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| 1 | 小胶质细胞对星形胶质细胞的免疫和神经保护功能的调节作用(英文)显示文摘在中枢神经系统中,小胶质细胞和星形胶质细胞对神经元的发育、功能维持及细胞存活具有重要的作用。但在炎症反应过程中,星形胶质细胞增生的作用及其对神经元的影响目前并不十分清楚。因此,本研究对不同种类的细胞进行培养,给予细菌脂多糖(lipopolysaccharide,LPS)刺激,观察各种细胞的反应。结果显示,星形胶质细胞可以减轻炎症反应的神经元毒性,提示星形胶质细胞增生主要具有神经保护作用。如果去掉上清液中由星形胶质细胞分泌的胶质细胞源性神经营养因子(glial cell line-derived neurotrophic factor,GDNF),这种神经保护作用显著降低。为了研究星形胶质细胞的免疫功能,本研究培养了高浓度的星形胶质细胞,并发现LPS不能诱导肿瘤坏死因子(tumor necrosis factor,TNF)-α及诱导型一氧化氮合酶(inducible nitric oxide synthase,iN OS)/一氧化氮(nitric oxide,NO)(iN OS/NO)释放。但如果在培养的高浓度星形胶质细胞中增加0.5%~1%的小胶质细胞,则可以诱导TNF-α及iN OS/NO的释放。这提示小胶质细胞和星形胶质细胞间的相互作用对于LPS诱导星形胶质细胞释放前炎症因子及GDNF是必须的。我们还发现,小胶质细胞释放的TNF-α可以通过旁分泌作用调节星形胶质细胞的神经保护功能。综上所述,本研究结果提示星形胶质细胞可能不会直接被LPS激活,而是通过与小胶质细胞相互作用被激活,释放神经营养因子,减少因炎症反应激活的小胶质细胞释放的毒性物质对神经元的损害作用。 | Chen SH Oyarzabal EA Sung YF Chu CH Wang Q Chen SL Lu RB Hong JS 唐颖馨 | 2015 | 神经损伤与功能重建2015，10，1： | 9 |
| 2 | Effects of partial portal vein arterialization on the hilar bile duct in a rat model显示文摘BACKGROUND: Liver revascularization is frequently required during the enlarged radical operation for hilar cholangio carcinoma involving the hepatic artery. Researchers have carried out a number of experiments applying partial porta vein arterialization (PVA) in clinical practice. In this study we aimed to establish a theoretical basis for clinical application o partial PVA and to investigate the effects of partial PVA on ra hilar bile duct and hepatic functions. METHODS: Thirty rats were randomly and equally assigned into 3 groups: control (group A), hepatic artery ligation+bile duct recanalization (group B), and partial PVA+bile duc recanalization (group C). Proliferation and apoptosis o rat hilar bile duct epithelial cells, arteriolar counts of the peribiliary plexus (PBP) of the bile duct wall, changes in serum biochemistry, and pathologic changes in the bile duc were assessed 1 month after operation. RESULTS: The proliferation of hilar bile duct epithelial cells in group B was greater than in groups A and C (P<0.01). No apoptotic hilar bile duct epithelial cells were detected in any of the groups. The PBP arteriolar counts of the hilar bile duc wall were similar in groups A and C (P>0.05), but the coun was lower in group B than in group A (P<0.01). No statistically significant differences in alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and albumin were found in the 3 groups. The gamma-glutamyltransferase value was higher in group B than in groups A and C (P<0.01) The hepatic tissues of groups A and C showed no significan abnormality. Chronic inflammatory changes in the hilar bile duct walls were observed only in group B. CONCLUSION: Partial PVA can restore the arterial blood supply of the hilar bile duct and significantly extenuate the injury to hilar bile duct epithelial cells resulting from hepatic artery ligation. | Shao-Hua Guo, Chong-Hui Li,Yong-Liang Chen, Jian-Ning Song,Ai-Qun Zhang and Cheng Zhou Department of Hepatobiliary Surgery (Guo SH, Li CH, Chen YL, Song JN, Zhang AQ and Zhou C) and Department of Surgical Oncology (Guo SH), General Hospital of PLA, Beijing 100853, China | 2011 | Hepatobiliary & Pancreatic Diseases International2011，10，5： | 8 |
| 3 | Seroepidemiology of Helicobacter pylori infection among asymptomatic Chinese children显示文摘INTRODUCTIONIncreasing data has demonstrated that Helicobacterpylori(H.pylori),a spiral gram negativebacterium,colonized in human stomach,can causetype B gastritis,is strongly associated withgastric and duodenal ulceration,and has beenimplicated in the causation of gastric carcinomaand mucosa-associated lymphoid tissue(MALT)lymphomas.It has been reported that there | Xu CD Chen SN Jiang SH Xu JY | 2000 | World Journal of Gastroenterology2000，6，5： | 6 |
| 4 | Phase Relations in TiAl+Nb System显示文摘The microstructures and phases of ternary TiAl+Nb alloys containing 50-60 at.-%Al, 0-21 at.-%Nb have been studied using transmission electron microscopy (TEM) and X-ray powder diffraction. The phases present in the alloys and their distribution were found to be a sensitive function of composition. The phase relations between γ-TiAl and γ1 (a new ordered ternary intermetallic compound based on γ-TiAl) were determined. Essentially single γ phase was determined for alloys with relativety low Nb content (≤10 at.-%Nb). the γ1 phase was determined to exist in the composition range containing higher Nb contents (15-21 at.-%Nb). Between γ and γ1 phases, with intermediate Nb contents there is a transitional phase γ1 (a superstructure of γ-TiAl). As for the influence of Al concentration on the phase relations. the γ1 phase was inclined to form in the alloys with relatively high Al contents. The ordering transformation of γ, to γ1 is a continuous ordering process and the transition may be second order. | Jingguo WANG Guoliang CHEN and Zuqing SUN (State Key Lab. for Advanced Metal Materials, University of Science and Technology Beijing, Beijing, 100083, China)Hengqiang YE (Lab. of Atomic Imaging of Solids, Institute of Metal Research, Academia Sinica, Sh | 1994 | Journal of Materials Science & Technology1994，10，5： | 3 |
| 5 | Synthesis and Characterization of Nanocrystalline Ni-Ti and Ni-Cr Powders by Mechanical Alloying显示文摘Nanocrystalline powders in the Ni-Ti and Ni-Cr systems were prepared by mechanical alloying (MA) of elemental crystalline powders in an inert atmosphere. The microstructure of the mechanically alloyed powders were characterized by XRD and TEM. The ball-milling process results in a drastic decrease of the crystallite size to the nanometer scale. X-ray diffraction analysis reveals that in the Ni-Cr system, no diffraction peaks from NiCr compound were observed even after 20 h of ball milling; while the lattice parameter of Ni increased with the milling time. In the Ni-Ti system, amorphous alloy was formed. Crystalline intermetallic compounds were obtained by post heat treatment of the amorphous alloy.The crystallization temperature of the amorphous NiTi alloy was obtained be DSC measurement. | Chen, SQ Zhou, YC Li, YY He, SH | 1997 | Journal of Materials Science & Technology1997，13，2： | 2 |
| 6 | A Multicenter Application and Evaluation of the Oxford Classification of IgA Nephropathy in Adult Chinese Patients显示文摘 | Cai-Hong Zeng Weibo Le Zhaohui Ni Minfang Zhang Lining Miao Ping Luo Rong Wang Zhimei Lv Jianghua Chen Jiong Tian Nan Chen Xiaoxia Pan Ping Fu Zhangxue Hu Lining Wang Qiuling Fan Hongguang Zheng Dewei Zhang Yaping Wang Yanhong Huo Hongli Lin Shuni Chen Sh | 2012 | American Journal of Kidney Diseases2012，，5： | 2 |
| 7 | Bcl-2 family gene products in cerebral ischemia and traumatic brain injury显示文摘 | Graham SH Chen J Clark RS | 2000 | J Neurotrauma2000，17，10： | 2 |
| 8 | Potential dengue virus-triggered apoptotic pathway in human neuroblastoma cells: arachidonic acid,superoxide anion, and NF-kappa B are sequentially involved显示文摘 | Jan JT Chen BH Ma SH | 2000 | Virol2000，74，： | 1 |
| 9 | Gr-1+ myeloid cells derived from tumor-bearing mice inhibit primary T cell activation induced through CD3/CD28 costimulation显示文摘 | Kusmartsev SA Li Y Chen SH | 2000 | J Immunol2000，165，2： | 1 |
| 10 | CuO impregnated activated carbon for catalytic wet peroxide oxidation of phenol显示文摘 | Liou RM Chen SH | 2009 | Journal of Hazardous Materi- als2009，172，1： | 1 |
| 11 | Vascularized toe joint transplantation显示文摘 | Chen SH Wei FC Chen HC | 1999 | Hand Clin1999，15，4： | 1 |
| 12 | Intradiseal pressure study of percutaneous disc decompression with nucleoplasty in human cadavers 显示文摘 | Chen YC Lee SH Chen D | 2003 | Spine2003，28，7： | 1 |
| 13 | Comparisons of propafenone and sotalol as an initial treatment in patients with symptomatic paroxysmal atrial fibrillation显示文摘 | Lee SH Chen SA Tai CT | 1997 | Am J Cardiol1997，79，： | 1 |
| 14 | Cloned pigs produced by nuclear transfer from adult somatic cells显示文摘 | Polejaeva IA Chen SH Vaught TD | 2000 | Nature2000，407，6800： | 1 |
| 15 | Inhibitory actions of MCI-154 on guinea-pig femoral artery and vein preparations显示文摘 | Suh SH Chen G Xue L Zhang G Yamamoto Y Suzuki H | 1992 | Eur J Pharmacol1992，219，3： | 1 |
| 16 | Identification and characterization of an Escherichia coli invasion gene locus, ibeB, required for penetration of brain microvascular endothelial cells 显示文摘 | Huang SH Chen YH Fu Q | 1999 | Infect Immun1999，67，5： | 1 |
| 17 | Nanostructured vanadium dioxide thin films with low phase transition temperature 显示文摘 | CHEN SH MA H DAI J | 2007 | Applied Physics Letters2007，90，0： | 1 |
| 18 | Video-assisted thoracoscopic surgery managing tuberculous spondylitis显示文摘 | Huang TJ Hsu RW Chen SH | 2000 | Clin orthop2000，379，9： | 1 |
| 19 | Papillary thyroid carcinoma on sonography显示文摘 | Li QS Chen SH Xiong HH | 2010 | Clin Imaging2010，34，2： | 1 |
| 20 | Cataract surgery and diabetes 显示文摘 | Shah As Chen SH | 2010 | Curt 0pin 0phthalmol2010，21，： | 1 |
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