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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 3 | Anti-N-methyl-D-aspartate receptor encephalitis that aggravates after acinetobacter baumannii pneumonia:A case report显示文摘We report an atypical case of anti-N-methyl-D-aspartate receptor encephalitis(ANMDARE). A 27-year-old man diagnosed with ANMDARE received immunotherapy and had a good recovery. However, within one month, he developed severe status epilepticus and decreased level of conscience with new hyperpyrexia and dyspnea, and was admitted to the emergency intensive care unit. Acinetobacter baumanii were found in the sputum culture; and anti-NMDAR antibodies were positive(titer: 1/80) in the cerebrospinal fluid. Repeated immunotherapy was administered with antibacterial agents, and the patient recovered except for mild psychiatric sequelae. This is the first report of ANMDARE that aggravates after acinetobacter baumannii pneumonia. Awareness and knowledge of this disorder should be extended, especially in the emergency medicine community. | Cheng C Wang Da J Li Yi Q Xia Kai Liu | 2017 | World Journal of Clinical Cases2017，5，9： | 3 |
| 4 | Genetic transformation of wheat mediated by Agrobacterium tumefaciens显示文摘 | Cheng M Fry J E Pang S Zhou H Hironaka C M Duncan D R Conner T W Wan Y | 1997 | Plant Physiol1997，，： | 2 |
| 5 | Effect of saikosaponin, a triterpene saponin, on apoptosis in lymphocytes: association with c-myc, p53, and bc1-2 mRNA 显示文摘 | Hsu M J Cheng J S Huang H C | 2000 | Br J Pharmacol2000，131，7： | 2 |
| 6 | Effects of the phase-separated melt on crystallization behavior and morphology in short chain branched metallocene polyethylenes显示文摘 | Fu Q Chiu F C McCreight K W Guo M Tseng W W Cheng S Z Keating M Y Hsieh E T and DesLauriers P J | | 0，，： | 2 |
| 7 | A micromachined high-Q x-band resonator显示文摘 | J C Cheng | 1997 | IEEE Microwave Guided Wave Letters1997，7，6： | 1 |
| 8 | Efficacy and safety of sorafenib in patients in the Asia Pacific region with advanced hepatocellular carcinoma: a phase Ⅲ randomised,double-blind, placebo controlled trial显示文摘 | Cheng A L Kang Y K Chen Z Tsao C J Qin S Kim J S | 2009 | Lancet Oncol2009，10，： | 1 |
| 9 | Seismic performance of repaired hollow - bridge piers显示文摘 | Cheng C T Yang J C Yeh Y K | 2003 | Construction and Building Material2003，17，： | 1 |
| 10 | Immobilizationof RGD peptide on HA coating through a chemical bondingapproach显示文摘 | YANG C L CHENG K WENG W J | 2009 | Journal of Materials Science:Materials in Medi-cine2009，20，11： | 1 |
| 11 | Isolation and characterization of an Enterococcus - like bacterium causing musclen ecrosis and mortality in Macrobrachium rosenbergii in Taiwan显示文摘 | Cheng W T Chen J C | 1998 | Diseases of Aquatic Organisms1998，34，2： | 1 |
| 12 | The application of competitive hopfield neural network to medical image segmentation显示文摘 | CHENG K S LIN J S MAO C W | 1996 | IEEE T Med Imaging1996，15，4： | 1 |
| 13 | Expression of cyclooxygenase-2 in prostate adenocarcinoma and benign prostatic hyperplasia 显示文摘 | Lee LM Pan C C Cheng C J | 2001 | Anticancer Res2001，21，： | 1 |
| 14 | Protection from Fas-mediated apoptosis by a soluble form of the Fas molecule显示文摘 | Cheng J Zhou T Liu C | 1994 | Science1994，263，5154： | 1 |
| 15 | Emergence of excitotoxicity in cultured forebrain neurons coincides with larger glutamate-stimulated i increases and NMDA receptor mRNA levels显示文摘 | CHENG C FASS D M REYNOLDS I J | 1999 | Brain Res1999，849，12： | 1 |
| 16 | Degradation of azo dye procion red by photocatalytic oxidation 显示文摘 | So C Cheng M Yu J | 2002 | Chemosphere2002，46，6： | 1 |
| 17 | Comparison of strain-rate dependent stress-strain behavior from K0-consolidated compression and Extension tests on natural Hong Kong marine deposits显示文摘 | YIN J H CHENG C M | 2006 | Marine Georesouces and Geotechnology2006，24，： | 1 |
| 18 | Accurate error- rate performance analysis of OFDM on frequency-se- lective Nakagami-m fading channels显示文摘 | DU Z CHENG J L BEAULIEU N C | 2006 | IEEE Trans Commun2006，54，2： | 1 |
| 19 | Common due- window assignment and scheduling of linear time- dependent deteriorating jobs and a deteriorating maintenance activity 显示文摘 | Cheng T C E Yang S J Yang D L | 2012 | International Journal of Production Economics2012，135，1： | 1 |
| 20 | Cellular differentiation regulated by gibberellin in the Arabidopsis thaliana picklemutant显示文摘 | Ogas J Cheng J C Sung Z R | 1997 | Science1997，277，： | 1 |
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