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| 1 | Intranasal delivery of paeoniflorin nanocrystals for brain targeting显示文摘Paeoniflorin(PA) is an anti-Parkinson Chinese medicine with inferior bioavailability and difficulty in delivery to the brain. This research is to develop an efficacious PA nanocrystal formulation(PA-NCs) that is suitable for intranasal administration to treat Parkinson’s disease(PD). PA-NCs were fabricated through an antisolvent precipitation method using TPGS as the stabilizer. The rod-shaped PA-NCs had particle size of 139.6 ± 1.3 nm and zeta potential of-23.2 ± 0.529 mV. A molecular dynamics simulation indicated that van der Waals forces are the primary drivers of interactions between PA and TPGS. In the ex vivo nasal mucosa permeation assay, the cumulative drug release at 24 h was 87.14% ± 5.34%,which was significantly higher than that of free PA. PA-NCs exhibited substantially improved cellular uptake as well as permeability on Calu-3 cells as compared to PA alone. FRET imaging analysis demonstrated that intact NCs could be internalized into Calu-3 cells.Moreover, PA-NCs conferred desirable protective effect against MPP+-induced SH-SY5Y cellular damage. Pharmacokinetic studies revealed a higher PA concentration in the brain following intranasal delivery of PA-NCs. In summary, the intranasal administration of PANCs is a promising treatment strategy for PD. | Chaoyin Wu Benyue Li Yi Zhang Tingting Chen Chuangrong Chen Wei Jiang Qi Wang Tongkai Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，3： | 4 |
| 2 | The dominant hepatitis B virus genotype identified in Tibet is a C/D hybrid显示文摘 | Chaoyin Cui Jinxiu Shi Lijian Hui Huifeng Xi Zhuoma Quni Tsedan and Gengxi Hu | 2002 | J Gen Virol2002，83，： | 1 |
| 3 | The Effect of the Guiding Directions of the Guiding Cylinders of an Area Ratio Modified Machine Cushion on the Capability of Suppressing Impact and Vibration显示文摘 | TENG Chinkun HSIAO Chaoyin WANG Chunshing | 2009 | Advances in En- gineering Software2009，40，10： | 1 |
| 4 | Desorption and re-adsorption of carbon nanotubes:Comparisons of sodium hydroxide and microwave irradiation processes显示文摘 | Kuo Chaoyin | 2008 | Journal of Hazardous Materials2008，152，3： | 1 |
| 5 | Fourier Transform Infrared (FT-IR) Spectroscopy for discrimination of Rhizoma gastrodiae (Tianma) from different producing areas 显示文摘 | Qimeng Fan Chaoyin Chen Yuping Lin | 2013 | Journal of Molecular Structures2013，，1051： | 1 |
| 6 | A double-crystal monochromator for EXAFS measurement at NSRL显示文摘 | Chaoyin XU Weichang ZHAO Guoqiang PAN | 1998 | Nuclear Instruments & Methods in Physics Research A1998，410，2： | 1 |
| 7 | Study on fuzzy comprehensive evaluation of rural house energy-saving renova- tion demonstration effects显示文摘 | Zhang Chaoyin | 2011 | BMEI 2011 - Proceedings 2011 International Conference on Business Management and Electronic Information2011，3，： | 1 |
| 8 | A new fast algorithm for multitarget tracking in dense clutter显示文摘A fast joint probabilistic data association (FJPDA) algorithm is proposed in this paper. Cluster probability matrix is approximately calculated by a new method, whose elements βt_i(K) can be taken as evaluation functions. According to values of βt_i(K),N events with larger joint probabilities can be searched out as the events with guiding joint probabilities, thus,the number of searching nodes will be greatly reduced. As a result, this method effectively reduces the calculation load and makes it possible to be realized on real_time. Theoretical analysis and Monte Carlo simulation results show that this method is efficient. | Weihua QIN Fei HU Chaoyin QIN | 2005 | 控制理论与应用(英文版)2005，3，4： | 1 |
| 9 | 显示文摘 | Kuo Chaoyin | 2009 | Journal of Hazardous Materials2009，163，： | 1 |
| 10 | Adsorption of aqueous cadmium(Ⅱ)onto modified multi-walled carbon nanotubes following microwave/chemical treatment显示文摘 | Kuo Chaoyin Lin Hanyu | | 0，，： | 1 |
| 11 | Mannose selection system used for cucumber transformation显示文摘 | Zhengquan He ZhenZhen Duan Wei Liang Faju Chen Wei Yao Hongwei Liang Chaoyin Yue Zongxiu Sun Fan Chen Jianwu Dai | 2006 | Plant Cell Reports2006，，9： | 1 |
| 12 | A double -crystal monochromator for EXAFS measurement at NSRL显示文摘 | XU CHAOYIN ZHAO WEICHANG | 1998 | Nuclear Instruments & Methods in Physics Research1998，，： | 1 |
| 13 | cFos-ANAB:A cFos-based Web Tool for Exploring Activated Neurons and Associated Behaviors显示文摘cFos is one of the most widely-studied genes in the field of neuroscience.Currently,there is no systematic database focusing on cFos in neuroscience.We developed a curated database-cFos-ANAB-a cFos-based web tool for exploring activated neurons and associated behaviors in rats and mice,comprising 398 brain nuclei and sub-nuclei,and five associated behaviors:pain,fear,feeding,aggression,and sexual behavior.Direct relationships among behaviors and nuclei(even cell types)under specific stimulating conditions were constructed based on cFos expression profiles extracted from original publications.Moreover,overlapping nuclei and sub-nuclei with potentially complex functions among different associated behaviors were emphasized,leading to results serving as important clues to the development of valid hypotheses for exploring as yet unknown circuits.Using the analysis function of cFos-ANAB,multi-layered pictures of networks and their relationships can quickly be explored depending on users’purposes.These features provide a useful tool and good reference for early exploration in neuroscience.The cFos-ANAB database is available at www.cfos-db.net. | Fan Wang Wenjie Sun Lei Chang Kefang Sun Leying Hou Linna Qian Chaoyin Jin Jiandong Chen Jiali Pu Panmeng Ye Shuang Qiu Jianhong Luo Shumin Duan Baorong Zhang Zhihua Gao Xiaojun Hu | 2021 | Neuroscience Bulletin2021，37，10： | 0 |
| 14 | THE EFFECTS OF WATERLOGGING CALAMITY ON THE RICE OUTPUT IN THE AREA OF MIDDLE AND LOWER REACHES OF THE YANGTZE RIVER | Song Lianchun Huang Chaoyin and Wang Ling(China Meteorology Center, Beijing 100081) | 1995 | Natural Disaster Reduction in China1995，，1： | 0 |
| 15 | 中国土地信托制度的成长路径与创新实践(英文)显示文摘从21世纪初开始,伴随着农村土地改革,我国有些地区出现了不同形式的土地信托。各种形式的土地信托都存在着不足,如农民向信托让渡了土地经营权,但却不能享有农业生产增加的全部收益。在现存的各种土地信托中,农民既不是严格意义上的委托人,也不是准确意义上的受益人,他们既不能行使信托委托人可以对信托行使的控制权,也无法获得让渡权利后产生的全部收益。中国土地信托创立过程中面临的主要问题是受托人不便与个体农民进行订约。单位信托或类似的信托类型或许能够成为避免高交易成本并带来应用前景的途径。 | Yu Chaoyin Robert D. Roderick | 2019 | China Legal Science2019，7，4： | 0 |
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