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| 1 | Prevalence and virological profiles of hepatitis B infection in human immunodeficiency virus patients显示文摘AIM: To determine the prevalence of hepatitis B virus (HBV) in adult human immunodeficiency virus (HIV) patients with CD4+ T-cell count less than 500/mm 3 and without antiretroviral therapy; to describe different HBV-HIV coinfection virological profiles; and to search for factors associated with HBs antigen (HBsAg) presence in these HIV positive patients.METHODS: During four months (June through September 2006), 491 patients were received in four HIV positive monitoring clinical centers in Abidjan. Inclusion criteria: HIV-1 or HIV-1 and 2 positive patients, age ≥ 18 years, CD4+ T-cell count < 500/mL and formal and signed consent of the patient. Realized blood tests included HIV serology, CD4+ T-cell count, quantitative HIV RNA load and HBV serological markers, such as HBsAg and HBc antibody (anti-HBcAb). We performed HBeAg, anti-HBe antibody (anti-HBeAb), anti-HBc IgM and quantitative HBV DNA load in HBsAg positive patients. Anti-HBsAb had been tested in HIV patients with HBsAg negative and anti-HBcAb-positive. HBV DNA was also tested in 188 anti-HBcAb positive patients with HBsAg negative status and without anti-HBsAb. Univariate analysis (Pearsonχ 2 test or Fischer exact test) and multivariate analysis (backward step-wise selection logistic regression) were performed as statistical analysis. RESULTS: Mean age of 491 patients was 36 ± 8.68 years and 73.3% were female. Type-1 HIV was found in 97% and dual-type HIV (type 1 plus type 2) in 3%. World Health Organization (WHO) clinical stage was 1, 2, 3 and 4 respectively in 61 (12.4%), 233 (47.5%), 172 (35%) and 25 patients (5.1%). Median CD4+ T-cell count was 341/mm 3 (interquartile range: 221-470). One hundred and twelve patients had less than 200 CD4+ T-cell/mm 3 . Plasma HIV-1 RNA load was elevated (≥ 5 log 10 copies/mL) in 221 patients (45%). HBsAg and anti-HBcAb prevalence was respectively 13.4% and 72.9%. Of the 66 HBsAg positive patients, 22 were inactive HBV carriers (33.3%), 21 had HBeAg positive hepatitis (31.8%) and 20 had HBeAg negative hepatitis (30.3%). HBeAg and anti-HBeAb were indeterminate in 3 of them. Occult B infection prevalence (HBsAg negative, anti-HBcAb positive, anti-HBsAb negative and detectable HBV DNA) was 21.3%. Three parameters were significantly associated with the presence of HBsAg: male [odds ratio (OR): 2.2;P = 0.005; 95% confidence interval (CI): 1.3-3.8]; WHO stage 4 (OR: 3.2;P = 0.01;95% CI: 1.3-7.9); and aspartate aminotransferase (AST) level higher than the standard (OR: 1.9;P = 0.04; 95% CI: 1.02-3.8). CONCLUSION: HBV infection prevalence is high in HIV-positive patients. HBeAg positive chronic hepatitis and occult HBV infection are more frequent in HIVpositive patients than in HIV negative ones. Parameters associated with HBsAg positivity were male gender, AIDS status and increased AST level. | Koffi Alain Attia Serge Eholié Eugène Messou Christine Danel Sandrine Polneau Henri Chenal Thomas Toni Myreille Mbamy Catherine Seyler Naomi Wakasugi Thérèse N'dri-Yoman Xavier Anglaret | 2012 | World Journal of Hepatology2012，4，7： | 4 |
| 2 | Type IIIsecretion effectors of the IpaH family are E3 ubiquitinligases 显示文摘 | Rohde J R Breitkreutz A Chenal A | 2007 | Cell Host Microbe2007，1，1： | 1 |
| 3 | Dependence of the phase separation process on the relative onset of network formation in simultaneous interpenetrating polymer networks显示文摘 | Jeanmichel Widmaier Alexandra Nilly Jeanmarc Chenal | 2005 | Polymer2005，46，10： | 1 |
| 4 | Membrane protein insertion regulated by bringing electrostatic and hydrophobic interactions into play显示文摘 | Chenal A Savarin P Nizard P | | 0，，45： | 1 |
| 5 | Interaction between the two subdomains of the C-terminal part of the betulinum neurotoxin A is essential for the generation of protective antibodies 显示文摘 | Tavallaie M Chenal A Gillet D | 2004 | FEBS2004，572，： | 1 |
| 6 | Determination of the degree of charge-transfer contributions to surface-enhanced Raman spectroscopy显示文摘 | Chenal C Birke R L Lombardi J R | 2008 | Chemphyschem2008，9，11： | 1 |
| 7 | Ionizing radiation:Advances in plant response显示文摘 | Esnault M A Legue F Chenal C | 2010 | Environmental and Experimental Botany2010，68，3： | 1 |
| 8 | Dependence of the phase separation process on the relative onset of network formation in simultaneous interpenetrating polymer networks 显示文摘 | WIDMAIER J M NILLY A CHENAL J M | 2005 | Polymer2005，46，10： | 1 |
| 9 | Dependence of the phase separation process on the relative onset of network formation in simultaneous interpenetrating polymer networks 显示文摘 | Widmaier J M Nilly A Chenal J M | 2005 | Polymer2005，46，10： | 1 |
| 10 | Grafted lanthanide amides : versatile catalysts for various transformations 显示文摘 | GAUVIN R M CHENAL T RAHMA A H | 2006 | Journal of Molecular Catalysis A: Chemical2006，257，1： | 1 |
| 11 | Type Ⅲ secretion effectors of the IpaH family are E3 ubiquitin ligases显示文摘 | Rhode JR Breitkreutz A Chenal A | 2007 | Cell Host Microbe2007，1，1： | 1 |
| 12 | Dependence of the phase separation process on the relative onset of network formation in simultaneous interpenetrating polymer networks显示文摘 | Widmaier J M Nilly A Chenal J M | 2005 | Polymer2005，46，10： | 1 |
| 13 | Increased levels of IL 5 are associated with generation of eosinophilia in drug-induced hypersensitivity syndrome显示文摘 | Choquet-Kastylevsky G Intrator L Chenal C | | 0，，： | 1 |
| 14 | Increased levels of interleukin 5 are associated with the generation of eosinophilia in drug-induced hypersensitivity syndrome显示文摘 | Choquet-Kastylevsky G Intrator L Chenal C | | 0，，06： | 1 |
| 15 | DFT,SERS,and Single-Molecule SERS of Crystal Violet显示文摘 | Canamares MV Chenal C Birke R L | 2008 | J Phys Chem C2008，112，20： | 1 |
| 16 | Rare Earth Alkoxides as Inorganic Precursors for Olefin Polymerization:An Alternative to Traditional Lanthanocene Chemistry 显示文摘 | GROMADA J CHENAL T NORTREUX A | 2000 | Chem Commun2000，，22： | 1 |
| 17 | Controlled polyethylene chain growth on magnesium catalyzed by lanthanidocene : A living transfer polymerization for the synthesis of higher dialkyl-magnesium 显示文摘 | Chenal T Olonde X Jean-Francois P | 2007 | Polymer2007，48，： | 1 |
| 18 | Type III secretioneffectors of the IpaH family are E3 ubiquitin ligases显示文摘 | Rohde J R Breitkreutz A Chenal A | 2007 | CellHost Microbe2007，1，1： | 1 |
| 19 | First peptide/protein PEGylation with functional polymers designed by nitroxide-mediated polymerization显示文摘 | Chenal M Boursier C Guillaneuf Y | 2011 | Polym Chem2011，2，7： | 1 |
| 20 | Dependence of the phase separation process on the relative onset of network formation in simultaneous interpenetrating polymer networks显示文摘 | Alexandra Nilly Jean-Marc Chenal | 2005 | polymer2005，46，： | 1 |
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