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| 1 | Preliminary analysis on the source properties and seismogenic structure of the 2017 M_s7.0 Jiuzhaigou earthquake显示文摘At GMT time 13:19, August 8, 2017, an Ms7.0 earthquake struck the Jiuzhaigou region in Sichuan Province, China,causing severe damages and casualties. To investigate the source properties, seismogenic structures, and seismic hazards, we systematically analyzed the tectonic environment, crustal velocity structure in the source region, source parameters and rupture process, Coulomb failure stress changes, and 3-D features of the rupture plane of the Jiuzhaigou earthquake. Our results indicate the following:(1) The Jiuzhaigou earthquake occurred on an unmarked fault belonging to the transition zone of the east Kunlun fault system and is located northwest of the Huya fault.(2) Both the mainshock and aftershock rupture zones are located in a region where crustal seismic velocity changes dramatically. Southeast to the source region, shear wave velocity at the middle to lower crust is significantly low, but it rapidly increases northeastward and lies close to the background velocity across the rupture fault.(3) The aftershock zone is narrow and distributes along the northwest-southeast trend, and most aftershocks occur within a depth range of 5–20 km.(4) The focal mechanism of the Jiuzhaigou earthquake indicates a left-lateral strike-slip fault, with strike, dip, and rake angles of 152°, 74° and 8°, respectively. The hypocenter depth measures 20 km, whereas the centroid depth is about 6 km. The co-seismic rupture mainly concentrates at depths of 3–13 km, with a moment magnitude(M_w) of 6.5.(5) The co-seismic rupture also strengthens the Coulomb failure stress at the two ends of the rupture fault and the east segment of the Tazang fault. Aftershocks relocation results together with geological surveys indicate that the causative fault is a near vertical fault with notable spatial variations: dip angle varies within 66°–89° from northwest to southeast and the average dip angle measures ~84°. The results of this work are of fundamental importance for further studies on the source characteristics, tectonic environment, and seismic hazard evaluation of the Jiuzhaigou earthquake. | Zujun XIE Yong ZHENG Huajian YAO Lihua FANG Yong ZHANG Chengli LIU Maomao WANG Bin SHAN Huiping ZHANG Junjie REN Lingyun JI Meiqin SONG | 2018 | Science China Earth Sciences2018，61，3： | 8 |
| 2 | High-Q microresonators on 4H-silicon-carbide-on-insulator platform for nonlinear photonics显示文摘The realization of high-quality(Q)resonators regardless of the underpinning material platforms has been a ceaseless pursuit,because the high-Q resonators provide an extreme environment for confining light to enable observations of many nonlinear optical phenomenon with high efficiencies.Here,photonic microresonators with a mean Q factor of 6.75×10^(6)were demonstrated on a 4H-silicon-carbide-on-insulator(4H-SiCOI)platform,as determined by a statistical analysis of tens of resonances.Using these devices,broadband frequency conversions,including second-,third-,and fourth-harmonic generations have been observed.Cascaded Raman lasing has also been demonstrated in our SiC microresonator for the first time,to the best of our knowledge.Meanwhile,by engineering the dispersion properties of the SiC microresonator,we have achieved broadband Kerr frequency combs covering from 1300 to 1700nm.Our demonstration represents a significant milestone in the development of SiC photonic integrated devices. | Chengli Wang Zhiwei Fang Ailun Yi Bingcheng Yang Zhe Wang Liping Zhou Chen Shen Yifan Zhu Yuan Zhou Rui Bao Zhongxu Li Yang Chen Kai Huang Jiaxiang Zhang Ya Cheng Xin Ou | 2021 | Light(Science & Applications)2021，10，8： | 4 |
| 3 | Soliton formation and spectral translation into visible on CMOS-compatible 4H-silicon-carbide-oninsulator platform显示文摘Recent advancements in integrated soliton microcombs open the route to a wide range of chip-based communication,sensing,and metrology applications.The technology translation from laboratory demonstrations to real-world applications requires the fabrication process of photonics chips to be fully CMOS-compatible,such that the manufacturing can take advantage of the ongoing evolution of semiconductor technology at reduced cost and with high volume.Silicon nitride has become the leading CMOS platform for integrated soliton devices,however,it is an insulator and lacks intrinsic second-order nonlinearity for electro-optic modulation.Other materials have emerged such as AlN,LiNbO_(3),AlGaAs and GaP that exhibit simultaneous second-and third-order nonlinearities.Here,we show that silicon carbide(SiC)--already commercially deployed in nearly ubiquitous electrical power devices such as RF electronics,MOSFET,and MEMS due to its wide bandgap properties,excellent mechanical properties,piezoelectricity and chemical inertia--is a new competitive CMOS-compatible platform for nonlinear photonics.High-quality-factor microresonators(Q=4×10^(6))are fabricated on 4H-SiC-on-insulator thin films,where a single soliton microcomb is generated.In addition,we observe wide spectral translation of chaotic microcombs from near-infrared to visible due to the second-order nonlinearity of SiC.Our work highlights the prospects of SiC for future low-loss integrated nonlinear and quantum photonics that could harness electro-opto-mechanical interactions on a monolithic platform. | Chengli Wang Jin Li Ailun Yi Zhiwei Fang Liping Zhou Zhe Wang Rui Niu Yang Chen Jiaxiang Zhang Ya Cheng Junqiu Liu Chun-Hua Dong Xin Ou | 2022 | Light(Science & Applications)2022，11，12： | 1 |
| 4 | A Kinetic Model for Hydrocracking Process显示文摘AKineticModelforHydrocrackingProcesWuXizhong,LiChenglie,FangXiangchen,ChangZhenming(EastChinaUniversityofScience&Technology,S... | Wu Xizhong, Li Chenglie, Fang Xiangchen, Chang Zhenming (East China University of Science & Technology, Shanghai 200237) | 1997 | 石油学报(石油加工)1997，13，S1： | 0 |
| 5 | Bacterial MerR family transcription regulators:activationby distortion显示文摘Transcription factors(TFs)modulate gene expression by regulating the accessibility of promoter DNA to RNA polymerases(RNAPs)in bacteria.The MerR family TFs are a large class of bacterial proteins unique in their physiological functions and molecular action:they function as transcription repressors under normal circumstances,but rapidly transform to transcription activators under various cellular triggers,including oxidative stress,imbalance of cellular metal ions,and antibiotic challenge.The promoters regulated by MerR TFs typically contain an abnormal long spacer between the-35 and-10 elements,where MerR TFs bind and regulate transcription activity through unique mechanisms.In this review,we summarize the function,ligand reception,DNA recognition,and molecular mechanism of transcription regulation of MerR-family TFs. | Chengli Fang Yu Zhang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 0 |
| 6 | DNA crosslinking and recombination-activating genes 1/2(RAG1/2)are required for oncogenic splicing in acute lymphoblastic leukemia显示文摘Background:Abnormal alternative splicing is frequently associated with carcinogenesis.In B-cell acute lymphoblastic leukemia(B-ALL),double homeobox 4 fused with immunoglobulin heavy chain(DUX4/IGH)can lead to the aberrant production of E-26 transformation-specific family related gene abnormal transcript(ERGalt)and other splicing variants.However,the molecular mechanism underpinning this process remains elusive.Here,we aimed to know how DUX4/IGH triggers abnormal splicing in leukemia.Methods:The differential intron retention analysis was conducted to identify novel DUX4/IGH-driven splicing in B-ALL patients.X-ray crystallography,small angle X-ray scattering(SAXS),and analytical ultracentrifugation were used to investigate how DUX4/IGH recognize double DUX4 responsive element(DRE)-DRE sites.The ERGalt biogenesis and B-cell differentiation assays were performed to characterize the DUX4/IGH crosslinking activity.To check whether recombination-activating gene 1/2(RAG1/2)was required for DUX4/IGH-driven splicing,the proximity ligation assay,co-immunoprecipitation,mammalian two hybrid characterizations,in vitro RAG1/2 cleavage,and shRNA knock-down assays were performed.Results:We reported previously unrecognized intron retention events in Ctype lectin domain family 12,member A abnormal transcript(CLEC12Aalt)and chromosome 6 open reading frame 89 abnormal transcript(C6orf89alt),where also harbored repetitive DRE-DRE sites.Supportively,X-ray crystallography and SAXS characterization revealed that DUX4 homeobox domain(HD)1-HD2 might dimerize into a dumbbell-shape trans configuration to crosslink two adjacent DRE sites.Impaired DUX4/IGH-mediated crosslinking abolishes ERGalt,CLEC12Aalt,and C6orf89alt biogenesis,resulting in marked alleviation of its inhibitory effect on B-cell differentiation.Furthermore,we also observed a rare RAG1/2-mediated recombination signal sequence-like DNA edition in DUX4/IGH target genes.Supportively,shRNA knock-down of RAG1/2 in leukemic Reh cells consistently impaired the biogenesis of ERGalt,CLEC12Aalt,and C6orf89alt.Conclusions:All these results suggest that DUX4/IGH-driven DNA crosslinking is required for RAG1/2 recruitment onto the double tandem DRE-DRE sites,catalyzing V(D)J-like recombination and oncogenic splicing in acute lymphoblastic leukemia. | Hao Zhang Nuo Cheng Zhihui Li Ling Bai Chengli Fang Yuwen Li Weina Zhang Xue Dong Minghao Jiang Yang Liang Sujiang Zhang Jianqing Mi Jiang Zhu Yu Zhang Sai-Juan Chen Yajie Zhao Xiang-Qin Weng Weiguo Hu Zhu Chen Jinyan Huang Guoyu Meng | 2021 | Cancer Communications2021，41，11： | 0 |
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