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| 1 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 2 | Elevated levels of α-synuclein oligomer in the cerebrospinal fluid of drug-nave patients with Parkinson's disease显示文摘 | Park M J Cheon S M Bae H R | 2011 | J Clin Neurol2011，，4： | 1 |
| 3 | Guggulsterone induces apoptosis in colon cancer cells and inhibits tumor growth in murine colorectal cancer xenografts显示文摘 | An M J Cheon J H Kim S W | 2009 | Cancer Lett2009，279，1： | 1 |
| 4 | Sterically induced shape and crystalline phase control of GaP nanocrystals显示文摘 | KIM Y H JUN Y W JUN B H LEE S M CHEON J | 2002 | J Am Chem Soc2002，124，13： | 1 |
| 5 | Measure of certainty with fuzzy entropy fimction 显示文摘 | LEE S H CHEON S P K/M J H | 2006 | Lecture Notes in Artificial Intelligence2006，4114，： | 1 |
| 6 | Comparison of insulation test of mini-models with different winding for a HTS transformer显示文摘 | Cheon H G Baek S M Kwag D S | 2006 | IEEE Trans on Applied Superconductivity2006，16，2： | 1 |
| 7 | Development of building fire safety system with automatic security firm monitoring capability显示文摘 | LEE W CHEON M HYUN C H | 2013 | Fire Safety Journal2013，58，： | 1 |
| 8 | Do patients with ul- cerative colitis diagnosed at a young age have more severe dis- ease activity than patients diagnosed when older? 显示文摘 | LEE J H CHEON J H MOON C M | 2010 | Diges- tion2010，81，4： | 1 |
| 9 | Molecular genotyping of Anisahis species from Korean sea fish by polymerase chain reaction-restriction fragment length polymorphism ( PCR- RFLP ) 显示文摘 | Lee M H Cheon D S Choi C | 2009 | Food Control2009，205，： | 1 |
| 10 | Dopamine tran- sporter density in the basal ganglia in obsessive-compulsive disorder, measured with IPT SPECT before and after treatment with serotonin reuptake inhibitors 显示文摘 | KIM C H CHEON K A KOO M S | 2007 | Neuropsychobiology2007，55，34： | 1 |
| 11 | A novel PPAR- gamma agonist, KR62776, suppresses RANKL-induced oste- oclast differentiation and activity by inhibiting MAP kinase pathways显示文摘 | PARK J Y BAE M A CHEON H G | 2009 | Biochem Biophys Res Commun2009，378，3： | 1 |
| 12 | CRTBased Fully Homomorphic Encryption over the Integers显示文摘 | CHEON J H KIM J LEE M S | 2015 | Information Sciences2015，310，： | 1 |
| 13 | Role of actin filaments in the hatching process of mouse blasocyst显示文摘 | GYE M C KIM C H | 2000 | Zygote2000，7，2： | 1 |
| 14 | Bovine colos- trum inhibits nuclear factor KB-mediated proinflamma- tory cytokine expression in intestinal epithelial cells显示文摘 | AN M J CHEON J H KIM S W | 2009 | Nutrition Research2009，29，4： | 1 |
| 15 | Total synthesis of a fully protected palytoxin carboxylic acid 显示文摘 | Armstrong R W Beau J M Cheon S H | 1989 | JAm Chem Soc1989，111，： | 1 |
| 16 | Analysis of flavonoids and characterization of the OsFNS gene involved in flavone biosynthesis in rice显示文摘 | Kim J H Cheon Y M Kim B G | 2008 | Journal of Plant Biology2008，51，2： | 1 |
| 17 | Comparison of Insulation Test of Mini-Models With Different Winding for a HTS Transformer显示文摘 | Cheon H G Baek S M Kwag D S | 2006 | IEEE Transactions on Applied Super- conductivity2006，16，2： | 1 |
| 18 | Two Juvenile hor- mone suppressible storage proteins may play different roles in Hyphantria cunea Drury显示文摘 | Cheon H M Hwang S J Kim H J | 2002 | Srehives of Insect Bi- ochemistry and Physiology2002，0，： | 1 |
| 19 | In vivo magnetic resonance detection of cancer by using multifunetional magnetic nanocrystals 显示文摘 | HUH Y M JUN Y W SONG H T KIM S CHOI J S LEE J H YOON S KIM K S SHIN J S SUH J S CHEON J | 2005 | J Am Chem Soc2005，127，12： | 1 |
| 20 | Investigation of bubble flow developments and its transition based on instabi- lities of void fraction waves 显示文摘 | SONG C H CHEON H N CHUNG M K | 1995 | Int J Muhiphase Flow1995，21，3： | 1 |
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