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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Protein profi- ting of microdissected prostate tissue links growth differ- entiation factor-15 to prostate carcinogenesis显示文摘 | Cheung PK Woolcock B Adomat H | 2004 | Cancer Res2004，64，32： | 1 |
| 3 | HLA-B alleles,high-risk HPV infection and risk for cervical neoplasia in southern Chinese women显示文摘 | Chan PK Cheung JL Cheung TH | 2006 | Int J Cancer2006，118，6： | 1 |
| 4 | Genotype spectrum of cervical human papillomavirus infection among sexually transmitted disease clinical patients in Hong Kong显示文摘 | Chan PK Mak KH Cheung JL | 2002 | J Med Virol2002，68，： | 1 |
| 5 | Diagnosing acute appendi- citis: are we overusing radiologic investigations 显示文摘 | Wong KK Cheung TW Tam PK | 2008 | J Pediatr Surg2008，43，： | 1 |
| 6 | Determinants of cervical human papino- mavirus infection:differences between high- and low-oncogenie risk types 显示文摘 | Chan PK Chang AR Cheung JL | 2002 | J Infect Dis2002，185，1： | 1 |
| 7 | Determinants of cervical human papillomavirus infection: differences betwwen high-andlow-oneogenic risktypes显示文摘 | Chan PK Chang AR Cheung JL | 2002 | J Infect Dis2002，85，7： | 1 |
| 8 | Genotype spectrum of cer vical human papillomavirus infection among sexually transmitted disease clinic patients in Hong Kong显示文摘 | Chan PK Mak KH Cheung JL | 2002 | J Med Virol2002，68，8： | 1 |
| 9 | Human papilloma- virus type 16 intratypic Variant infection and risk for cervical neoplasia in southern China 显示文摘 | Chan PK Lam CW Cheung TH | 2002 | J Infect Dis2002，186，5： | 1 |
| 10 | In vivo multiplexed interrogation of amplified genes identifies GAB2as an ovarian cancer oncogene显示文摘 | Dunn GP Cheung HW Agarwalla PK | 2014 | Proc Natl Acad Sci USA2014，111，3： | 1 |
| 11 | T-cell response to human papillo- mavirus type 58 L1, E6, and E7 peptides in women with cleared infec- tion,cervical intraepithelia neoplasia,or invasive 显示文摘 | Chan PK Liu S J Cheung TH | 2010 | Cancer2010，，09： | 1 |
| 12 | Attribution of human papillomavirus types to cervical intraepithelial neoplasia and invasive cancers in Southern China显示文摘 | Chan PK Cheung TH Li WH | 2012 | Int J Cancer2012，131，3： | 1 |
| 13 | Determinants of cervical human papillomavirns infection : differences between high - and low- oncogenic risk types 显示文摘 | Chan PK Chang AR Cheung JL | 2002 | J Infect Dis2002，185，1： | 1 |
| 14 | Protein profiling of microdissected prostate tissue links growth diferentiation factor 15 to prostate carcinogenesis显示文摘 | Cheung PK Woolcoc KB Adomat H | 2004 | Cancer Res2004，64，17： | 1 |
| 15 | Protein profiling of microdissected prostate tissue links growth differentiation factor 15 to prostate carcinogenesis显示文摘 | Cheung PK Woolcock B Adomat H | 2004 | Cancer Res2004，64，17： | 1 |
| 16 | Detection and quantitation of human papillomavirus DNA in primary tumour and lymph nodes of patients with early stage cervical carcinoma 显示文摘 | CHAN PK YU MM CHEUNG TH | 2005 | J Clin Virol2005，33，3： | 1 |
| 17 | Attribution of human papillomavirus types to cervical intraepithelial neoplasia and invasive cancers in Southern China显示文摘 | Chan PK Cheung TH Li WH | | 0，，： | 1 |
| 18 | Determinants of cervi- cal human papillomavirus infection: differences betweenhighand low-oncogenic risk types显示文摘 | Chan PK Chang AR Cheung JL | 2002 | J Infect Dis2002，185，1： | 1 |
| 19 | Early swallowing problems in a cohort of patients with nasopharyngeal carci- noma: Symptomatology and videofluoroscopic findings 显示文摘 | Ku PK Yuen EH Cheung DM | 2007 | Laryngoscope2007，117，1： | 1 |
| 20 | HLA-B alleles, high-risk HPV infection and risk for cervical neoplasia in southern Chinese women 显示文摘 | Chan PK Cheung JL Cheung TH | 2006 | Int J Cancer2006，6，： | 1 |
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