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| 1 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 2 | Expressions of apoptosis-related proteins in rats with focal cerebral ischemia after Angong Niuhuang sticker point application显示文摘In this study, we extracted and purified components in the Angong Niuhuang pill. Then we applied transdermal enhancers to Angong Niuhuang stickers by modern technology. The Angong Niuhuang sticker includes extracts from curcuma, berberine hydrochloride, baicalin, geniposide, borneol, and musk. Angong Niuhuang stickers at different point application doses (1.35, 2.7, and 5.4 g/kg) were administered to Dazhui (DU14), Qihai (RN6) and Mingmen (DU4). Rats in the different dose point application and acupuncture groups were continuously administered for 7 days. Then a middle cerebral artery occlusion model was prepared for simulating human cerebral ischemia. Twelve hours later, expressions of Bcl-2, Bax and p53 protein in hippocampal CA1 were detected with immunohistochemistry. The expression level of Bcl-2, an anti-apoptotic protein, significantly increased in the high-, medium- and low-dose point application groups and the acupuncture group, while the expression of the pro-apoptotic proteins, Bax and p53, significantly decreased compared with the middle cerebral artery occlusion rats; and the Bcl-2/Bax ratio was significantly increased. The difference was noticeable for the high-dose point application group, which showed statistical difference compared with the low-dose point application group and the acupuncture group. Our experimental findings indicate that point application with Angong Niuhuang stickers promotes the expression of Bcl-2, and inhibits the expressions of Bax and p53 in the hippocampal CA1 area of rats after focal cerebral ischemia. Thus, point application of Angong Niuhang stickers protects brain tissues from cerebral ischemia. | Dongshu Zhang Maodong Fu Chenglong Song Caiyun Wang Xiaochun Lin Yuanliang Liu | 2012 | Neural Regeneration Research2012，7，30： | 6 |
| 3 | Colour compound lenses for a portable fluorescence microscope显示文摘In this article,we demonstrated a handheld smartphone fluorescence microscope(HSFM)that integrates dualfunctional polymer lenses with a smartphone.The HSFM consists of a smartphone,a field-portable illumination source,and a dual-functional polymer lens that performs both optical imaging and filtering.Therefore,compared with the existing smartphone fluorescence microscope,the HSFM does not need any additional optical filters.Although fluorescence imaging has traditionally played an indispensable role in biomedical and clinical applications due to its high specificity and sensitivity for detecting cells,proteins,DNAs/RNAs,etc.,the bulky elements of conventional fluorescence microscopes make them inconvenient for use in point-of-care diagnosis.The HSFM demonstrated in this article solves this problem by providing a multifunctional,miniature,small-form-factor fluorescence module.This multifunctional fluorescence module can be seamlessly attached to any smartphone camera for both bright-field and fluorescence imaging at cellular-scale resolutions without the use of additional bulky lenses/filters;in fact,the HSFM achieves magnification and light filtration using a single lens.Cell and tissue observation,cell counting,plasmid transfection evaluation,and superoxide production analysis were performed using this device.Notably,this lens system has the unique capability of functioning with numerous smartphones,irrespective of the smartphone model and the camera technology housed within each device.As such,this HSFM has the potential to pave the way for realtime point-of-care diagnosis and opens up countless possibilities for personalized medicine. | Bo Dai Ziao Jiao Lulu Zheng Hunter Bachman Yongfeng Fu Xinjun Wan Yule Zhang Yu Huang Xiaodian Han Chenglong Zhao Tony Jun Huang Songlin Zhuang Dawei Zhang | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 4 | Engineering practice and economic analysis of ozone oxidation wet denitrification technology显示文摘SO_(2)and NO emitted from coal-fired power plants have caused serious air pollution in China.In this study,a test system for NO oxidation using O_(3)is established.The basic characteristics of NO oxidation and products forms are studied.A separate test system for the combined removal of SO_(2)and NO_(x)is also established,and the absorption characteristics of NO_(x)are studied.The characteristics of NO oxidation and NO_(x)absorption were verified in a 35 t·h^(-1)industrial boiler wet combined desulfurization and denitrification project.The operating economy of ozone oxidation wet denitrification technology is analyzed.The results show that O_(3)has a high rate and strong selectivity for NO oxidation.When O_(3)is insufficient,the primary oxidation product is NO_(2).When O_(3)is present in excess,NO_(2)continues to get oxidized to N_(2)O_(5)or NO_(3).The removal efficiency of NO_(2)in alkaline absorption system is low(only about 15%).NOx removal efficiency can be improved by oxidizing NO_(x)to N_(2)O_(5)or NO_(3)by increasing ozone ratio.When the molar ratio of O_(3)/NO is 1.77,the NOx removal efficiency reaches 90.3%,while the operating cost of removing NO_(x)per kilogram is 6.06 USD(NO_(2)). | Yang Li Defu Che Chenglong Yang Mingyu Yao Tingwen Zhao Kangli Fu Hanchen Zhao | 2021 | Chinese Journal of Chemical Engineering2021，34，1： | 3 |
| 5 | Stability and control of dynamic walking for a five-link planar biped robot with feet显示文摘在两足动物机器人的动态走期间,在旋转激活下面,自由度(DOF ) 出现在支持英尺和地面之间,它做两足动物模型混血儿和尺寸变体。这篇论文为 dimension-varianthybrid 系统(DVHS ) 探讨 asymptotic 轨道稳定性。基于概括 Poincare 地图,为 DVHS 的稳定性标准也是介绍,并且结果然后被用来学习的动态走有脚的一个五连接的平面两足动物机器人。时间不变的步法为与扁平的脚的动态走计划和非线性的控制策略也被介绍。模拟结果显示动态走的一个 asymptotically 稳定的限制周期被建议方法完成。 | Chenglong FU Ken CHEN Jing XIONG Leon XU | 2007 | 控制理论与应用(英文版)2007，5，2： | 2 |
| 6 | Gait synthesis and sensory control of stair climbing for a humanoid robot显示文摘 | Fu Chenglong Chen Ken | 2008 | IEEE Transactions on Industrial Electronics2008，55，5： | 1 |
| 7 | Gait synthesis and sensory control of stair climbing for a httmanoid robot显示文摘 | Fu Chenglong Chen Ken | 2008 | IEEE Transactions on Industrial Electronics2008，55，5： | 1 |
| 8 | An integrated rice panicle phenotyping method based on X-ray and RGB scanning and deep learning显示文摘Rice panicle phenotyping is required in rice breeding for high yield and grain quality.To fully evaluate spikelet and kernel traits without threshing and hulling,using X-ray and RGB scanning,we developed an integrated rice panicle phenotyping system and a corresponding image analysis pipeline.We compared five methods of counting spikelets and found that Faster R-CNN achieved high accuracy(R~2 of 0.99)and speed.Faster R-CNN was also applied to indica and japonica classification and achieved 91%accuracy.The proposed integrated panicle phenotyping method offers benefit for rice functional genetics and breeding. | Lejun Yu Jiawei Shi Chenglong Huang Lingfeng Duan Di Wu Debao Fu Changyin Wu Lizhong Xiong Wanneng Yang Qian Liu | 2021 | The Crop Journal2021，9，1： | 1 |
| 9 | Panicle-3D: A low-cost 3D-modeling method for rice panicles based on deep learning, shape from silhouette, and supervoxel clustering显示文摘Self-occlusions are common in rice canopy images and strongly influence the calculation accuracies of panicle traits. Such interference can be largely eliminated if panicles are phenotyped at the 3 D level.Research on 3 D panicle phenotyping has been limited. Given that existing 3 D modeling techniques do not focus on specified parts of a target object, an efficient method for panicle modeling of large numbers of rice plants is lacking. This paper presents an automatic and nondestructive method for 3 D panicle modeling. The proposed method integrates shoot rice reconstruction with shape from silhouette, 2 D panicle segmentation with a deep convolutional neural network, and 3 D panicle segmentation with ray tracing and supervoxel clustering. A multiview imaging system was built to acquire image sequences of rice canopies with an efficiency of approximately 4 min per rice plant. The execution time of panicle modeling per rice plant using 90 images was approximately 26 min. The outputs of the algorithm for a single rice plant are a shoot rice model, surface shoot rice model, panicle model, and surface panicle model, all represented by a list of spatial coordinates. The efficiency and performance were evaluated and compared with the classical structure-from-motion algorithm. The results demonstrated that the proposed method is well qualified to recover the 3 D shapes of rice panicles from multiview images and is readily adaptable to rice plants of diverse accessions and growth stages. The proposed algorithm is superior to the structure-from-motion method in terms of texture preservation and computational efficiency. The sample images and implementation of the algorithm are available online. This automatic, cost-efficient, and nondestructive method of 3 D panicle modeling may be applied to high-throughput 3 D phenotyping of large rice populations. | Dan Wu Lejun Yu Junli Ye Ruifang Zhai Lingfeng Duan Lingbo Liu Nai Wu Zedong Geng Jingbo Fu Chenglong Huang Shangbin Chen Qian Liu Wanneng Yang | 2022 | The Crop Journal2022，10，5： | 1 |
| 10 | Changes in wheat protein digestibility and allergenicity: role of Pediococcus acidilactici XZ31 and yeast during dough fermentation显示文摘Wheat flour,as the most important source of food globally,is one of the most common causative agents of food allergy.This study aimed to investigate the effects of fermentation on wheat protein digestibility and allergenicity.Protein digestibility were evaluated using the sodium dodecyl sulfate-polyacrylamide gel electrophoresis analysis and enzyme-linked immunosorbent assay.The effect of protein on intestinal permeability was investigated by Caco-2 cell monolayers.Co-culture fermentation with Pediococcus acidilactici XZ31 and yeast leads to improvement in digestibility of wheat protein compared to single strain fermentation.Fermentation leads to a decrease in albumin/globulin antigenicity and an increase in gluten R5 reactivity,with the most significant changes in the co-culture group.Digestion strengthen the decrease of protein antigenicity and counteracts the difference in antigenicity induced by fermentation between groups.However,pretreatment with P.acidilactici XZ31 reduces the amount of allergens across Caco-2 monolayer and attenuates the gluten-induced increase in permeability of Caco-2 cell monolayer by reducing actin polymerization and villous atrophy.Co-culture fermentation reduces gluten-induced cell monolayer damage to a greater extent than P.acidilactici XZ31 monoculture.These results gives valuable insight into the effects of P.acidilactici XZ31 fermentation on the allergenicity and toxicity of wheat proteins,which contribute to promoting the application of multi-strain leavening agent in hypoallergenic and gluten-free wheat products. | Wenhui Fu Chen Chen Chenglong Liu Sha Tao Wentong Xue | 2023 | Food Science and Human Wellness2023，12，6： | 0 |
| 11 | Assessment of immune responses and intestinal flora in BALB/c mice model of wheat food allergy via different sensitization methods显示文摘Increasing incidences showed that food allergies have attracted more and more attention from researchers.BALB/c mice were sensitized with wheat gluten combined with aluminum hydroxide adjuvant via intraperitoneal injection,transdermal sensitization,and oral gavage sensitization route.Results showed that all the three sensitization methods could induce allergic symptoms;increase the serum antibody(total immunoglobulin E(IgE),specific IgE,IgG,IgA)and histamine content;promote the secretion of Th2 cytokines(interleukin(IL)-4,IL-5,IL-13)and inflammatory factors(IL-6,IL-17 A,IL-10);and inhibit the production of Th1 cytokines(IFN-γ,IL-2).However,the allergic symptoms of mice sensitized by intraperitoneal injection were the most obvious among the three models.The level of serum antibodies in intraperitoneal injection group was significantly higher than control.Subsequently,16 S rRNA sequencing technology was used to analyze the intestinal flora of mice.The results showed that the abundance of Firmicutes in the wheat protein sensitized group was lower than that in the normal group,while the abundance of Bacteroidetes was higher,and Lactobacillus was the difference marker in normal group.Bacterial species diversity analysis showed that the species richness and diversity of intestinal flora in mice were decreased,the difference between mice induced by intraperitoneal injection and normal control group mice was the most significant.Taken together,these results show that among three sensitization methods used to build a mouse model with aluminum hydroxide as adjuvant,intraperitoneal injection is the comparably best way to build a mouse sensitization mode. | Chenglong Liu Chen Chen Xingyu Yan Shimin Gu Xin Jia Wenhui Fu Xiao Meng Wentong Xue | 2023 | Food Science and Human Wellness2023，12，3： | 0 |
| 12 | Influence of tower anticorrosion coating as contaminant on operation characteristics of composite insulator显示文摘Anticorrosion coatings are commonly applied to prevent rust-based corrosion in transmission towers.Unfortunately,anticorrosion coatings may drip onto the surface of composite insulators during the construction process,which is likely to do harm to operation characteristics of composite insulators.This Letter was conducted to determine the influence of anticorrosion coatings on composite insulator performance.The mechanical properties,hydrophobicity,hydrophobic transfer,and flashover voltage of high-temperature vulcanised(HTV)silicone rubber specimens with and without the coating were investigated in detail.Appropriate solutions for avoiding unwanted effects on insulator performance are proposed accordingly.The influence of coating on the pollution flashover voltage of the composite insulator was also determined by changing the type,area,and shape of coating attached to the insulator surface.Finite element software was also used to analyse the effects of coatings on the electric field distribution of the composite insulator.The coating slightly affects the mechanical properties of HTV silicone rubber,but significantly impacts its hydrophobicity and hydrophobicity transfer.The pollution flashover characteristics of test composite insulators covered with the anticorrosion coating are also worst than those without coating. | Mei Hongwei Guan Xiyuan Fu Xiangyun Zhao Chenglong Wang Liming | 2018 | High Voltage2018，3，3： | 0 |
| 13 | Bioinspired cellulose-integrated MXene-based hydrogels for multifunctional sensing and electromagnetic interference shielding显示文摘Bioinspired hydrogels are complex materials with distinctive properties comparable to biological tissues.Their exceptional sensitivity to various external stimuli leads to substantial application potential in wearable smart devices.However,these multifaceted hydrogels are often challenging to be combined with pattern customization,stimulus responsiveness,self-healing,and biocompatibility.Herein,inspired by mussel secretions,a printable,self-healing,and biocompatible MXene-based composite hydrogel was designed and prepared by incorporating Ti3C2Tx MXene nanosheets into the hydrogel framework through the chelation of calcium ions(Ca2+)with polyacrylic acid and cellulose nanofibers at alkaline conditions.The biocompatible conductive hydrogel exhibited sensitivity(gauge factor of 2.16),self-healing(within 1 s),recognition,and adhesion,distinguishing it as an ideal candidate for wearable multifunctional sensors toward strain sensing,vocal sensing,signature detection,and Morse code transmission.Additionally,the multifunctional hydrogel manifested efficient electromagnetic interference shielding properties(reaching more than 30 dB at a thickness of 2.0 mm),protecting electronics and humans from electromagnetic radiation and pollution.Therefore,the presented work represents a versatile strategy for developing environmentally friendly conductive hydrogels,demonstrating the perspectives of intelligent hydrogels for multifunctional applications. | Jingjiang Wei Chenglong Zhu Zhihui Zeng Fei Pan Fuqiang Wan Liwen Lei Gustav Nyström Zhengyi Fu | 2022 | Interdisciplinary Materials2022，1，4： | 0 |
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