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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 3 | Cognitive disorder and dementia in type 2 diabetes mellitus显示文摘Insulin,a key pleiotropic hormone,regulates metabolism through several signaling pathways in target tissues including skeletal muscle,liver,and brain.In the brain,insulin modulates learning and memory,and impaired insulin signaling is associated with metabolic dysregulation and neurodegenerative diseases.At the receptor level,in aging and Alzheimer’s disease(AD)models,the amount of insulin receptors and their functions are decreased.Clinical and animal model studies suggest that memory improvements are due to changes in insulin levels.Furthermore,diabetes mellitus(DM)and insulin resistance are associated with age-related cognitive decline,increased levels ofβ-amyloid peptide,phosphorylation of tau protein;oxidative stress,pro-inflammatory cytokine production and dyslipidemia. Recent evidence shows that deleting brain insulin receptors leads to mildobesity and insulin resistance without influencing brain size and apoptosis development.Conversely, deleting insulin-like growth factor 1 receptor (IGF-1R) affects brain size anddevelopment, and contributes to behavior changes. Insulin is synthesized locally in the brain andis released from the neurons. Here, we reviewed proposed pathophysiological hypotheses toexplain increased risk of dementia in the presence of DM. Regardless of the exact sequence ofevents leading to neurodegeneration, there is strong evidence that mitochondrial dysfunctionplays a key role in AD and DM. A triple transgenic mouse model of AD showed mitochondrialdysfunction, oxidative stress, and loss of synaptic integrity. These alterations are comparable tothose induced in wild-type mice treated with sucrose, which is consistent with the proposal thatmitochondrial alterations are associated with DM and contribute to AD development. Alterationsin insulin/IGF-1 signaling in DM could lead to mitochondrial dysfunction and low antioxidantcapacity of the cell. Thus, insulin/IGF-1 signaling is important for increased neural processing andsystemic metabolism, and could be a specific target for therapeutic strategies to decreasealterations associated with age-related cognitive decline. | Genaro G Ortiz Miguel Huerta Héctor A González-Usigli Erandis D Torres-Sánchez Daniela LC Delgado-Lara Fermín P Pacheco-Moisés Mario A Mireles-Ramírez Blanca MG Torres-Mendoza Roxana I Moreno-Cih Irma E Velázquez-Brizuela | 2022 | World Journal of Diabetes2022，13，4： | 2 |
| 4 | Open reduction and interfragmentary screw fixation for symptomatic nonunion of distal phalangeal fractures显示文摘 | Chim H Teoh LC Yong FC | 2008 | J Hand Surg Eur2008，33，： | 1 |
| 5 | Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation 显示文摘 | Lu H Kraut D Gerstenfeld LC | 2003 | Endocrinology2003，144，1： | 1 |
| 6 | Molecular epidemiol- ogy of enteroviras 71 in Taiwan 显示文摘 | Chu PY Lin KH Hwang KP Chou LC Wang CF Shih SR Wang JR Shimada Y lshiko H | 2001 | Arch Virol2001，146，3： | 1 |
| 7 | Predictive value of DNA cy- tometry in CIN I and II :image analysis of 193 cases显示文摘 | Herring B Horn LC Nanning H | 2000 | Anal Quant Citole Pistol2000，22，2： | 1 |
| 8 | Oxidative stress and a key metabolic enzyme in Alzheimer brains, cultured cells, and an ani- mal model of chronic oxidative deficits 显示文摘 | Gibson GE Park LC Zhang H | 1999 | Ann N Y Acad Sci1999，893，： | 1 |
| 9 | Oxidative stress and diabetesmellitus显示文摘 | Yang H Jin X Kei LC | 2011 | Clin Chem Lab Med2011，49，11： | 1 |
| 10 | Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer 显示文摘 | Zhang H Stephens LC Kumar R | 2006 | Clinical Cancer Research2006，12，5： | 1 |
| 11 | Cytochrome P450 1B1 is overexpressed and regulated by hypomethylation in prostate cancer显示文摘 | Tokizane T Shiina H Igawa M Enokida H Urakami S Kawakami T Ogishima T Okino ST Li LC Tanaka Y Nonomura N Okuyama A Dahiya R | 2005 | Clin Cancer Res2005，11，16： | 1 |
| 12 | US appearance of ductal carcinoma in situ显示文摘 | Wang LC Sullivan M Du H | 2013 | Radiographics2013，33，1： | 1 |
| 13 | Angiotensin Ⅱ hyperten sion is attenuated in interleukin-6 knockout mice显示文摘 | Lee DL Sturgis LC Labazi H | 2006 | Am J Physiol Heart Circ Physiol2006，290，3： | 1 |
| 14 | Reliability and validity ofa Chinese version of the multidimensional fatigue symptominventory-short form (MFSI-SF-C) 显示文摘 | Pien LC Chu H Chen WC | 2011 | J Clin Nurs2011，20，16： | 1 |
| 15 | Trends in influenza vacci- nation in Canada, 1996/1997 to 2005 显示文摘 | Kwong JC Rosella LC Johansen H | 2007 | Health Rep2007，18，4： | 1 |
| 16 | Endometrial resection after vacuum curettage显示文摘 | Maia H Calmon LC Marques D | 1997 | Gynecol Endoscopy1997，，6： | 1 |
| 17 | Combining ability for grain chemistry quality traits in a white oat dial- lelic cross显示文摘 | Crestani M Silveira Silveira SF Tessmann EW Mezzalira I Souza Luche H Silva JAG Gutkoski LC Carvalho FIF Oliveira AC | 2012 | Euphytica2012，185，1： | 1 |
| 18 | Assessment of pre - and post - methionine load homoeysteine for prediction of recurrent stroke and coronary artery disease in the Vitamin Intervention for Stroke Prevention Trial 显示文摘 | Pettigrew LC Bang H Chambless LE | 2008 | Atheroselerosis2008，200，2： | 1 |
| 19 | Cytologic diagnosis of malignant mesothelioma, with particular emphasis on the epithelial noncohesive cell type 显示文摘 | Kho-Duffin J Tao LC Cramer H | 1999 | Diagn Cytopathol1999，20，2： | 1 |
| 20 | Operation for N2 small cell lung carcinoma显示文摘 | Salzer GM Muller LC Huber H | 1990 | Ann Thorac Surg1990，49，： | 1 |
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