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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 3 | Reproducibility of transmission line measurement of bipolar I-V characteristics of MOSFET's 显示文摘 | CHEN T P CHAN R | 1999 | IEEE Trans Instrum and Measur1999，48，3： | 1 |
| 4 | A multicenter trial of photorefractive keratectomy for residual myopia after previous ocular surgery显示文摘 | Maloney RK chan WK Steinert R Hersh P O' Connell M | 1995 | Ophthalmology1995，102，7： | 1 |
| 5 | Investigation of crystallinity effects on the surface of oxygen plasma treated low density polyethylene using X-ray photoelectron spectroscopy显示文摘 | Kwang S K Chang M R Chan S P | 2003 | Polymer2003，，44： | 1 |
| 6 | Oxidative stress and diabetic retinopathy显示文摘 | Kowluru R A Chan P S | | 0，，： | 1 |
| 7 | Evaluating the product quality level under multiple L-type quality characteristics显示文摘 | CHAN W M IBRAHIM R N LOCHERT P B | 2005 | International Journal of Advanced Manufacturing Technology2005，27，12： | 1 |
| 8 | Synthesis and spectroscopic properties of heteroleptic Sandwich Complexes with the Porphyrin/Phthalocyanine/Porphyrin Ligand System显示文摘 | J Jiang R L C Lau T W D Chan T C W Mak D K P Ng | 1997 | Inorg Chim Acta1997，255，： | 1 |
| 9 | Plasma concentrations of plant ste-rols:physiology and relationship with coronary heart disease显示文摘 | Chan Y M Varady K A Lin Y Trautwein E Mensink R P Plat J | 2006 | Nutr Rev2006，64，： | 1 |
| 10 | Subchronic toxici-ty of a medium-chain chlorinated paraffin in the rat显示文摘 | Poon R Lecavalier P Chan P | | 0，，06： | 1 |
| 11 | Coordination and virtualization: The role of electronic networks and personal relationships显示文摘 | Kraut R Steinfield C Chan A P | 1999 | Organization Science1999，10，6： | 1 |
| 12 | Effect of atorvastatin and fish oil on plasma high-sensitivity C-reactive protein concentrations in individuals with visceral obesity显示文摘 | CHAN D C WATTS G F BARRETT P H R | 2002 | Clin Chem2002，48，6： | 1 |
| 13 | Near surface char- acteristics of concrete: abrasion resistance 显示文摘 | Dhir R K Hewlett P C Chan Y N | 1991 | Mater Struct1991，24，： | 1 |
| 14 | Using case - based reasoning to e- valuate supplier environmental management performance 显示文摘 | Humphreys P McIvor R Chan F | 2003 | Expert Systems with Applications2003，，2： | 1 |
| 15 | The effects of ulnar styloid fractures on patients sustaining distal radius fi-actures 显示文摘 | Daneshvar P Chan R MacDermid J | 2014 | Journal of hand surgery2014，39，10： | 1 |
| 16 | Mercury as a global pollutant: sources, pathways, and effects显示文摘 | Driscoll C T Mason R P Chan H M | 2013 | Environmental Science & technology2013，47，10： | 1 |
| 17 | Evaluation of the analytical and clinical performance of the Elecsys CA 15-3 immunoassay显示文摘 | Stieber P Molina R Chan DW | 2001 | Clin Chem2001，47，21： | 1 |
| 18 | Bacterial Clp Bheat-shock protein,an antigen-mimetic of the anorexigenic peptideα-MSH,at the origin of eating disorders显示文摘 | Tennoune N Chan P Breton J Legrand R Chabane YN Akkermann K | 2014 | Transl Psychiatry2014，4，： | 1 |
| 19 | Embolotherapy of pulmonary arteriovenous malformations: efficacy of platinum versus stainless steel coils显示文摘 | Prasd V Chan R P Faughnan M E | 2004 | J Vasc Interv Radiol2004，15，2： | 1 |
| 20 | Synthesis, structure, and superconductivity in B%09 ]33 显示文摘 | Chan J Y Fronczek F R Young D P | 2002 | J Solid State Chem2002，163，2： | 1 |
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