
| 4 | The salt-cocrystal continuum: The influence of crystal structure on ionization state显示文摘 | Childs S L Stahly G P Park A | 2007 | Mol Pharm2007，4，3： | 1 |
| 5 | Localization of the fourth locus(GLC1E) for adult-onset primary open-angle glaucoma to the 10p15-p14 region 显示文摘 | Sarfarazi M Child A Stoilova D | 1998 | Am J Hum Genet1998，62，3： | 1 |
| 6 | Experimental investigation of drying shrinkage and creep of concrete using fibre-optic sensors 显示文摘 | Wong A C L Childs P A Terry W | 2007 | Advances in Structural Engineering2007，10，3： | 1 |
| 7 | Dynamic R&D investment poli- cies 显示文摘 | Childs P D Triantis A J | 1999 | Management Science1999，45，10： | 1 |
| 8 | Critical role of ring structure in the differential uptake of cholesterol and plant sterols by membrane preparations in vitro显示文摘 | CHILD P KUKSIS A | 1983 | J Lipid Res1983，24，： | 1 |
| 9 | Adult-onset primary open-angle glaucoma caused by mutations in optineurin显示文摘 | Rezaie T Child A Hitchings R | 2002 | Science2002，295，5557： | 1 |
| 10 | On the Relationship Between Continuous- and Discrete-Time Quantum Walk 显示文摘 | Childs A M | 2010 | Communications in Mathematics Physics2010，294，： | 1 |
| 11 | Magnetic resonance and cranial ultrasound characteristics of periventricular white matter abnormalities in newborn infants显示文摘 | Childs A M Cornette L Ramenghi L A | 2001 | Clin Radiol2001，56，8： | 1 |
| 12 | Polyamine-dependent gene expression显示文摘 | CHILDS A C MEHTA D J GERNER E W | 2003 | Cellular and Molecular Life Sciences2003，60，7： | 1 |
| 13 | Endurance timesfor low back stabilization exercises: clinical targets fortesting and training from a normal database显示文摘 | McGill S Childs A Liebenson C | 1999 | ArchPhys Med Rehabil1999，80，8： | 1 |
| 14 | Events Associated with Current Zero Passage during the Rapid Commutation of Vacuum Arc显示文摘 | Childs S Greenwood A Sullivan J | 1983 | IEEE Transaction on Plasma Science1983，11，3： | 1 |
| 15 | Demonstration of significant abiotic iron isotope fractionation in nature显示文摘 | Bullen T D White A F Childs C W | 2001 | Geology2001，29，： | 1 |
| 16 | Experimental rotordynamic coefficient results for (a) a labyrinth seal with and without shunt injection and (b) a honeycomb seal显示文摘 | Soto E A Childs D W | 1999 | Journal of Engineering for Gas Turbines and Power1999，121，1： | 1 |
| 17 | A new class of polyelectrolyte-filled microfihration membranes with environ- mentally controlled porosity 显示文摘 | MIKA A CHILDS R DICKSON J | 1995 | J Membr Sci1995，108，1： | 1 |
| 18 | Rotordynamic coefficients for a tooth-on- stator labyrinth gas seal at 70 bar supply pressures: measurements versus theory and comparisons to a hole-pattern stator seal 显示文摘 | Picardo A Childs D W | 2005 | ASME Journal of Engineering for Gas Turbines and Power2005，127，10： | 1 |
| 19 | Venuvinod,present situation and future trends in modelling of machining operations-progress report of the CIRP working group modelling of machining operations显示文摘 | LUTTERVELT C A Van CHILDS T H C JAWAHIR I S | 1998 | CIRP Annals-Manufacturing Technology1998，47，： | 1 |
| 20 | Assessment of primary cancers in growth hormone-treated adult hypopituitary patients:an analysis from the hypopituitary control and complications study (hypoccs)显示文摘 | Child C Zimmermann A Woodmansee W | | 0，，02： | 1 |
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