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| 1 | Acetylenes and fatty acids from Codonopsis pilosula显示文摘Four new acetylenes(1–4) and one new unsaturated ω-hydroxy fatty acid(5),together with 5known analogues,were isolated from an aqueous extract of Codonopsis pilosula roots.Their structures were determined by spectroscopic and chemical methods.The new acetylenes are categorized as an unusual cyclotetradecatrienynone(1),tetradecenynetriol(2),and rare octenynoic acids(3 and 4),respectively,and 3 and 4 are possibly derived from oxidative metabolic degradation of 1 and/or 2.The absolute configuration of 1 was assigned by comparison of the experimental circular dichroism(CD)spectrum with the calculated electronic circular dichroism(ECD) spectra of stereoisomers based on the quantum-mechanical time-dependent density functional theory,while the configuration of 2 was assigned by using modified Mosher's method based on the MPA determination rule of ΔδRSvalues for diols. | Yueping Jiang Yufeng Liu Qinglan Guo Zhibo Jiang Chengbo Xu Chenggen Zhu Yongchun Yang Sheng Lin Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 15 |
| 2 | Sulfur-enriched alkaloids from the root of Isatis indigotica显示文摘Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known scalemic enantiomers epigoitrin and goitrin(8 a and 8 b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and theoretical calculations of electronic circular dichroism(ECD) spectra based on the quantum-mechanical time-dependent density functional theory(TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6 a and 6 b support the postulated biosynthetic pathways for the diastereomers 9 a and 9 b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95(H3 N2, IC500.60 and 1.92 μmol/L) and the herpes simplex virus 1(HSV-1, IC503.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3(IC500.71 μmol/L).& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dhpkuqx5ccnovn6oqx.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Qinglan Guo Chengbo Xu Minghua Chen Sheng Lin Yuhuan Li Chenggen Zhu JiANDong Jiang Yongchun Yang Jiangong Shi | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 8 |
| 3 | Natural and unnatural anthraquinones isolated from the ethanol extract of the roots of Knoxia valerianoides显示文摘Eight new 9,10-anthraquinones(1-8)including three acetonide derivatives of 3-hydroxy-2-hydroxymethyl-9,10-anthraquinones(68)were isolated from an ethanol extract of the roots of Knoxia valeriamoides.On the basis of chemical transformation reactions of the co-occurring 14 and 15 combined with HPLC-DAD-ESI-MS analysis of the extracts,the previously and newly isolated 2-methoxymethy-and 2-ethoxymethyl-9,10-anthraquinones(4,5,and 9-13),as well as the 3-hydroxy-2-hydroxymethyl-9,10-anthraquinone acetonide derivatives(68),were shown to be solvolytic artifacts.In the in vitro assays,compound 4 was active to protect hepatocyte(WB-F344)damage. | Feng Zhao Sujuan Wang Sheng Lin Chenggen Zhu Zhenggang Yue Yang Yu Bo Liu Xiuli Wu Yongchun Yang Yan Li Jiangong Shi | 2012 | Acta Pharmaceutica Sinica B2012，2，3： | 7 |
| 4 | Insight into Medicinal Chemistry Behind Traditional Chinese Medicines: p-Hydroxybenzyl Alcohol-Derived Dimers and Trimers from Gastrodia elata显示文摘From an aqueous extract of“tian ma”(the steamed and dried rhizomes of Gastrodia elata),ten new compounds gastrodiben-zins A−D(1−4)and gastrotribenzins A−F(5−10),along with known analogues(11−20),having structure features coupling between two and three p-hydroxybenzyl-derived units via carbon-and/or ether-bonds,were isolated and characterized by spectroscopic data analysis.Meanwhile,the new compounds 5a,6a,8a,22,and 23,as well as the known derivatives 13a,14a,15,17−21,24,25,and p-hydroxybenzyl aldehyde were isolated and identified from a refluxed aqueous solution of p-hydroxybenzyl alcohol.Methylation of 5a and 6a in methanol and ethylation of 6a,8a,13a,and 14a in ethanol produced 5 and 6 and 7,8,13,and 14,respectively.using ultra-performance liquid chromatography high-resolution electrospray ioniza-tion mass spectrometry(UPLC-HRESIMS)analysis of the refluxed solutions of p-hydroxybenzyl alcohol and the refluxed extracts of the fresh G.elata rhizome and“tian ma”extracts indicated consistent production and variation of the dimeric and trimeric derivatives of p-hydroxybenzyl alcohol upon extracting solvents and refluxing time.In various assays,the dimeric and trimeric derivatives showed more potent activities than p-hydroxybenzyl alcohol itself and gastrodin,which are the main known active constituents of“tian ma”.These results revealed for the first time that the more effective dimers and trimers can be produced through condensation of the co-occurring p-hydroxybenzyl alcohol during processing and decocting of the G.elata rhizomes,demonstrating insights into medicinal chemistry behind application protocols of traditional Chinese medicines. | Yanan Wang Min Zhang Xue Zhou Chengbo Xu Chenggen Zhu Yuhe Yuan Naihong Chen Yongchun Yang Qinglan Guo Jiangong Shi | 2021 | Natural Products and Bioprospecting2021，11，1： | 6 |
| 5 | Gram-scale preparation of dialkylideneacetones through Ca(OH)_2-catalyzed Claisen-Schmidt condensation in dilute aqueous EtOH显示文摘A synthetic method of dialkylideneacetones has been developed. Compared with known protocols, the method employed catalytic Ca(OH)_2 as the cheap, mild base catalyst and dilute aqueous EtOH(20%, v/v)as the green and safe solvent. The procedure was easily operated: In most cases, the product could be isolated by a simple filtration, and purified by washing with water. This paper provided experimental details of the reactions, which could be applied in gram-scale synthesis and should be a very reliable and practical protocol to prepare these useful compounds in laboratory and at the industrial level. | Hao Zhang Mengting Han Chenggen Yang Lei Yu Qing Xu | 2019 | Chinese Chemical Letters2019，30，1： | 4 |
| 6 | Characterization of dynamic microgyroscopes by use of temporal digital image correlation 显示文摘 | Yang Fujun He Xiaoyuan Quan Chenggen | 2006 | Applied Optics2006，45，30： | 1 |
| 7 | Extraordinary Compatibility to Mass Loading and Rate Capability of Hierarchically Porous Carbon Nanorods Electrode Derived from the Waste Tire Pyrolysis Oil显示文摘The conversion of waste tire pyrolysis oil(WTPO)into S-doped porous carbon nanorods(labeled as WPCNs)with hierarchical pore structure is realized by a simple template-directed approach.The specific surface area of as-obtained porous carbon nanorods can reach up to 1448 m^(2) g^(−1) without the addition of any activating agent.As the capacitive electrode,WPCNs possess the extraordinary compatibility to capacitance,different electrolyte systems as well as long-term cycle life even at a commercial-level areal mass loading(10 mg cm^(−2)).Besides,only an extremely small capacitance fluctuation is observed under the extreme circumstance(−40 to 80℃),reflecting the excellent high-and low-temperature performance.The relationship between the pore structure and capacitive behavior is analyzed by comparing WPCNs with mesopores-dominated asphalt-derived porous carbon nanorods(APCNs)and micropores-dominated activated carbon.The molecular dynamics simulation further reveals the ion diffusion and transfer ability of the as-prepared carbon materials under different pore size distribution.The total ion flow(NT)of WPCNs calculated by the simulation is obviously larger than APCNs and the N_(T) ratio between them is similar with the experimental average capacitance ratio.Furthermore,this work also provides a valuable strategy to prepare the electrode material with high capacitive energy storage ability through the high value-added utilization of WTPO. | Shengping Li Zipan Yang Mingzhen Wu Chenggen Xu Xilu Zhang Rundan Lin Xuejie Wang Lu Zhao Dong Sun Xinlong Ma Jinsen Gao | 2022 | Energy & Environmental Materials2022，5，4： | 0 |
| 8 | Porous carbon spheres anode with the stable output of low delithiation plateau and constant delithiation ratio for lithium ion hybrid capacitor显示文摘Porous carbon spheres derived from the facile hydrothermal treatment associated with the calcination process exhibit the good spherical morphology and unique porous structure.For the Li-based half-cell test,porous carbon spheres electrode not only exhibits larger reversible capacities and better compatibility as compared to the widely-used graphite,but also provides stable delithiation plateaus under different current density.Additionally,the delithiation ratio below 1 V almost accounts for a constant value(around 70%)with the increase of current density,evidencing that Li intercalation storage is the dominant model and Li insertion/extraction processes are propitious.The lithium ion hybrid capacitor configured with S-doped mesoporous graphene and porous carbon spheres as cathode and anode,delivers satisfied energy and power densities(up to 177 Wh kg^(−1) and 12,303 W kg^(−1),respectively)as well as long-term cyclability,which is superior to the corresponding S-doped mesoporous graphene//graphite and activated carbon//porous carbon spheres.In addition,the developed synthesis strategy is in favor of the realization of the scalable production of porous carbon spheres. | Mingzhen Wu Zipan Yang Shengping Li Xuejie Wang Chenggen Xu Rundan Lin Xilu Zhang Xinlong Ma Guoyong Huang Jinsen Gao | 2021 | Particuology2021，19，5： | 0 |
| 9 | Control Effects of Different Agents on Tobacco Mosaic Virus Disease显示文摘[Objectives] This study was conducted to screen out suitable agents for controlling tobacco mosaic virus disease and the best control period in Zhangzhou tobacco area, providing a theoretical basis for the control of virus diseases, thereby improving the quality of flue-cured tobacco and the income of tobacco farmers. [Methods] The effects on tobacco mosaic virus disease under the interaction between different agents and different application periods were investigated. The incidence of tobacco mosaic virus disease was investigated, and its control effect was analyzed. [Results] Different agents and different application periods had different control effects on tobacco mosaic virus disease. The incidence of tobacco mosaic virus disease: At 30 and 45 d after transplanting, the incidences of A2B1 treatment were the lowest, at 0.85%, 1.71%, respectively;and at 60 d after transplanting, the incidence of A3B1 treatment was the lowest, only 10.68%. The control effect: At 30 and 45 d after transplanting, A2B1 treatment had better control effects, reaching 79.39% and 73.06%, respectively. [Conclusions] 3% hypersensitive protein sprayed at 1 d before transplanting and 7 and 15 d after transplanting achieved the best effect, followed by 10% ningnanmycin sprayed at 1 d before transplanting and 7 and 15 d after transplanting. In tobacco production, it is recommended to apply 1 000 times dilution of 3% supersensitive protein microgranules for three times(at 1 d before transplanting and 7 and 15 d after transplanting), which can effectively prevent tobacco mosaic virus disease. | Weiwei OUYANG Zhengyang ZHANG Qiuzan ZHONG Changyou SHEN Runsheng LIU Xianyi XIAO Qinggen YANG Wenping RAO Yi LIU Chenggen FAN Hai LIAN Lifang XIE | 2019 | Agricultural Biotechnology2019，8，6： | 0 |
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