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| 1 | Three-dimensional-printed individualized porous implants:A new“implant-bone”interface fusion concept for large bone defect treatment显示文摘Bone defect repairs are based on bone graft fusion or replacement.Current large bone defect treatments are inadequate and lack of reliable technology.Therefore,we aimed to investigate a simple technique using three-dimensional(3D)-printed individualized porous implants without any bone grafts,osteoinductive agents,or surface biofunctionalization to treat large bone defects,and systematically study its long-term therapeutic effects and osseointegration characteristics.Twenty-six patients with large bone defects caused by tumor,infection,or trauma received treatment with individualized porous implants;among them,three typical cases underwent a detailed study.Additionally,a large segmental femur defect sheep model was used to study the osseointegration characteristics.Immediate and long-term biomechanical stability was achieved,and the animal study revealed that the bone grew into the pores with gradual remodeling,resulting in a long-term mechanically stable implant-bone complex.Advantages of 3D-printed microporous implants for the repair of bone defects included 1)that the stabilization devices were immediately designed and constructed to achieve early postoperative mobility,and 2)that osseointegration between the host bone and implants was achieved without bone grafting.Our osseointegration method,in which the“implant-bone”interface fusion concept was used instead of“bone-bone”fusion,subverts the traditional idea of osseointegration. | Teng Zhang Qingguang Wei Hua Zhou Zehao Jing Xiaoguang Liu Yufeng Zheng Hong Cai Feng Wei Liang Jiang Miao Yu Yan Cheng Daoyang Fan Wenhao Zhou Xinhong Lin Huijie Leng Jian Li Xinyu Li Caimei Wang Yun Tian Zhongjun Liu | 2021 | Bioactive Materials2021，6，11： | 9 |
| 2 | Hierarchical Micropore/Nanorod Apatite Hybrids In-Situ Grown from 3-D Printed Macroporous Ti6Al4V Implants with Improved Bioactivity and Osseointegration显示文摘The advent of three-dimensional(3-D) printed technique provides great possibility in the fabrication of customized porous titanium(Ti) implant. However, the bioinert property of the printed Ti poses an outstanding problem. Hybrid micro-arc oxidation and hydrothermal(MAO–HT) treatment on porous metals is able to produce multi-scaled hierarchical orthopedic implant, showing great potential for surface modification of 3-D printed implant. In this study, cylindrical porous Ti6Al4V(Ti64) scaffolds with pore size of 640 μm, porosity of 73% were 3-D printed by electron beam melting process, and their surfaces were left untreated or treated by a combined MAO–HT procedure. In vitro bioactivity was tested by immersion in simulated body fluid for different time points. Then, 12 scaffolds in each group were implanted into the femoral condyles of New Zealand rabbit for 8 weeks. Osseointegration was evaluated by qualitative and quantitative histological analysis, and the bone ingrowth features were probed by sequential fluorescent labeling at 3 and 6 weeks post-surgery. Following the MAO–HT treatment, the porous Ti64 scaffold was endowed with multi-scaled micro/nano-topographies and high amounts of Ca P on its surface.The treated scaffold exhibited drastically enhanced apatite forming ability compared with the untreated one. In vivo test revealed significantly that a higher amount of bone ingrowth and bone implant contact at the treated scaffold. The 2 types of scaffolds had different patterns of bone ingrowth: the treated scaffold exhibited a pattern of contact osteogenesis, by which bone formed directly on the treated implant surface, whereas bone formed distal to the implant surface of the untreated scaffold. MAO–HT treatment can significantly enhance the in vitro apatite-inducing ability and in vivo osseointegration capacity of 3-D porous Ti64 scaffold and may provide as a viable approach for the fabrication of bioactive 3-D printed porous implant for orthopedic applications. | Peng Xiu Zhaojun Jia Jia Lv Chuan Yin Hong Cai Chunli Song Huijie Leng Yufeng Zheng Zhongjun Liu Yan Cheng | 2017 | Journal of Materials Science & Technology2017，33，2： | 2 |
| 3 | Surface treatment of 3D printed porous Ti6Al4V implants by ultraviolet photofunctionalization for improved osseointegration显示文摘Three-dimensional(3D)-printed porous Ti6Al4V implants play an important role in the reconstruction of bone defects.However,its osseointegration capacity needs to be further improved,and related methods are inadequate,especially lacking customized surface treatment technology.Consequently,we aimed to design an omnidirectional radiator based on ultraviolet(UV)photofunctionalization for the surface treatment of 3D-printed porous Ti6Al4V implants,and studied its osseointegration promotion effects in vitro and in vivo,while elucidating related mechanisms.Following UV treatment,the porous Ti6Al4V scaffolds exhibited significantly improved hydrophilicity,cytocompatibility,and alkaline phosphatase activity,while preserving their original mechanical properties.The increased osteointegration strength was further proven using a rabbit condyle defect model in vivo,in which UV treatment exhibited a high efficiency in the osteointegration enhancement of porous Ti6Al4V scaffolds by increasing bone ingrowth(BI),the bone-implant contact ratio(BICR),and the mineralized/osteoid bone ratio.The advantages of UV treatment for 3D-printed porous Ti6Al4V implants using the omnidirectional radiator in the study were as follows:1)it can significantly improve the osseointegration capacity of porous titanium implants despite the blocking out of UV rays by the porous structure;2)it can evenly treat the surface of porous implants while preserving their original topography or other morphological features;and 3)it is an easy-to-operate low-cost process,making it worthy of wide clinical application. | Chuan Yin Teng Zhang Qingguang Wei Hong Cai Yan Cheng Yun Tian Huijie Leng Caimei Wang Shiqing Feng Zhongjun Liu | 2022 | Bioactive Materials2022，7，1： | 2 |
| 4 | Characterization of the multiple CRISPR loci on Streptomyces linear plasmid pSHK1显示文摘包括 Streptomyces 线性 plasmid pSHK1 的新奇 telomere 顺序的完全的核苷酸顺序由 187,263-bp, 158 基因, 51 基因 Streptomyces coelicolor A3 (2 ) 的线性 plasmid SCP1 在类似于那些,和 20 基因组成编码 transposases。惊人地,重复 CRISPR (定期聚类短 palindromic 重复的 interspaced ) 并且 cas (联系 CRISPR ) 基因被发现包括八 cas 基因的簇,在顺序 cas2B-cas1B-cas3B-cas5-cas4-cas2A-cas1A-cas3A,被一双分叉的 CRISPR,和五另外的驱散的 CRISPR 括。cas2B-cas1B-cas3B-cas5 或 cas4-cas2A-cas1A 基因被共同抄录。在 Cas5 和 Cas1A 之间的 Proteinprotein 相互作用, 2A, 2B, 3B 被酵母检测二混血儿,为蛋白质建筑群的形成显示 Cas5 的一个关键角色。由聚合酶链反应和南部的杂交,线性 plasmids 上的包括三的 12 cas4 基因在 75 最新孤立的 Streptomyces 紧张之中被发现。paired-CRISPRs 和括的 cas 也在几另外的 Streptomyces 或放射菌类种类被保存。然而,在 pSHK1 的 CRISPRs-cas 不同于另外的细菌,不能对在 Streptomyces 包含特别分隔符的噬菌体 C31 和 plasmid 的介绍提供免疫。 | Peng Guo Qiuxiang Cheng Pengfei Xie Yun Fan Weihong Jiang Zhongjun Qi | 2011 | Acta Biochimica et Biophysica Sinica2011，43，8： | 1 |
| 5 | A putative transglycosylase encoded by SC04132 influences morphological differentiation and actinorhodin production in Streptomyces coelicolor显示文摘这里,我们报导那 tgdA,编码通常认为的 transglycosylase 的新奇基因,在 Streptomyces coelicolor 影响词法区别和蓝颜料的复合 actinorhodin 的收益。tgdA 0 异种显示稀少的天线 hyphae 和经常缺乏 chromosomal DNA 的不规则的孢子链。提高的 actinorhodin 生产在异种与 actII-orf4 的 overexpression 与一致。tgdA 表示时间地并且发展地被调整。在 Streptomyces avermilitis 和 Streptomyces lividans 的 tgdA orthologs 也影响区别。 | Pengfei Xie Ana Zeng Xiaoting Lv Qiuxiang Cheng Zhongjun Qin | 2013 | Acta Biochimica et Biophysica Sinica2013，45，4： | 1 |
| 6 | Preparation and magnetic properties of Y3Fe3O12 nanoparticles doped with the gadolinium oxide显示文摘 | Cheng Zhongjun Yang Hua Yu Lianxiang | 2006 | J Magn Magn Mater2006，302，： | 1 |
| 7 | Current treatment paradigm and survival outcomes among patients with newly diagnosed multiple myeloma in China:a retrospective multicenter study显示文摘Objective:Evidence on the prognostic value of autologous stem cell transplantation(ASCT)and minimal residual disease(MRD)dynamics of patients with newly diagnosed multiple myeloma(NDMM)in China is limited.Our objective in the current study was to understand the current care paradigm and outcomes of these patients.Methods:This longitudinal cohort study used historical data from three top-tier hematologic disease care hospitals that contributed to the National Longitudinal Cohort of Hematological Diseases-Multiple Myeloma.Treatment regimens[proteasome inhibitor(PI)-,immunomodulatory drug(IMiD)-,PI+IMiD-based,and conventional],post-induction response,ASCT and MRD status,and survival outcomes[progression-free survival(PFS)and overall survival(OS)]were evaluated.Results:In total,454 patients with NDMM were included(median age,57 years;59.0%males)with a median follow-up of 58.7 months.The overall response rate was 91.0%,83.9%,90.6%,and 60.9%for PI-,IMiD-,PI+IMiD-based,and conventional regimens,respectively.Patients with ASCT during first-line therapy(26.2%)had a longer PFS and OS than patients who did not receive ASCT[median PFS,42.9 vs.21.2 months,P<0.001;median OS,not reached(NR)vs.65.8 months,P<0.001].The median OS was NR,71.5,and 56.6 months among patients with sustained MRD negativity,loss of MRD negativity,and persistent MRD,respectively(P<0.001).Multivariate analysis revealed that the lactic dehydrogenase level,International Staging System stage,extra-medullary disease,and upfront ASCT were independent factors in predicting OS among NDMM patients.Conclusions:Our study showed that novel agent-based regimens,first-line ASCT,and sustained MRD negativity were associated with a superior outcome for patients with NDMM in China(Identifier:NCT04645199). | Huishou Fan Weida Wang Ya Zhang Jianxiang Wang Tao Cheng Lugui Qiu Xin Wang Zhongjun Xia Gang An | 2023 | Cancer Biology & Medicine2023，20，1： | 1 |
| 8 | Smart Multiple Wetting Control on ZnO Coated Shape Memory Polymer Arrays显示文摘Recently,surfaces with intelligent wetting controllability have aroused increased attention.Endowing the surface with stimuli-responsive surface chemistry and tunable surface microstructure can achieve a surface with smart wetting performances.However,almost all existing surfaces only focused on single surface chemistry or micromorphology,thus to achieve smart multiple wetting regulation is still difficult.Herein,we report a ZnO coated shape memory polymer(SMP)surface,and the surface chemistry and micromorphology can be synergistically regulated.ZnO can provide adjustable surface chemistry under UV irradiation,and SMP can offer tunable micromorphology due to its shape memory effect(SME).Based on the combined effect between the above two features,surface wetting performance can be smartly regulated among multiple states.Moreover,due to the excellent controllability of the surface,the application in directional droplet transportation was also demonstrated.This paper offers a new surface with tunability in both surface chemistry and micromorphology,and given the excellent wetting controllability,the surface is believed to be applied in a lot of fields,such as droplet manipulation,fluidic devices and selective catalysis. | WANG Xiaonan WANG Bohan LAI Hua CHENG Zhongjun | 2023 | Chemical Research in Chinese Universities2023，39，1： | 0 |
| 9 | Investigating evolutionary perspective of carcinogenesis with single-cell transcriptome analysis显示文摘We developed phase-switch microfluidic devices for molecular profiling of a large number of single cells.Whole genome microarrays and RNA-sequencing are commonly used to determine the expression levels of genes in cell lysates(a physical mix of millions of cells)for inferring gene functions.However,cellular heterogeneity becomes an inherent noise in the measurement of gene expression.The unique molecular characteristics of individual cells,as well as the temporal and quantitative information of gene expression in cells,are lost when averaged among all cells in cell lysates.Our single-cell technology overcomes this limitation and enables us to obtain a large number of single-cell transcriptomes from a population of cells.A collection of single-cell molecular profiles allows us to study carcinogenesis from an evolutionary perspective by treating cancer as a diverse population of cells with abnormal molecular characteristics.Because a cancer cell population contains cells at various stages of development toward drug resistance,clustering similar single-cell molecular profiles could reveal how drug-resistant subclones evolve during cancer treatment.Here,we discuss how single-cell transcriptome analysis technology could enable the study of carcinogenesis from an evolutionary perspective and the development of drugresistance in leukemia.The single-cell transcriptome analysis reported here could have a direct and significant impact on current cancer treatments and future personalized cancer therapies. | Xi Zhang Cheng Zhang Zhongjun Li Jiangjian Zhong Leslie P.Weiner Jiang F.Zhong | 2013 | Chinese Journal of Cancer2013，32，12： | 0 |
| 10 | Geological context and vents morphology in the ultramafic-hosted Tianxiu field, Carlsberg Ridge显示文摘The Tianxiu hydrothermal field(TXHF) located on Carlsberg Ridge is one of the few active ultramafic-hosted venting systems known in the Indian Ocean. Despite numerous investigations, there is limited understanding of its sulfide structure morphology, and the factors controlling the formation of TXHF are poorly understood. In this study, we conducted detailed seafloor mapping using visual data obtained by dives using the human-occupied vehicle(HOV) Jiaolong. The TXHF is found to be an active, off-axis, ultramafic-hosted, high-temperature hydrothermal area in which serpentine peridotite is exposed. Two main hydrothermal sites were identified, i.e., P and Y, both of which feature a complex of chimneys and beehive diffusers constituting a “chimney jungle” and isolated large steep-sided structures developed on flat-lying sulfide mounds. In addition, some sporadic inactive chimneys and outcrops of hydrothermal deposits were noted. The chimneys are rich in Fe and Zn sulfide, and lack the central fluid channel formed by focused high-temperature fluid flow. Hydrothermal venting at TXHF is likely related to low-angle detachment faults that focus and transport hydrothermal fluids away from a heat source along the valley wall. Our results complement and expand upon previous works concerning sulfide chimney morphology and their corresponding mineral paragenesis in ultramafic-hosted hydrothermal systems in the Indian Ocean and further our understanding of modern seafloor hydrothermal systems. | Jin Liang Chunhui Tao Xiangxin Wang Cheng Su Wei Gao Yadong Zhou Weikun Xu Xiaohe Liu Zhongjun Ding | 2023 | Acta Oceanologica Sinica2023，42，9： | 0 |
| 11 | Fabrication of ulcer-adhesive oral keratin hydrogel for gastric ulcer healing in a rat显示文摘Hydrogel has been used for in suit gastric ulcer therapy by stopping bleeding,separating from ulcer from gastric fluids and providing extracellular matrix scaffold for tissue regeneration,however,this treatment guided with endoscopic catheter in most cases.Here,we developed an oral keratin hydrogel to accelerate the ulcer healing without endoscopic guidance,which can specially adhere to the ulcer because of the high-viscosity gel formation on the wound surface in vivo.Approximately 50%of the ulcer-adhesive keratin hydrogel can resident in ethanol-treated rat stomach within 12 h,while approximately 18%of them maintained in health rat stomach in the same amount of time.Furthermore,Keratin hydrogels accelerated the ethanol-induced gastric ulcer healing by stopping the bleeding,preventing the epithelium cells from gastric acid damage,suppressing inflammation and promoting re-epithelization.The oral administration of keratin hydrogel in gastric ulcer treatment can enhance the patient compliance and reduce the gastroscopy complications.Our research findings reveal a promising biomaterial-based approach for treating gastrointestinal ulcers. | Zhongjun Cheng Rui Qing Shilei Hao Yi Ding Haimeng Yin GuoDong Zha Xiaoliang Chen Jingou Ji Bochu Wang | 2021 | Regenerative Biomaterials2021，8，2： | 0 |
| 12 | A High Gain, Noise Cancelling 2515-4900 MHz CMOS LNA for China Mobile 5G Communication Application显示文摘With the development of the times,people’s requirements for communication technology are becoming higher and higher.4G communication technology has been unable to meet development needs,and 5G communication technology has emerged as the times require.This article proposes the design of a low-noise amplifier(LNA)that will be used in the 5G band of China Mobile Communications.A low noise amplifier for mobile 5G communication is designed based on Taiwan Semiconductor Manufacturing Company(TSMC)0.13μm Radio Frequency(RF)Complementary Metal Oxide Semiconductor(CMOS)process.The LNA employs self-cascode devices in current-reuse configuration to enable lower supply voltage operation without compromising the gain.This design uses an active feedback amplifier to achieve input impedance matching,avoiding the introduction of resistive negative feedback to reduce gain.A common source(CS)amplifier is used as the input of the low noise amplifier.In order to achieve the low power consumption of LNA,current reuse technology is used to reduce power consumption.Noise cancellation techniques are used to eliminate noise.The simulation results in a maximum power gain of 22.783,the reverse isolation(S12)less than-48.092 dB,noise figure(NF)less than 1.878 dB,minimum noise figure(NFmin)=1.203 dB,input return loss(S11)and output return loss(S22)are both less than-14.933 dB in the frequency range of 2515-4900 MHz.The proposed Ultra-wideband(UWB)LNA consumed 1.424 mW without buffer from a 1.2 V power supply. | Xiaorong Zhao Weili Cheng Hongjin Zhu Chunpeng Ge Gengyuan Zhou Zhongjun Fu | 2020 | Computers, Materials & Continua2020，，8： | 0 |
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