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| 1 | Kinematics and Dynamics of Deployable Structures with Scissor-Like-Elements Based on Screw Theory显示文摘Because the deployable structures are complex multi-loop structures and methods of derivation which lead to simpler kinematic and dynamic equations of motion are the subject of research effort, the kinematics and dynamics of deployable structures with scissor-like-elements are presented based on screw theory and the principle of virtual work respectively. According to the geometric characteristic of the deployable structure examined, the basic structural unit is the common scissor-like-element(SLE). First, a spatial deployable structure, comprised of three SLEs, is defined, and the constraint topology graph is obtained. The equations of motion are then derived based on screw theory and the geometric nature of scissor elements. Second, to develop the dynamics of the whole deployable structure, the local coordinates of the SLEs and the Jacobian matrices of the center of mass of the deployable structure are derived. Then, the equivalent forces are assembled and added in the equations of motion based on the principle of virtual work. Finally, dynamic behavior and unfolded process of the deployable structure are simulated. Its figures of velocity, acceleration and input torque are obtained based on the simulate results. Screw theory not only provides an efficient solution formulation and theory guidance for complex multi-closed loop deployable structures, but also extends the method to solve dynamics of deployable structures. As an efficient mathematical tool, the simper equations of motion are derived based on screw theory. | SUN Yuantao WANG Sanmin MILLS James K ZHI Changjian | 2014 | Chinese Journal of Mechanical Engineering2014，27，4： | 19 |
| 2 | Pyrite Surface after ThiobaciUusferrooxidans Leaching at 30℃显示文摘In order to investigate the effect of Thiobacillus ferrooxidans on the oxidation of pyrite, two parallel experiments, which employed H2SO4 solutions and acidic solutions inoculated with Thiobacillus ferrooxidans, were designed and carried out at 30℃. The initial pH of the two solutions was adjusted to 2.5 by dropwise addition of concentrated sulphuric acid. The surfaces of pyrite before exposure to leaching solutions and after exposure to the H2SO4 solutions and acidic solutions inoculated with Thiobacillus ferrooxidans were observed by scanning electron microscopy (SEM). There were a variety of erosion patterns by Thiobacillus ferrooxidans on the bio-leached pyrite surfaces. A conclusion can be drawn that the oxidation of pyrite might have been caused by erosion of the surfaces. Attachment of the bacteria to pyrite surfaces resulted in erosion pits, leading to the oxidation of pyrite. It is possible that the direct mechanism plays the most important role in the oxidation of pyrite. The changes in iron ion concentrations of both the experimental solutions with time suggest that Thiobacillus ferrooxidans can enhance greatly the oxidation of pyrite. | LU Jianjun LU Xiancai WANG Rucheng LI Juan ZHU Changjian GAO Jianfeng | 2006 | Acta Geologica Sinica(English Edition)2006，80，3： | 16 |
| 3 | Preliminary analysis on the relationships between Tibetan Plateau NDVI change and its surface heat source and precipitation of China显示文摘Using the automatic weather station data obtained from the Tibetan Plateau (TP), the normalized dif- ference vegetation index and the monthly precipitation data of China and by the methods of correlation and composite analysis, preliminary analytical results are achieved concerning the relationships be- tween TP NDVI change and its surface heat source and precipitation of China. The results of our re- search may lead to the following conclusions: (1) A positive correlation relationship exists between TP NDVI change and its surface heat source, including the sensible heat and the latent heat. As to the correlation of the former, it is more remarkable in western TP than in eastern TP, and as to the correla- tion of the latter, however it turns out contrary. (2) With the improvement of TP vegetation, its surface heat source of every season is also mainly reinforced, especially in summer. As to the contribution of the sensible heat and the latent heat to the increment of the TP surface heat source intensity, the for- mer is comparatively more significant than the latter in winter and spring, while in summer and autumn, the two have almost the same importance. (3) The correlation coefficient between summer NDVI over TP and the corresponding period precipitation of China displays a belt distribution of '+?+' from south to north China. (4) Anomalous surface heating field over TP derived from vegetation change is probably an important factor to affect summer precipitation of China. | HUA Wei FAN GuangZhou ZHOU DingWen NI ChangJian LI XueMin WANG YongLi LIU YaQin HUANG XianLun | 2008 | Science China Earth Sciences2008，51，5： | 14 |
| 4 | Mobility Analysis of the Deployable Structure of SLE Based on Screw Theory显示文摘Scissor-like element has a number of applications in deployable structures such as planar deployable structure (PDS) and ring deployable structure(RDS). However, the mobility analysis of the multi-loop deployable structures is made more difficulty by the traditional mobility formula, because the deployable structure is a very complex structure with multi-loop. Therefore, On the basis of screw theory, the calculation method of mobility of deployable structures of SLE is thoroughly discussed. In order to investigate the mobility, decomposing and composing structures(DCS) are developed, and the basic units are able to be obtained. On the basis of the deployable structures' geometrical characteristics, there exists a closed-loop quadrilateral structure and some non-closed-loop quadrilateral structures in PDS. Also, a six legs parallel structure is present in RDS. The basic units' mobility can be solved by both the methods of screw theory and topology constraint graphs. Then, composing the related basic units, the formula of planar deployable structures' mobility can be built and solves the mobility of ring deployable structure. The analysis method solves the mobility analysis of the multi-loop deployable structures which is difficulty by the traditional method, and plays an important role in further research about the mobility of other complex deployable structures. | SUN Yuantao WANG Sanmin LI Jianfeng ZHI Changjian | 2013 | Chinese Journal of Mechanical Engineering2013，26，4： | 14 |
| 5 | Decomposition of energy-related carbon emissions in Xinjiang and relative mitigation policy recommendations显示文摘地区性的碳排出物研究为在实现减小目标的中国必要、有用。LMDI 我(对数的吝啬的 Divisia 索引我) 技术基于扩大 Kaya 身份被进行揭开主要为在 Xinjiang 的精力相关的碳排出物的五个驱动力,在中国的一个重要精力底。富裕效果和人口完成的分解结果表演是到增加的碳排出物的二个很重要的贡献者。精力紧张效果在预先改革时期期间在碳排出物上有积极影响,然后在在 1978 以后限制碳排出物成为了主导的因素。可更新的精力穿入效果和排放系数效果在碳排出物上显示出重要否定却相对次要的效果。基于本地现实,缓解政策的一间全面套房被这些影响因素考虑所有提起。缓解政策将需要显著地减少精力紧张并且对地区性的经济发展路径给予更多的注意。石块燃料替换应该严重被考虑。可更新的精力应该在精力混合被增加。如果由中央、本地的政府实现了,所有应该这些政策建议做大贡献到精力在 Xinjiang 节省和排放减小。 | Changjian WANG Xiaolei ZHANG Fei WANG Jun LEI Li ZHANG | 2015 | Frontiers of Earth Science2015，9，1： | 13 |
| 6 | Hyperhomocysteinemia induces cardiac injury by up-regulation of p53-dependent Noxa and Bax expression through the p53 DNA methylation in ApoE-/- mice显示文摘Hyperhomocysteinemia (HHcy ) 是为心血管的疾病的一个风险因素并且与心失败有强壮的关联。然而,心脏的织物上的 HHcy 的效果仍然保持不太好理解。阐明在导致 HHcy 的心脏的损害的 p53 依赖的 apoptosis 的角色,我们用高蛋氨酸饮食喂了 ApoE/ 老鼠建立 HHcy 模型。浆液 Hcy,心脏的酶,和类脂化合物被测量。Noxa, DNMT1, caspases-3/9,和 p53 的蛋白质层次被连接酶的 immunosorbent 试金决定。Bcl-2 和 Bax 蛋白质被染色的 immunohistochemistry 检测。S-adenosyl 蛋氨酸和 S-adenosyl homocysteine 集中被高效的液体层析决定。p53 和 DNMT1 的 mRNA 层次被即时聚合酶链反应(PCR ) 分析, p53 的 methylation 层次被嵌套的 methylation-specific-PCR 分析。我们的数据证明浆液 Hcy 和类脂化合物的集中与 N 控制组相比在 Meth 组被增加,它显示模型成功地被建立。p53 和 Noxa 的表示层次在 Meth 组被增加,当 p53 的 methylation 地位是 hypomethylation 时。caspase-3/9 的活动与 N 控制组相比在 Meth 组被增加。另外,染色的 immunohistochemistry 证明 Bax 的表示显著地与 N 控制组相比在 Meth 和 Meth-F 组被增加。在摘要, HHcy 由 p53 依赖的 pro-apoptotic 的起来规定导致心脏的损害联系了基因 Noxa 和 Bax,当 p53 DNA hypomethylation 是在 HHcy 导致的病理学的过程的关键分子的机制时。 | ShengchaoMa Huiping Zhang Weiwei Sun HuiHui Gong YanhuaWang Changjian Ma Ju Wang Chengjian Cao Xiaoling Yang Jue Tian Yideng Jiang | 2013 | Acta Biochimica et Biophysica Sinica2013，45，5： | 12 |
| 7 | Force-induced charge carrier storage:a new route for stress recording显示文摘Stress sensing is the basis of human-machine interface,biomedical engineering,and mechanical structure detection systems.Stress sensing based on mechanoluminescence(ML)shows significant advantages of distributed detection and remote response to mechanical stimuli and is thus expected to be a key technology of next-generation tactile sensors and stress recorders.However,the instantaneous photon emission in ML materials generally requires real-time recording with a photodetector,thus limiting their application fields to real-time stress sensing.In this paper,we report a force-induced charge carrier storage(FICS)effect in deep-trap ML materials,which enables storage of the applied mechanical energy in deep traps and then release of the stored energy as photon emission under thermal stimulation.The FICS effect was confirmed in five ML materials with piezoelectric structures,efficient emission centres and deep trap distributions,and its mechanism was investigated through detailed spectroscopic characterizations.Furthermore,we demonstrated three applications of the FICS effect in electronic signature recording,falling point monitoring and vehicle collision recording,which exhibited outstanding advantages of distributed recording,longterm storage,and no need for a continuous power supply.The FICS effect reported in this paper provides not only a breakthrough for ML materials in the field of stress recording but also a new idea for developing mechanical energy storage and conversion systems. | Yixi Zhuang Dong Tu Changjian Chen Le Wang Hongwu Zhang Hao Xue Conghui Yuan Guorong Chen Caofeng Pan Lizong Dai Rong-Jun Xie | 2020 | Light(Science & Applications)2020，9，1： | 10 |
| 8 | Inequalities for polars of mixed projection bodies显示文摘In 1993 Lutwak established some analogs of the Brunn-Minkowsi inequality and the Aleksandrov-Fenchel inequality for mixed projection bodies. In this paper, following Lutwak, we give their polars forms. Further, as applications of our methods, we give a generalization of Pythagorean inequality for mixed volumes. | LENG Gangsong, ZHAO Changjian, HE Binwu & LI XiaoyanDepartment of Mathematics, Shanghai University, Shanghai 200436, China Department of Mathematics, Binzhou Teachers College, Binzhou 256604, China | 2004 | Science China Mathematics2004，47，2： | 9 |
| 9 | Layered double hydroxide(LDH) for multi-functionalized corrosion protection of metals: A review显示文摘Layered double hydroxide(LDH) has been widely developed in the field of corrosion and protection in recent years based on its unique characteristics including anion capacity, anion exchange ability, structure memory effect, and barrier resistance. This paper comprehensively reviews recent work on the preparations, properties of LDH in the forms of powder and film and their applications in different environments in corrosion and protection. Some novel perspectives are also proposed at the end of the review for future research in corrosion and protection field. | Yanhui Cao Dajiang Zheng Fan Zhang Jinshan Pan Changjian Lin | 2022 | Journal of Materials Science & Technology2022，，7： | 9 |
| 10 | Origin, Flow of Formation Water and Hydrocarbon Accumulation in the Zhenwu Area of the North Jiangsu Basin, China显示文摘In order to understand the origin and flow of formation water and to evaluate the hydrocarbon accumulation and preservation conditions, the properties of formation water chemistry and dynamics of the Zhenwu area in the southern Gaoyou Sag, North Jiangsu Basin, China, have been investigated. The results show that Xuzhuang oilfield is infiltrated discontinuously by meteoric water under gravity, which consequently leads to the desalination of formation water. Formation water in the Zhenwu and Caozhuang oilfields is less influenced by meteoric water infiltration, and the origin is interpreted to be connate water. Hydrocarbon migration, accumulation and preservation are closely related to the hydrodynamic field of formation water. Formation water concentrates gradually during the process of centrifugal flow released by mudstone compaction and the centripetal flow of meteoric water infiltration, leading to the high salinity of the central part. The geological conditions of the southern fault-terrace belt are poor for hydrocarbon accumulation and preservation as meteoric water infiltration, leaching and oxidation, while the central part, i.e., northern Zhenwu and Caozhuang oilfields is beneficial for an abundance of hydrocarbon accumulation. Most of the large scale oil-gas fields locate herein. | LI Mei LOU Zhanghua JIN Aimin ZHU Rong SHANG Changjian YE Ying ZHU Zhenhong | 2013 | Acta Geologica Sinica(English Edition)2013，87，3： | 8 |
| 11 | Al_2O_3-TiO_2 composite oxide films on etched aluminum foil fabricated by electrodeposition and anodization显示文摘Ti species have been deposited on low-voltage etched aluminum foils by a simple electrochemical method using a Ti anode as Ti source in a Ti-free I2-dissolved acetone solution. After annealing at 500-600℃ in air, an Al2O3-TiO2 composite oxide film was formed on the surface of the etched aluminum foil by anodizing galvanostatically in an ammonium adipate solution. The effects of I2 concentration in the acetone solution, applied anode voltage, electrolysis time, and annealing temperature on the specific capacitance of the aluminum anode foils were investigated. The TiO2-deposited specimens prepared by applying a po-tential of 50V for 3 min in 2.5m MI2-added acetone solution followed by annealing at 550℃ after anodization exhibited the highest specific capacitance, with an enhancement of 22% compared with pure etched aluminum foil specimens. The electro-deposition process and the change of the anode voltage during the anodization were analyzed. | BU JunFu SUN Lan WU Qi WANG MengYe LIN ChangJian | 2011 | Science China Chemistry2011，54，10： | 7 |
| 12 | Influencing mechanism of energy-related carbon emissions in Xinjiang based on the input-output and structural decomposition analysis显示文摘碳排放机制的分析基于地区性的观点是能够完成精力积蓄和排放减小的一个重要研究方法。Xinjiang,一个重要中国精力生产库,当前为快速的开发正在通过战略机会的一个时期。当完成精力积蓄和会议排放减小时,保证稳定的社会经济的开发指向,关键问题当前正在面对这个区域。这篇论文基于输入产量理论,并且在从 1997 ~ 2007 在 Xinjiang 影响精力相关的碳排出物的因素上进行结构的分解分析;这分析采用精力的一个混合输入产量分析框架 - 经济 - 碳排出物。(1 ) 从精力消费的 Xinjiangs 碳排出物在 2007 在 1997 ~ 40.34 百万吨从 2070 万吨增加了;碳排出物生长主要在生产被集中并且精力资源,矿物质资源的采矿,和处理工业处理。( 2 )碳排出物上的影响因素的直接效果的分析证明在人均的 GDP ,最后的需求结构,人口规模,和生产结构的变化是在碳排出物引起增加的重要因素,当在碳排放紧张的减少在这个时期期间是在停止碳排出物的生长的重要影响因素时。这证明当 Xinjiangs 经济和人口的尺寸正在成长时,经济结构有效地没被优化,生产技术高效地没被改进,导致从精力消费的碳排出物的快速的生长。(3 ) 碳排放的影响因素的间接效果的分析证明由城市的居民的内部省的出口,固定大写的形成,和消费在 Xinjiang 从精力消费在碳排出物在变化上有重要影响。(4 ) 在碳的固定资产的投资的生长集中的工业部门除了精力资源产品的内部省的出口的生长,做内部省的表达的碳的转移效果很重要。 | WANG Changjian WANG Fei ZHANG Xiaolei ZHANG Hongou | 2017 | Journal of Geographical Sciences2017，27，3： | 7 |
| 13 | A survey of visual analytics techniques for machine learning显示文摘Visual analytics for machine learning has recently evolved as one of the most exciting areas in the field of visualization.To better identify which research topics are promising and to learn how to apply relevant techniques in visual analytics,we systematically review259 papers published in the last ten years together with representative works before 2010.We build a taxonomy,which includes three first-level categories:techniques before model building,techniques during modeling building,and techniques after model building.Each category is further characterized by representative analysis tasks,and each task is exemplified by a set of recent influential works.We also discuss and highlight research challenges and promising potential future research opportunities useful for visual analytics researchers. | Jun Yuan Changjian Chen Weikai Yang Mengchen Liu Jiazhi Xia Shixia Liu | 2021 | Computational Visual Media2021，7，1： | 6 |
| 14 | A New Flexible Multibody Dynamics Analysis Methodology of Deployable Structures with Scissor-Like Elements显示文摘There are vast constraint equations in conventional dynamics analysis of deployable structures,which lead to differential-algebraic equations(DAEs)solved hard.To reduce the difficulty of solving and the amount of equations,a new flexible multibody dynamics analysis methodology of deployable structures with scissor-like elements(SLEs)is presented.Firstly,a precise model of a flexible bar of SLE is established by the higher order shear deformable beam element based on the absolute nodal coordinate formulation(ANCF),and the master/slave freedom method is used to obtain the dynamics equations of SLEs without constraint equations.Secondly,according to features of deployable structures,the specification matrix method(SMM)is proposed to eliminate the constraint equations among SLEs in the frame of ANCF.With this method,the inner and the boundary nodal coordinates of element characteristic matrices can be separated simply and efficiently,especially on condition that there are vast nodal coordinates.So the element characteristic matrices can be added end to end circularly.Thus,the dynamic model of deployable structure reduces dimension and can be assembled without any constraint equation.Next,a new iteration procedure for the generalized-a algorithm is presented to solve the ordinary differential equations(ODEs)of deployable structure.Finally,the proposed methodology is used to analyze the flexible multi-body dynamics of a planar linear array deployable structure based on three scissor-like elements.The simulation results show that flexibility has a significant influence on the deployment motion of the deployable structure.The proposed methodology indeed reduce the difficulty of solving and the amount of equations by eliminating redundant degrees of freedom and the constraint equations in scissor-like elements and among scissor-like elements. | Qi’an Peng Sanmin Wang Changjian Zhi Bo Li | 2019 | Chinese Journal of Mechanical Engineering2019，32，5： | 5 |
| 15 | A reactive oxygen species-responsive dendrimer with low cytotoxicity for efficient and targeted gene delivery显示文摘Nonviral vectors have been attracting more attention for several advantages in gene delivery and the development of nonviral gene ca rriers with high delivery efficiency and low cytotoxicity has long been a key project.Starburst polyamidoamine dendrimers are a class of synthetic polymers with unique structural and physical characteristics.However,when they are used as gene carrier,the gene transfection efficiency is not satisfactory.Herein,a novel thioketal-core polyamidoamine dendrimer(i.e.,ROS-PAMAM)was synthesized and characterized.Compared to ethylenediamine-core dendrimers or widely used cationic polymers of polyetherimide,ROS-PAMAM showed lower cytotoxicity.Moreover,ROS-PAMAM demonstrated reactive oxygen species responsive characteristics,which can facilitate the release of siRNA in the tumor microenvironment.In vitro gene transfection experiments based on A549 cells confirmed that siRNA/ROS-PAMAM exhibits high gene transfection efficiency.It is concluded that ROS-PAMAM shows great potential as a generalizable vehicle for gene therapy applications. | Yueqi Wang Changjian Li Libo Du Yang Liu | 2020 | Chinese Chemical Letters2020，31，1： | 5 |
| 16 | Bias-drift-free Mach–Zehnder modulators based on a heterogeneous silicon and lithium niobate platform显示文摘Optical modulators have been and will continue to be essential devices for energy-and cost-efficient optical communication networks.Heterogeneous silicon and lithium niobate modulators have demonstrated promising performances of low optical loss,low drive voltage,and large modulation bandwidth.However,DC bias drift is a major drawback of optical modulators using lithium niobate as the active electro-optic material.Here,we demonstrate high-speed and bias-drift-free Mach–Zehnder modulators based on the heterogeneous silicon and lithium niobate platform.The devices combine stable thermo-optic DC biases in silicon and ultra-fast electro-optic modulation in lithium niobate,and exhibit a low insertion loss of 1.8 d B,a low half-wave voltage of 3 V,an electro-optic modulation bandwidth of at least 70 GHz,and modulation data rates up to 128 Gb/s. | SHIHAO SUN MINGBO HE MENGYUE XU SHENGQIAN GAO ZIYAN CHEN XIAN ZHANG ZILIANG RUAN XIONG WU LIDAN ZHOU LIN LIU CHAO LU CHANGJIAN GUO LIU LIU SIYUAN YU XINLUN CAI | 2020 | Photonics Research2020，8，12： | 5 |
| 17 | Kinematic and Dynamic Characteristics Analysis of Bennett's Linkage显示文摘Bennett's linkage is a spatial fourlink linkage,and has an extensive application prospect in the deployable linkages.Its kinematic and dynamic characteristics analysis has a great significance in its synthesis and application. According to the geometrical conditions of Bennett 's linkage,the motion equations are established,and the expressions of angular displacement,angular velocity and angular acceleration of the followers and the displacement,velocity and acceleration of mass center of link are shown. Based on Lagrange's equation,the multi-rigid-body dynamic model of Bennett's linkage is established. In order to solve the reaction forces and moments of joint,screw theory and reciprocal screw method are combined to establish the computing method.The number of equations and unknown reaction forces and moments of joint are equal through adding link deformation equations. The influence of the included angle of adjacent axes on Bennett 's linkage 's kinematic characteristics,the dynamic characteristics and the reaction forces and moments of joint are analyzed.Results show that the included angle of adjacent axes has a great effect on velocity,acceleration,the reaction forces and moments of Bennett's linkage. The change of reaction forces and moments of joint are apparent near the singularity configuration. | Changjian Zhi Sanmin Wang Yuantao Sun Jianfeng Li | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，3： | 5 |
| 18 | Microstructure evolution of an Mg-Zn-Nd-Zr magnesium alloy during recrystallization and partial remelting process显示文摘To obtain a spheroidal microstructure of a semi-solid Mg-Zn-Nd-Zr alloy,which is favorable for the subsequent thixocasting process,the recrystallization and partial remelting(RAP)method was used in this study,and the microstructure evolution of the alloy and the mechanism of the shape factor change during the RAP process were invesigated.The as-cast Mg-Zn-Nd-Zr alloy was prepared in a metal mold and then extruded into bars with an extrusion ratio of 16:1.Partial remelting was carried out on the extruded samples at 589℃(at a heating rate of 0.5℃·s-1)for different holding times ranging from 0 to 90 min.To examine the effect of heating rate,partial remelting of samples at the heating rate of 2℃·s-1was also performed.Results show that the extruded microstructure rapidly evolutes into recrystallized grains in the semi-solid state;the liquid f ilm initially forms at grain boundaries during the partial remelting,and then gradually changes from continuous into discontinuous state with the increase of holding time;this results in the agglomeration of adjacent grains and the decrease in shape factor.The value of shape factor increases continuously with holding time at f irst and reaches the maximum 0.62 when holding for 60 min,while decreases rapidly after a prolonged holding time.Moreover,local melting,mainly due to the inhomogeneous deformation during extrusion,becomes more signif icant and less uniformly distributed at a relatively higher reheating rate.The Mg-Zn-Nd-Zr magnesium alloy components have been thixo-cast successfully using the RAP method,which strongly proves the feasibility of RAP process in Mg-Zn-Nd-Zr alloy. | Tao Jianquan Wan Yuanyuan Sun Changjian Su Zhiquan Deng Tianquan Huang Jing | 2013 | China Foundry2013，10，4： | 4 |
| 19 | Evolution and propagation of a mesoscale eddy in the northern South China Sea during winter显示文摘在 situ,从一个解决旋涡的海洋发行量模型的观察,卫星数据,和产量被用来在 20092010 的冬季期间在北华南海(NSCS ) 学习一个逆旋风的旋涡的代和繁殖。在 NSCS,逆旋风的旋涡第一出现了到吕宋岛海峡的西方,沿着大陆人斜坡通常移居了并且在 Xisha 群岛附近驱散。温暖的旋涡的进化包含三个阶段:开发,成熟,和腐烂。旋涡主要在 119.7 附近留下来 ???萀 吗?? | LIU Changjian DU Yan ZHUANG Wei XIA Huayong XIE Qiang | 2013 | Acta Oceanologica Sinica2013，32，7： | 4 |
| 20 | Effect of size and crystalline phase of TiO2 nanotubes on cell behaviors: A high throughput study using gradient TiO2 nanotubes显示文摘The research of TiO2 nanotubes(TNTs)in the field of biomedicine has been increasingly active.However,given the diversity of the nanoscale dimension and controversial reports,our understanding of the structure-property relationships of TNTs is not yet complete.In this paper,gradient TNTs with a wide diameter range of 20-350 nm were achieved by bipolar electrochemistry and utilized for a thorough high-throughput study of the effect of nanotube dimension and crystalline phase on protein adsorption and cell behaviors.Results indicated that protein adsorption escalated with nanotube dimension whereas cell proliferation and differentiation are preferred on small diameter(<70 nm)nanotubes.Large diameter anatase nanotubes had higher adsorption of serum proteins than as-prepared ones.But only as-prepared small diameter nanotubes presented slightly higher cell proliferation than corresponding annealed nanotubes whereas there was no discernible difference between as-prepared and annealed nanotubes on cell differentiation for the entire gradient.Those findings replenish previous research about how cell responses to TNTs with a wide diameter range and provide scientific guidance for the optimal design of biomedical materials. | Yanran Li Si Wang Yuanjun Dong Ping Mu Yun Yang Xiangyang Liu Changjian Lin Qiaoling Huang | 2020 | Bioactive Materials2020，5，4： | 3 |
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