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| 1 | Compound Formula Rehmannia alleviates levodopainduced dyskinesia in Parkinson's disease显示文摘Compound Formula Rehmannia has been shown to be clinically effective in treating Parkinson's disease and levodopa-induced dyskinesia; however,the mechanisms remain unclear.In this study,we established a model of Parkinson's disease dyskinesia in rats,and treated these animals with Compound Formula Rehmannia.Compound Formula Rehmannia inhibited the increase in mRNA expression of N-methyl-D-aspartate receptor subunits 1 and 2 and excitatory amino acid neurotransmitter genes,and it inhibited the reduction in expression of γ-aminobutyric acid receptor B1,an inhibitory amino acid neurotransmitter gene,in the corpus striatum.In addition,Compound Formula Rehmannia alleviated dyskinesia symptoms in the Parkinson's disease rats.These experimental findings indicate that Compound Formula Rehmannia alleviates levodopa-induced dyskinesia in Parkinson's disease by modulating neurotransmitter signaling in the corpus striatum. | Long Teng Fang Hong Chenguang Zhang Jiancheng He Haiying Wang | 2014 | Neural Regeneration Research2014，9，4： | 8 |
| 2 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 3 | Effect of Ni,Fe and Fe-Ni alloy catalysts on the synthesis of metal contained carbon nano-onions and studies of their electrochemical hydrogen storage properties显示文摘Three types of carbon nano-onions(CNOs) including Ni@CNOs.Fe_3C@CNOs and Fe_(0.64)Ni_(0.36)@CNOs nanoparticles have been synthesized by catalytic decomposition of methane at 850 ℃ using nickel,iron and iron-nickel alloy catalysts.Comparative and systematic studies have been carried out on the morphology,structural characteristics and graphitic crystallinity of these CNOs products.Furthermore,the electrochemical hydrogen storage properties of three types of CNOs have been investigated.Measurements show that the Ni@CNOs have the highest discharge capacity of 387.2 mAh/g,coiTesponding to a hydrogen storage of 1.42%.This comparison study shows the advantages of each catalyst in the growth of CNOs.enabling the controllable synthesis and tuning the properties of CNOs by mediating different metals and their alloy for using in the fuel cell system. | Chenguang Zhang Jiajun Li Chunsheng Shi Chunnian He Enzuo Liu Naiqin Zhao | 2014 | Journal of Energy Chemistry2014，23，3： | 5 |
| 4 | Review of protection and fault handling for a flexible DC grid显示文摘With the development of power electronics technology,the flexible DC grid will play a significant role in promoting the transformation and reformation of the power grid.It is immune to commutation failure and has high flexibility in power control and renewable energy grid integration.However,the protection and fault handling technology for a flexible DC grid is a big challenge because of the limited overcurrent capability of the converters.This paper summarizes the development of the flexible DC grid,and analyzes the fault characteristics in detail.Next,the applicability,advantages and disadvantages of the existing protection principle,fault isolation and recovery schemes are reviewed.Finally,the key problems and development trend of the future flexible DC grid are pointed out and forecasted respectively. | Jinghan He Keao Chen Meng Li Yiping Luo Chenguang Liang Yin Xu | 2020 | Protection and Control of Modern Power Systems2020，5，1： | 5 |
| 5 | Light-triggered interfacial charge transfer and enhanced photodetection in CdSe/ZnS quantum dots/MoS_(2)mixed-dimensional phototransistors显示文摘Mix-dimensional van der Waals heterostructures(vdWHs)have inspired worldwide interests and efforts in the field of ad-vanced electronics and optoelectronics.The fundamental understanding of interfacial charge transfer is of vital import-ance for guiding the design of functional optoelectronic applications.In this work,type-Ⅱ0D-2D CdSe/ZnS quantum dots/MoS_(2)vdWHs are designed to study the light-triggered interfacial charge behaviors and enhanced optoelectronic performances.From spectral measurements in both steady and transient states,the phenomena of suppressed photolu-minescence(PL)emissions,shifted Raman signals and changed PL lifetimes provide strong evidences of efficient charge transfer at the 0D-2D interface.A series of spectral evolutions of heterostructures with various QDs overlapping concentrations at different laser powers are analyzed in details,which clarifies the dynamic competition between exciton and trion during an efficient doping of 3.9×10^(13)cm^(−2).The enhanced photoresponses(1.57×10^(4)A·W^(-1))and detectivities(2.86×10^(11)Jones)in 0D/2D phototransistors further demonstrate that the light-induced charge transfer is still a feasible way to optimize the performance of optoelectronic devices.These results are expected to inspire the basic understand-ing of interfacial physics at 0D/2D interfaces,and shed the light on promoting the development of mixed-dimensional op-toelectronic devices in the near future. | Ziwei Li Wen Yang Ming Huang Xin Yang Chenguang Zhu Chenglin He Lihui Li Yajuan Wang Yunfei Xie Zhuoran Luo Delang Liang Jianhua Huang Xiaoli Zhu Xiujuan Zhuang Dong Li Anlian Pan | 2021 | Opto-Electronic Advances2021，4，9： | 4 |
| 6 | A mini-review on ion fluxes that regulate NLRP3 inflammasome activation显示文摘The activation of NLR family pyrin domain containing 3(NLRP3)inflammasome can be induced by a wide spectrum of activators.This is unlikely achieved by the binding of different activators directly to the NLRP3 protein itself,as the activators found so far show different forms of chemical structures.Previous studies have shown that these activators can induce potassium ion(K+)and chloride ion(Cl−)efflux,calcium(Ca2+)and other ion mobilization,mitochondrial dysfunction,and lysosomal disruption,all of which are believed to cause NLRP3 inflammasome activation;how these events are induced by the activators and how they coordinate with each other in inducing the NLRP3 inflammasome activation are not fully understood.Increasing evidence suggests that the coordinated change of intracellular ion concentrations may be a common mechanism for the NLRP3 activation by different activators.In this mini-review,we present a brief summary of the current knowledge about how different ionic flows(including K+,sodium ion,Ca2+,magnesium ion,manganese ion,zinc ion,iron ion,and Cl−)are involved in regulating the NLRP3 inflammasome activation in macrophages. | Chenguang Li Mingye Chen Xianhui He Dongyun Ouyang | 2021 | Acta Biochimica et Biophysica Sinica2021，53，2： | 3 |
| 7 | Oil-soluble Ni-Mo sulfide nanoparticles and their hydrogenation catalytic properties显示文摘Oil-soluble bimetallic Ni-Mo sulfide nanoparticles(NiMoS) with narrow size distribution were successfully synthesized through a composite-surfactants-assisted-solvothermal process.The surface functionality and lipophilicity of the Ni-Mo sulfides were shown by transmission electronic microscopy,Fourier transform infrared and ultraviolet spectroscopy.The as-prepared Ni-Mo sulfides supported on activated carbon(NiMoS/AC) exhibited enhanced catalytic activity towards naphthalene hydrogenation instead of cracking.For comparison,CoMoS/AC and MoS2/AC catalysts were also prepared through similar procedures,and it was found that their catalytic performance decreased in the order of NiMoS/AC>CoMoS/AC>MoS2/AC.Furthermore,the activity of the bimetallic NiMoS nanocatalyst can be effectively tuned via variation of the atomic ratio of Ni/(Ni+Mo). | Liu Chenguang Wang Shutao An Changhua Yan Fang He Jie Wang Zongxian Zhang Qin-Hui | 2013 | Petroleum Science2013，10，4： | 2 |
| 8 | Bioactive phenolics from the fruits of Livistona chinensis显示文摘 | Xiaobin Zeng Yihai Wang Qian Qiu Chenguang Jiang Yuntiao Jing Guofu Qiu Xiangjiu He | 2011 | Fitoterapia2011，，1： | 1 |
| 9 | DNA tetrahedron-mediated immune-sandwich assay for rapid and sensitive detection of PSA through a microfluidic electrochemical detection system显示文摘Prostate-specific antigen(PSA)is the most widely used biomarker for the early diagnosis of prostate cancer.Existing methods for PSA detection are burdened with some limitations and require improvement.Herein,we developed a novel microfluidic–electrochemical(μFEC)detection system for PSA detection.First,we constructed an electrochemical biosensor based on screen-printed electrodes(SPEs)with modification of gold nanoflowers(Au NFs)and DNA tetrahedron structural probes(TSPs),which showed great detection performance.Second,we fabricated microfluidic chips by DNA TSP-Au NF-modified SPEs and a PDMS layer with designed dense meandering microchannels.Finally,theμFEC detection system was achieved based on microfluidic chips integrated with the liquid automatic conveying unit and electrochemical detection platform.TheμFEC system we developed acquired great detection performance for PSA detection in PBS solution.For PSA assays in spiked serum samples of theμFEC system,we obtained a linear dynamic range of 1–100 ng/mL with a limit of detection of 0.2 ng/mL and a total reaction time<25 min.Real serum samples of prostate cancer patients presented a strong correlation between the“gold-standard”chemiluminescence assays and theμFEC system.In terms of operation procedure,cost,and reaction time,our method was superior to the current methods for PSA detection and shows great potential for practical clinical application in the future. | Dezhi Feng Jing Su Yi Xu Guifang He Chenguang Wang Xiao Wang Tingrui Pan Xianting Ding Xianqiang Mi | 2021 | Microsystems & Nanoengineering2021，7，2： | 1 |
| 10 | Mineral change of Philippine and Indonesia nickel lateritic ore during sintering and mineralogy of their sinter显示文摘 | LU Xuewei BAI Chenguang HE Shengping | 2010 | ISIJ International2010，50，3： | 1 |
| 11 | Synthesis and characterization of γ-alumina nanospheres templated by lauric acid显示文摘A novel route for the synthesis of alumina nanospheres was reported by a surfactant-governed approach in the presence of lauric acid.The products were characterized using X-ray diffraction (XRD),scanning electron microscope (SEM) and N2 adsorption-desorption techniques.The results show that the produced alumina nanospheres possess uniform nanosphere sizes ranging from 80 120 nm,and high surface area of 550 m2/g.It suggests that the synthesized alumina nanospheres are formed through self-assembly of surfactant/alumina species complex in 1-propanol system. | Qingtao Fu Tingting He lianqing Yu Yongming Chai Chenguang Liu | 2010 | Journal of Natural Gas Chemistry2010，19，6： | 1 |
| 12 | Self-anchored catalysts for substrate-free synthesis of metal-encapsulated carbon nano-onions and study of their magnetic properties显示文摘我们表明包含阶段分离为碳 nanostructures 的没有底层的合成产生的 Fe-Ni 合金 nanosheet 的新奇自我抛锚的催化剂结构的合成。快 Fourier 变换分析被执行以便在减小和化学蒸汽免职(CVD ) 期间调查阶段和合金 nanosheet 的结构的进化生长。-Fe-Ni (Fe 0.64 Ni 0.36) 和 -Fe-Ni (铁镍合金) 分阶段执行在 NiFe 2 O 4 nanosheet 催化剂先锋在 H 2 减小期间,在一个 -Fe-Ni 矩阵上形成 selfanchored 单音分散 -Fe-Ni nanocrystals。Fe-Ni 合金 nanosheet 为种包含金属的碳 nano 洋葱(CNO ) 催化剂用作,并且作为对抛锚的支持这些 preformed nanoparticles,没有为 CVD 生长的另外的底层的要求的让步的单音分散催化剂 nanoparticles。这合成能够减轻结合并且 Ostwald 没有另外的底层的帮助,成熟。这结构允许尽管有聚集的制服大小的 CNO 的生长,弄碎,并且合金表叠。这研究在大规模向碳 nanostructures 的没有底层的合成由阶段分离为新奇催化剂结构提供一个有希望的图案。最后,铁磁性的 Fe 0.64 Ni 0.36@CNOs 粒子在磁性的存储和水纯化演示他们的应用程序,,无毒的水处理材料。 | Chenguang Zhang Jiajun Li Chunsheng Shi Chunnian He Enzuo Liu Naiqin Zhao | 2016 | Nano Research2016，9，4： | 1 |
| 13 | Synthesis of hollow carbon nano-onions and their use for electrochemical hydrogen storage显示文摘 | Chenguang Zhang Jiajun Li Enzuo Liu Chunnian He Chunsheng Shi Xiwen Du Robert H. Hauge Naiqin Zhao | 2012 | Carbon2012，，10： | 1 |
| 14 | Cucurbitacin E suppresses cytokine expression in human Jurkat T cells through down-regulating the NF-κB signaling显示文摘Cucurbitacin E (CucE ) ,从 Cucurbitaceae 植物孤立的 triterpenoid,被显示了在 vitro 并且在 vivo 拥有 anti-inammatory 或抑制免疫力的活动,然而,内在的机制不完全地被理解。现在的学习的目的是作为一个细胞的模型在人的 Jurkat T 房间在 cytokine 表示和内在的机制上探索它的效果。结果证明 CucE 显著地禁止了 interleukin-2 的生产,肿瘤坏死因素 -- ,并且干扰素 -- 在加 ionomycin (离子) 与 phorbol 12,13-dibutyrate (PDB ) 对待的房间的文化媒介。而且, mRNA 在激活的 Jurkat T 房间这些 cytokines 铺平,建议为 cytokine 表示的批评发信号小径上的潜在的调节效果,包括原子 factor-B (NF-B ) 或激活 mitogen 的蛋白质 kinases (MAPK ) 是也在 CucE 处理之上减少了。在它表明小径的 NF-B 上的效果的支持, CucE 减少了 B (IB ) 和在 PDB + 刺激离子的房间的 NF-B/p65 的禁止者的 phosphorylation 层次。进一步支持这, NF-B/p65 的原子 translocation 显著地面对 CucE 响应 PDB 正离子刺激被压制。然而, p38MAPK, c6 月 N 终端 kinase (JNK ) ,和 Erk1/2 的 phosphorylation 没被 CucE 处理在一些时间点减少或稍微增加了。一起,这些数据建议 CucE 可以由 attenuating 展出抑制免疫力的效果批评 cytokine 表示通过下面调整发信号的 NF-B 小径。 | Lixian Wang Chenguang Li Qiuru Li Xiaoyu Zhang Hao Pan Lihui Xu Zijian Shi Dongyun Ouyang Xianhui He | 2015 | Acta Biochimica et Biophysica Sinica2015，47，6： | 1 |
| 15 | Effects of new rare earth additions on properties and microstructure of WC 14TiC-SCo cemented carbide 显示文摘 | Lin Chenguang He Congxun Shi Yunhua | 1996 | Journal of Materials Science Letters1996，15，14： | 1 |
| 16 | Preparation and properties of magnetic alumina microspheres with a γ-Fe_2O_3/SiO_2 core and Al_2O_3 shell显示文摘Magnetic alumina composite microspheres with γ-Fe 2 O 3 core/Al 2 O 3 shell structure were prepared by the oil column method. A dense silica layer was deposited on the surface of γ-Fe 2 O 3 particles (denoted as γ-Fe 2 O 3 /SiO 2 ) with a desired thickness to protect the iron oxide core against acidic or high temperature conditions. γ-Fe 2 O 3 /SiO 2 /Al 2 O 3 particles with about 85 wt% Al 2 O 3 were obtained and showed to be suitable for practical applications as a magnetic catalyst or catalyst support due to their magnetic properties and pore structure. The products were characterized with scanning electron microscope (SEM) and transmission electron microscope (TEM), nitrogen adsorption-desorption, and vibrating sample magnetometer (VSM). The specific surface area and pore volume of the γ-Fe 2 O 3 /SiO 2 /Al 2 O 3 composite microspheres calcined at 500 ? C were 200 m 2 /g and 0.77 cm 3 /g, respectively. | Qingtao Fu Tingting He Lianqing Yu Yongming Chai Chenguang Liu | 2011 | Journal of Natural Gas Chemistry2011，20，1： | 0 |
| 17 | Microstructural evolution and mechanical properties of in situ nano Ta_(4)HfC_(5) reinforced SiBCN composite ceramics显示文摘The in situ nano Ta_(4)HfC_(5) reinforced SiBCN-Ta_(4)HfC_(5) composite ceramics were prepared by a combination of two-step mechanical alloying and reactive hot-pressing sintering.The microstructural evolution and mechanical properties of the resulting SiBCN-Ta_(4)HfC_(5) were studied.After the first-step milling of 30 h,the raw materials of TaC and HfC underwent crushing,cold sintering,and short-range interdiffusion to finally obtain the high pure nano Ta_(4)HfC_(5).A hybrid structure of amorphous SiBCN and nano Ta_(4)HfC_(5) was obtained by adopting a second-step ball-milling.After reactive hot-pressing sintering,amorphous SiBCN has crystallized to 3C-SiC,6H-SiC,and turbostratic BN(C)phases and Ta_(4)HfC_(5) retained the form of the nanostructure.With the in situ generations of 2.5 wt% Ta_(4)HfC_(5),Ta_(4)HfC_(5) is preferentially distributed within the turbostratic BN(C);however,as Ta_(4)HfC_(5) content further raised to 10 wt%,it mainly distributed in the grain-boundary of BN(C) and SiC.The introduction of Ta_(4)HfC_(5) nanocrystals can effectively improve the flexural strength and fracture toughness of SiBCN ceramics,reaching to 344.1 MPa and 4.52 MPa·m^(1/2),respectively.This work has solved the problems of uneven distribution of ultra-high temperature phases in the ceramic matrix,which is beneficial to the real applications of SiBCN ceramics. | Bingzhu WANG Daxin LI Zhihua YANG Dechang JIA Jingyi GUAN Hao PENG Delong CAI Peigang HE Xiaoming DUAN Yu ZHOU Tao ZHANG Chenguang GAO | 2020 | Journal of Advanced Ceramics2020，9，6： | 0 |
| 18 | A Similarity Comparison Based Pilot Protection Scheme for VSC-HVDC Grids Considering Fault Current Limiting Strategy显示文摘In the voltage source converter based high-voltage direct current(VSC-HVDC)grids,fast and reliable protections are the key technologies.The traditional protection schemes are easily affected by fault resistance,line distributed capacitance,etc.Meanwhile,the influence of fault current limiting strategy(FCLS)has not been fully considered.In this paper,the fault characteristics under FCLS and the feasibility of traditional travelling wave protections are analyzed.To improve the reliability and sensibility,a similarity comparison based pilot protection scheme is proposed,which focuses on the relationship between the fault characteristics and the state of the protected transmission line,with the establishment of a precise frequencydependent transmission line model.The criteria based on the similarity comparison calculated by cross-wavelet can identify the fault effectively.Meanwhile,the protection scheme can also endure the influence of error synchronization.Finally,the protection performance is verified in the PSCAD/EMTDC under different fault conditions. | Keao Chen Jinghan He Meng Li Yong Tang Ming Nie Chenguang Liang | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，4： | 0 |
| 19 | Monsoon boosted radiation of the endemic East Asian carps显示文摘Major historical events often trigger the rapid flourishing of a few lineages,which in turn shape established biodiversity patterns.How did this process occur and develop?This study provides a window into this issue.The endemic East Asian carps(EEAC)dominated the ichthyofauna of East Asia and exhibited a high degree of adaptation to monsoonal river-lake ecosystems.A series of evidence,including ecogeography,phylogenetics,and macroevolution,suggests that the EEAC is a lineage that arose with the East Asian monsoon and thrived intimately with subsequent monsoon activities.We further deduce the evolution of the EEAC and find that a range of historical events in the monsoon setting(e.g.,marine transgression and regression and glacial-interglacial cycle)have further reshaped the distribution patterns of EEAC’s members.Comparative genomics analyses reveal that introgressions during the initial period of EEAC radiation and innovations in the regulation of the brain and nervous system may have aided their adaptation to river-lake ecosystems in a monsoon setting,which boosted radiation.Overall,this study strengthens knowledge of the evolutionary patterns of freshwater fishes in East Asia and provides a model case for understanding the impact of major historical events on the evolution of biota. | Chenguang Feng Kun Wang Wenjie Xu Liandong Yang Kunyuan Wanghe Ning Sun Baosheng Wu Feixiang Wu Lei Yang Qiang Qiu Xiaoni Gan Yiyu Chen Shunping He | 2023 | Science China(Life Sciences)2023，66，3： | 0 |
| 20 | Voxel modeling and association of ubiquitous spatiotemporal information in natural language texts显示文摘The ubiquitous spatiotemporal information extracted from Internet texts limits its application in spatiotemporal association and analysis due to its unstructured nature and uncertainty.This study uses ST-Voxel modeling to solve the problem of structured modeling and the association of ubiquitous spatiotemporal information in natural language texts.It provides a new solution for associating ubiquitous spatiotemporal information on the Internet and discovering public opinion.The main contributions of this paper include:(1)It proposes a convolved method for ST-Voxel,which solves the voxel modeling problem of unstructured and uncertain spatiotemporal objects and spatiotemporal relation in natural language texts.Experiments show that this method can effectively model 5 types of spatiotemporal objects and 16 types of uncertain spatiotemporal relation founded in texts;(2)It realizes the unknown event discovery based on voxelized spatiotemporal information association.Experiments show that this method can effectively solve the aggregation of ubiquitous spatiotemporal information in multi-natural language texts,which is conducive to discovering spatiotemporal events.The selection of convolution parameters in voxel modeling is also discussed.A parameter selection method for balancing the discovery capability and discovery accuracy of spatiotemporal events is given. | Dali Wang Xiaochong Tong Chenguang Dai Congzhou Guo Yi Lei Chunping Qiu He Li Yuekun Sun | 2023 | International Journal of Digital Earth2023，16，1： | 0 |
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