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| 1 | Efficacy of pancreatoscopy for pancreatic duct stones:A systematic review and meta-analysis显示文摘BACKGROUND Pancreatic duct stones can lead to significant abdominal pain for patients.Per oral pancreatoscopy(POP)-guided intracorporal lithotripsy is being increasingly used for the management of main pancreatic duct calculi(PDC)in chronic pancreatitis.POP uses two techniques:Electrohydraulic lithotripsy(EHL)and laser lithotripsy(LL).Data on the safety and efficacy are limited for this procedure.We performed a systematic review and meta-analysis with a primary aim to calculate the pooled technical and clinical success rates of POP.The secondary aim was to assess pooled rates of technical success,clinical success for the two individual techniques,and adverse event rates.AIM To perform a systematic review and meta-analysis of POP,EHL and LL for management of PDC in chronic pancreatitis.METHODS We conducted a comprehensive search of multiple electronic databases and conference proceedings including PubMed,EMBASE,Cochrane,Google Scholar and Web of Science databases(from 1999 to October 2019)to identify studies with patient age greater than 17 and any gender that reported on outcomes of POP,EHL and LL.The primary outcome assessed involved the pooled technical success and clinical success rate of POP.The secondary outcome included the pooled technical success and clinical success rate for EHL and LL.We also assessed the pooled rate of adverse events for POP,EHL and LL including a subgroup analysis for the rate of adverse event subtypes for POP:Hemorrhage,post-endoscopic retrograde cholangiopancreatography pancreatitis(PEP),perforation,abdominal pain,fever and infections.Technical success was defined as the rate of clearing pancreatic duct stones and clinical success as the improvement in pain.Randomeffects model was used for analysis.Heterogeneity between study-specific estimates was calculated using the Cochran Q statistical test and I2 statistics.Publication bias was ascertained,qualitatively by visual inspection of funnel plot and quantitatively by the Egger test.RESULTS A total of 16 studies including 383 patients met the inclusion criteria.The technical success rate of POP was 76.4%(95%CI:65.9-84.5;I2=64%)and clinical success rate was 76.8%(95%CI:65.2-85.4;I2=66%).The technical success rate of EHL was 70.3%(95%CI:57.8-80.3;I2=36%)and clinical success rate of EHL was 66.5%(95%CI:55.2-76.2;I2=19%).The technical success rate of LL was 89.3%(95%CI:70.5-96.7;I2=70%)and clinical success rate of LL was 88.2%(95%CI:66.4-96.6;I2=77%).The incidence of pooled adverse events for POP was 14.9%(95%CI:9.2-23.2;I2=49%),for EHL was 11.2%(95%CI:5.9-20.3;I2=15%)and for LL was 13.1%(95%CI:6.3-25.4;I2=31%).Subgroup analysis of adverse events showed rates of PEP at 7%(95%CI:3.5-13.6;I2=38%),fever at 3.7%(95%CI:2-6.9;I2=0),abdominal pain at 4.7%(95%CI:2.7-7.8;I2=0),perforation at 4.3%(95%CI:2.1-8.4;I2=0),hemorrhage at 3.4%(95%CI:1.7-6.6;I2=0)and no mortality.There was evidence of publication bias based on funnel plot analysis and Egger’s test.CONCLUSION Our study highlights the high technical and clinical success rates for POP,EHL and LL.POP-guided lithotripsy could be a viable option for management of chronic pancreatitis with PDC. | Syed M Saghir Harmeet S Mashiana Babu P Mohan Banreet S Dhindsa Amaninder Dhaliwal Saurabh Chandan Neil Bhogal Ishfaq Bhat Shailender Singh Douglas G Adler | 2020 | World Journal of Gastroenterology2020，26，34： | 5 |
| 2 | Revisiting the essential role of oxygen in wound healing显示文摘 | Gayle M Gordillo Chandan K Sen | 2003 | The American Journal of Surgery2003，，3： | 2 |
| 3 | A rapid and sensitive assay of muramidase显示文摘 | Parry R M Chandan R C Shahani K M | 1965 | Proc Soc Exp Biol Med1965，119，： | 1 |
| 4 | Nutritional and healthful aspects of cultured and culture-containing dairy foods显示文摘 | K M Shahani R C Chandan | 1979 | J Dairy Sci1979，62，10： | 1 |
| 5 | High temperature (HT) polymer electrolyte membrane fuel cells (PEMFC) : A review显示文摘 | Chandan A Hattenberger M El-kharouf A | 2013 | Journal of Power Sources2013，231，1： | 1 |
| 6 | Synthesis of 9- D-glycopyranosyl xanthotoxol and CNS depressant activity of 9-D-arabinopyranosyl xanthotoxol 显示文摘 | Jain S M Anand K K Chandan B K | 1987 | Indian Journal of Pharmaceutical Sciences1987，49，1： | 1 |
| 7 | Fixed Points in a Hopfield Model with Random Asymmetric Interactions 显示文摘 | Zhang Cheng-xiang Chandan Dasgupta | 1995 | Phys Rev1995，52，： | 1 |
| 8 | Retrieval Properties of a Hopfield Model with Random Asymmetric Interactions 显示文摘 | Chandan Dasgupta Singh M P | 2000 | Neural Computation2000，12，： | 1 |
| 9 | Nutritional and healthful aspects of euhured and culture-containing dairy roods显示文摘 | Shahani K M Chandan R C | 1979 | Journal of Dairy Science1979，62，10： | 1 |
| 10 | Oxidation of an o-Iminobenzosemiquinone radical ligand by molecular bromine: Structural, spectroscopic, and reactivity studies of a copper(II) o-iminobenzoquinone complex显示文摘 | Chandan M Thomas W Eberhard B | 2008 | Inorg Chem2008，47，7： | 1 |
| 11 | Poly(amidoamine) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy显示文摘 | Istvan J M Thommey P T Chandan B M | 2005 | Journal of Medicinal Chemistry2005，48，： | 1 |
| 12 | Isolation and characterization of human milk lysozyme显示文摘 | R M Parry jr R C Chandan K M Shahani | | 0，，： | 1 |
| 13 | Isolation and characterization of human milk lysozyme显示文摘 | Parry R M Chandan R C Shahani K M | 1969 | Arch Biochem Biophys1969，130，： | 1 |
| 14 | A rapid and sensitive assay of muramidase显示文摘 | PARRY R M CHANDAN R C SHAHANI K M | 1965 | Proceedings of the Society for Experimental Biology and Medicine1965，119，： | 1 |
| 15 | Model reference adaptive controller-based rotor resistance and speed estimation techniques for vector controlled induction motor drive utilizing reactive power显示文摘 | Suman M Chandan C Yoichi H | 2008 | IEEE Transactions on Industrial electronics2008，55，2： | 1 |
| 16 | Model reference adaptive controller-based rotor resistance and speed estimation techniques for vector controlled induction motor drive utilizing re-active power显示文摘 | SUMAN M CHANDAN C YOICHI HORI | | 0，，2： | 1 |
| 17 | Evolu- tion of phases in Pgl steel in various heat treatment conditions and their effect on microstructure stability and mechanical properties 显示文摘 | Pandey Chandan Giri Anoj Mahapatra M M | 2016 | Materials Science and Engineering(A)2016，664，5： | 1 |
| 18 | CAIDSA:Computer-aided intelligent diagnostic system for bronchial asthma显示文摘 | Chandan C Tamoghna M Amaradri M | 2009 | Expert Systems with Applications2009，36，1： | 1 |
| 19 | Characterization of pearl millet protein fractions显示文摘 | Chandan M Matta N K | 1990 | Phytochemistry (Oxford)1990，29，11： | 1 |
| 20 | Dynamic strain ageing of an austenitic superalloy: Temperature and strain rate effects显示文摘 | AJIT K R JOYDEEP P CHANDAN M | 2008 | Materials Science and Engi- neering A2008，474，12： | 1 |
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