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| 1 | Stability of cirrhotic systemic hemodynamics ensures sufficient splanchnic blood flow after living-donor liver transplantation in adult recipients with liver cirrhosis显示文摘AIM: To investigate the correlation between systemic hemodynamics and splanchnic circulation in recipients with cirrhosis undergoing living-donor liver transplantation (LDLT), and to clarify how systemic hemodynamics impact on local graft circulation after LDLT. METHODS: Systemic hemodynamics, indocyanine green (ICG) elimination rate (KICG) and splanchnic circulation were simultaneously and non-invasively investigated by pulse dye densitometry (PDD) and ultrasound. Accurate estimators of optimal systemic hyperdynamics after LDLT [i.e., balance of cardiac output (CO) to blood volume (BV) and mean transit time (MTT), defined as the timerequired for half the administered ICG to pass through an attached PDD sensor in the first circulation] were also measured. Thirty recipients with cirrhosis were divided into two groups based on clinical outcomes corresponding to postoperative graft function. RESULTS: Cirrhotic systemic hyperdynamics characterized by high CO, expanded BV and low total peripheral resistance (TPR) were observed before LDLT. TPR reflecting cirrhotic vascular alterations was slowly restored after LDLT in both groups. Although no significant temporal differences in TPR were detected between the two groups, CO/BV and MTT differed significantly. Recipients with good outcomes showed persistent cirrhotic systemic hyperdynamics after LDLT, whereas recipients with poor outcomes presented with unstable cirrhotic systemic hyperdynamics and severely decreased KICG. Systemic hyperdynamic disorders after LDLT impacted on portal venous flow but not hepatic arterial flow. CONCLUSION: We conclude that subtle systemic hyperdynamics disorders impact on splanchnic circulation, and that an imbalance between CO and BV decreases portal venous flow, which results in critical outcomes. | Tomohide Hori Shintaro Yagi Taku Iida Kentaro Taniguchi Kentaro Yamagiwa Chiduru Yamamoto Takashi Hasegawa Koichiro Yamakado Takuma Kato Kanako Saito Linan Wang Mie Torii Yukinobu Hori Kan Takeda Kazuo Maruyama Shinji Uemoto | 2007 | World Journal of Gastroenterology2007，13，44： | 5 |
| 2 | Assessment of cardiac output in liver transplantation recipients显示文摘BACKGROUND:Liver cirrhosis causes peculiar systemic hemodynamics,and accurate evaluation of systemic hemodynamic state is important for cirrhotic recipients who underwent living donor liver transplantation(LDLT). We investigated the clinical advantages of a novel non- invasive method for measuring systemic hemodynamic parameters using indocyanine green(ICG). METHODS:Twenty-eight LDLT recipients were evaluated. Simultaneous measurements of cardiac output(CO)using Swan-Ganz catheters and pulse dye densitometry(PDD) were performed every 12 hours after LDLT.A total of 155 sets of simultaneous CO measurements were obtained. RESULTS:The CO values obtained by PDD correlated well with those obtained by the invasive catheter technique.In addition,none of the recipients developed any side-effects, and we verified the safety of repeated ICG injections.ICG is safe,even for repeated use over time in the same recipient. Moreover,PDD can measure the blood volume(BV).CONCLUSIONS:Since the cirrhotic systemic hemody- namics characterized by high CO and large BV remains, even after LDLT,the ability to measure CO and BV in a non-invasive,simple and real-time manner using PDD has advantages for cirrhotic LDLT recipients. | Tomohide Hori Chiduru Yamamoto Shintaro Yagi Taku Iida Kentaro Taniguchi Takashi Hasegawa Koichiro Yamakado Yukinobu Hori Kan Takeda Kazuo Maruyama Shinji Uemoto | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，4： | 2 |
| 3 | Significance of Portal Venous VEGF During Liver Regeneration After Hepatectomy显示文摘 | Chiduru Yamamoto Shintaro Yagi Tomohide Hori Taku Iida Kentaro Taniguchi Shuji Isaji Shinji Uemoto | 2010 | Journal of Surgical Research2010，，2： | 1 |
| 4 | K显示文摘 | Tomohide Hori Taku Iida Shintaro Yagi Kentaro Taniguchi Chiduru Yamamoto Shugo Mizuno Kentaro Yamagiwa Shuji Isaji Shinji Uemoto | 2006 | Liver Transpl2006，，4： | 1 |
| 5 | Quaternary primary productivity in Porcupine Seabight,NE North Atlantic显示文摘Biogenic opal and calcium carbonate contents in the Quaternary fine-grained sediments in the deep sea coral mound area (Hole U1317E and Hole U1318B drilled by IODP Expedition 307) in Porcupine Seabight, southwest off Ireland, were measured to estimate the primary productivity (Pp) of the surface seawater in NE Atlantic. The results from the two holes commonly show relatively high Pp values of 10-30 g cm-2 ky-1, having stratigraphic cyclicity reversely correlated with the δ13C profile. The high Pp could be attributed to the oceanic setting controlled by the Eastern North Atlantic (Central) Water and Shelf Edge Current, which have been strongly influenced by the obliquity forcing of the Milankovitch cycle. A positive covariance was observed between high Pp and the mound development in U1317E, implying that the organic matter was the principal food source for the mound coral community. It is proposed that the pelagic marl matrix of the mound sediments provides information of the surface water productivity that is useful for reconstructing the paleoceanography and the paleoclimate in the NW Atlantic. | LI XiangHui Akihiro KANO CHEN YunHua Chiduru TAKASHIMA XU WenLi XU BaoLiang WANG RuiJian | 2012 | Science China Earth Sciences2012，55，2： | 0 |
| 6 | 北大西洋Porcupine Seabight海区第四纪原始生产力显示文摘对北大西洋东北爱尔兰西南陆架和斜坡PorcupineSeabight海区综合大洋钻探307航次1317E井灰泥杂基样品的生物硅和碳酸钙含量、1318B井全岩样品的生物硅含量进行了测量,在减除珊瑚文石质骨屑、同生白云石、岩屑高镁方解石基础上估算了第四纪原始生产力.结果显示,原始生产力与世界其他地区同期相比均较高(一般10~30gcm-2ky-1),存在明显的旋回性变化,与δ13C值变化呈镜像负相关.进一步研究表明,较高的原始生产力可能与温暖的北大西洋东北中心流(ENAW)和陆棚边界流(SEC)有关,其与δ13C值镜像相关则可能受控于北大西洋深部冷水团和/或地中海暖水团侵入,而生产力快速增加-减少旋回周期可能与米兰科维奇的斜率轨道应力有联系.分析还发现,冷水碳酸盐泥丘的发育与表层海水原始生产力具有正相关性,暗示高的原始生产力会促进冷水碳酸盐泥丘的生长,但不一定是碳酸盐泥丘形成的必要条件.进而提出,研究区碳酸盐泥丘中的远洋灰泥杂基记录了北大西洋东北表层海水生产力变化信息. | 李祥辉 Akihiro KANO 陈云华 Chiduru TAKASHIMA 徐文礼 徐宝亮 王汝建 | 2012 | 中国科学:地球科学2012，42，1： | 0 |
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