5篇
您的检索式：作者名="Changmin Peng"
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| 1 | OGT Mediated Histone H2B S112 Glc NAcylation Regulates DNA Damage Response显示文摘O-GlcNAcylation is an important post-translational modification and has been implicated in many fundamental cellular processes. Recent studies showed that O-linked N-acetylglucosamine(GlcNAc) transferase(OGT) mediated O-Glc NAcylation of histone H2B Ser 112(H2B S112 Glc NAcylation) plays an important role in gene transcription. However, the role of this histone modification in DNA damage response has not been studied yet. In this study, we found that OGT and OGT mediated H2B S112 Glc NAcylation are involved in DNA damage response for maintaining genomic stability and are required for resistance to many DNA-damaging and replication stressinducing agents. OGT mediated H2B S112 GlcNAcylation increased locally upon the induction of double-strand breaks(DSBs), and depletion of OGT or overexpression of H2B S112A mutant impaired homologous recombination(HR) and nonhomologous end-joining(NHEJ). Mechanistically, H2B S112 GlcNAcylation could bind Nijmegen breakage syndrome 1(NBS1) and regulate NBS1 foci formation. Taken together, our results demonstrate a new function of histone O-GlcNAcylation in DNA damage response(DDR). | Panfei Wang Changmin Peng Xia Liu Hailong Liu Yali Chen Li Zheng Baolin Han Huadong Pei | 2015 | Journal of Genetics and Genomics2015，42，9： | 3 |
| 2 | Study on Deformation Prediction of the Tunnel Surrounding Rocks Based on Non-equal Time-interval Grey Model显示文摘 | GENG Pengfei YANG Changmin GUO Weidong WANG Peng | 2014 | Applied Mechanics and Materials2014，，7： | 1 |
| 3 | Growth of Nd : YAG Free from Core and Dislocation显示文摘Nd:YAG crystals free from core and dislocation have been grown by using the“controlled reversion of solid-liquid interface” method.The basic idea of the method is to combine the respective advantages of both the convex and the flat interface growth and to overpass 'safely'the interface reversion so that the whole crystal could be grown in stable fluid How states. | XU Tianhua WU Zihe PENG Weiqing ZHEN Qimeng ZHOU Jianmin ZHANG Shengxiu XIE Sanwen XU Guangyu HANG Changmin | 1993 | Chinese Physics Letters1993，10，11： | 0 |
| 4 | Older adults’social participation and social relationship and association with partner’s cognition:a latent profile analysis显示文摘Older adults’social participation and social relationship may be affected by their partners’cognitive function.In 3,722 cognitively intact married/partnered Health and Retirement Study respondents,latent profile analysis identified three social participation profiles(Limited overall social participation(prevalence:69%);Frequent volunteer participation(10%);Frequent non-volunteer participation(21%)),and three social relationship profiles(Social support from all relationships(68%);Mixed social support and strain from all relationships(18%);Social strain from partner with support from other relationships(14%)).Spouse/partner’s cognition was not significantly associated with social participation profiles.Impaired cognition in spouses/partners increased older adults’likelihood of perceiving social strain from their partners with support from other relationships.Frequent volunteer and non-volunteer participation and perceiving social support from all relationships predicted better self-rated health and lower odds of depressive symptoms.These findings highlight the need of community programs that promote social connectedness for older adults living with cognitively impaired spouses/partners. | Yiyang Yuan Changmin Peng Yan Lin Shan Qu | 2023 | China Population and Development Studies2023，7，4： | 0 |
| 5 | OGT介导的糖修饰在Hippo通路激活和肿瘤发生中发挥重要作用显示文摘文章简介研究人员发现,肿瘤细胞可以响应细胞外葡萄糖浓度的变化,Hippo通路的核心蛋白YAP可以发生O-糖基化修饰。YAP的O-糖修饰由O糖基化转移酶OGT和糖苷酶OGA调控。 | Changmin Peng Yue Zhu Wanjun Zhang Qinchao Liao Yali Chen Xinyuan Zhao Qiang Guo Pan Shen Bei Zhen Xiaohong Qian Dong Yang Jin-San Zhang Dongguang Xiao 秦伟捷 裴华东 | 2018 | 科学新闻2018，0，4： | 0 |
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