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| 1 | 肛裂临床诊治指南(第三次修订)显示文摘“美国结直肠外科医师协会(American Societyof ColonandRectal Surgeons.ASCRS)”(协会)致力于推进结直肠和肛门疾病的相关理论以及预防和诊疗水平的提高,给患者提供优质的医疗服务。“标准委员会”由协会中在结直肠外科方面有显著专长的成员组成。该委员会的建立是为了引领国际结直肠和肛门疾病诊治的发展,以建立具有循证医学证据的临床诊疗指南。指南是涵盖性的,非指令性的,目的是为临床决策提供信息,而非具体的治疗方法。指南适用于所有相关的医护人员以及希望得到相应指南中疾病的相关诊治信息的患者。 | Farshid Araghizadeh ~ Robin Boushey Sridhar Chalasani George Chang Robert Cima Gary Dunn Daniel Feingold Philip Fleshner Daniel Geisler Jill Genua Sharon Gregorcyk Daniel Herzig Andreas Kaiser Ravin Kumar David Larson Steven Mills John Monson P. Terry Phang Feza Remzi David Rivadeneira Howard Ross Peter Senatore Elin Sigurdson Thomas Stahl Scott Steele Scott Strong Charles Tement Judith Trudel Madhulika Varnna Martin Weiser 丁义江(译) 皇甫少华(译) 丁曙晴(译) | 2013 | 中华胃肠外科杂志2013，16，7： | 70 |
| 2 | Source apportionment of atmospheric particulate carbon in Las Vegas,Nevada,USA显示文摘研究被进行确定到在在拉斯维加斯山谷的四个城市的地点的碳的 PM2.5 的来源类型的冬贡献,在西南的美国的最快成长的城市的区域之一。24 个小时平均的周围的样品为质量,离子,元素,器官的碳(OC ) ,元素的碳(EC ) ,和踪迹被收集器官的标记分析。另外的大小被做决定日报在轻吸收的黑碳(BC ) 的模式作为为燃烧来源的一个标记。在道路上汽油车辆,在道路上柴油机车辆,和越野的柴油机引擎的碳的下午来源与他们的化学侧面,以及基于燃料的排放因素被描绘,用一个在里面羽毛采样系统。有效变化化学集体平衡(EV-CMB ) 来源分配模型被用于收集的周围的样品,用在象从另外的相关研究的侧面一样的这研究开发的来源侧面。四主要来源在拉斯维加斯山谷以内贡献了 PM2.5 碳:(1 ) 铺了道路灰尘,(2 ) 在道路上汽油车辆,(3 ) 居住木头燃烧,并且(4 ) 在道路上柴油机车辆。CMB 估计在道路上混合了舰队汽油车辆根本是为 OC 和 EC 的最大的来源这些地点。到 OC 和 EC 的铺的道路灰尘的贡献在四个地点是 510% 。在道路上柴油机车辆在城市中心附近在一个地点贡献 22% OC 和 34% EC,它被定位一条主要马路立即顺风。居住木头燃烧比为二个居住邻居地点的在道路上柴油机车辆是更重要的来源。这些结果与我们的概念的模型一致,并且研究方法论可以被用于学习另外的城市的区域。 | Mark C.Green Judith C.Chow M.-C.Oliver Chang L.-W.Antony Chen Hampden D.Kuhns Vicken R.Etyemezian John G.Watson | 2013 | Particuology2013，11，1： | 5 |
| 3 | Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7显示文摘The voltage-gated Na^+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a Nav1.7-targeting monoclonal antibody(SVmab) reduces Na+ currents and pain and itch responses in mice. Here, we investigated whether recombinant SVmab(rSVmab) binds to and blocks Nav1.7 similar to SVmab. ELISA tests revealed that SVmab was capable of binding to Nav1.7-expressing HEK293 cells,mouse DRG neurons, human nerve tissue, and the voltagesensor domain Ⅱ of Nav1.7. In contrast, rSVmab showed no or weak binding to Nav1.7 in these tests. Patch-clamp recordings showed that SVmab, but not rSVmab, markedly inhibited Na+ currents in Nav1.7-expressing HEK293 cells. Notably, electrical field stimulation increased the blocking activity of SVmab and rSVmab in Nav1.7-expressing HEK293 cells. SVmab was more effective than rSVmab in inhibiting paclitaxel-induced mechanical allodynia. SVmab also bound to human DRG neurons and inhibited their Na^+ currents. Finally, potential reasons for the differential efficacy of SVmab and rSVmab and future directions are discussed. | Sangsu Bang Jiho Yoo Xingrui Gong Di Liu Qingjian Han Xin Luo Wonseok Chang Gang Chen Sang-Taek Im Yong Ho Kim Judith A.Strong Ma-Zhong Zhang Jun-Ming Zhang Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 2 |
| 4 | Comparison of four scanning mobility particle sizers at the Fresno Supersite显示文摘Size distributions of ambient aerosols at the Fresno Supersite were measured with four commercially available scanning mobility particle sizers(SMPS) . TSI nano,TSI standard,Grimm,and MSP instruments were collocated at the Fresno Supersite and particle size distributions were measured continuously from August 18 through September 18,2005. For particles with diameters between 10 and 200 nm,differences among hourly-average ambient particle concentrations ranged from 0% between the TSI nano and Grimm in the 30-50 nm size range to 39% between the Grimm and MSP in the 10-30 nm size range. MSP concen-trations were 10-33% lower than those measured with the TSI standard for particles smaller than 200 nm. The TSI nano and TSI standard agreed to within 5% in their overlapping size range(10-84 nm) . The TSI nano and Grimm agreed to within 40% for 5-10 nm particles. | John G. Watson Judith C. Chow David A. Sodeman Douglas H. Lowenthal M.-C. Oliver Chang Kihong Park Xiaoliang Wang | 2011 | Particuology2011，9，3： | 2 |
| 5 | A retrospective review of ampicillin - sulbactam and amoxicillin + clavulanate vs cefazolin/cephalexin and erythromycin in the setting of preterm premature rupture of membranes: maternal and neonatal outcomes 显示文摘 | Ehsanipoor Robert Chang Judith Clock Charlotte | 2008 | 198(5 ) :e54 - e562008，198，5： | 1 |
| 6 | Reducing systemic absorption and macrophages clearance of genistein by lipid-coated nanocrystals for pulmonary delivery显示文摘Pulmonary delivery is an effective drug delivery strategy for the treatment of local respiratory diseases.However,the rapid systemic absorption through the lung due to the thin barrier and persistent lung clearances influence the drug retention in the lung.In this study,we designed a lipid-coated genistein nanocrystals(Lipo-NCs)formulation to achieve enhanced efficiency of local pulmonary delivery.The LipoNCs were fabricated by modifying genistein nanocrystals(NCs)with phospholipid membrane through thin film hydration following the homogenization method.The prepared Lipo-NCs exhibited a decreased drug release rate compared with the naked NCs.Our results demonstrated that intracellular uptake and transcellular transport of NCs by the Calu-3 epithelial layer were reduced after lipid coating.Furthermore,the macrophages clearance was also impeded by this Lipo-NCs formulation.In vivo lung retention and distribution revealed that more genistein was retained in the lung after intratracheal administration of Lipo-NCs.The pharmacokinetic study displayed that the AUC((0-t))values of Lipo-NCs were 1.59-fold lesser than those of the NCs group,indicating a reduced systemic absorption.In conclusion,this research indicated that Lipo-NCs could be a suitable formulation for reducing systemic absorption and macrophages clearance,and thus enhancing drug concentration in lung by pulmonary delivery. | Yuan He Chang Liu Run Han Yingmin Liang Judith Choi Wo Mak Yinghao Zhu Haifeng Li Ying Zheng | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
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